JP6339548B2 - 微細藻類における異種ポリペプチド、微細藻類細胞外体、組成物の産生、ならびにそれらの作製および使用の方法 - Google Patents
微細藻類における異種ポリペプチド、微細藻類細胞外体、組成物の産生、ならびにそれらの作製および使用の方法 Download PDFInfo
- Publication number
- JP6339548B2 JP6339548B2 JP2015206158A JP2015206158A JP6339548B2 JP 6339548 B2 JP6339548 B2 JP 6339548B2 JP 2015206158 A JP2015206158 A JP 2015206158A JP 2015206158 A JP2015206158 A JP 2015206158A JP 6339548 B2 JP6339548 B2 JP 6339548B2
- Authority
- JP
- Japan
- Prior art keywords
- protein
- membrane
- extracellular body
- schizochytrium
- microalgal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/12—Unicellular algae; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16123—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
- C12N2760/16152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29046909P | 2009-12-28 | 2009-12-28 | |
US29044109P | 2009-12-28 | 2009-12-28 | |
US61/290,441 | 2009-12-28 | ||
US61/290,469 | 2009-12-28 | ||
US41335310P | 2010-11-12 | 2010-11-12 | |
US61/413,353 | 2010-11-12 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012547250A Division JP5838496B6 (ja) | 2009-12-28 | 2010-12-28 | 微細藻類における異種ポリペプチド、微細藻類細胞外体、組成物の産生、ならびにそれらの作製および使用の方法 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018091280A Division JP6666950B2 (ja) | 2009-12-28 | 2018-05-10 | 微細藻類における異種ポリペプチド、微細藻類細胞外体、組成物の産生、ならびにそれらの作製および使用の方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016047055A JP2016047055A (ja) | 2016-04-07 |
JP6339548B2 true JP6339548B2 (ja) | 2018-06-06 |
Family
ID=44307127
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015206158A Active JP6339548B2 (ja) | 2009-12-28 | 2015-10-20 | 微細藻類における異種ポリペプチド、微細藻類細胞外体、組成物の産生、ならびにそれらの作製および使用の方法 |
JP2018091280A Active JP6666950B2 (ja) | 2009-12-28 | 2018-05-10 | 微細藻類における異種ポリペプチド、微細藻類細胞外体、組成物の産生、ならびにそれらの作製および使用の方法 |
JP2023072538A Active JP7585382B2 (ja) | 2009-12-28 | 2023-04-26 | 微細藻類における異種ポリペプチド、微細藻類細胞外体、組成物の産生、ならびにそれらの作製および使用の方法 |
JP2025081042A Pending JP2025114812A (ja) | 2009-12-28 | 2025-05-14 | 微細藻類における異種ポリペプチド、微細藻類細胞外体、組成物の産生、ならびにそれらの作製および使用の方法 |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018091280A Active JP6666950B2 (ja) | 2009-12-28 | 2018-05-10 | 微細藻類における異種ポリペプチド、微細藻類細胞外体、組成物の産生、ならびにそれらの作製および使用の方法 |
JP2023072538A Active JP7585382B2 (ja) | 2009-12-28 | 2023-04-26 | 微細藻類における異種ポリペプチド、微細藻類細胞外体、組成物の産生、ならびにそれらの作製および使用の方法 |
JP2025081042A Pending JP2025114812A (ja) | 2009-12-28 | 2025-05-14 | 微細藻類における異種ポリペプチド、微細藻類細胞外体、組成物の産生、ならびにそれらの作製および使用の方法 |
Country Status (9)
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI350854B (en) | 2001-04-16 | 2011-10-21 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
TWI504749B (zh) * | 2009-03-16 | 2015-10-21 | Dsm Ip Assets Bv | 於網黏菌門微生物中生產蛋白質之技術 |
CA2785653C (en) * | 2009-12-28 | 2018-05-01 | Merial Limited | Recombinant ndv antigen and uses thereof |
CN103068984B (zh) * | 2009-12-28 | 2017-12-01 | Dsm Ip资产公司 | 微藻中血凝素‑神经氨酸酶蛋白的生产 |
EP2444495A1 (en) * | 2010-10-20 | 2012-04-25 | Algenics | Secretion of recombinant polypeptides in the extracellular medium of diatoms |
CN107630017A (zh) * | 2011-03-07 | 2018-01-26 | Dsm营养产品股份公司 | 工程化破囊壶菌属微生物 |
