JP6219841B2 - 放射性構成物およびそれらの治療的使用方法 - Google Patents

放射性構成物およびそれらの治療的使用方法 Download PDF

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Publication number
JP6219841B2
JP6219841B2 JP2014548954A JP2014548954A JP6219841B2 JP 6219841 B2 JP6219841 B2 JP 6219841B2 JP 2014548954 A JP2014548954 A JP 2014548954A JP 2014548954 A JP2014548954 A JP 2014548954A JP 6219841 B2 JP6219841 B2 JP 6219841B2
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formula
equal
radioactive
composition
present
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Japanese (ja)
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JP2015510496A (ja
JP2015510496A5 (enExample
Inventor
エー．ウィルソン デイビッド
エー．ウィルソン デイビッド
フランク アール．キース
フランク アール．キース
サイモン ジェイミー
サイモン ジェイミー
ケー．クランプ ドゥルース
ケー．クランプ ドゥルース
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IsoTherapeutics Group LLC
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IsoTherapeutics Group LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/121—Solutions, i.e. homogeneous liquid formulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1244—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Nanotechnology (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
JP2014548954A 2011-12-21 2012-12-21 放射性構成物およびそれらの治療的使用方法 Active JP6219841B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161578630P 2011-12-21 2011-12-21
US61/578,630 2011-12-21
US201261606734P 2012-03-05 2012-03-05
US61/606,734 2012-03-05
PCT/US2012/071256 WO2013096776A2 (en) 2011-12-21 2012-12-21 Radioactive compositions and methods for their therapeutic use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017047326A Division JP6356854B2 (ja) 2011-12-21 2017-03-13 放射性構成物およびそれらの治療的使用方法

Publications (3)

Publication Number Publication Date
JP2015510496A JP2015510496A (ja) 2015-04-09
JP2015510496A5 JP2015510496A5 (enExample) 2016-04-07
JP6219841B2 true JP6219841B2 (ja) 2017-10-25

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JP2014548954A Active JP6219841B2 (ja) 2011-12-21 2012-12-21 放射性構成物およびそれらの治療的使用方法
JP2017047326A Active JP6356854B2 (ja) 2011-12-21 2017-03-13 放射性構成物およびそれらの治療的使用方法

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Country Status (8)

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US (3) US9687574B2 (enExample)
EP (1) EP2793955B1 (enExample)
JP (2) JP6219841B2 (enExample)
KR (2) KR102006599B1 (enExample)
AU (1) AU2012358364B2 (enExample)
CA (1) CA2859971C (enExample)
ES (1) ES2671622T3 (enExample)
WO (1) WO2013096776A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017149722A (ja) * 2011-12-21 2017-08-31 アイソセラピューティクス グループ リミティド ライアビリティー カンパニーＩｓｏＴｈｅｒａｐｅｕｔｉｃｓ Ｇｒｏｕｐ ＬＬＣ 放射性構成物およびそれらの治療的使用方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016520650A (ja) * 2013-06-05 2016-07-14 アール−エヌエーヴィ・エルエルシー スズ−１１７ｍでの免疫性、炎症性及び変形性関節炎の治療
EP3893943A1 (en) * 2018-12-14 2021-10-20 QUIREM Medical BV Particle comprising lanthanide hydroxide
WO2020257409A1 (en) * 2019-06-18 2020-12-24 Serene, Llc A novel tin-117m colloid formulation with the ability to distinguish it from existing tin-117m colloid formulations
WO2021154746A1 (en) 2020-01-28 2021-08-05 Reflexion Medical, Inc. Joint optimization of radionuclide and external beam radiotherapy

