JP6336067B2 - 関節症の場合のペプスタチンの関節内適応 - Google Patents

関節症の場合のペプスタチンの関節内適応 Download PDF

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Publication number
JP6336067B2
JP6336067B2 JP2016532244A JP2016532244A JP6336067B2 JP 6336067 B2 JP6336067 B2 JP 6336067B2 JP 2016532244 A JP2016532244 A JP 2016532244A JP 2016532244 A JP2016532244 A JP 2016532244A JP 6336067 B2 JP6336067 B2 JP 6336067B2
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JP
Japan
Prior art keywords
pepstatin
intra
arthropathy
cathepsin
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2016532244A
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English (en)
Japanese (ja)
Other versions
JP2016527284A (ja
JP2016527284A5 (enExample
Inventor
クライン,マルクス
ヴォドピア,ラルフ
グーリンク,ハンス
リンデマン,スヴェン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
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Publication date
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Publication of JP2016527284A5 publication Critical patent/JP2016527284A5/ja
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Publication of JP6336067B2 publication Critical patent/JP6336067B2/ja
Expired - Fee Related legal-status Critical Current
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016532244A 2013-08-06 2014-07-07 関節症の場合のペプスタチンの関節内適応 Expired - Fee Related JP6336067B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13003923.3 2013-08-06
EP13003923 2013-08-06
PCT/EP2014/001861 WO2015018472A1 (de) 2013-08-06 2014-07-07 Intraartikuläre applikation von pepstatin bei arthrose

Publications (3)

Publication Number Publication Date
JP2016527284A JP2016527284A (ja) 2016-09-08
JP2016527284A5 JP2016527284A5 (enExample) 2017-08-17
JP6336067B2 true JP6336067B2 (ja) 2018-06-06

Family

ID=48948200

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016532244A Expired - Fee Related JP6336067B2 (ja) 2013-08-06 2014-07-07 関節症の場合のペプスタチンの関節内適応

Country Status (9)

Country Link
US (2) US9750784B2 (enExample)
EP (1) EP3030250B1 (enExample)
JP (1) JP6336067B2 (enExample)
CN (1) CN105451754A (enExample)
AU (1) AU2014304950B2 (enExample)
CA (1) CA2920420C (enExample)
ES (1) ES2759060T3 (enExample)
IL (1) IL243983B (enExample)
WO (1) WO2015018472A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020235567A1 (ja) * 2019-05-21 2020-11-26 国立大学法人 東京大学 脳腫瘍の検出用蛍光プローブ

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3906085A (en) * 1973-05-21 1975-09-16 Lilly Co Eli Determination of hypertension associated with elevated renin levels
CA1286846C (en) 1985-02-12 1991-07-23 Catherine Cazaubon Peptide derivatives which inhibit renin and acid proteases
US6251928B1 (en) 1994-03-16 2001-06-26 Eli Lilly And Company Treatment of alzheimer's disease employing inhibitors of cathepsin D
JP2001510474A (ja) 1997-02-04 2001-07-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア カテプシンdのナノモルの非ペプチド阻害剤
US5962506A (en) 1997-07-07 1999-10-05 Pharmacopeia, Inc. Glycol and hydroxyphosphonate peptidomimetics as inhibitors of aspartyl proteases
US5986102A (en) 1998-04-29 1999-11-16 Pharmacopeia, Inc. Hydroxypropylamide peptidomimetics as inhibitors of aspartyl proteases
JP2000300266A (ja) 1999-04-20 2000-10-31 St Marianna Univ School Of Medicine ポリペプチド及びdna
CA2489095A1 (en) 2002-06-17 2003-12-24 Sunesis Pharmaceuticals, Inc. Aspartyl protease inhibitors
JP4448134B2 (ja) 2003-08-08 2010-04-07 シェーリング コーポレイション ベンズアミド置換基を有する環状アミンbase−1阻害剤
EP1654380A4 (en) * 2003-08-14 2009-09-09 Insight Biopharmaceuticals Ltd METHODS AND PHARMACEUTICAL COMPOSITIONS FOR MODULATING HEPARANASE ACTIVATION AND USES THEREOF
GB0325830D0 (en) 2003-11-05 2003-12-10 Novartis Ag Organic compounds
US20050239836A1 (en) 2004-03-09 2005-10-27 Varghese John Substituted hydroxyethylamine aspartyl protease inhibitors
CA2558249A1 (en) 2004-03-09 2005-09-22 Elan Pharmaceuticals, Inc. Substituted urea and carbamate, phenacyl-2-hydroxy-3-diaminoalkane, and benzamide-2-hydroxy-3-diaminoalkane aspartyl-protease inhibitors
EP1851208A1 (en) 2005-01-13 2007-11-07 Novartis AG Macrocyclic compounds useful as bace inhibitors
CN101193892A (zh) 2005-06-14 2008-06-04 先灵公司 大环杂环天冬氨酰基蛋白酶抑制剂
US20070021413A1 (en) 2005-07-20 2007-01-25 Peter Herold Diamino alcohols as therapeutic compounds
US20070021400A1 (en) 2005-07-20 2007-01-25 Peter Herold Amino alcohols as therapeutic compounds
US20070021399A1 (en) 2005-07-20 2007-01-25 Peter Herold Amido-amino alcohols as therapeutic compounds
GB0526614D0 (en) 2005-12-30 2006-02-08 Novartis Ag Organic compounds
EP1867329A3 (en) 2006-06-14 2008-05-07 Speedel Experimenta AG 5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamides as therapeutic compounds
EP1872780A3 (en) 2006-06-14 2008-04-30 Speedel Experimenta AG Omega-Phenyloctanamides as therapeutic compounds
EP1987834A3 (en) 2007-02-13 2008-11-19 Speedel Experimenta AG Substituted piperidines as therapeutic compounds
WO2008119772A1 (en) 2007-03-30 2008-10-09 Medivir Ab Amide derivatives as inhibitors of aspartyl proteases
WO2009013293A1 (en) 2007-07-24 2009-01-29 Novartis Ag Substituted cyclohexanecarboxamides useful as bace inhibitors
CA2826622C (en) * 2011-02-08 2021-03-02 Merck Patent Gmbh Aminostatin derivatives for the treatment of arthrosis
AU2013307688A1 (en) * 2012-08-29 2015-04-09 Merck Patent Gmbh Ddr2 inhibitors for the treatment of osteoarthritis

Also Published As

Publication number Publication date
IL243983B (en) 2020-04-30
US9750784B2 (en) 2017-09-05
EP3030250B1 (de) 2019-08-28
AU2014304950A1 (en) 2016-03-17
CN105451754A (zh) 2016-03-30
JP2016527284A (ja) 2016-09-08
CA2920420A1 (en) 2015-02-12
US20170348380A1 (en) 2017-12-07
CA2920420C (en) 2021-11-23
AU2014304950B2 (en) 2019-09-12
WO2015018472A1 (de) 2015-02-12
IL243983A0 (en) 2016-04-21
ES2759060T3 (es) 2020-05-07
US20160175381A1 (en) 2016-06-23
EP3030250A1 (de) 2016-06-15

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