JP6306213B2 - キサンタンガムとアカシアガムとの共顆粒物 - Google Patents
キサンタンガムとアカシアガムとの共顆粒物 Download PDFInfo
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- JP6306213B2 JP6306213B2 JP2016566818A JP2016566818A JP6306213B2 JP 6306213 B2 JP6306213 B2 JP 6306213B2 JP 2016566818 A JP2016566818 A JP 2016566818A JP 2016566818 A JP2016566818 A JP 2016566818A JP 6306213 B2 JP6306213 B2 JP 6306213B2
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- weight
- gum
- granulate
- xanthan gum
- composition
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- 239000010949 copper Substances 0.000 description 1
- 229960004544 cortisone Drugs 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 229940043075 fluocinolone Drugs 0.000 description 1
- FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 description 1
- 229960002390 flurbiprofen Drugs 0.000 description 1
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000002443 hepatoprotective effect Effects 0.000 description 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000000905 isomalt Substances 0.000 description 1
- 235000010439 isomalt Nutrition 0.000 description 1
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 1
- 229960000991 ketoprofen Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000001102 lavandula vera Substances 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 150000002828 nitro derivatives Chemical class 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229960000381 omeprazole Drugs 0.000 description 1
- 229960004570 oxprenolol Drugs 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- FHFYDNQZQSQIAI-UHFFFAOYSA-N pefloxacin Chemical class C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCN(C)CC1 FHFYDNQZQSQIAI-UHFFFAOYSA-N 0.000 description 1
- 229960004236 pefloxacin Drugs 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 229960003893 phenacetin Drugs 0.000 description 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 1
- 229960002695 phenobarbital Drugs 0.000 description 1
- 229960002895 phenylbutazone Drugs 0.000 description 1
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical class [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 230000036316 preload Effects 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 150000007660 quinolones Chemical class 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- DZZWHBIBMUVIIW-DTORHVGOSA-N sparfloxacin Chemical class C1[C@@H](C)N[C@@H](C)CN1C1=C(F)C(N)=C2C(=O)C(C(O)=O)=CN(C3CC3)C2=C1F DZZWHBIBMUVIIW-DTORHVGOSA-N 0.000 description 1
- 229960004954 sparfloxacin Drugs 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000011885 synergistic combination Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 235000016788 valerian Nutrition 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
- A61K9/025—Suppositories; Bougies; Bases therefor; Ovules characterised by shape or structure, e.g. hollow layered, coated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
