JP6247302B2 - 異常な短縮率（ｆｒａｃｔｉｏｎａｌｓｈｏｒｔｅｎｉｎｇ）を持つ患者の同定 - Google Patents

異常な短縮率（ｆｒａｃｔｉｏｎａｌｓｈｏｒｔｅｎｉｎｇ）を持つ患者の同定 Download PDF

Info

Publication number
JP6247302B2
JP6247302B2 JP2015531492A JP2015531492A JP6247302B2 JP 6247302 B2 JP6247302 B2 JP 6247302B2 JP 2015531492 A JP2015531492 A JP 2015531492A JP 2015531492 A JP2015531492 A JP 2015531492A JP 6247302 B2 JP6247302 B2 JP 6247302B2
Authority
JP
Japan
Prior art keywords
subject
amount
fgf
sample
vitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2015531492A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015531873A (ja
JP2015531873A5 (https=
Inventor
ブロック，ディルク
マッソン，セルジェ
ヴィーンヒューズ−テレン，ウルスラ−ヘンリケ
ツァウグ，クリスティアン
ラティーニ，ロベルト
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2015531873A publication Critical patent/JP2015531873A/ja
Publication of JP2015531873A5 publication Critical patent/JP2015531873A5/ja
Application granted granted Critical
Publication of JP6247302B2 publication Critical patent/JP6247302B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0883—Clinical applications for diagnosis of the heart
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G01N2333/4706—Regulators; Modulating activity stimulating, promoting or activating activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/50—Fibroblast growth factors [FGF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/329—Diseases of the aorta or its branches, e.g. aneurysms, aortic dissection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
JP2015531492A 2012-09-12 2013-03-28 異常な短縮率（ｆｒａｃｔｉｏｎａｌｓｈｏｒｔｅｎｉｎｇ）を持つ患者の同定 Active JP6247302B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12184085 2012-09-12
EP12184085.4 2012-09-12
PCT/EP2013/056706 WO2014040759A1 (en) 2012-09-12 2013-03-28 Identification of patients with abnormal fractional shortening

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017220660A Division JP6615848B2 (ja) 2012-09-12 2017-11-16 異常な短縮率（ｆｒａｃｔｉｏｎａｌ ｓｈｏｒｔｅｎｉｎｇ）を持つ患者の同定

Publications (3)

Publication Number Publication Date
JP2015531873A JP2015531873A (ja) 2015-11-05
JP2015531873A5 JP2015531873A5 (https=) 2016-05-19
JP6247302B2 true JP6247302B2 (ja) 2017-12-13

Family

ID=46826365

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015531492A Active JP6247302B2 (ja) 2012-09-12 2013-03-28 異常な短縮率（ｆｒａｃｔｉｏｎａｌｓｈｏｒｔｅｎｉｎｇ）を持つ患者の同定
JP2017220660A Active JP6615848B2 (ja) 2012-09-12 2017-11-16 異常な短縮率（ｆｒａｃｔｉｏｎａｌ ｓｈｏｒｔｅｎｉｎｇ）を持つ患者の同定

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017220660A Active JP6615848B2 (ja) 2012-09-12 2017-11-16 異常な短縮率（ｆｒａｃｔｉｏｎａｌ ｓｈｏｒｔｅｎｉｎｇ）を持つ患者の同定

Country Status (7)

