JP6238979B2 - 置換トリアゾロピリジンを調製する方法 - Google Patents
置換トリアゾロピリジンを調製する方法 Download PDFInfo
- Publication number
- JP6238979B2 JP6238979B2 JP2015520907A JP2015520907A JP6238979B2 JP 6238979 B2 JP6238979 B2 JP 6238979B2 JP 2015520907 A JP2015520907 A JP 2015520907A JP 2015520907 A JP2015520907 A JP 2015520907A JP 6238979 B2 JP6238979 B2 JP 6238979B2
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- amino
- triazolo
- pyridin
- fluorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CNc1n[n]2c(*)c(*)c(*)c(*)c2n1 Chemical compound CNc1n[n]2c(*)c(*)c(*)c(*)c2n1 0.000 description 4
- XNFVSVYKPFFTFT-UHFFFAOYSA-N CC(C(Nc(cc1)ccc1-c1c[n]2nc(Nc(ccc(C(NCC(F)(F)F)=O)c3)c3OC)nc2cc1)=O)c(cc1)ccc1F Chemical compound CC(C(Nc(cc1)ccc1-c1c[n]2nc(Nc(ccc(C(NCC(F)(F)F)=O)c3)c3OC)nc2cc1)=O)c(cc1)ccc1F XNFVSVYKPFFTFT-UHFFFAOYSA-N 0.000 description 1
- OSCACGWGFVYFLS-GDLZYMKVSA-N CC(C)(C)OC(N[C@@H](C(Nc(cc1)ccc1-c1c[n]2nc(Nc(ccc(S(C)(=O)=O)c3)c3OC)nc2cc1)=O)c(cc1)ccc1F)=O Chemical compound CC(C)(C)OC(N[C@@H](C(Nc(cc1)ccc1-c1c[n]2nc(Nc(ccc(S(C)(=O)=O)c3)c3OC)nc2cc1)=O)c(cc1)ccc1F)=O OSCACGWGFVYFLS-GDLZYMKVSA-N 0.000 description 1
- OPIPTYFTRROUGX-PRVZDSGASA-N CC(C)(C)OC(N[C@@H](C1OC1Nc(cc1)ccc1-c1c[n]2nc(Nc(ccc(C(N3CCC3)=O)c3)c3OC)nc2cc1)c(cc1)ccc1F)=O Chemical compound CC(C)(C)OC(N[C@@H](C1OC1Nc(cc1)ccc1-c1c[n]2nc(Nc(ccc(C(N3CCC3)=O)c3)c3OC)nc2cc1)c(cc1)ccc1F)=O OPIPTYFTRROUGX-PRVZDSGASA-N 0.000 description 1
- WHBRHFSVTZPRII-VQJSHJPSSA-O CC(C)(C)[SH+](c1ccccc1)(c1ccccc1)OC[C@@H](C(Nc(cc1)ccc1-c1c[n]2nc(Nc(c(OCC(F)(F)F)c3)ccc3C(N(C3)CC3F)=O)nc2cc1)=O)c(cc1)ccc1F Chemical compound CC(C)(C)[SH+](c1ccccc1)(c1ccccc1)OC[C@@H](C(Nc(cc1)ccc1-c1c[n]2nc(Nc(c(OCC(F)(F)F)c3)ccc3C(N(C3)CC3F)=O)nc2cc1)=O)c(cc1)ccc1F WHBRHFSVTZPRII-VQJSHJPSSA-O 0.000 description 1
- RIIPQBVKRKWNFS-UHFFFAOYSA-N CCOc(cc(cc1)S(C)(=O)=O)c1Br Chemical compound CCOc(cc(cc1)S(C)(=O)=O)c1Br RIIPQBVKRKWNFS-UHFFFAOYSA-N 0.000 description 1
- XNWGQXGCCUWJHO-UHFFFAOYSA-N COC(Sc(cc1)ccc1F)=O Chemical compound COC(Sc(cc1)ccc1F)=O XNWGQXGCCUWJHO-UHFFFAOYSA-N 0.000 description 1
- UEVXVBKBOFGKIN-UHFFFAOYSA-N COc(cc(cc1)C(O)=O)c1Br Chemical compound COc(cc(cc1)C(O)=O)c1Br UEVXVBKBOFGKIN-UHFFFAOYSA-N 0.000 description 1
- PLULOZSQQAESJA-UHFFFAOYSA-N CS(c(cc1)cc(OCC(F)(F)F)c1Br)(=O)=O Chemical compound CS(c(cc1)cc(OCC(F)(F)F)c1Br)(=O)=O PLULOZSQQAESJA-UHFFFAOYSA-N 0.000 description 1
- XNFVSVYKPFFTFT-GOSISDBHSA-N C[C@@H](C(Nc(cc1)ccc1-c1c[n]2nc(Nc(ccc(C(NCC(F)(F)F)=O)c3)c3OC)nc2cc1)=O)c(cc1)ccc1F Chemical compound C[C@@H](C(Nc(cc1)ccc1-c1c[n]2nc(Nc(ccc(C(NCC(F)(F)F)=O)c3)c3OC)nc2cc1)=O)c(cc1)ccc1F XNFVSVYKPFFTFT-GOSISDBHSA-N 0.000 description 1
- ZPBBFCKACCNCMI-QGZVFWFLSA-N C[C@@H](C(Nc(cc1)ccc1C(C=C1)=CN/C1=N\C(Nc(ccc(C(N)=O)c1)c1OCC(F)(F)F)=N)=O)c(cc1)ccc1F Chemical compound C[C@@H](C(Nc(cc1)ccc1C(C=C1)=CN/C1=N\C(Nc(ccc(C(N)=O)c1)c1OCC(F)(F)F)=N)=O)c(cc1)ccc1F ZPBBFCKACCNCMI-QGZVFWFLSA-N 0.000 description 1
- JKRNJRAPYFXOHE-SNVBAGLBSA-N C[C@@H](C(Nc1ccc(B(O)O)cc1)=O)c(cc1)ccc1F Chemical compound C[C@@H](C(Nc1ccc(B(O)O)cc1)=O)c(cc1)ccc1F JKRNJRAPYFXOHE-SNVBAGLBSA-N 0.000 description 1