−100μm〜300μmの、好ましくは約150μmに等しい平均直径を有する、上記に定義するとおりの共顆粒物。
−共顆粒物の粒子の高々4重量%が500μmより大きい平均直径を有し、且つ共顆粒物の粒子の65〜90重量%が80μmより大きい平均直径を有する(欧州薬局方、第8版 2014年(方法2.9.38.))ことを特徴とする、上記に定義するとおりの共顆粒物。
−0.3mg/ml〜0.8mg/ml、好ましくは0.35mg/ml〜0.7mg/mlの密度を有する(欧州薬局方、第8版 2014年(方法2.9.34.))、上記に定義するとおりの共顆粒物。
−キサンタンガムとアカシアガムとの重量比が4/1から1/1まで異なり、好ましくは3/1に等しいことを特徴とする、上記に定義するとおりの共顆粒物。
−少なくとも1つの活性成分及び/又は少なくとも1つの栄養剤を含有する少なくとも1つの錠剤を含む組成物であって、前記錠剤が15〜50重量%、好ましくは20〜40重量%の上記に定義するとおりの共顆粒物を含むことを特徴とする、組成物。
−錠剤が、少なくとも:希釈剤、滑沢剤、結合剤から選択される少なくとも1つの賦形剤もさらに含むことを特徴とする、上記に定義するとおりの組成物。
−その重量の100%当たり20〜35重量%の上記に定義するとおりの共顆粒物と、0.1〜60重量%の活性成分及び/又は栄養剤と、10〜50重量%の希釈剤又は結合剤と、0.5〜3重量%の滑沢剤とを含むことを特徴とする、上記に定義するとおりの組成物。
−持続放出効果を有する、医薬、栄養補助又はダイエタリー組成物であることを特徴とする、上記に定義するとおりの組成物。
−上記に定義するとおりの組成物の調製方法であって、重量基準で15%〜50%、好ましくは20%〜40%の上記に定義するとおりの共顆粒物と、少なくとも1つの活性成分及び/又は少なくとも1つの栄養剤とを含む混合物を直接圧縮する少なくとも1つのステップを含む方法。
−前記組成物が、少なくとも:希釈剤、滑沢剤、結合剤から選択される少なくとも1つの賦形剤もさらに含む、上記に定義するとおりの方法。
上記に定義するとおりの医薬組成物又は栄養補助若しくはダイエタリー組成物を製造するための、上記に定義するとおりの少なくとも1つの共顆粒物の使用。
−可能な限り高い破壊強度(理想的には>90N);
−可能な限り低い摩損度(理想的には<0.5%);
−水性媒体への曝露後の活性成分の徐放(錠剤の崩壊時間>1時間)。
活性成分、この場合合成カフェインと、様々なマトリックス構成成分、即ちキサンタンガム−アカシアガム共顆粒物、及び任意選択で他の賦形剤、例えばリン酸二カルシウムとからなる700gの粉末混合物を、Turbula T2Cタイプのミキサーで予め混合する。この粉末混合物はまた、前記混合物に対して1重量%で計量した滑沢剤、即ちステアリン酸マグネシウムも含有する。
重量基準で種々の割合のキサンタンガム及びアカシアガムを含有する共顆粒物を製造した。
2種類の市販のガムで持続放出錠を製剤化した:
−キサンタンガム粉末(平均粒径:74μm)
−顆粒状キサンタンガム(平均粒径:185μm)
−直径11mmの8本の杵
−目標重量:500mg/錠
重量基準で種々の割合のキサンタンガム及びアカシアガムを含有する共顆粒物を製造した。これらの共顆粒物で以下の組成により錠剤を調製した:
Claims (12)
- キサンタンガムとアカシアガムのみからなる共顆粒物であって、当該共顆粒物が50μm〜1000μmの平均直径を有し、前記キサンタンガムと前記アカシアガムとの重量比が4/1から1/1まで異なることを特徴とする、共顆粒物。
- 100μm〜300μm、好ましくは約150μmに等しい平均直径を有する、請求項1に記載の共顆粒物。
- 前記共顆粒物の粒子の高々4重量%が500μmより大きい平均直径を有し、且つ前記共顆粒物の粒子の65〜90重量%が80μmより大きい平均直径を有することを特徴とする、請求項1及び2のいずれかに記載の共顆粒物。
- 0.3mg/ml〜0.8mg/ml、好ましくは0.35mg/ml〜0.7mg/mlの密度を有する、請求項1〜3のいずれか一項に記載の共顆粒物。
- 前記キサンタンガムと前記アカシアガムとの重量比が3/1に等しいことを特徴とする、請求項1〜4のいずれか一項に記載の共顆粒物。
- 少なくとも1つの活性成分及び/又は少なくとも1つの栄養剤を含有する少なくとも1つの錠剤を含む組成物であって、前記錠剤が15〜50重量%、好ましくは20〜40重量%の請求項1〜5のいずれか一項に記載の共顆粒物を含むことを特徴とする、組成物。
- 前記錠剤が、少なくとも:希釈剤、滑沢剤、結合剤から選択される少なくとも1つの賦形剤もさらに含むことを特徴とする、請求項6に記載の組成物。
- その重量の100%当たり20〜35重量%の請求項1〜5のいずれか一項に記載の共顆粒物と、0.1〜60重量%の活性成分及び/又は栄養剤と、10〜50重量%の希釈剤又は結合剤と、0.5〜3重量%の滑沢剤とを含むことを特徴とする、請求項7に記載の組成物。
- 持続放出効果を有する、医薬、栄養補助又はダイエタリー組成物であることを特徴とする、請求項6〜8のいずれか一項に記載の組成物。
- 請求項6〜9のいずれか一項に記載の組成物の調製方法であって、重量基準で15%〜40重量%、好ましくは20%〜40重量%の請求項1〜5のいずれか一項に記載の共顆粒物と、少なくとも1つの活性成分及び/又は少なくとも1つの栄養剤とを含む混合物を直接圧縮する少なくとも1つのステップを含む方法。
- 前記組成物が、少なくとも:希釈剤、滑沢剤、結合剤から選択される少なくとも1つの賦形剤もさらに含む、請求項10に記載の方法。
- 請求項6〜9のいずれか一項に記載の医薬組成物又は栄養補助若しくはダイエタリー組成物を製造するための、請求項1〜5のいずれか一項に記載の少なくとも1つの共顆粒物の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1454061A FR3020571B1 (fr) | 2014-05-05 | 2014-05-05 | Co-granules de gomme de xanthane et de gomme d'acacia |
FR1454061 | 2014-05-05 | ||
