CN104620111B - 鉴定具有异常分数缩短的患者 - Google Patents

鉴定具有异常分数缩短的患者 Download PDF

Info

Publication number
CN104620111B
CN104620111B CN201380047272.0A CN201380047272A CN104620111B CN 104620111 B CN104620111 B CN 104620111B CN 201380047272 A CN201380047272 A CN 201380047272A CN 104620111 B CN104620111 B CN 104620111B
Authority
CN
China
Prior art keywords
subject
amount
sample
fgf
purposes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201380047272.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN104620111A (zh
Inventor
D.布洛克
S.马森
U-H.温休斯-西伦
C.佐格
R.拉蒂尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN104620111A publication Critical patent/CN104620111A/zh
Application granted granted Critical
Publication of CN104620111B publication Critical patent/CN104620111B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0883—Clinical applications for diagnosis of the heart
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G01N2333/4706—Regulators; Modulating activity stimulating, promoting or activating activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/50—Fibroblast growth factors [FGF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/329—Diseases of the aorta or its branches, e.g. aneurysms, aortic dissection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
CN201380047272.0A 2012-09-12 2013-03-28 鉴定具有异常分数缩短的患者 Active CN104620111B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12184085 2012-09-12
EP12184085.4 2012-09-12
PCT/EP2013/056706 WO2014040759A1 (en) 2012-09-12 2013-03-28 Identification of patients with abnormal fractional shortening

Publications (2)

Publication Number Publication Date
CN104620111A CN104620111A (zh) 2015-05-13
CN104620111B true CN104620111B (zh) 2017-08-08

Family

ID=46826365

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380047272.0A Active CN104620111B (zh) 2012-09-12 2013-03-28 鉴定具有异常分数缩短的患者

Country Status (7)

Country Link
US (3) US20150185230A1 (https=)
EP (3) EP2895866B1 (https=)
JP (2) JP6247302B2 (https=)
CN (1) CN104620111B (https=)
CA (1) CA2883890C (https=)
ES (2) ES2913539T3 (https=)
WO (1) WO2014040759A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103998938B (zh) 2011-10-17 2016-06-15 霍夫曼-拉罗奇有限公司 风险患者和中风原因的基于肌钙蛋白和bnp的诊断
EP2924438B1 (en) 2014-03-26 2018-04-18 Roche Diagnostics GmbH IGFBP7 for diagnosing diastolic dysfunction
CN107110871B (zh) 2014-10-29 2019-09-27 豪夫迈·罗氏有限公司 用于死亡的风险预测的生物标志物
JP6859334B2 (ja) 2015-10-08 2021-04-14 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 手術前に測定した際にａｋｉのリスクを予測するためのｉｇｆｂｐ７
WO2017125406A1 (en) * 2016-01-19 2017-07-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting left ventricular remodeling in subjects suffering from hypertension
JP7269182B2 (ja) * 2017-05-30 2023-05-08 アボット・ラボラトリーズ 心臓トロポニンｉ及び早期バイオマーカーを使用する、ヒト対象における軽度外傷性脳損傷を診断及び査定する一助となるための方法
CN111480081A (zh) 2017-12-13 2020-07-31 豪夫迈·罗氏有限公司 用于预测脑卒中的循环血管生成素-2(Ang-2)和胰岛素样生长因子结合蛋白7(IGFBP7)
JP7024576B2 (ja) * 2018-04-20 2022-02-24 オムロンヘルスケア株式会社 電子血圧計および心不全検出器
US12400762B2 (en) 2018-12-11 2025-08-26 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy
US11446009B2 (en) 2018-12-11 2022-09-20 Eko.Ai Pte. Ltd. Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images
US11931207B2 (en) 2018-12-11 2024-03-19 Eko.Ai Pte. Ltd. Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device
US12001939B2 (en) 2018-12-11 2024-06-04 Eko.Ai Pte. Ltd. Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views
US12322100B2 (en) 2018-12-11 2025-06-03 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity
US20250232875A1 (en) * 2022-03-18 2025-07-17 Roche Diagnostics Operations, Inc. Cmybpc marker combinations for early discrimination of type 2 versus type 1 acute myocardial infarction
US12333413B1 (en) * 2024-03-01 2025-06-17 Mayo Foundation For Medical Education And Research Apparatus and method for training an artificial intelligence-supported diagnostic assessment tool

