JP6283689B2 - うつ病性障害の処置のためのプレグナ‐4‐エン‐20‐イン‐3‐オンの使用 - Google Patents

うつ病性障害の処置のためのプレグナ‐4‐エン‐20‐イン‐3‐オンの使用 Download PDF

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Publication number
JP6283689B2
JP6283689B2 JP2015550497A JP2015550497A JP6283689B2 JP 6283689 B2 JP6283689 B2 JP 6283689B2 JP 2015550497 A JP2015550497 A JP 2015550497A JP 2015550497 A JP2015550497 A JP 2015550497A JP 6283689 B2 JP6283689 B2 JP 6283689B2
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pharmaceutical composition
composition according
pregna
depressive disorder
administered
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Japanese (ja)
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JP2016504361A (ja
JP2016504361A5 (enExample
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ルイス・モンティ
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Pherin Pharmaceuticals Inc
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Pherin Pharmaceuticals Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
JP2015550497A 2012-12-28 2013-12-19 うつ病性障害の処置のためのプレグナ‐4‐エン‐20‐イン‐3‐オンの使用 Active JP6283689B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261747167P 2012-12-28 2012-12-28
US61/747,167 2012-12-28
PCT/US2013/076497 WO2014105620A1 (en) 2012-12-28 2013-12-19 Use of pregn-4-en-20-yn-3-one for the treatment of depressive disorders

Publications (3)

Publication Number Publication Date
JP2016504361A JP2016504361A (ja) 2016-02-12
JP2016504361A5 JP2016504361A5 (enExample) 2017-02-02
JP6283689B2 true JP6283689B2 (ja) 2018-02-21

Family

ID=49950051

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015550497A Active JP6283689B2 (ja) 2012-12-28 2013-12-19 うつ病性障害の処置のためのプレグナ‐4‐エン‐20‐イン‐3‐オンの使用

Country Status (11)

Country Link
US (1) US10322138B2 (enExample)
EP (1) EP2938346B1 (enExample)
JP (1) JP6283689B2 (enExample)
KR (1) KR102209475B1 (enExample)
CN (1) CN104936600B (enExample)
AU (1) AU2013371025B2 (enExample)
CA (1) CA2894686C (enExample)
DK (1) DK2938346T3 (enExample)
ES (1) ES2625778T3 (enExample)
MX (1) MX369774B (enExample)
WO (1) WO2014105620A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020087031A1 (en) 2018-10-26 2020-04-30 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
PL3955933T3 (pl) * 2019-04-15 2024-04-29 Vistagen Therapeutics, Inc. Leczenie migreny
WO2024254005A1 (en) 2023-06-04 2024-12-12 Vistagen Therapeutics, Inc. 1,3,5(10),16-estratetraen-3-yl acetate for use in improving psychomotor or cognitive performance
US20250312356A1 (en) * 2024-04-08 2025-10-09 Vistagen Therapeutics, Inc. Treatment of dysmenorrhea

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5303703A (en) 1991-10-03 1994-04-19 Pherin Corporation Combined neuroepithelial sample delivery electrode device and methods of using same
ES2210243T3 (es) * 1993-06-15 2004-07-01 Pherin Corporation Esteroides de androstano utiles como iniciadores del cambio de la funcion hipotalamica humana, composiciones farmaceuticas y procedimientos asociados.
US6057439A (en) 1994-08-04 2000-05-02 Pherin Corporation Steroids as neurochemical stimulators of the VNO to alleviate symptoms of PMS and anxiety
US5563131A (en) * 1994-08-04 1996-10-08 Pherin Corporation Pregnane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods
US6066627A (en) 1994-08-04 2000-05-23 Pherin Corporation Steroids as neurochemical initiators of change in human blood levels of LH
US5994333A (en) * 1994-08-04 1999-11-30 Pherin Corporation Pregnane and cholane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods
US6331534B1 (en) 1994-08-04 2001-12-18 Pherin Pharmaceuticals, Inc. Steroids as neurochemical stimulators of the VNO to alleviate pain
US6117860A (en) 1994-08-04 2000-09-12 Pherin Pharmaceuticals, Inc. Steroids as neurochemical stimulators of the VNO to treat paroxistic tachycardia
ATE342721T1 (de) * 1996-07-23 2006-11-15 Pherin Pharm Inc Steroide als neurochemische stimulatoren des nasenraumes zur linderung der prämenstrualen symptome
US20020123138A1 (en) 2000-11-30 2002-09-05 Jian Zhang Human VNO receptor (R1)
US20030045514A1 (en) 2001-05-03 2003-03-06 Louis Monti 17-Methyleneandrostan-3alpha-ol analogs as CRH inhibitors

Also Published As

Publication number Publication date
CA2894686C (en) 2021-05-04
EP2938346B1 (en) 2017-04-05
KR102209475B1 (ko) 2021-01-28
JP2016504361A (ja) 2016-02-12
HK1210421A1 (en) 2016-04-22
US10322138B2 (en) 2019-06-18
AU2013371025B2 (en) 2018-01-18
WO2014105620A1 (en) 2014-07-03
CA2894686A1 (en) 2014-07-03
MX369774B (es) 2019-11-21
MX2015008454A (es) 2016-05-16
CN104936600A (zh) 2015-09-23
ES2625778T3 (es) 2017-07-20
CN104936600B (zh) 2018-08-03
DK2938346T3 (en) 2017-06-12
AU2013371025A1 (en) 2015-07-09
EP2938346A1 (en) 2015-11-04
US20140187524A1 (en) 2014-07-03
KR20150100884A (ko) 2015-09-02

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