JP6321401B2 - 化粧料 - Google Patents
化粧料 Download PDFInfo
- Publication number
- JP6321401B2 JP6321401B2 JP2014032308A JP2014032308A JP6321401B2 JP 6321401 B2 JP6321401 B2 JP 6321401B2 JP 2014032308 A JP2014032308 A JP 2014032308A JP 2014032308 A JP2014032308 A JP 2014032308A JP 6321401 B2 JP6321401 B2 JP 6321401B2
- Authority
- JP
- Japan
- Prior art keywords
- extract
- yellow
- lactic acid
- root
- fermentation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000004310 lactic acid Substances 0.000 claims description 67
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Landscapes
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Description
具体的には特許文献1には抗酸化、抗炎症、美白作用のある皮膚外用組成物の記載が、特許文献2には線維芽細胞賦活作用、チロシナーゼ活性抑制作用の記載が、特許文献3には脂肪組織の分解を促進することによる痩身効果の記載が、特許文献4にはむくみ防止・改善効果、肌のひきしめ効果の記載が、特許文献5にはタンパク質糖化抑制作用によるシワ改善作用、くすみ改善作用の記載が、特許文献6にはTie2活性化効果により、血管の正常化又は安定化によるしわ防止・改善効果の記載が示されている。しかし、これらの効果はいずれも黄花菜植物そのものの抽出物を利用した効果を記載しているものである。
一方、特許文献7には、ユリ科ワスレグサ属に属する植物をタンパク分解酵素等で処理した後、酵母で発酵させて、脱顆粒抑制作用とプロスタグランジンE2生成抑制作用、ラジカル消去作用が得られる発酵物を配合したことを特徴とする化粧料の例が記載されている。
付属的には、一つの有効成分で複数の肌悩みを一度に解決することが出来る有効成分を提供することを課題とする。
まず、本願発明の概要を説明する。
大きくは次の工程に分けられる。
(第一工程)黄花菜の根部を浸出させた浸出液を得る工程。
(第二工程)第一工程で得られた浸出液に、予め培養しておいた乳酸菌を植菌し、一定条件下で培養して発酵処理物を得る工程。
(第三工程)第二工程で得られた発酵処理物をろ過等により、発酵培養液と残渣に分ける工程。
(第四工程)第三工程で得られた残渣に更に溶媒等を加えて発酵抽出液を得る工程。
本願では、第三工程、第四工程で得られた有効物を利用する。
(1)浸出液とは、本願で用いる黄花菜の根部を精製水、エタノール等の溶媒で浸出させたものを言い、黄花菜の根部をろ過等により取り除く前の段階のものを指す。適宜熱を加えた、所謂植物抽出液も含まれる。
(2)培養前エキスとは、浸出液から黄花菜の根部をろ過等により、取り除いたものを指す。
(3)発酵処理物とは、浸出液に乳酸菌等を植菌し、一定期間培養したものを指す。
(4)発酵培養液とは、発酵処理物から、ろ過等により発酵させた根部を取り除いたものを指す。
(5)発酵抽出液とは、(4)にて取り除いた発酵済みの根部に、更に精製水などの抽出溶媒を加え、一定条件下で抽出した後、ろ過などにより残渣を取り除いたものを指す。
(6)発酵物とは、発酵培養液と発酵抽出液を合わせた総称である。
本願では、後に乳酸菌で処理した場合と酵母菌で処理した場合の比較実験を行っているが、両者を区別する為、「発酵処理物」を「乳酸菌発酵処理物」と、「発酵培養液」を「乳酸菌発酵培養液」と、「発酵抽出液」を「乳酸菌発酵抽出液」と表示する場合があるが同義である。
