JP6248112B2 - アピキサバン液体製剤 - Google Patents
アピキサバン液体製剤 Download PDFInfo
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- JP6248112B2 JP6248112B2 JP2015534679A JP2015534679A JP6248112B2 JP 6248112 B2 JP6248112 B2 JP 6248112B2 JP 2015534679 A JP2015534679 A JP 2015534679A JP 2015534679 A JP2015534679 A JP 2015534679A JP 6248112 B2 JP6248112 B2 JP 6248112B2
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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| US201361773032P | 2013-03-05 | 2013-03-05 | |
| US61/773,032 | 2013-03-05 | ||
| PCT/US2013/062051 WO2014052678A1 (en) | 2012-09-26 | 2013-09-26 | Apixaban liquid formulations |
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| EP2907507A1 (en) * | 2014-02-17 | 2015-08-19 | Sandoz Ag | Pharmaceutical composition comprising apixaban |
| WO2017221209A1 (en) | 2016-06-23 | 2017-12-28 | Lupin Limited | Pharmaceutical formulations of apixaban |
| SI3781132T1 (sl) * | 2018-04-16 | 2024-07-31 | Bristol-Myers Squibb Company | Formulacije apiksabana |
| WO2020034989A1 (zh) | 2018-08-14 | 2020-02-20 | 江苏恒瑞医药股份有限公司 | 一种可注射的药物组合物及其制备方法 |
| PH12022551126A1 (en) | 2019-11-13 | 2023-08-23 | Unison Pharmaceuticals Pvt Ltd | Orally disintegrating pharmaceutical compositions of apixaban |
| EP4259098A1 (en) | 2020-12-13 | 2023-10-18 | Dafechem Ltd | Liquid apixaban formulation in small dose volume |
| CN113384526A (zh) * | 2021-08-03 | 2021-09-14 | 合肥医工医药股份有限公司 | 一种稳定的阿哌沙班口服溶液制剂及其制备方法 |
| NL2029536B1 (en) | 2021-10-27 | 2023-05-26 | Pharma Data S A | Apixaban suspension and preparation method |
| US12214075B2 (en) | 2021-10-27 | 2025-02-04 | Pharma-Data Research And Development Single Member S.A. | Apixaban suspension and preparation method |
| US12194028B2 (en) * | 2022-03-09 | 2025-01-14 | Slayback Pharma Llc | Stable pharmaceutical compositions of apixaban |
| EP4522123A1 (en) * | 2022-05-09 | 2025-03-19 | SYRI Research Private Limited | Liquid oral formulation of apixaban or pharmaceutically acceptable salt thereof |
| US12213972B2 (en) * | 2022-07-27 | 2025-02-04 | Slayback Pharma Llc | Stable pharmaceutical compositions of apixaban |
| US11833138B1 (en) | 2023-01-30 | 2023-12-05 | Tap Pharmaceuticals Ag | Liquid pharmaceutical formulations of apixaban |
| WO2024160789A1 (en) | 2023-01-30 | 2024-08-08 | Tap Pharmaceuticals Ag | Liquid pharmaceutical formulations of apixaban |
| US20250319077A1 (en) | 2023-04-14 | 2025-10-16 | Novick BioSciences Private Limited | Apixaban compositions |
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| US5763449A (en) * | 1996-08-07 | 1998-06-09 | Ascent Pediatrics, Inc. | Pleasant-tasting aqueous liquid composition of a bitter-tasting drug |
| KR100558239B1 (ko) | 1999-12-23 | 2006-03-10 | 화이자 프로덕츠 인크. | 증가된 약물 농도를 제공하는 제약학적 조성물 |
| MY129350A (en) * | 2001-04-25 | 2007-03-30 | Bristol Myers Squibb Co | Aripiprazole oral solution |
| EP1269994A3 (en) | 2001-06-22 | 2003-02-12 | Pfizer Products Inc. | Pharmaceutical compositions comprising drug and concentration-enhancing polymers |
| TWI320039B (en) | 2001-09-21 | 2010-02-01 | Lactam-containing compounds and derivatives thereof as factor xa inhibitors | |
| RS51444B (sr) * | 2001-09-21 | 2011-04-30 | Bristol-Myers Squibb Company | JEDINJENJA KOJA SADRŽE LAKTAM I NJIHOVI DERIVATI KAO INHIBITORI FAKTORA Xa |
| US7101572B2 (en) * | 2001-12-07 | 2006-09-05 | Unilab Pharmatech, Ltd. | Taste masked aqueous liquid pharmaceutical composition |
| CA2597155A1 (en) * | 2005-02-25 | 2006-09-08 | Biomarin Pharmaceutical Inc. | Room temperature stable aqueous liquid pharmaceutical composition |
| US20070191306A1 (en) * | 2005-08-17 | 2007-08-16 | Bristol-Myers Squibb Company | FACTOR Xa INHIBITOR FORMULATION AND METHOD |
| AU2009205314A1 (en) * | 2008-01-14 | 2009-07-23 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
| CA2761455C (en) * | 2009-05-13 | 2018-06-12 | Cydex Pharmaceuticals, Inc. | Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same |
| SMT202000093T1 (it) * | 2009-06-16 | 2020-03-13 | Pfizer | Forme di dosaggio di apixaban |
| PE20160042A1 (es) * | 2010-02-25 | 2016-01-28 | Bristol Myers Squibb Holdings Ireland | Formulaciones de apixaban |
| EP2484775A1 (de) | 2011-02-07 | 2012-08-08 | Siemens Healthcare Diagnostics Products GmbH | Heparin-insensitives Verfahren zur Bestimmung von direkten Gerinnungsfaktorinhibitoren |
| RU2638155C1 (ru) * | 2016-02-29 | 2017-12-12 | Общество С Ограниченной Ответственностью "Сай Фарма" | Производные бензо[d]изоксазола и их применение |
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| JP2015531377A (ja) | 2015-11-02 |
| RU2015115127A (ru) | 2016-11-20 |
| AU2013323435A1 (en) | 2014-04-03 |
| AU2013323435B2 (en) | 2017-10-19 |
| HK1212900A1 (zh) | 2016-06-24 |
| RU2660358C2 (ru) | 2018-07-05 |
| US9452134B2 (en) | 2016-09-27 |
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| CN104736142A (zh) | 2015-06-24 |
| PH12015500590A1 (en) | 2015-05-25 |
| MY179191A (en) | 2020-10-30 |
| AU2013323435C1 (en) | 2018-04-12 |
| US20160263097A1 (en) | 2016-09-15 |
| MX358097B (es) | 2018-08-06 |
| CA2885899A1 (en) | 2014-04-03 |
| EP2900217A1 (en) | 2015-08-05 |
| CN104736142B (zh) | 2020-03-03 |
| IL237804A0 (en) | 2015-05-31 |
| KR102035373B1 (ko) | 2019-10-22 |
| AU2013323435A8 (en) | 2015-04-23 |
| KR20150058243A (ko) | 2015-05-28 |
| SG11201501743UA (en) | 2015-04-29 |
| SG10201702048VA (en) | 2017-04-27 |
| WO2014052678A1 (en) | 2014-04-03 |
| US10016362B2 (en) | 2018-07-10 |
| NZ630763A (en) | 2017-01-27 |
| BR112015005995A2 (pt) | 2017-07-04 |
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