US9404101B2 (en) * | 2011-08-24 | 2016-08-02 | Novozymes, Inc. | Methods for obtaining positive transformants of a filamentous fungal host cell |
CA2879680A1 (en) * | 2012-07-24 | 2014-01-30 | Bp Corporation North America Inc. | Xylose isomerases and their uses |
WO2014045191A2 (en) * | 2012-09-18 | 2014-03-27 | Myko Tech Private Limited | Extracellular polysaccharides from labyrinthulomycetes with broad-spectrum antiviral activities |
EP3200606B1 (de) * | 2014-10-02 | 2021-03-31 | Evonik Operations GmbH | Verfahren zur herstellung eines pufas enthaltenden futtermittels durch extrusion einer pufas enthaltenden biomasse des typs labyrinthulomycetes |
EP3200603A1 (de) | 2014-10-02 | 2017-08-09 | Evonik Degussa GmbH | Pufas enthaltendes futtermittel mit hoher abriebfestigkeit und hoher wasserstabilität |
US11324234B2 (en) | 2014-10-02 | 2022-05-10 | Evonik Operations Gmbh | Method for raising animals |
ES2870093T3 (es) | 2014-10-02 | 2021-10-26 | Evonik Operations Gmbh | Biomasa que contiene PUFA con estabilidad celular elevada y su empleo para la producción de piensos |
EP3265567B1 (en) | 2015-03-02 | 2020-07-29 | Conagen Inc. | Regulatory elements from labyrinthulomycetes microorganisms |
AU2016293487B2 (en) | 2015-07-13 | 2021-07-01 | MARA Renewables Corporation | Enhancing microalgal metabolism of xylose |
FR3038913B1 (fr) * | 2015-07-17 | 2020-05-01 | Fermentalg | Biomasse de thraustochytrides, procede de culture et utilisations |
US20190216857A1 (en) * | 2016-09-09 | 2019-07-18 | Cornell University | Delivery of nucleic acids, proteins and small molecules in vitreous vesicular bodies |
US10633454B2 (en) | 2016-11-01 | 2020-04-28 | Conagen Inc. | Expression of modified glycoproteins and glycopeptides |
EP3544994B1 (en) | 2016-11-27 | 2024-09-25 | Triton Algae Innovations, Inc. | Method of purification of recombinant osteopontin from microalgae |
CN111954713A (zh) * | 2018-03-05 | 2020-11-17 | 科纳根公司 | 用于产生具有低硫酸化的糖分子的生物体和方法 |
WO2020004144A1 (ja) | 2018-06-27 | 2020-01-02 | 住友電気工業株式会社 | フレキシブルプリント配線板の原形体、フレキシブルプリント配線板の製造方法、集光型太陽光発電モジュール、及び、発光モジュール |
US11752175B2 (en) | 2018-09-21 | 2023-09-12 | Cornell University | Compositions and methods for glaucoma |
CN109161576B (zh) * | 2018-09-26 | 2020-08-07 | 武汉中科光谷绿色生物技术有限公司 | 促进枯草芽孢杆菌发酵生产n-乙酰神经氨酸的方法 |
WO2021100642A1 (ja) * | 2019-11-21 | 2021-05-27 | パナソニックIpマネジメント株式会社 | 改変シアノバクテリア、改変シアノバクテリアの製造方法、及び、タンパク質の製造方法 |
IT201900024580A1 (it) | 2019-12-18 | 2021-06-18 | Consiglio Nazionale Ricerche | Vescicole extracellulari da microalghe |
CN111363045B (zh) * | 2020-02-18 | 2021-12-17 | 厦门大学 | 一种流感、hiv嵌合蛋白及嵌合病毒疫苗的制备方法 |
CN111621471B (zh) * | 2020-06-12 | 2022-03-11 | 成都世联康健生物科技有限公司 | 一种软组织胞外囊泡的提取方法及应用 |
CN112452506A (zh) * | 2020-11-06 | 2021-03-09 | 五原县沃丰生物科技有限责任公司 | 一种培养基粉末的生产方法 |
US11175293B1 (en) | 2021-01-04 | 2021-11-16 | University Of Utah Research Foundation | Rapid assay for detection of SARS-CoV-2 antibodies |
US20240287443A1 (en) * | 2021-06-24 | 2024-08-29 | Reliance Industries Limited | Recombinant algae and production of spider silk protein from the recombinant algae |
CN113698451B (zh) * | 2021-08-02 | 2023-04-11 | 广东海洋大学 | 一种微藻多肽及其制备方法和应用 |