- YCDUEKOIMBQNQF-UHFFFAOYSA-N Cc1ccc(CNC=O)cc1 Chemical compound Cc1ccc(CNC=O)cc1 YCDUEKOIMBQNQF-UHFFFAOYSA-N 0.000 description 1
- OXOKWCYRLSCZGM-UHFFFAOYSA-N Nc(cc1)ccc1-c1c[n]2nc(Nc(c(OCC(F)(F)F)c3)ccc3C(N(C3)CC3O)=O)nc2cc1 Chemical compound Nc(cc1)ccc1-c1c[n]2nc(Nc(c(OCC(F)(F)F)c3)ccc3C(N(C3)CC3O)=O)nc2cc1 OXOKWCYRLSCZGM-UHFFFAOYSA-N 0.000 description 1
- MKZIIZYJPRYKMM-UHFFFAOYSA-N O=CN(C1)CC1F Chemical compound O=CN(C1)CC1F MKZIIZYJPRYKMM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12175640.7 | 2012-07-10 | ||
| EP12175640 | 2012-07-10 | ||
| EP12185590.2 | 2012-09-24 | ||
| EP12185590 | 2012-09-24 | ||
| EP13170585.7 | 2013-06-05 | ||
| EP13170585 | 2013-06-05 | ||
| PCT/EP2013/064017 WO2014009219A1 (en) | 2012-07-10 | 2013-07-03 | Method for preparing substituted triazolopyridines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015523372A JP2015523372A (ja) | 2015-08-13 |
| JP6238979B2 true JP6238979B2 (ja) | 2017-11-29 |
Family
ID=48793197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015520907A Expired - Fee Related JP6238979B2 (ja) | 2012-07-10 | 2013-07-03 | 置換トリアゾロピリジンを調製する方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9388177B2 (show.php) |
| EP (1) | EP2872506A1 (show.php) |
| JP (1) | JP6238979B2 (show.php) |
| KR (1) | KR20150040845A (show.php) |
| CN (1) | CN104603136B (show.php) |
| AP (1) | AP3778A (show.php) |
| AU (1) | AU2013289381A1 (show.php) |
| BR (1) | BR112015000308A2 (show.php) |
| CA (1) | CA2878481A1 (show.php) |
| CL (1) | CL2015000038A1 (show.php) |
| CO (1) | CO7160002A2 (show.php) |
| CR (1) | CR20150006A (show.php) |
| DO (1) | DOP2015000007A (show.php) |
| EA (1) | EA027544B1 (show.php) |
| HK (1) | HK1206731A1 (show.php) |
| IL (1) | IL236265A (show.php) |
| IN (1) | IN2015DN00085A (show.php) |
| MX (1) | MX2015000348A (show.php) |
| NZ (1) | NZ703020A (show.php) |
| PE (1) | PE20150354A1 (show.php) |
| PH (1) | PH12015500061A1 (show.php) |
| SG (1) | SG11201408419QA (show.php) |
| TN (1) | TN2015000008A1 (show.php) |
| WO (1) | WO2014009219A1 (show.php) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016526534A (ja) * | 2013-06-11 | 2016-09-05 | バイエル・ファルマ・アクティエンゲゼルシャフト | 置換トリアゾロピリジンのプロドラッグ誘導体 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014195276A1 (en) * | 2013-06-07 | 2014-12-11 | Bayer Pharma Aktiengesellschaft | Substituted triazolopyridines having activity as mps-1 inhibitors |
| EA201600003A1 (ru) | 2013-06-11 | 2016-06-30 | Байер Фарма Акциенгезельшафт | КОМБИНАЦИИ ДЛЯ ЛЕЧЕНИЯ РАКА, СОДЕРЖАЩИЕ ИНГИБИТОР Mps-1 КИНАЗЫ И ИНГИБИТОР МИТОЗА |
| CA2981844A1 (en) | 2015-04-17 | 2016-10-20 | Netherlands Translational Research Center B.V. | Prognostic biomarkers for ttk inhibitor chemotherapy |
| TW201800408A (zh) | 2016-06-15 | 2018-01-01 | 拜耳製藥公司 | Mps-1抑制劑 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003030937A1 (en) * | 2001-10-05 | 2003-04-17 | Ono Pharmaceutical Co., Ltd. | Remedies for stress diseases comprising mitochondrial benzodiazepine receptor antagonists |
| US20060074102A1 (en) * | 2004-05-14 | 2006-04-06 | Kevin Cusack | Kinase inhibitors as therapeutic agents |
| UA89503C2 (uk) * | 2004-09-13 | 2010-02-10 | Х. Луннбек А/С | Заміщені похідні аніліну |
| US7524860B2 (en) * | 2004-10-07 | 2009-04-28 | Pfizer Inc. | Antibacterial agents |
| US20060194823A1 (en) * | 2004-12-22 | 2006-08-31 | Georg Kettschau | Sulfonamido-macrocycles as Tie2 inhibitors and the salts thereof, a pharmaceutical composition comprising these compounds, the method of preparing and the use thereof |
| AR061229A1 (es) * | 2006-06-06 | 2008-08-13 | Schering Corp | Imidazopirazinas como inhibidores de la proteina quinasa |
| EP1870416A1 (en) * | 2006-06-21 | 2007-12-26 | Bayer Schering Pharma Aktiengesellschaft | Sulphonamido-macrocycles as tie2 inhibitors |
| CA2662074A1 (en) | 2006-08-30 | 2008-03-06 | Cellzome Limited | Triazole derivatives as kinase inhibitors |
| JO3598B1 (ar) * | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
| AR067562A1 (es) | 2007-07-18 | 2009-10-14 | Novartis Ag | Compuestos heterociclicos inhibidores de kinasa |
| WO2009024824A1 (en) | 2007-08-23 | 2009-02-26 | Astrazeneca Ab | 2-anilinopurin-8-ones as inhibitors of ttk/mps1 for the treatment of proliferative disorders |
| AU2008291075A1 (en) | 2007-08-31 | 2009-03-05 | Merck Serono S.A. | Triazolopyridine compounds and their use as ask inhibitors |
| GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| GB0724342D0 (en) * | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Anitbacterial compositions |
| US8530689B2 (en) * | 2008-05-05 | 2013-09-10 | The Trustees Of The University Of Pennsylvania | Processes for the preparation of biphenyl compounds |
| US20110212053A1 (en) * | 2008-06-19 | 2011-09-01 | Dapeng Qian | Phosphatidylinositol 3 kinase inhibitors |
| JP2012517971A (ja) | 2009-02-13 | 2012-08-09 | フォーヴィア・ファーマシューティカルズ | キナーゼ阻害薬としての［１，２，４］トリアゾロ［１，５−ａ］ピリジン類 |
| CA2760077A1 (en) | 2009-04-29 | 2010-11-04 | Marcus Koppitz | Substituted imidazoquinoxalines |
| CA2763900A1 (en) * | 2009-06-05 | 2010-12-09 | Cephalon, Inc. | Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives |
| WO2010141360A1 (en) * | 2009-06-05 | 2010-12-09 | Merck Sharp & Dohme Corp. | Biaryl benzotriazole derivatives |
| CN102596932A (zh) | 2009-09-04 | 2012-07-18 | 拜耳医药股份有限公司 | 作为酪氨酸苏氨酸激酶抑制剂的取代氨基喹喔啉 |
| EP2343295A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridine derivates |
| EP2343297A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines |
| EP2343294A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Substituted triazolopyridines |
| UY33452A (es) * | 2010-06-16 | 2012-01-31 | Bayer Schering Pharma Ag | Triazolopiridinas sustituidas |
| WO2012044567A2 (en) * | 2010-09-30 | 2012-04-05 | Merck Sharp & Dohme Corp. | Imidazole derivatives |
| CN103608350B (zh) * | 2011-04-21 | 2015-11-25 | 拜耳知识产权有限责任公司 | 三唑并吡啶类化合物 |
| WO2012160029A1 (en) * | 2011-05-23 | 2012-11-29 | Bayer Intellectual Property Gmbh | Substituted triazolopyridines |
| UA112096C2 (uk) * | 2011-12-12 | 2016-07-25 | Байєр Інтеллектуал Проперті Гмбх | Заміщені триазолопіридини та їх застосування як інгібіторів ttk |
-
2013
- 2013-07-03 EP EP13737181.1A patent/EP2872506A1/en not_active Withdrawn
- 2013-07-03 SG SG11201408419QA patent/SG11201408419QA/en unknown
- 2013-07-03 MX MX2015000348A patent/MX2015000348A/es unknown
- 2013-07-03 AU AU2013289381A patent/AU2013289381A1/en not_active Abandoned
- 2013-07-03 WO PCT/EP2013/064017 patent/WO2014009219A1/en not_active Ceased
- 2013-07-03 IN IN85DEN2015 patent/IN2015DN00085A/en unknown
- 2013-07-03 JP JP2015520907A patent/JP6238979B2/ja not_active Expired - Fee Related
- 2013-07-03 CN CN201380045913.9A patent/CN104603136B/zh not_active Expired - Fee Related
- 2013-07-03 US US14/414,164 patent/US9388177B2/en not_active Expired - Fee Related
- 2013-07-03 NZ NZ703020A patent/NZ703020A/en not_active IP Right Cessation
- 2013-07-03 CA CA2878481A patent/CA2878481A1/en not_active Abandoned
- 2013-07-03 AP AP2014008177A patent/AP3778A/en active
- 2013-07-03 HK HK15107242.4A patent/HK1206731A1/xx unknown
- 2013-07-03 BR BR112015000308A patent/BR112015000308A2/pt not_active IP Right Cessation
- 2013-07-03 KR KR20157000338A patent/KR20150040845A/ko not_active Withdrawn
- 2013-07-03 PE PE2015000017A patent/PE20150354A1/es not_active Application Discontinuation
- 2013-07-03 EA EA201590116A patent/EA027544B1/ru not_active IP Right Cessation
-
2014
- 2014-12-15 IL IL236265A patent/IL236265A/en not_active IP Right Cessation
-
2015
- 2015-01-07 TN TNP2015000008A patent/TN2015000008A1/fr unknown
- 2015-01-08 CL CL2015000038A patent/CL2015000038A1/es unknown
- 2015-01-09 PH PH12015500061A patent/PH12015500061A1/en unknown
- 2015-01-09 CO CO15004251A patent/CO7160002A2/es unknown
- 2015-01-09 DO DO2015000007A patent/DOP2015000007A/es unknown
- 2015-01-09 CR CR20150006A patent/CR20150006A/es unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016526534A (ja) * | 2013-06-11 | 2016-09-05 | バイエル・ファルマ・アクティエンゲゼルシャフト | 置換トリアゾロピリジンのプロドラッグ誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| IN2015DN00085A (show.php) | 2015-05-29 |
| CL2015000038A1 (es) | 2015-03-13 |
| IL236265A0 (en) | 2015-02-26 |
| IL236265A (en) | 2017-07-31 |
| US20150148542A1 (en) | 2015-05-28 |
| BR112015000308A2 (pt) | 2017-06-27 |
| NZ703020A (en) | 2017-08-25 |
| CA2878481A1 (en) | 2014-01-16 |
| JP2015523372A (ja) | 2015-08-13 |
| DOP2015000007A (es) | 2015-02-15 |
| US9388177B2 (en) | 2016-07-12 |
| SG11201408419QA (en) | 2015-01-29 |
| AU2013289381A1 (en) | 2015-01-22 |
| CN104603136B (zh) | 2017-06-27 |
| CR20150006A (es) | 2015-02-16 |
| PE20150354A1 (es) | 2015-03-21 |
| MX2015000348A (es) | 2015-04-14 |
| TN2015000008A1 (en) | 2016-06-29 |
| CO7160002A2 (es) | 2015-01-15 |
| EA201590116A1 (ru) | 2015-07-30 |
| HK1206731A1 (en) | 2016-01-15 |
| PH12015500061A1 (en) | 2015-03-02 |
| EA027544B1 (ru) | 2017-08-31 |
| EP2872506A1 (en) | 2015-05-20 |
| AP3778A (en) | 2016-08-31 |
| CN104603136A (zh) | 2015-05-06 |
| KR20150040845A (ko) | 2015-04-15 |
| AP2014008177A0 (en) | 2014-12-31 |
| WO2014009219A1 (en) | 2014-01-16 |
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