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
GB9211686D0 (en) 1992-06-03 1992-07-15 Medisinsk Innovation A S Chemical compounds
US6709855B1 (en) 1998-12-18 2004-03-23 Scios, Inc. Methods for detection and use of differentially expressed genes in disease states
JP2004532202A (ja) * 2001-03-15 2004-10-21 シアオ，ヨング−フー 生存哺乳動物における臨床的に認められた形態の心臓の病状を治療的に処置する方法
US7632647B2 (en) 2001-04-13 2009-12-15 Biosite Incorporated Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
EP1322957B1 (en) * 2001-05-04 2009-08-12 Biosite Incorporated Diagnostic markers of acute coronary syndromes and methods of use thereof
US20050095646A1 (en) * 2001-11-19 2005-05-05 Sherman Michael I. Method of using a non-antibody protein to detect and measure an analyte
JP2005291899A (ja) * 2004-03-31 2005-10-20 Akira Matsumori 心疾患の検査法
US8563328B2 (en) * 2004-07-26 2013-10-22 University Of Louisville Research Foundation, Inc. Fiber-optic biosensor and biosensing methods
US20080027330A1 (en) * 2006-05-15 2008-01-31 Endothelix, Inc. Risk assessment method for acute cardiovascular events
WO2008060618A2 (en) * 2006-11-15 2008-05-22 University Of Florida Research Foundation Use of genetic determinants in cardiovascular risk assessment
CN106908603B (zh) * 2007-01-25 2019-04-02 霍夫曼-拉罗奇有限公司 Igfbp-7在心力衰竭评估中的用途
WO2008134054A1 (en) * 2007-04-26 2008-11-06 Genera Doo Blood biomarkers for bone fracture and cartilage injury
EP2515116A1 (en) 2007-05-18 2012-10-24 Duke University Serum biomarkers for the early detection of lung cancer
WO2009091556A2 (en) * 2008-01-17 2009-07-23 The General Hospital Corporation Diagnostic methods and kits using fibroblast growth factor-23
AU2009313561A1 (en) * 2008-11-06 2011-06-30 Musc Foundation For Research Development Detecting and monitoring left ventricular hypertrophy and congestive heart failure by profiling biomarkers
BRPI1006780A2 (pt) 2009-04-01 2019-03-26 Lek Pharmaceuticals D. D. processo para preparar um composto, processo para a preparação de 3-amino-2, 2-dimetilpropanamida,processo para preparar um agente terapêutico, profilático ou de diagnóstico, processo para preparar alisquireno, processo para preparar um derivado de criptoficina,uso de um composto,uso de 3-amino-2,2-dimetilpropanamida e uso de agente terapêutico,profilático ou de diagnóstico.
CN102422157B (zh) 2009-04-27 2014-10-29 霍夫曼-拉罗奇有限公司 内皮抑制素作为心力衰竭标记的应用
CN102549436A (zh) 2009-07-27 2012-07-04 霍夫曼-拉罗奇有限公司 mimecan在评价心力衰竭中的用途
JP5763098B2 (ja) * 2009-12-20 2015-08-12 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
JP6092092B2 (ja) * 2010-03-26 2017-03-08 マイカーティス エヌ．ヴェ．ＭｙＣａｒｔｉｓ ＮＶ 腎機能障害、糸球体濾過速度、呼吸困難、急性心不全、左心室肥大、心線維症、子癇前症、妊娠関連蛋白尿のバイオマーカーとしてのｌｔｂｐ２
US20120142632A1 (en) * 2010-08-04 2012-06-07 St. Vincent's Institute Of Medical Research Diagnostic and prognostic assay
CN108387744A (zh) 2010-08-26 2018-08-10 弗·哈夫曼-拉罗切有限公司 生物标志物在评估从动脉高血压向心力衰竭的早期转变中的用途
US10422796B2 (en) * 2010-08-31 2019-09-24 Kyowa Medex Co., Ltd. Method for measuring fibroblast growth factor-23 and reagent therefor

Also Published As

Publication number Publication date
US20150185230A1 (en) 2015-07-02
US20220412991A1 (en) 2022-12-29
EP2895866B1 (en) 2018-05-30
CA2883890A1 (en) 2014-03-20
ES2680149T3 (es) 2018-09-04
WO2014040759A1 (en) 2014-03-20
HK1206097A1 (zh) 2015-12-31
EP3428649A2 (en) 2019-01-16
CN104620111A (zh) 2015-05-13
US20180196067A1 (en) 2018-07-12
EP4075143A1 (en) 2022-10-19
EP3428649B1 (en) 2022-03-23
JP2018049032A (ja) 2018-03-29
JP6615848B2 (ja) 2019-12-04
CA2883890C (en) 2021-11-09
EP3428649A3 (en) 2019-02-13
US11454634B2 (en) 2022-09-27
JP6247302B2 (ja) 2017-12-13
ES2913539T3 (es) 2022-06-02
JP2015531873A (ja) 2015-11-05
EP2895866A1 (en) 2015-07-22

Similar Documents

Publication Publication Date Title
CN104620111B (zh) 鉴定具有异常分数缩短的患者
JP6654668B2 (ja) 発作性心房細動のｂｎｐ型ペプチドに基づく診断をするためのデータを提供する方法
US11047866B2 (en) IGFBP7 for diagnosing diastolic dysfunction
JP6756772B2 (ja) 心不全の治療選択におけるバイオマーカー
JP5419968B2 (ja) 心臓治療を必要とする個体におけるｌ−ｆａｂｐ、ナトリウム利尿ペプチド及び心筋トロポニン
JP6608285B2 (ja) 心不全リスクの予測改善のためのバイオマーカー
WO2017182446A1 (en) Soluble st2 for the identification of progressors to lvh in the general population
HK1206097B (en) Identification of patients with abnormal fractional shortening
HK1234493A1 (en) Igfbp7 for diagnosing diastolic dysfunction
HK1234493B (zh) 用於诊断舒张功能障碍的igfbp7
HK1212434B (en) Tnt based diagnosis of paroxysmal atrial fibrillation

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1206097

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1206097

Country of ref document: HK