AU2012358364B2 - Radioactive compositions and methods for their therapeutic use - Google Patents

Radioactive compositions and methods for their therapeutic use Download PDF

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Publication number
AU2012358364B2
AU2012358364B2 AU2012358364A AU2012358364A AU2012358364B2 AU 2012358364 B2 AU2012358364 B2 AU 2012358364B2 AU 2012358364 A AU2012358364 A AU 2012358364A AU 2012358364 A AU2012358364 A AU 2012358364A AU 2012358364 B2 AU2012358364 B2 AU 2012358364B2
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AU
Australia
Prior art keywords
equal
formula
composition
radioactive
present
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AU2012358364A
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AU2012358364A1 (en
Inventor
Druce K. Crump
R. Keith Frank
Jaime Simon
David A. Wilson
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Igl Pharma Inc
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Igl Pharma Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/121—Solutions, i.e. homogeneous liquid formulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1244—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nanotechnology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
AU2012358364A 2011-12-21 2012-12-21 Radioactive compositions and methods for their therapeutic use Active AU2012358364B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161578630P 2011-12-21 2011-12-21
US61/578,630 2011-12-21
US201261606734P 2012-03-05 2012-03-05
US61/606,734 2012-03-05
PCT/US2012/071256 WO2013096776A2 (en) 2011-12-21 2012-12-21 Radioactive compositions and methods for their therapeutic use

Publications (2)

Publication Number Publication Date
AU2012358364A1 AU2012358364A1 (en) 2014-08-07
AU2012358364B2 true AU2012358364B2 (en) 2017-08-10

Family

ID=48669706

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012358364A Active AU2012358364B2 (en) 2011-12-21 2012-12-21 Radioactive compositions and methods for their therapeutic use

Country Status (8)

Country Link
US (3) US9687574B2 (enExample)
EP (1) EP2793955B1 (enExample)
JP (2) JP6219841B2 (enExample)
KR (2) KR102006599B1 (enExample)
AU (1) AU2012358364B2 (enExample)
CA (1) CA2859971C (enExample)
ES (1) ES2671622T3 (enExample)
WO (1) WO2013096776A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013096776A2 (en) * 2011-12-21 2013-06-27 Iso Therapeutics Group Llc Radioactive compositions and methods for their therapeutic use
WO2014197681A1 (en) * 2013-06-05 2014-12-11 Rheumco Llc Treatment of immune, inflammatory and degenerative arthritides with tin-117m
CN113260386A (zh) * 2018-12-14 2021-08-13 桂仁医疗有限公司 包括镧系元素氢氧化物的颗粒
CA3143686A1 (en) * 2019-06-18 2020-12-24 Serene, Llc A novel tin-117m colloid formulation with the ability to distinguish it from existing tin-117m colloid formulations
CA3169406A1 (en) 2020-01-28 2021-08-05 Reflexion Medical, Inc. Joint optimization of radionuclide and external beam radiotherapy

Citations (8)

* Cited by examiner, † Cited by third party
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WO1992014494A1 (en) * 1991-02-15 1992-09-03 The Dow Chemical Company Layered mixed metal hydroxides for the stabilization of radioactive colloids
US5320824A (en) * 1989-10-12 1994-06-14 Mallinckrodt Medical, Inc. Radionuclide labelled particles useful for radiation synovectomy
WO1995029706A1 (en) * 1994-05-02 1995-11-09 Associated Universities, Inc. TIN-117m-CONTAINING RADIOTHERAPEUTIC AGENTS
US6231832B1 (en) * 1998-03-23 2001-05-15 Brookhaven Science Associates Radiopharmaceutical stannic Sn-117m chelate compositions and methods of use
WO2003051403A1 (en) * 2001-12-13 2003-06-26 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
WO2009045230A1 (en) * 2007-10-05 2009-04-09 Iso Therapeutics Group Llc Compositions for treatment of tumors by direct administration of a radioisotope
WO2009073193A2 (en) * 2007-12-03 2009-06-11 The Johns Hopkins University Methods of synthesis and use of chemospheres
US20100196268A1 (en) * 2008-02-15 2010-08-05 Isotherapeutics Group Llc Compositions and methods for treatment of tumors by direct administration of a radioisotope

