JP6310470B2 - 前立腺がんを処置するための方法 - Google Patents
前立腺がんを処置するための方法 Download PDFInfo
- Publication number
- JP6310470B2 JP6310470B2 JP2015540806A JP2015540806A JP6310470B2 JP 6310470 B2 JP6310470 B2 JP 6310470B2 JP 2015540806 A JP2015540806 A JP 2015540806A JP 2015540806 A JP2015540806 A JP 2015540806A JP 6310470 B2 JP6310470 B2 JP 6310470B2
- Authority
- JP
- Japan
- Prior art keywords
- androgen
- cells
- prostate cancer
- cdk8
- cdk19
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261721134P | 2012-11-01 | 2012-11-01 | |
| US61/721,134 | 2012-11-01 | ||
| PCT/US2013/067990 WO2014071143A1 (en) | 2012-11-01 | 2013-11-01 | Method for treating prostate cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016501845A JP2016501845A (ja) | 2016-01-21 |
| JP2016501845A5 JP2016501845A5 (cg-RX-API-DMAC10.html) | 2016-12-22 |
| JP6310470B2 true JP6310470B2 (ja) | 2018-04-11 |
Family
ID=49641849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540806A Expired - Fee Related JP6310470B2 (ja) | 2012-11-01 | 2013-11-01 | 前立腺がんを処置するための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9636342B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2914266B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP6310470B2 (cg-RX-API-DMAC10.html) |
| KR (1) | KR20160014568A (cg-RX-API-DMAC10.html) |
| CA (1) | CA2890108C (cg-RX-API-DMAC10.html) |
| WO (1) | WO2014071143A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106282378A (zh) * | 2016-09-28 | 2017-01-04 | 湖北工业大学 | 一种用于细胞周期依赖性蛋白激酶8基因突变检测的试剂及应用 |
| AU2018333072B2 (en) | 2017-09-18 | 2022-09-29 | Cz Biohub Sf, Llc | Methods for treating triple-negative breast cancer |
| US12281080B2 (en) | 2018-08-21 | 2025-04-22 | University Of South Carolina | Quinoline-based compounds and methods of inhibiting CDK8/19 |
| US11014906B2 (en) | 2018-08-21 | 2021-05-25 | University Of South Carolina | Quinoline-based compounds and methods of inhibiting CDK8/19 |
| ES2991429T3 (es) * | 2019-02-01 | 2024-12-03 | Univ South Carolina | Compuestos de piridina bicíclicos para su uso en el tratamiento del cáncer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008518964A (ja) * | 2004-11-01 | 2008-06-05 | ユニバーシティ オブ サザン カリフォルニア | 癌と、血管新生機能に関連する疾患との治療用新規化合物 |
| US8598344B2 (en) * | 2009-11-30 | 2013-12-03 | Senex Biotechnology | CDKI pathway inhibitors and uses thereof |
| BR112012023021A2 (pt) * | 2010-03-16 | 2016-05-31 | Dana Farber Cancer Inst Inc | compostos de indazol e seus usos |
| UA112197C2 (uk) | 2011-09-13 | 2016-08-10 | Ігор Ронінсон | СПОСІБ ЛІКУВАННЯ ЗАХВОРЮВАНЬ АБО ПОРУШЕНЬ, СПРИЧИНЮВАНИХ ІНДУКОВАНОЮ ТРАНСКРИПЦІЙНОЮ АКТИВНІСТЮ NF-kB |
| CN104363913B (zh) | 2012-02-02 | 2018-08-21 | 申内克斯生物科技公司 | Cdk8/cdk19选择性抑制剂及其在癌症的抗转移和化学预防方法中的用途 |
-
2013
- 2013-11-01 JP JP2015540806A patent/JP6310470B2/ja not_active Expired - Fee Related
- 2013-11-01 US US14/439,127 patent/US9636342B2/en active Active
- 2013-11-01 CA CA2890108A patent/CA2890108C/en active Active
- 2013-11-01 KR KR1020157014380A patent/KR20160014568A/ko not_active Ceased
- 2013-11-01 EP EP13795625.6A patent/EP2914266B1/en active Active
- 2013-11-01 WO PCT/US2013/067990 patent/WO2014071143A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US9636342B2 (en) | 2017-05-02 |
| US20150272953A1 (en) | 2015-10-01 |
| KR20160014568A (ko) | 2016-02-11 |
| EP2914266A1 (en) | 2015-09-09 |
| EP2914266B1 (en) | 2019-06-19 |
| JP2016501845A (ja) | 2016-01-21 |
| CA2890108C (en) | 2021-03-02 |
| WO2014071143A1 (en) | 2014-05-08 |
| CA2890108A1 (en) | 2014-05-08 |
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