EP4426346A1 (en) | 2021-11-05 | 2024-09-11 | Sanofi Pasteur, Inc. | Multivalent influenza vaccines comprising recombinant hemagglutinin and neuraminidase and methods of using the same |
CN118302190A (zh) | 2021-11-05 | 2024-07-05 | 赛诺菲 | 包含血凝素和神经氨酸酶的杂合多价流感疫苗及其使用方法 |
CA3239417A1 (en) | 2021-11-30 | 2023-06-08 | Yvonne CHAN | Human metapneumovirus vaccines |
WO2023232976A1 (en) * | 2022-06-03 | 2023-12-07 | Ags Therapeutics Sas | Extracellular vesicles from genetically-modified microalgae containing endogenously-loaded cargo, their preparation, and uses |
EP4525900A1 (en) | 2022-06-14 | 2025-03-26 | Hun-Ren Támogatott Kutatócsoportok Irodája | Extracellular vesicles for use in therapy |
CN115992052A (zh) * | 2022-11-18 | 2023-04-21 | 暨南大学 | 一种微藻类外泌体、其制备方法和应用 |
JP7546136B1 (ja) | 2023-12-27 | 2024-09-05 | ロート製薬株式会社 | 微細藻類由来の細胞外小胞を含有する組成物 |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4659669A (en) * | 1981-03-02 | 1987-04-21 | Regents Of The Univ. Of California | Microbial expression of human influenza hemagglutinin proteins |
US4752473A (en) * | 1984-10-12 | 1988-06-21 | The Regents Of The University Of California | Expression of glycosylated human influenza hemagglutinin proteins |
US5340742A (en) | 1988-09-07 | 1994-08-23 | Omegatech Inc. | Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids |
US5762939A (en) * | 1993-09-13 | 1998-06-09 | Mg-Pmc, Llc | Method for producing influenza hemagglutinin multivalent vaccines using baculovirus |
PT733113E (pt) * | 1994-01-11 | 2007-08-10 | Vlaams Interuniv Inst Biotech | Vacina contra a gripe |
US5824309A (en) * | 1995-12-05 | 1998-10-20 | University Of Massachusetts | Recombinant gas vesicles and uses thereof |
US8003772B2 (en) | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
KR20000075076A (ko) * | 1999-05-28 | 2000-12-15 | 최태진 | 형질전환된 미세조류를 이용하여 외래 단백질을 생산하는 방법 |
DK1294892T3 (da) * | 2000-06-23 | 2008-01-28 | Wyeth Corp | Aggregering af vildtype- og kimære influenzaviruslignende partikler (VLP'er) |
US20060029604A1 (en) | 2000-06-28 | 2006-02-09 | Gerngross Tillman U | Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform |
US7625756B2 (en) | 2000-06-28 | 2009-12-01 | GycoFi, Inc. | Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells |
US20060257399A1 (en) | 2000-06-28 | 2006-11-16 | Glycofi, Inc. | Immunoglobulins comprising predominantly a Man5GIcNAc2 glycoform |
EP2322644A1 (en) | 2000-06-28 | 2011-05-18 | GlycoFi, Inc. | Methods for producing modified glycoproteins |
US7795002B2 (en) | 2000-06-28 | 2010-09-14 | Glycofi, Inc. | Production of galactosylated glycoproteins in lower eukaryotes |
TWI350854B (en) * | 2001-04-16 | 2011-10-21 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
AU2007249124B2 (en) * | 2001-04-16 | 2012-05-17 | Dsm Ip Assets B.V. | Product and process for transformation of thraustochytriales microorganisms |
AU2003213060A1 (en) * | 2002-02-14 | 2003-09-04 | Novavax, Inc. | Optimization of gene sequences of chimeric virus-like particles for expression in insect cells |