また、上記(1)から(6)に定義される処理を行うにあたり、乳酸菌に代えて酵母菌を使用した場合は、「酵母発酵処理物」、「酵母発酵培養液」、「酵母発酵抽出液」、「酵母発酵物」と称する。この場合において「酵母」を「酵母菌」と称する場合があるが、同義である。
まず、浸出しようとする黄花菜の根部を前記溶媒に浸漬、または分散させる。この場合、黄花菜の根部は生のまま用いても、又予め乾燥もしくは半乾燥した上用いてもよい。又、形状としては、採取したものをそのまま用いることもできるが、細断或いは粉砕して微細化すれば、後の発酵工程において発酵効率を上げることができる。本願発明においては、当該浸出液は、浸出させた黄花菜根部を取り除かないまま、次工程である発酵工程に供する。乳酸菌を植菌して発酵させることにより、黄花菜根部の組織を乳酸菌により分解させることが出来る。これにより、従来法による抽出では抽出できなかった成分も抽出が可能となり、今までにない効果を得られる。もっとも、浸出を十分に行っている場合等においては、根部から成分を十分抽出出来ているので、黄花菜根部を取り除いて使用しても差し支えない。この場合は抽出された成分が乳酸菌により発酵されて、新たな有効成分に変換される。その意味では、通常の植物エキスに該当する状態のものであっても浸出液として利用することが出来る。
加熱殺菌法としては、黄花菜を加えた発酵液を105〜121℃で10〜20分間加熱するオートクレーブ殺菌法や、黄花菜を加えた発酵液を80〜90℃に60〜120分間保持することを1日1回2〜3日間繰り返す間断殺菌法が一般に用いられる。もっとも、本殺菌工程は必須工程ではない。次工程の発酵工程において障害にならなければ、本殺菌工程を省いても差し支えない。
尚、発酵抽出液を得る際の抽出温度、及び抽出時間は目的に応じて適宜調整可能であるが、殺菌処理を兼ねて抽出温度は、80〜120℃、好ましくは90℃〜105℃である。抽出時間は、15〜120分間、好ましくは30〜60分間である。
乳酸菌は(独)製品評価技術基盤機構より分譲を受けたLactobacillus plantarum(NBRC 101975)を用いた。乳酸菌の培養はMRS培地にて、培地30mlに、分譲を受けた菌株の1白金耳を摂取し、30℃にて3日間静置培養を行い、乳酸菌培養液とした。(MRS培地組成:ペプトン10g、牛肉エキス10g、酵母エキス5g、グルコース20g、Tween80 1g、K2HPO4 2g、酢酸Na 5g、クエン酸二アンモニウム 2g、MgSO4・7H2O 0.2g、MnSO4・nH2O 0.05g、精製水1L)
乾燥黄花菜の根部10gにグルコース1gおよび精製水100mlを加え、室温で浸出させた。その後、105℃、15分間滅菌処理を行い、浸出液を得た。冷却後前記乳酸菌培養液5mlを前記浸出液に加えよく撹拌した。乳酸菌を植え付けた浸出液は30℃にて28日間静置培養を行い、黄花菜根部発酵処理物を得た。
得られた発酵処理物は、発酵工程を停止させる為、105℃、15分間の滅菌処理を行う。滅菌後、ろ布で培養液を絞り出す。ろ液は6,000rpm×10min.で遠心分離を行い、上清を取り効果試験の発酵培養液とした。さらに、ろ布に残った黄花菜の根部残渣1gに、精製水を10mlの割合で加え、105℃、15分間滅菌抽出した。滅菌抽出後、ろ布で抽出液を絞り出し、効果試験の黄花菜根部発酵抽出液とした。また、陰性対照物として[0042]で黄花菜を添加しない乳酸菌だけで培養を行った後、遠心分離処理を行った培養液(「無植物・発酵培養液」)を調製した。
黄花菜の根部浸出液に植菌する酵母菌の調製酵母菌は(独)製品評価技術基盤機構より分譲を受けたSaccharomyces cereviciae(NBRC 0308)を用いた。酵母菌の培養は、YNB(Yeast Nitrogen Base) with Ammonium Sulfate 合成培地にグルコースを2.0%添加した(以下、本明細書中では、YNB-SG培地と称す)培地50mlに分譲を受けた菌株の1白金耳を摂取し、25℃にて5日間静置培養を行い、酵母菌培養液とした。
<YNB-SG培地組成>