PCT/FR2015/051149 WO2015170038A1 (fr) | 2014-05-05 | 2015-04-28 | Co-granules de gomme de xanthane et de gomme d'acacia |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2017514869A JP2017514869A (ja) | 2017-06-08 |
JP6306213B2 true JP6306213B2 (ja) | 2018-04-04 |
Family
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Family Applications (1)
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JP2016566818A Active JP6306213B2 (ja) | 2014-05-05 | 2015-04-28 | キサンタンガムとアカシアガムとの共顆粒物 |
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US (1) | US11439596B2 (ja) |
EP (1) | EP3139905B1 (ja) |
JP (1) | JP6306213B2 (ja) |
KR (1) | KR102387742B1 (ja) |
CA (1) | CA2947331C (ja) |
ES (1) | ES2796055T3 (ja) |
FR (1) | FR3020571B1 (ja) |
WO (1) | WO2015170038A1 (ja) |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3551133A (en) | 1966-08-01 | 1970-12-29 | Diamond Shamrock Corp | Granular thickening agent and preparation |
JPS5774072A (en) | 1980-10-29 | 1982-05-10 | Yamanouchi Pharmaceut Co Ltd | Granule of dietary fiber and its preparation |
GB8515484D0 (en) | 1985-06-19 | 1985-07-24 | Shell Int Research | Heteropolysaccharide particles |
US4994276A (en) * | 1988-09-19 | 1991-02-19 | Edward Mendell Co., Inc. | Directly compressible sustained release excipient |
FR2729857B1 (fr) | 1995-01-27 | 1997-04-04 | Rhone Poulenc Chimie | Compositions pharmaceutiques sous forme de comprimes a liberation prolongee a base de granules en polysaccharides de haut poids moleculaire |
DE102005014141B4 (de) * | 2005-03-23 | 2006-12-21 | Hennig Arzneimittel Gmbh & Co. Kg | Tablettenförmige Retardzubereitung gegen Schwindel |
FR2983409B1 (fr) * | 2011-12-06 | 2013-12-27 | Ethypharm Sa | Comprime susceptible de lutter contre le detournement par voie injectable |
JP6416479B2 (ja) * | 2014-01-22 | 2018-10-31 | 三栄源エフ・エフ・アイ株式会社 | 固形状糊料製剤 |
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2014
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- 2015-04-28 KR KR1020167032476A patent/KR102387742B1/ko active IP Right Grant
- 2015-04-28 EP EP15723273.7A patent/EP3139905B1/fr active Active
- 2015-04-28 ES ES15723273T patent/ES2796055T3/es active Active
- 2015-04-28 JP JP2016566818A patent/JP6306213B2/ja active Active
- 2015-04-28 US US15/308,697 patent/US11439596B2/en active Active
- 2015-04-28 WO PCT/FR2015/051149 patent/WO2015170038A1/fr active Application Filing
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Also Published As
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FR3020571A1 (fr) | 2015-11-06 |
WO2015170038A1 (fr) | 2015-11-12 |
FR3020571B1 (fr) | 2017-08-25 |
JP2017514869A (ja) | 2017-06-08 |
US20170189336A1 (en) | 2017-07-06 |
EP3139905A1 (fr) | 2017-03-15 |
ES2796055T3 (es) | 2020-11-25 |
US11439596B2 (en) | 2022-09-13 |
KR20170032222A (ko) | 2017-03-22 |
CA2947331A1 (en) | 2015-11-12 |
KR102387742B1 (ko) | 2022-04-15 |
CA2947331C (en) | 2022-08-30 |
EP3139905B1 (fr) | 2020-04-22 |
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