Country Link
US (3) US20150185230A1 (https=)
EP (3) EP3428649B1 (https=)
JP (2) JP6247302B2 (https=)
CN (1) CN104620111B (https=)
CA (1) CA2883890C (https=)
ES (2) ES2913539T3 (https=)
WO (1) WO2014040759A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014007007B1 (pt) 2011-10-17 2022-04-19 F. Hoffmann-La Roche Ag Método in-vitro para diferenciação precoce da apoplexia isquêmica cardioembólica, uso de uma troponina cardíaca e dispositivo de diferenciação precoce da apoplexia isquêmica cardioembólica
EP3413052B1 (en) 2014-03-26 2022-12-28 Roche Diagnostics GmbH Igfbp7 for diagnosing diastolic dysfunction
CN107110871B (zh) 2014-10-29 2019-09-27 豪夫迈·罗氏有限公司 用于死亡的风险预测的生物标志物
CN108139409B (zh) 2015-10-08 2020-07-24 豪夫迈·罗氏有限公司 当在外科手术之前测量时用于预测aki的风险的igfbp7
WO2017125406A1 (en) * 2016-01-19 2017-07-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting left ventricular remodeling in subjects suffering from hypertension
BR112019025313A2 (pt) * 2017-05-30 2020-06-23 Abbott Laboratories Métodos para auxílio no diagnóstico e avaliação de uma lesão cerebral traumática leve em um indivíduo humano usando troponina cardíaca i
BR112020011454A2 (pt) 2017-12-13 2021-02-09 F. Hoffmann-La Roche Ag métodos para prever o risco de acidente vascular, para prever o risco de acidente vascular cerebral e para aprimorar a precisão da previsão e usos do (i) biomarcador ang-2 e/ou do biomarcador igfbp7
JP7024576B2 (ja) * 2018-04-20 2022-02-24 オムロンヘルスケア株式会社 電子血圧計および心不全検出器
US12322100B2 (en) 2018-12-11 2025-06-03 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity
US11446009B2 (en) 2018-12-11 2022-09-20 Eko.Ai Pte. Ltd. Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images
US11931207B2 (en) 2018-12-11 2024-03-19 Eko.Ai Pte. Ltd. Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device
US12400762B2 (en) 2018-12-11 2025-08-26 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy
US12001939B2 (en) 2018-12-11 2024-06-04 Eko.Ai Pte. Ltd. Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views
US12333413B1 (en) * 2024-03-01 2025-06-17 Mayo Foundation For Medical Education And Research Apparatus and method for training an artificial intelligence-supported diagnostic assessment tool

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
GB9211686D0 (en) 1992-06-03 1992-07-15 Medisinsk Innovation A S Chemical compounds
US6709855B1 (en) 1998-12-18 2004-03-23 Scios, Inc. Methods for detection and use of differentially expressed genes in disease states
EP1379869A4 (en) * 2001-03-15 2004-08-11 Xiao Yong Fu METHOD FOR THERAPEUTICALLY TREATING A CLINICALLY DETECTED CARDIOPATHOLOGICAL FORM IN A MAMMAL
US7632647B2 (en) 2001-04-13 2009-12-15 Biosite Incorporated Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
ATE458199T1 (de) 2001-05-04 2010-03-15 Biosite Inc Diagnostische marker der akuten koronaren syndrome und ihre verwendungen
EP1451579A4 (en) * 2001-11-19 2005-12-28 Protometrix Inc METHOD OF USING NON-ANTIBODY PROTEIN FOR DETECTING AND MEASURING AN ANALYTE
JP2005291899A (ja) * 2004-03-31 2005-10-20 Akira Matsumori 心疾患の検査法
US8563328B2 (en) * 2004-07-26 2013-10-22 University Of Louisville Research Foundation, Inc. Fiber-optic biosensor and biosensing methods
US20080027330A1 (en) * 2006-05-15 2008-01-31 Endothelix, Inc. Risk assessment method for acute cardiovascular events
WO2008060618A2 (en) * 2006-11-15 2008-05-22 University Of Florida Research Foundation Use of genetic determinants in cardiovascular risk assessment
JP2010517023A (ja) * 2007-01-25 2010-05-20 エフ．ホフマン−ラ ロシュ アーゲー 心不全の評価におけるｉｇｆｂｐ−７の使用
AU2008246125B2 (en) * 2007-04-26 2013-01-24 Genera Istrazivanja D.O.O. Blood biomarkers for bone fracture and cartilage injury
CA2681667A1 (en) * 2007-05-18 2008-11-27 Duke University Serum biomarkers for the early detection of lung cancer
US20110183434A1 (en) * 2008-01-17 2011-07-28 Myles Wolf Diagnostic methods and kits using fibroblast growth factor-23
NZ593221A (en) * 2008-11-06 2012-10-26 Musc Found For Res Dev Detecting and monitoring left ventricular hypertrophy and congestive heart failure by profiling biomarkers
JP2012522746A (ja) 2009-04-01 2012-09-27 レツク・フアーマシユーテイカルズ・デー・デー 活性メチレン基のジメチル化の方法
EP2425245B1 (en) 2009-04-27 2016-10-05 Roche Diagnostics GmbH Use of endostatin as a marker of heart failure
WO2011012268A1 (en) 2009-07-27 2011-02-03 Roche Diagnostics Gmbh Use of mimecan in the assessment of heart failure
WO2011075744A1 (en) * 2009-12-20 2011-06-23 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2011117371A2 (en) * 2010-03-26 2011-09-29 Pronota N.V. Ltbp2 as a biomarker for renal dysfunction
US20120142632A1 (en) * 2010-08-04 2012-06-07 St. Vincent's Institute Of Medical Research Diagnostic and prognostic assay
CN105044349B (zh) * 2010-08-26 2018-04-06 弗·哈夫曼-拉罗切有限公司 生物标志物在评估从动脉高血压向心力衰竭的早期转变中的用途
KR101882533B1 (ko) * 2010-08-31 2018-07-26 교와 메덱스 가부시키가이샤 섬유아세포 증식 인자-２３ 의 측정 방법 및 측정 시약

Also Published As

Publication number Publication date
JP6615848B2 (ja) 2019-12-04
EP3428649B1 (en) 2022-03-23
US11454634B2 (en) 2022-09-27
US20180196067A1 (en) 2018-07-12
CA2883890A1 (en) 2014-03-20
US20220412991A1 (en) 2022-12-29
CN104620111B (zh) 2017-08-08
ES2680149T3 (es) 2018-09-04
WO2014040759A1 (en) 2014-03-20
EP2895866A1 (en) 2015-07-22
CN104620111A (zh) 2015-05-13
US20150185230A1 (en) 2015-07-02
CA2883890C (en) 2021-11-09
EP2895866B1 (en) 2018-05-30
HK1206097A1 (zh) 2015-12-31
EP3428649A3 (en) 2019-02-13
JP2015531873A (ja) 2015-11-05
EP4075143A1 (en) 2022-10-19
EP3428649A2 (en) 2019-01-16
JP2018049032A (ja) 2018-03-29
ES2913539T3 (es) 2022-06-02

Similar Documents

Publication Publication Date Title
JP6615848B2 (ja) 異常な短縮率（ｆｒａｃｔｉｏｎａｌ ｓｈｏｒｔｅｎｉｎｇ）を持つ患者の同定
JP6654668B2 (ja) 発作性心房細動のｂｎｐ型ペプチドに基づく診断をするためのデータを提供する方法
JP7033634B2 (ja) 心不全の治療選択におけるバイオマーカー
US11047866B2 (en) IGFBP7 for diagnosing diastolic dysfunction
JP5676763B2 (ja) 動脈性高血圧症から心不全への初期移行の評価におけるバイオマーカーの使用
JP5419968B2 (ja) 心臓治療を必要とする個体におけるｌ−ｆａｂｐ、ナトリウム利尿ペプチド及び心筋トロポニン
JP6313319B2 (ja) 心不全におけるＮＴｐｒｏＢＮＰおよびｃＴｎＴをベースとする療法ガイダンス
JP2017505906A (ja) ナトリウム利尿ペプチドによってガイドされる、心不全患者におけるリスク評価および治療監視のためのバイオマーカー
EP2597466A1 (en) Means and methods for proSP-B based diagnosis of alveolar damage in pulmonary hypertension patients
WO2017182446A1 (en) Soluble st2 for the identification of progressors to lvh in the general population
HK1206097B (en) Identification of patients with abnormal fractional shortening
WO2013017690A2 (en) Troponin based rule in and rule out algorithm of myocardial infarction
HK1234493A1 (en) Igfbp7 for diagnosing diastolic dysfunction

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160325

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160325

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20170208

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170228

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170516

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170809

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20171017

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20171116

R150 Certificate of patent or registration of utility model

Ref document number: 6247302

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250