WO2008114831A1 - スルホンアミド基を有する抗菌剤 - Google Patents

スルホンアミド基を有する抗菌剤 Download PDF

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Publication number
WO2008114831A1
WO2008114831A1 PCT/JP2008/055140 JP2008055140W WO2008114831A1 WO 2008114831 A1 WO2008114831 A1 WO 2008114831A1 JP 2008055140 W JP2008055140 W JP 2008055140W WO 2008114831 A1 WO2008114831 A1 WO 2008114831A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
antibacterial agent
disclosed
sulfonamide group
prodrug
Prior art date
Application number
PCT/JP2008/055140
Other languages
English (en)
French (fr)
Inventor
Hiroki Kakuta
Keinosuke Okamoto
Kenji Sasaki
Xiaoxia Zheng
Kensuke Nanba
Kenichi Morishita
Kazunori Motoshima
Kentaro Katayama
Hiroyuki Oda
Original Assignee
National University Corporation Okayama University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University Corporation Okayama University filed Critical National University Corporation Okayama University
Priority to JP2009505247A priority Critical patent/JPWO2008114831A1/ja
Publication of WO2008114831A1 publication Critical patent/WO2008114831A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
    • A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
    • A01N41/04—Sulfonic acids; Derivatives thereof
    • A01N41/06—Sulfonic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Communicable Diseases (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Pest Control & Pesticides (AREA)
  • Oncology (AREA)
  • Dentistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

　構造が単純で、簡便にかつ工業規模で安価に製造でき、ＭＲＳＡやＶＲＥ等の薬剤耐性菌に対しても優れた抗菌効果を有する化合物含む抗菌剤等を提供する。また、該化合物のプロドラッグとして有用な化合物を提供する。 　化合物（Ｉ）又はその塩若しくはそのプロドラッグを含有する抗菌剤。化合物（ＩＩ）又はその塩。   （式中、各記号は明細書中と同意義を示す。）
PCT/JP2008/055140 2007-03-20 2008-03-19 スルホンアミド基を有する抗菌剤 WO2008114831A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009505247A JPWO2008114831A1 (ja) 2007-03-20 2008-03-19 スルホンアミド基を有する抗菌剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-073738 2007-03-20
JP2007073738 2007-03-20

Publications (1)

Publication Number Publication Date
WO2008114831A1 true WO2008114831A1 (ja) 2008-09-25

Family

ID=39765935

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/055140 WO2008114831A1 (ja) 2007-03-20 2008-03-19 スルホンアミド基を有する抗菌剤

Country Status (2)

Country Link
JP (1) JPWO2008114831A1 (ja)
WO (1) WO2008114831A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016502540A (ja) * 2012-11-30 2016-01-28 ノボメディックス, エルエルシーNovomedix, Llc 置換ビアリールスルホンアミドおよびその利用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06505735A (ja) * 1991-03-25 1994-06-30 ロシュ ダイアグノスティックス ゲーエムベーハー 新規なスルホンアミド、その製造方法およびこれらの化合物を含む医薬組成物
JPH1067734A (ja) * 1996-06-28 1998-03-10 F Hoffmann La Roche Ag スルホンアミド及びその用途
WO2001044195A1 (fr) * 1999-12-14 2001-06-21 Nippon Shinyaku Co., Ltd. Dérivés hétérocycliques et médicaments
JP2002193916A (ja) * 2000-10-18 2002-07-10 Takeda Chem Ind Ltd スルホンアミド基を有する光学活性体の製造法およびその合成中間体
JP2003500470A (ja) * 1999-05-28 2003-01-07 アボット・ラボラトリーズ 細胞増殖抑制剤
JP2003512319A (ja) * 1999-10-15 2003-04-02 アロウ セラピューティクス リミテッド 酵素阻害剤
JP2004507521A (ja) * 2000-08-29 2004-03-11 ノベックス・コーポレイション 抗炎症活性および抗生物質活性を有する５−ａｓａ誘導体およびこれを用いて疾患を治療する方法
WO2005113490A1 (en) * 2004-05-21 2005-12-01 Icagen, Inc. Sulfone-containing prodrugs

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06505735A (ja) * 1991-03-25 1994-06-30 ロシュ ダイアグノスティックス ゲーエムベーハー 新規なスルホンアミド、その製造方法およびこれらの化合物を含む医薬組成物
JPH1067734A (ja) * 1996-06-28 1998-03-10 F Hoffmann La Roche Ag スルホンアミド及びその用途
JP2003500470A (ja) * 1999-05-28 2003-01-07 アボット・ラボラトリーズ 細胞増殖抑制剤
JP2003512319A (ja) * 1999-10-15 2003-04-02 アロウ セラピューティクス リミテッド 酵素阻害剤
WO2001044195A1 (fr) * 1999-12-14 2001-06-21 Nippon Shinyaku Co., Ltd. Dérivés hétérocycliques et médicaments
JP2004507521A (ja) * 2000-08-29 2004-03-11 ノベックス・コーポレイション 抗炎症活性および抗生物質活性を有する５−ａｓａ誘導体およびこれを用いて疾患を治療する方法
JP2002193916A (ja) * 2000-10-18 2002-07-10 Takeda Chem Ind Ltd スルホンアミド基を有する光学活性体の製造法およびその合成中間体
WO2005113490A1 (en) * 2004-05-21 2005-12-01 Icagen, Inc. Sulfone-containing prodrugs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FARMACO, EDIZIONE SCIENTIFICA, vol. 33, no. 8, 1978, pages 595 - 603 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016502540A (ja) * 2012-11-30 2016-01-28 ノボメディックス, エルエルシーNovomedix, Llc 置換ビアリールスルホンアミドおよびその利用
US10040757B2 (en) 2012-11-30 2018-08-07 Novomedix, Llc Substituted biaryl sulfonamides and the use thereof
US11713293B2 (en) 2012-11-30 2023-08-01 Novomedix, Llc Substituted biaryl sulfonamides and the use thereof

Also Published As

Publication number Publication date
JPWO2008114831A1 (ja) 2010-07-08

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