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4533541A (en) 1983-08-25 1985-08-06 The United States Of America As Represented By The United States Department Of Energy Tin-117m-labeled stannic (Sn4+) chelates
JPH02501062A (ja) * 1986-11-17 1990-04-12 クラークソン ユニバーシティ 希土類酸化物の均一なコロイド状粒子の合成方法
US4906450A (en) 1987-03-26 1990-03-06 Ephraim Lieberman Treatment of arthritis, including rheumatoid arthritis, with the radionuclide, tin SN-121
US5045289A (en) 1989-10-04 1991-09-03 Research Corporation Technologies, Inc. Formation of rare earth carbonates using supercritical carbon dioxide
US5320824A (en) 1989-10-12 1994-06-14 Mallinckrodt Medical, Inc. Radionuclide labelled particles useful for radiation synovectomy
US5061476A (en) * 1989-12-27 1991-10-29 The Dow Chemical Company Radiolabeled colloid compositions and method for preparing same
US5137709A (en) 1991-02-15 1992-08-11 The Dow Chemical Company Layered mixed metal hydroxides for the stabilization of radioactive colloids
JP3122319B2 (ja) 1994-05-02 2001-01-09 アソシエーティド ユニバーシティーズ，インコーポレイティド 錫−１１７ｍ−含有放射性治療剤
JP3734502B2 (ja) * 1994-07-01 2006-01-11 サーノフ コーポレイション 小さな粒子サイズの蛍光体の調製方法
US6132642A (en) * 1994-07-01 2000-10-17 Sarnoff Corporation Method of preparing small particle size phosphors
US6231832B1 (en) 1998-03-23 2001-05-15 Brookhaven Science Associates Radiopharmaceutical stannic Sn-117m chelate compositions and methods of use
US6004532A (en) 1998-06-08 1999-12-21 Brookhaven Science Associates Formulation for Tin-117m /diethylenetriaminepentaacetic acids
US7045166B2 (en) 1998-08-27 2006-05-16 Silver Barnard S Sweetener compositions containing fractions of inulin
GB0020610D0 (en) 2000-08-21 2000-10-11 Dytech Corp Ltd Uses of porous carriers
US7893223B2 (en) * 2001-07-17 2011-02-22 Bracco Imaging S.P.A. Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy
US7731648B2 (en) 2001-07-25 2010-06-08 Aduro Biotech Magnetic nanoscale particle compositions, and therapeutic methods related thereto
EP1458416A1 (en) * 2001-12-13 2004-09-22 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
CA2509328A1 (en) 2002-12-10 2004-06-24 University Of Miami Radioablation of hemolymphopoietic cell populations
CN100418585C (zh) * 2003-07-24 2008-09-17 伯拉考成像股份公司 稳定的放射性药物组合物及制备方法
US20060014938A1 (en) * 2004-07-14 2006-01-19 Groman Ernest V Stable aqueous colloidal lanthanide oxides
US20070259052A1 (en) * 2006-05-05 2007-11-08 Shire International Licensing B.V. Assay for lanthanum hydroxycarbonate
EP2195036A4 (en) * 2007-10-05 2011-03-09 Isotherapeautics Group Llc COMPOSITIONS FOR THE TREATMENT OF TUMORS BY DIRECT ADMINISTRATION OF A RADIO ISOTOPE
US20100196268A1 (en) 2008-02-15 2010-08-05 Isotherapeutics Group Llc Compositions and methods for treatment of tumors by direct administration of a radioisotope
US20090191126A1 (en) * 2007-11-27 2009-07-30 The Regents Of The University Of California Peptide and multivalent peptide conjugate for diagnosis and treatment of vascular plaques
WO2009073193A2 (en) * 2007-12-03 2009-06-11 The Johns Hopkins University Methods of synthesis and use of chemospheres
JP2011518198A (ja) * 2008-04-24 2011-06-23 ジ オーストラリアン ナショナル ユニバーシティー 放射性標識合成ポリマーのための方法
US20120316633A1 (en) * 2011-06-07 2012-12-13 Boston Scientific Scimed, Inc. Durable Stent Drug Eluting Coating
AU2012358364B2 (en) * 2011-12-21 2017-08-10 Igl Pharma, Inc. Radioactive compositions and methods for their therapeutic use
MY150861A (en) 2012-07-18 2014-03-06 Univ Malaya Neutron activated 153sm labelled microspheres

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017149722A (ja) * 2011-12-21 2017-08-31 アイソセラピューティクス グループ リミティド ライアビリティー カンパニーＩｓｏＴｈｅｒａｐｅｕｔｉｃｓ Ｇｒｏｕｐ ＬＬＣ 放射性構成物およびそれらの治療的使用方法

Also Published As

Publication number Publication date
JP2017149722A (ja) 2017-08-31
EP2793955A4 (en) 2016-01-06
WO2013096776A2 (en) 2013-06-27
US20200155716A1 (en) 2020-05-21
AU2012358364A1 (en) 2014-08-07
JP2015510496A (ja) 2015-04-09
KR101973830B1 (ko) 2019-04-29
US10918746B2 (en) 2021-02-16
EP2793955A2 (en) 2014-10-29
JP6356854B2 (ja) 2018-07-11
US20170258949A1 (en) 2017-09-14
CA2859971C (en) 2020-08-04
ES2671622T3 (es) 2018-06-07
WO2013096776A3 (en) 2015-01-08
KR20140105016A (ko) 2014-08-29
US9687574B2 (en) 2017-06-27
EP2793955B1 (en) 2018-04-11
CA2859971A1 (en) 2013-06-27
US10583211B2 (en) 2020-03-10
US20150023869A1 (en) 2015-01-22
AU2012358364B2 (en) 2017-08-10
KR20190047101A (ko) 2019-05-07
KR102006599B1 (ko) 2019-08-01

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