WO2004042001A2 (en) * | 2002-05-17 | 2004-05-21 | Emory University | Virus-like particles, methods of preparation, and immonogenic compositions |
US7332299B2 (en) * | 2003-02-20 | 2008-02-19 | Glycofi, Inc. | Endomannosidases in the modification of glycoproteins in eukaryotes |
WO2005047501A1 (en) * | 2003-02-24 | 2005-05-26 | Johns Hopkins University | Molecular vaccines employing nucleic acid encoding anti-apoptotic proteins |
AU2004265232A1 (en) * | 2003-06-05 | 2005-02-24 | Wyeth Holdings Corporation | Immunogenic compositions comprising venezuelan equine encephalitis virus replicon vectors and paramyxovirus protein antigens |
WO2005116258A2 (en) * | 2004-05-25 | 2005-12-08 | Medimmune Vaccines, Inc. | Influenza hemagglutinin and neuraminidase varians |
US8936930B2 (en) * | 2004-08-05 | 2015-01-20 | Ben-Gurion University Of The Negev Research And Development Authority | Red microalgae expressing exogenous polypeptides and methods of generating and utilizing same |
WO2006073970A2 (en) * | 2005-01-06 | 2006-07-13 | The Johns Hopkins University | Rna interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by dna and transfected dendritic cell vaccines |
JP4796786B2 (ja) * | 2005-04-28 | 2011-10-19 | 富士フイルム株式会社 | ラビリンチュラ類を形質転換可能なベクター |
JP4796787B2 (ja) | 2005-04-28 | 2011-10-19 | 富士フイルム株式会社 | ラビリンチュラ類への遺伝子導入法 |
US9216212B2 (en) * | 2005-08-05 | 2015-12-22 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
US20070042001A1 (en) * | 2005-08-16 | 2007-02-22 | Hawaii Biotech, Inc. | Influenza recombinant subunit vaccine |
EP1991571A2 (en) * | 2006-02-16 | 2008-11-19 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Antiviral agents and vaccines against influenza |
CA2638760A1 (en) * | 2006-03-07 | 2007-09-13 | Vaxinnate Corporation | Compositions that include hemagglutinin, methods of making and methods of use thereof |
EP2004835A4 (en) * | 2006-03-15 | 2011-02-23 | Martek Biosciences Corp | MERHFACH UNSATURATED FATTY ACIDS CONTAINING PLANT SEA OILS |
WO2007130327A2 (en) * | 2006-05-01 | 2007-11-15 | Technovax, Inc. | Influenza virus-like particle (vlp) compositions |
AU2007345682B2 (en) * | 2006-07-27 | 2013-07-18 | Ligocyte Pharmaceuticals, Inc. | Chimeric virus-like particles |
US20100330105A1 (en) * | 2006-08-22 | 2010-12-30 | John Hopkins University | Anticancer Combination Therapies |
CA2615372A1 (en) * | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
EP2238253B1 (en) * | 2007-11-27 | 2012-09-12 | Medicago Inc. | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
EP2090648A1 (en) * | 2008-02-12 | 2009-08-19 | Institut Francais de Recherche pour l'Exploitation de la Mere(Ifremer) | Production of glycosylated polypeptides in microalgae |
KR20090096890A (ko) * | 2008-03-10 | 2009-09-15 | 전남대학교산학협력단 | 대장균에서 조류인플루엔자 바이러스의 뉴라미니다제 n1을발현하기 위한 벡터 및 방법, 이의 사용방법, 및뉴라미니다제 저해제 |
FR2928926B1 (fr) * | 2008-03-18 | 2015-08-21 | Centre Nat Rech Scient | Polynucleotides et polypeptides chimeriques permettant la secretion d'un polypeptide d'interet en association avec des exosomes et leur utilisation pour la production de compositions immunogenes |