硫酸アンモニウム5,000、リン酸二水素カリウム1,000、硫酸マグネシウム500、塩化ナトリウム100、塩化カルシウム100、ビオチン0.002、パントテン酸カルシウム0.4、葉酸0.002、イノシトール2.0、ナイアシン0.4、パラアミノ安息香酸0.2、塩酸ピリドキシン0.4、リボフラビン0.2、塩酸チアミン0.4、ホウ酸0.5、硫酸銅0.04、ヨウ化カリウム0.1、塩化第二鉄0.2、硫酸マンガン0.4、モリブデン酸ナトリウム0.2、硫酸亜鉛0.4、グルコース20,000(単位は全てmg/L)。
乾燥黄花菜の根部10gにグルコース1gおよび精製水100mlを加え、室温で浸出させた。その後、105℃、15分間滅菌処理を行い、浸出液を得た。冷却後前記酵母菌培養液5mlを前記浸出液に加えよく撹拌した。酵母菌を植え付けた浸出液は25℃にて28日間静置培養を行い、酵母菌発酵処理物を得た。
得られた発酵処理物は、発酵工程を停止させる為、105℃、15分間の滅菌処理を行う。滅菌後、ろ布で培養液を絞り出す。ろ液は6,000rpm×10min.で遠心分離を行い、上清を取り効果試験の黄花菜の根部の酵母菌発酵培養液とした。さらに、ろ布に残った黄花菜の根部残渣1gに、精製水を10mlの割合で加え、105℃、15分間滅菌抽出した。滅菌抽出後、ろ布で抽出液を絞り出し、効果試験の黄花菜の根部の酵母菌発酵抽出液とした。また、陰性対照物として[0049][0050]で黄花菜を添加しない酵母菌だけで培養を行った後、遠心分離処理を行った培養液を調製した。
バリア機能が異常な皮膚においては、未分化状態の角質細胞が多く、正常な角層が形成されなくなっている。このため、肌の炎症が起こりやすく、またその炎症により、バリア機能が異常になるという悪循環を繰り返す原因となっている。
従って、細胞分化を促進することが出来れば、バリア機能改善効果が期待出来ると考えられる。
そこで、黄花菜の根部の乳酸菌発酵物の細胞分化促進効果を確認した。
細胞:Hacat細胞
培地:Humedia KG2
D-MEM (Ca濃度:1.8mM)
固定液:Mildform 10NM(和光純薬工業)
染色:0.05%ナフトールブルーブラック溶液(9%酢酸、0.1M酢酸ナトリウム)
ヒト表皮細胞であるHacat細胞をHumedia KG2(クラボウ)培地で培養した。
細胞を12 well plateに50%コンフルーエント程度に植え付け培養した。翌日各試料を添加した。添加後、72時間培養後に細胞を固定し、ナフトールブルーブラック溶液で染色し、細胞の形態を顕微鏡観察し、分化の程度を判定した。
表皮細胞であるケラチノサイトは分化すると細胞同士が接着し、無定形の形を取る。一方、未分化の細胞は一つ一つの細胞が独立し、お互いに接着しないことが一般に知られている。ケラチノサイトの分化は培地内のCa濃度により促進される。[図-1]の写真のようにHacat細胞をCa濃度1.8mMのD-MEM培地で培養すると細胞は完全に分化し(評価点5番の写真に該当)、Ca濃度が低いHumedia KG2培地では細胞は未分化の状態で増殖する(評価点1番の写真に該当)。この未分化と分化状態の細胞同士の接着具合を5段階で顕微鏡による目視評価を行い、細胞分化度を評価した。細胞分化度の判定基準は[図-1]に示した基準により判定を行った。
加齢とともに進行するハリ・弾力の低下、たるみ等の皮膚の機能低下は、細胞レベルの老化によって引き起こされている。
一方、ヒトの皮膚線維芽細胞においては細胞継代、および採取されたヒトの年齢とともに細胞中のSA-β-Gal活性(senescence-associated beta-galactosidase)が増加することが知られており、SA-β-Gal活性は細胞の老化マーカーとして使用されている。
従って、SA-β-Gal活性を抑制することが出来れば、細胞老化抑制効果が期待出来ると考えられる。
そこで、黄花菜の根部の乳酸菌発酵代謝物のSA-β-Gal活性を確認した。
細胞の培養
細胞:正常ヒト線維芽細胞NB1-RGB(理化学研究所)
培地:D-MEM FBS10%
正常ヒト線維芽細胞NB1-RGBを培養し、細胞培養液に過酸化水素200μMを1日2時間添加した。これを連続で2日間繰り返すことにより、細胞老化を起こさせた。この細胞に[0042]で調製した試料を細胞培養培地に2.5%の濃度で3日間添加した後、SA-β-Gal染色を行い、細胞の染色度合いにより細胞老化度を測定した。なお、陽性対照としてはニコチンアミドを用いた。
SA-β-Gal染色
固定液で5分間細胞を固定する。細胞をPBS(−)で洗浄後、SA-β-Gal溶液を添加して、37℃で16時間放置した。SA-β-Gal染色液で染色した細胞を集め、2N-NaOH溶液で溶解し、655nmの吸光度を測定(A値)し、SA-β-Gal活性を測定した。 溶解液の一部は、BCA法で540nmの吸光度を測定(B値)し、タンパク量を測定した。下記の計算式により細胞タンパク量当りのSA-β-Gal活性を求めた。
SA-β-Gal活性
=655nmの吸光度値(A値)/BCA法で測定した540nmの吸光度値(B値)
固定液 :ホルムアルデヒド液(試薬ホルマリン37%濃度)5mLにPBS(−)95mLを加える。
X-Gal溶液 :20mgのX-Gal(和光純薬)を1mLのDMSOに溶解する。
SA-β-Gal染色液 :X-Galが1mg/mLの濃度になるように、下記の染色bufferに溶解する。
染色Buffer :40mMクエン酸:40mMリン酸水素二ナトリウム(1:3)で
pH6.0に調製した水溶液に以下の4試薬を溶解する。
5mMフェロシアン化カリウム
5mMフェリシアン化カリウム
150mM NaCl
2mM MgCl2
BCA法 :下記のC液とD液を50:1の割合で測定直前に混合する。
2N-NaOHに溶解した細胞溶解液40μLに、C液とD液の混合液200μLを添加し、37℃で30分間反応させた後、540nmの吸光度を測定し、タンパク量とする。
C液 Sodium bicinchoninate 10g
Na2CO3 20g
Sodium tartrate 1.6g
NaOH 4g
NaHCO3 9.5g
精製水で溶解後、10N-NaOHでpHを11.25に調整した後、1Lにする。
D液 CuSO4・5H2O 4g
精製水で100mLとする。
細胞内で生成された活性酸素は、細胞を構成する成分に不可逆的な化学変化を引き起こすことにより細胞にダメージを与え、そのダメージが加齢とともに蓄積して細胞機能の低下を引き起こし、細胞老化につながることが知られている。
一方、DPPH(ジフェニルピクリルヒドラジル)は人工的に作られた安定なラジカルで、抗酸化剤のスクリーニング試験として一般に使用されている。
従って、DPPHラジカルを消去できる物質は、活性酸素による細胞構成成分の酸化劣化を防ぎ、細胞機能の低下を防止する効果、さらには老化抑制効果が期待できると考えられる。
そこで、黄花菜の根部の乳酸菌発酵代謝物のDPPHラジカル消去活性を確認した。
[0042]で調製した試料および0mM、0.3mM、0.5mM、0.7mM、1.0mM、3.0mM、5.0mM、10mMのTrolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid)溶液10μLに、下記の割合で用事調製したDPPH溶液190μLを加え、15分後に540nmの吸光度を測定し、DPPHラジカル消去能を評価した。 濃度既知のTrolox溶液の吸光度から検量線を作成し、試料のDPPHラジカル消去能の強さをtrolox当量として表示した。
Trolox溶液:trolox 25mgをDMSO (Dimethyl sulfoxide)10mlに溶解し、trolox10mM溶液とした。
DPPH溶液
0.4mM-DPPH(1,1-Diphenyl-2-picrylhydrazyl) 40
400mM-MES buffer(2-Morpholinoethanesulfonic acid )(PH6.1)10
蒸留水 30
黄花菜・根・発酵前エキスを添加した比較例-10では、DPPHラジカル消去能が0.37mM trolox当量であった。しかし、実施例-5の黄花菜・根・発酵培養液添加区では0.94mM trolox当量、また実施例-6として黄花菜・根・発酵抽出液添加区では0.72mM trolox当量を示し非常に高い酸化抑制効果を示した。また、陰性対照として試験を行った比較例-11では、DPPHラジカル消去能が0.11mM trolox当量であり、乳酸菌の培養液だけではDPPHラジカル消去活性が無いことが示された。さらに、比較対照として比較例-12には酵母菌により黄花菜の根部を発酵処理した酵母菌発酵培養液のDPPHラジカル消去能を示した。比較例-12のDPPHラジカル消去能は、0.39mM trolox当量であったことから、酵母菌の発酵処理によるDPPHラジカル消去効果は低いものであることがわかった。
陰性対照として試験を行った比較例-13のDPPHラジカル消去能が0.13mM trolox当量であり、酵母菌の培養液だけではDPPHラジカル消去活性が無いことも示された。
この結果より、乳酸菌による発酵処理により黄花菜・根部から抽出される成分が変化し、DPPHラジカル消去活性能が高まったことが明らかとなった。
被験者として、20〜60歳の女性10名に1日2回(朝、夜)連続1ヵ月間、試験品と比較品のそれぞれの皮膚外用剤を使用させ、塗布部位の状態を試験前後で比較し、改善効果を調べた。本試験には、試験品として処方例7で示した皮膚外用剤を用い(実施例−7)、比較品には処方例7に示した皮膚外用剤から乳酸菌発酵物(黄花菜・根・発酵培養液、および発酵抽出液)を除き、黄花菜・根・発酵前エキスと置き換えた皮膚外用剤を作成し(比較例−12)、その使用による効果について調べた。評価は肌の弾力に関する評価項目を表-4に、肌の潤いに関する評価項目を表-5に示す基準に従って行った。本発明の有効成分を配合した皮膚外用剤を毎日使用しながら肌の状態を塗布開始前及び1ヶ月塗布後におけるアンケートで集計し、効果の確認を行った。結果は表−6、7に示す。表中の数字は、人数を示している。表−6からも明らかなように、乳酸菌発酵物の入った試験品の皮膚外用剤では、肌の弾力評価点数が78点を示した。一方、試験品から発酵物を除き、黄花菜・根・発酵前エキスと置き換えた比較品では、評価点数が38点であった。この結果から明らかなように、乳酸菌の発酵物を添加することにより高い肌の弾力効果が得られることが明らかとなった。さらに、表-7より、乳酸菌発酵物の入った試験品の皮膚外用剤では、肌の潤い評価点数が80点を示した。一方、試験品から発酵物を除き、黄花菜・根・発酵前エキスと置き換えた比較品では、評価点数が40点であった。この結果から明らかなように、乳酸菌の発酵物を添加することにより高い肌の潤い効果が得られることが明らかとなった。
以下の化粧料の処方例で示す発酵処理液は、[0042]で示した方法で調製した、各培養液、抽出液を示す。尚、「発酵培養液(黄花菜・根)」は、「黄花菜の根部の乳酸菌発酵培養液」を意味する。以下、同様に示す。
(処方例1)化粧用クリーム(質量%)
a)ミツロウ・・・2.0
b)ステアリルアルコール・・・5.0
c)ステアリン酸・・・8.0
d)スクワラン・・・10.0
e)自己乳化型グリセリルモノステアレート・・・3.0
f)ポリオキシエチレンセチルエーテル(20E.O.)・・・1.0
g)発酵培養液(黄花菜・根)・・・5.0
h) 発酵抽出液(黄花菜・根)・・・5.0
i)1,3−ブチレングリコール・・・5.0
j)水酸化カリウム・・・0.3
k)防腐剤・酸化防止剤・・・適量
l)精製水・・・残部
製法
a)〜f)までを加熱溶解し、80℃に保つ。i)〜l)までを加熱溶解し、80℃に保ち、a)〜f)に加えて乳化し、40℃まで撹拌しながら冷却する。その後、g)、h)を加え、攪拌し均一に溶解する。
(処方例2)化粧用クリーム(質量%)
a)ミツロウ・・・2.0
b)ステアリルアルコール・・・5.0
c)ステアリン酸・・・8.0
d)スクワラン・・・10.0
e)自己乳化型グリセリルモノステアレート・・・3.0
f)ポリオキシエチレンセチルエーテル(20E.O.)・・・1.0
g)発酵培養液(黄花菜・根)・・・10.0
h) 発酵抽出液(黄花菜・根)・・・5.0
i)1,3−ブチレングリコール・・・5.0
j)水酸化カリウム・・・0.3
k)防腐剤・酸化防止剤・・・適量
l)精製水・・・残部
製法
a)〜f)までを加熱溶解し、80℃に保つ。i)〜l)までを加熱溶解し、80℃に保ち、a)〜f)に加えて乳化し、40℃まで撹拌しながら冷却する。その後、g)、h)を加え、攪拌し均一に溶解する。
a)ミツロウ・・・0.5
b)ワセリン・・・2.0
c)スクワラン・・・8.0
d)ソルビタンセスキオレエート・・・0.8
e)ポリオキシエチレンオレイルエーテル(20E.O.)・・・1.2
f)発酵抽出液(黄花菜・根)・・・0.1
g) 発酵培養液(黄花菜・根)・・・1.0
h)1,3−ブチレングリコール・・・7.0
i)カルボキシビニルポリマー・・・0.2
j)水酸化カリウム・・・0.1
k)精製水・・・残部
l)防腐剤・酸化防止剤・・・適量
m)エタノール・・・7.0
製法
a)〜e)までを加熱溶解し、80℃に保つ。h)〜k)までを加熱溶解し、80℃に保ち、a)〜e)に加えて乳化し、50℃まで撹拌しながら冷却する。50℃でf)、g)、m)を添加し、40℃まで攪拌、冷却する。
a)発酵抽出液(黄花菜・根)・・・0.01
b)発酵培養液(黄花菜・根)・・・0.001
c)グリセリン・・・5.0
d)ポリオキシエチレンソルビタンモノラウレート(20E.O.)・・・1.0
e)エタノール・・・6.0
f)香料・・・適量
g)防腐剤・酸化防止剤・・・適量
h)精製水・・・残部製法
a)〜h)までを混合し、均一に溶解する。
a)発酵培養液(黄花菜・根)・・・0.001
b)発酵抽出液(黄花菜・根)・・・10.0
c)グリセリン・・・5.0
d)ポリオキシエチレンソルビタンモノラウレート(20E.O.)・・・1.0
e)エタノール・・・6.0
f)香料・・・適量
g)防腐剤・酸化防止剤・・・適量
h)精製水・・・残部
製法
a)〜h)までを混合し、均一に溶解する。
a)ステアリン酸・・・12.0
b)ミリスチン酸・・・14.0
c)ラウリン酸・・・5.0
d)ホホバ油・・・3.0
e)グリセリン・・・10.0
f)ソルビトール・・・15.0
g)1,3−ブチレングリコール・・・10.0
h)POE(20)グリセロールモノステアリン酸・・・2.0
i)水酸化カリウム・・・5.0
j)水・・・残部
k)キレート剤・・・適量
l)香料・・・適量
m)発酵抽出液(黄花菜・根)・・・1.0
n)発酵培養液(黄花菜・根)・・・1.0
製法
a)〜h)までを加熱溶解し70℃に保つ。j)にi)を溶解後a)〜h)に加えケン化する。その後k)、l)を入れ攪拌しながら冷却する。50℃でm)、n)を添加し、40℃まで攪拌、冷却する。
a)発酵抽出液(黄花菜・根)・・・2.0
b)発酵培養液(黄花菜・根)・・・2.0
c)カルボキシビニルポリマー・・・0.05
d)L-アルギニン・・・適量
e)グリセリン・・・5.0
f)ポリオキシエチレンソルビタンモノラウレート(20E.O.)・・・1.0
g)エタノール・・・6.0
h)香料・・・適量
i)防腐剤・酸化防止剤・・・適量
j)精製水・・・残部
製法
c)をj)の一部で分散した後、d)を加えてpHを6.5に調製する。その後a)〜j)までを混合し、均一に溶解する。
Claims (6)
- 黄花菜の根部を乳酸菌により発酵させて得られる発酵物を有効成分として配合したことを特徴とする細胞分化促進剤。
- 黄花菜の根部を乳酸菌により発酵させて得られる発酵物を有効成分として配合したことを特徴とするバリア機能改善剤。
- 黄花菜の根部を乳酸菌により発酵させて得られる発酵物を有効成分として配合したことを特徴とするSA-β-Gal活性抑制剤。
- 黄花菜の根部を乳酸菌により発酵させて得られる発酵物を有効成分として配合したことを特徴とするラジカル消去促進剤。
- 乳酸菌がLactobacillus plantarumであることを特徴とする請求項1乃至4記載の剤。
- 黄花菜の根部を乳酸菌により発酵させて得られる発酵物を有効成分として配合したことを特徴とする細胞分化促進用、バリア機能改善用、SA-β-Gal活性抑制用及びラジカル消去促進用から選択されるいずれかの用途の化粧料。
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