JP6227636B2 - 使い捨てバイオリアクタおよびヘッドプレート、並びにそれらを製造するプロセス - Google Patents
使い捨てバイオリアクタおよびヘッドプレート、並びにそれらを製造するプロセス Download PDFInfo
- Publication number
- JP6227636B2 JP6227636B2 JP2015516610A JP2015516610A JP6227636B2 JP 6227636 B2 JP6227636 B2 JP 6227636B2 JP 2015516610 A JP2015516610 A JP 2015516610A JP 2015516610 A JP2015516610 A JP 2015516610A JP 6227636 B2 JP6227636 B2 JP 6227636B2
- Authority
- JP
- Japan
- Prior art keywords
- head plate
- bioreactor
- magnetic
- disposable bioreactor
- dip
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/40—Manifolds; Distribution pieces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/42—Integrated assemblies, e.g. cassettes or cartridges
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/10—Methods of surface bonding and/or assembly therefor
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
Description
Claims (10)
- 使い捨てバイオリアクタ(1)用のヘッドプレート(100)であって、
内側部分(101)と、内側部分(101)とは反対側に位置する外側部分(102)とを有し、
内側部分(101)は、複数の浸漬チューブ(110)を有し、外側部分(102)は、複数のコネクタ(120)を有し、これらによってヘッドプレート(100)の一体的パーツを構成し、
浸漬チューブ(110)の長さは、使い捨てバイオリアクタ(1)が最小限の充填ボリュームまで満たされたときに、浸漬チューブが内容物又は細胞培養液に浸漬する長さ、かつ、ヘッドプレート(100)の直径の50%よりも大きい長さに設定される、ヘッドプレート(100)。 - 浸漬チューブ(110)は、ヘッドプレート(100)の直径よりも大きい長さを有する、請求項1に記載のヘッドプレート(100)。
- 浸漬チューブ(110)は、5mmよりも小さい内径および/又は3mmよりも小さい壁厚を有する、請求項1又は2に記載のヘッドプレート(100)。
- 少なくとも2つの浸漬チューブ(110)は、異なる内径を有する、請求項1から3のいずれか1つに記載のヘッドプレート(100)。
- 少なくとも2つの浸漬チューブ(110)は、異なる長さを有する、請求項1から4のいずれか1つに記載のヘッドプレート(100)。
- 攪拌機(300)の軸受(500)を収容するための窪みをさらに備える、請求項1から5のいずれか1つに記載のヘッドプレート(100)。
- 複数の浸漬チューブ(110)のうちの少なくとも1つの直径は、ヘッドプレート(100)の反対側に位置する端部がテーパ状である、請求項1から6のいずれか1つに記載のヘッドプレート(100)。
- テーパ状の浸漬チューブ(110)および/又はその他の浸漬チューブの1つ又は複数は、ヘッドプレート(100)の反対側に位置する端部にて閉じている、請求項7に記載のヘッドプレート(100)。
- ヘッドプレート(100)の外側部分に配置されたコネクタ(120)のうちの少なくとも1つは、内側にねじ山を有する、請求項1から8のいずれか1つに記載のヘッドプレート(100)。
- 使い捨てバイオリアクタ(1)用のヘッドプレート(100)を製造する方法であって、
内側部分(101)と、内側部分(101)とは反対側に位置する外側部分(102)とを有するヘッドプレート(100)を射出成形により製造するステップを含み、
内側部分(101)は、複数の浸漬チューブ(110)を有し、外側部分(102)は、複数のコネクタ(120)を有し、これらによってヘッドプレート(100)の一体的パーツを構成し、
浸漬チューブ(110)の長さは、使い捨てバイオリアクタ(1)が最小限の充填ボリュームまで満たされたときに、浸漬チューブが内容物又は細胞培養液に浸漬する長さ、かつ、ヘッドプレート(100)の直径の50%よりも大きい長さに設定される、ヘッドプレート(100)の製造方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261660554P | 2012-06-15 | 2012-06-15 | |
EP12172304.3 | 2012-06-15 | ||
EP12172304.3A EP2674479B1 (de) | 2012-06-15 | 2012-06-15 | Einwegbioreaktor und Kopfplatte sowie Herstellungsverfahren |
US61/660,554 | 2012-06-15 | ||
PCT/EP2013/062225 WO2013186294A1 (en) | 2012-06-15 | 2013-06-13 | Single-use bioreactor and head plate, and a process for manufacturing same |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017150939A Division JP6527919B2 (ja) | 2012-06-15 | 2017-08-03 | 使い捨てバイオリアクタおよびヘッドプレート、並びにそれらを製造するプロセス |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2015525073A JP2015525073A (ja) | 2015-09-03 |
JP6227636B2 true JP6227636B2 (ja) | 2017-11-08 |
Family
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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JP2015516610A Expired - Fee Related JP6227636B2 (ja) | 2012-06-15 | 2013-06-13 | 使い捨てバイオリアクタおよびヘッドプレート、並びにそれらを製造するプロセス |
JP2017150939A Active JP6527919B2 (ja) | 2012-06-15 | 2017-08-03 | 使い捨てバイオリアクタおよびヘッドプレート、並びにそれらを製造するプロセス |
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JP2017150939A Active JP6527919B2 (ja) | 2012-06-15 | 2017-08-03 | 使い捨てバイオリアクタおよびヘッドプレート、並びにそれらを製造するプロセス |
Country Status (6)
Country | Link |
---|---|
US (1) | US10030220B2 (ja) |
EP (2) | EP2674479B1 (ja) |
JP (2) | JP6227636B2 (ja) |
CN (1) | CN104379722B (ja) |
DK (2) | DK2674479T3 (ja) |
WO (1) | WO2013186294A1 (ja) |
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CN108350405A (zh) * | 2015-08-08 | 2018-07-31 | 施托贝制药技术股份有限公司 | 支持生物活性的一次性生物处理系统 |
US10836989B2 (en) * | 2015-10-16 | 2020-11-17 | Global Life Sciences Solutions Usa Llc | Disposable container, mixing system and packaging |
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2012
- 2012-06-15 EP EP12172304.3A patent/EP2674479B1/de active Active
- 2012-06-15 DK DK12172304.3T patent/DK2674479T3/en active
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2013
- 2013-06-13 CN CN201380031555.6A patent/CN104379722B/zh active Active
- 2013-06-13 US US14/408,069 patent/US10030220B2/en active Active
- 2013-06-13 DK DK13730518.1T patent/DK2861711T3/da active
- 2013-06-13 EP EP13730518.1A patent/EP2861711B1/en active Active
- 2013-06-13 JP JP2015516610A patent/JP6227636B2/ja not_active Expired - Fee Related
- 2013-06-13 WO PCT/EP2013/062225 patent/WO2013186294A1/en active Application Filing
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- 2017-08-03 JP JP2017150939A patent/JP6527919B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
US20150132840A1 (en) | 2015-05-14 |
EP2674479A1 (de) | 2013-12-18 |
EP2861711B1 (en) | 2022-07-20 |
JP2015525073A (ja) | 2015-09-03 |
WO2013186294A1 (en) | 2013-12-19 |
US10030220B2 (en) | 2018-07-24 |
DK2674479T3 (en) | 2015-04-13 |
EP2674479B1 (de) | 2015-03-18 |
JP2017225454A (ja) | 2017-12-28 |
EP2861711A1 (en) | 2015-04-22 |
DK2861711T3 (da) | 2022-08-01 |
CN104379722A (zh) | 2015-02-25 |
JP6527919B2 (ja) | 2019-06-12 |
CN104379722B (zh) | 2018-11-09 |
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