EP2260010A4 (en) * | 2008-03-19 | 2012-07-11 | Momentive Specialty Chemicals Res Belgium | ADJUVANT FOR CONCRETE AND CEMENT FORMULATIONS AND PROCESSES FOR PREPARING THE SAME |
TWI504749B (zh) | 2009-03-16 | 2015-10-21 | Dsm Ip Assets Bv | 於網黏菌門微生物中生產蛋白質之技術 |
CN103068984B (zh) * | 2009-12-28 | 2017-12-01 | Dsm Ip资产公司 | 微藻中血凝素‑神经氨酸酶蛋白的生产 |
CA2785653C (en) * | 2009-12-28 | 2018-05-01 | Merial Limited | Recombinant ndv antigen and uses thereof |
-
2010
- 2010-12-28 EP EP22181704.2A patent/EP4130273B1/en active Active
- 2010-12-28 CA CA3028175A patent/CA3028175C/en active Active
- 2010-12-28 CA CA3153553A patent/CA3153553A1/en active Pending
- 2010-12-28 WO PCT/US2010/062276 patent/WO2011090731A1/en active Application Filing
- 2010-12-28 EA EA201290567A patent/EA022841B1/ru unknown
- 2010-12-28 AU AU2010343095A patent/AU2010343095B2/en active Active
- 2010-12-28 EP EP18205786.9A patent/EP3505632B1/en active Active
- 2010-12-28 EP EP10844276.5A patent/EP2519635B1/en active Active
- 2010-12-28 US US12/980,319 patent/US20110189228A1/en not_active Abandoned
- 2010-12-28 CN CN201710860445.0A patent/CN107746869A/zh active Pending
- 2010-12-28 CN CN201080064882.8A patent/CN102822343B/zh active Active
- 2010-12-28 IN IN6277DEN2012 patent/IN2012DN06277A/en unknown
- 2010-12-28 CA CA2785971A patent/CA2785971C/en active Active
-
2014
- 2014-10-17 US US14/516,634 patent/US20150110826A1/en not_active Abandoned
-
2015
- 2015-10-20 JP JP2015206158A patent/JP6339548B2/ja active Active
-
2017
- 2017-04-03 AU AU2017202195A patent/AU2017202195B2/en active Active
-
2018
- 2018-05-10 JP JP2018091280A patent/JP6666950B2/ja active Active
-
2019
- 2019-07-17 AU AU2019206054A patent/AU2019206054B2/en active Active
- 2019-09-03 US US16/559,103 patent/US20200063174A1/en active Pending
-
2022
- 2022-06-08 AU AU2022203980A patent/AU2022203980B2/en active Active
-
2023
- 2023-04-26 JP JP2023072538A patent/JP7585382B2/ja active Active
-
2025
- 2025-05-14 JP JP2025081042A patent/JP2025114812A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6666950B2 (ja) | 微細藻類における異種ポリペプチド、微細藻類細胞外体、組成物の産生、ならびにそれらの作製および使用の方法 | |
JP5838473B2 (ja) | 微細藻類におけるヘマグルチニン−ノイラミニダーゼタンパク質の産生方法 | |
EA034733B1 (ru) | Нуклеиновая кислота для увеличенной экспрессии гемагглютинина вируса гриппа в растении и ее применение | |
KR20210024625A (ko) | 인플루엔자 바이러스 헤마글루티닌 돌연변이들 | |
CN111315408A (zh) | 在嗜热毁丝霉(myceliophthora thermophila)中生产流感疫苗 | |
JP5838496B6 (ja) | 微細藻類における異種ポリペプチド、微細藻類細胞外体、組成物の産生、ならびにそれらの作製および使用の方法 | |
WO2016078466A1 (zh) | 用糖基工程酵母制备具有动物细胞糖基化修饰流感血凝素糖蛋白的方法 | |
KR102568329B1 (ko) | 조류인플루엔자 뉴라미니다아제를 포함하는 바이러스-유사입자 및 이를 이용한 범용 백신 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160825 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20161122 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170329 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20171101 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20171102 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20180411 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20180510 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6339548 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |