JP6313779B2 - 置換ビアリールスルホンアミドおよびその利用 - Google Patents

置換ビアリールスルホンアミドおよびその利用 Download PDF

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Publication number
JP6313779B2
JP6313779B2 JP2015545447A JP2015545447A JP6313779B2 JP 6313779 B2 JP6313779 B2 JP 6313779B2 JP 2015545447 A JP2015545447 A JP 2015545447A JP 2015545447 A JP2015545447 A JP 2015545447A JP 6313779 B2 JP6313779 B2 JP 6313779B2
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Prior art keywords
cancer
compound
alkyl
formula
pharmaceutical composition
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JP2015545447A
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English (en)
Japanese (ja)
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JP2016502540A5 (enExample
JP2016502540A (ja
Inventor
ファン，リア，エム．
スウィンドルハースト，キャシー，エー．
チャン，カイル，ダブリュー．エイチ．
サリバン，ロバート，ダブリュー．
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Novomedix LLC
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Novomedix LLC
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Publication of JP2016502540A5 publication Critical patent/JP2016502540A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2015545447A 2012-11-30 2013-11-27 置換ビアリールスルホンアミドおよびその利用 Active JP6313779B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261732218P 2012-11-30 2012-11-30
US61/732,218 2012-11-30
PCT/US2013/072303 WO2014085633A1 (en) 2012-11-30 2013-11-27 Substituted biaryl sulfonamides and the use thereof

Publications (3)

Publication Number Publication Date
JP2016502540A JP2016502540A (ja) 2016-01-28
JP2016502540A5 JP2016502540A5 (enExample) 2018-03-01
JP6313779B2 true JP6313779B2 (ja) 2018-04-18

Family

ID=49765712

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015545447A Active JP6313779B2 (ja) 2012-11-30 2013-11-27 置換ビアリールスルホンアミドおよびその利用

Country Status (14)

Country Link
US (6) US9156781B2 (enExample)
EP (2) EP3447046A1 (enExample)
JP (1) JP6313779B2 (enExample)
KR (1) KR102180342B1 (enExample)
CN (2) CN107698470A (enExample)
AU (1) AU2013352106B2 (enExample)
CA (1) CA2892227C (enExample)
DK (1) DK2925718T3 (enExample)
ES (1) ES2689921T3 (enExample)
MX (1) MX370519B (enExample)
NZ (1) NZ630786A (enExample)
SG (1) SG11201504041WA (enExample)
WO (1) WO2014085633A1 (enExample)
ZA (1) ZA201503797B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107698470A (zh) * 2012-11-30 2018-02-16 诺沃梅迪科斯有限公司 取代的二芳基磺酰胺及其用途
AU2015213721B2 (en) 2014-02-07 2021-05-20 Effector Therapeutics, Inc. Methods for treating fibrotic disease
CA3093749A1 (en) * 2018-03-28 2019-10-03 Blade Therapeutics, Inc. Method of treating fibrotic disease
JP2021008453A (ja) * 2019-07-02 2021-01-28 エフェクター・セラピューティクス，インコーポレーテッド 翻訳阻害剤およびその使用
US20230201144A1 (en) * 2020-05-29 2023-06-29 Novomedix, Llc Biarylsulfonamides and pharmaceutical compositions thereof, and their use for treating fibrotic lung disease

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Also Published As

Publication number Publication date
CN104955801B (zh) 2017-10-31
ES2689921T3 (es) 2018-11-16
AU2013352106B2 (en) 2018-04-26
US20200062700A1 (en) 2020-02-27
MX2015006544A (es) 2015-09-24
CA2892227A1 (en) 2014-06-05
US20170158627A1 (en) 2017-06-08
ZA201503797B (en) 2017-09-27
KR20150118088A (ko) 2015-10-21
US9156781B2 (en) 2015-10-13
KR102180342B1 (ko) 2020-11-18
US9604924B2 (en) 2017-03-28
US20160016899A1 (en) 2016-01-21
DK2925718T3 (en) 2018-10-22
MX370519B (es) 2019-12-17
CN107698470A (zh) 2018-02-16
SG11201504041WA (en) 2015-06-29
US11713293B2 (en) 2023-08-01
CN104955801A (zh) 2015-09-30
NZ630786A (en) 2017-03-31
CA2892227C (en) 2020-12-15
US10040757B2 (en) 2018-08-07
US20180327353A1 (en) 2018-11-15
WO2014085633A1 (en) 2014-06-05
JP2016502540A (ja) 2016-01-28
AU2013352106A1 (en) 2015-06-11
EP3447046A1 (en) 2019-02-27
US20220002240A1 (en) 2022-01-06
EP2925718B1 (en) 2018-08-01
US20140155477A1 (en) 2014-06-05
EP2925718A1 (en) 2015-10-07

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