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US4533541A (en) 1983-08-25 1985-08-06 The United States Of America As Represented By The United States Department Of Energy Tin-117m-labeled stannic (Sn4+) chelates
WO1988003910A1 (en) * 1986-11-17 1988-06-02 Clarkson University Process for synthesis of uniform colloidal particles of rare earth oxides
US4906450A (en) 1987-03-26 1990-03-06 Ephraim Lieberman Treatment of arthritis, including rheumatoid arthritis, with the radionuclide, tin SN-121
US5045289A (en) * 1989-10-04 1991-09-03 Research Corporation Technologies, Inc. Formation of rare earth carbonates using supercritical carbon dioxide
US5061476A (en) * 1989-12-27 1991-10-29 The Dow Chemical Company Radiolabeled colloid compositions and method for preparing same
US6132642A (en) 1994-07-01 2000-10-17 Sarnoff Corporation Method of preparing small particle size phosphors
EP0797649B1 (en) * 1994-07-01 2000-09-06 Sarnoff Corporation Method of preparing small particle size phosphors
US6004532A (en) 1998-06-08 1999-12-21 Brookhaven Science Associates Formulation for Tin-117m /diethylenetriaminepentaacetic acids
US7045166B2 (en) 1998-08-27 2006-05-16 Silver Barnard S Sweetener compositions containing fractions of inulin
GB0020610D0 (en) 2000-08-21 2000-10-11 Dytech Corp Ltd Uses of porous carriers
US7893223B2 (en) * 2001-07-17 2011-02-22 Bracco Imaging S.P.A. Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy
US7731648B2 (en) * 2001-07-25 2010-06-08 Aduro Biotech Magnetic nanoscale particle compositions, and therapeutic methods related thereto
EP1572247A1 (en) 2002-12-10 2005-09-14 University Of Miami Radioablation of hemolymphopoietic cell populations
AU2004259028C1 (en) * 2003-07-24 2009-12-24 Bracco Imaging S.P.A. Stable radiopharmaceutical compositions and methods for preparation
US20060014938A1 (en) * 2004-07-14 2006-01-19 Groman Ernest V Stable aqueous colloidal lanthanide oxides
US20070259052A1 (en) 2006-05-05 2007-11-08 Shire International Licensing B.V. Assay for lanthanum hydroxycarbonate
US20090191126A1 (en) * 2007-11-27 2009-07-30 The Regents Of The University Of California Peptide and multivalent peptide conjugate for diagnosis and treatment of vascular plaques
CN102065905B (zh) 2008-04-24 2013-02-13 澳大利亚国立大学 用于放射性标记合成聚合物的方法
US20120316633A1 (en) * 2011-06-07 2012-12-13 Boston Scientific Scimed, Inc. Durable Stent Drug Eluting Coating
WO2013096776A2 (en) * 2011-12-21 2013-06-27 Iso Therapeutics Group Llc Radioactive compositions and methods for their therapeutic use
MY150861A (en) 2012-07-18 2014-03-06 Univ Malaya Neutron activated 153sm labelled microspheres

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5320824A (en) * 1989-10-12 1994-06-14 Mallinckrodt Medical, Inc. Radionuclide labelled particles useful for radiation synovectomy
WO1992014494A1 (en) * 1991-02-15 1992-09-03 The Dow Chemical Company Layered mixed metal hydroxides for the stabilization of radioactive colloids
WO1995029706A1 (en) * 1994-05-02 1995-11-09 Associated Universities, Inc. TIN-117m-CONTAINING RADIOTHERAPEUTIC AGENTS
US6231832B1 (en) * 1998-03-23 2001-05-15 Brookhaven Science Associates Radiopharmaceutical stannic Sn-117m chelate compositions and methods of use
WO2003051403A1 (en) * 2001-12-13 2003-06-26 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
WO2009045230A1 (en) * 2007-10-05 2009-04-09 Iso Therapeutics Group Llc Compositions for treatment of tumors by direct administration of a radioisotope
WO2009073193A2 (en) * 2007-12-03 2009-06-11 The Johns Hopkins University Methods of synthesis and use of chemospheres
US20100196268A1 (en) * 2008-02-15 2010-08-05 Isotherapeutics Group Llc Compositions and methods for treatment of tumors by direct administration of a radioisotope

Also Published As

Publication number Publication date
US10918746B2 (en) 2021-02-16
EP2793955A4 (en) 2016-01-06
EP2793955A2 (en) 2014-10-29
JP6356854B2 (ja) 2018-07-11
US20170258949A1 (en) 2017-09-14
US10583211B2 (en) 2020-03-10
US20150023869A1 (en) 2015-01-22
CA2859971A1 (en) 2013-06-27
JP2015510496A (ja) 2015-04-09
EP2793955B1 (en) 2018-04-11
WO2013096776A3 (en) 2015-01-08
JP2017149722A (ja) 2017-08-31
KR102006599B1 (ko) 2019-08-01
KR20140105016A (ko) 2014-08-29
WO2013096776A2 (en) 2013-06-27
ES2671622T3 (es) 2018-06-07
AU2012358364A1 (en) 2014-08-07
JP6219841B2 (ja) 2017-10-25
KR20190047101A (ko) 2019-05-07
US9687574B2 (en) 2017-06-27
CA2859971C (en) 2020-08-04
US20200155716A1 (en) 2020-05-21
KR101973830B1 (ko) 2019-04-29

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Owner name: IGL PHARMA, INC.

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