JP6215707B2 - 抗ｃｃｒ４抗体およびその使用 - Google Patents
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42037010P | 2010-12-07 | 2010-12-07 | |
| GB1020738.9 | 2010-12-07 | ||
| GB201020738A GB201020738D0 (en) | 2010-12-07 | 2010-12-07 | Antibodies |
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| GB2512857A (en) | 2013-04-09 | 2014-10-15 | Cancer Res Technology | Cancer biomarker |
| WO2015191997A1 (en) * | 2014-06-12 | 2015-12-17 | The General Hospital Corporation | Anti-human chemokine (c-c motif) receptor 4 immunotoxins |
| CA2954934C (en) | 2014-06-30 | 2023-09-26 | Glykos Finland Oy | Drug derivative and conjugates |
| WO2016057488A1 (en) * | 2014-10-06 | 2016-04-14 | Dana-Farber Cancer Institute, Inc. | Humanized cc chemokine receptor 4 (ccr4) antibodies and methods of use thereof |
| KR102644875B1 (ko) | 2015-07-23 | 2024-03-06 | 베링거잉겔하임인터내쇼날유한회사 | Il-23a 및 b-세포 활성화 인자(baff)를 표적화하는 화합물 및 이의 용도 |
| CN116903741A (zh) | 2016-06-20 | 2023-10-20 | 科马布有限公司 | 特异性结合于pd-l1的抗体或其抗原结合片段及其用途 |
| CN110494563A (zh) * | 2017-01-30 | 2019-11-22 | 奥菲尔·努斯鲍姆 | 适用于治疗的化学实体 |
| JP6811480B2 (ja) * | 2017-02-28 | 2021-01-13 | 日本全薬工業株式会社 | イヌ皮膚ｔ細胞リンパ腫細胞株 |
| US20210163607A1 (en) * | 2017-05-19 | 2021-06-03 | Nippon Zenyaku Kogyo Co., Ltd. | Method for suppressing regulatory t cell infiltration by ccr4 inhibition and method for treating canine neoplastic disease |
| KR102776166B1 (ko) | 2017-08-07 | 2025-03-04 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 안전한 세포 치료제를 생성하기 위한 플랫폼 |
| CN108250290B (zh) * | 2018-02-23 | 2024-03-12 | 上海捌加壹医药科技有限公司 | Ccr4的n端重组蛋白及其用途 |
| US20220249560A1 (en) * | 2019-05-24 | 2022-08-11 | City Of Hope | Ccr4 targeted chimeric antigen receptor modified t cells for treatment of ccr4 positive malignancies |
| CN111135310B (zh) * | 2019-12-24 | 2021-05-07 | 江苏省人民医院（南京医科大学第一附属医院） | 一种定制化t细胞表位疫苗的双靶向纳米药、其制备方法及应用 |
| JP6960642B2 (ja) * | 2020-04-16 | 2021-11-05 | 国立研究開発法人国立国際医療研究センター | 呼吸器感染症の重症化の予測を補助する方法、バイオマーカーの測定値をモニタリングする方法、これらの方法に用いられる試薬キット、呼吸器感染症の重症化の予測を補助する装置およびコンピュータプログラム |
| CN111704668B (zh) * | 2020-06-27 | 2021-03-30 | 天津金域医学检验实验室有限公司 | 抗ccr4抗体及其在治疗癌症中的应用 |
| CN117187180B (zh) * | 2023-11-03 | 2024-01-26 | 四川大学 | 一种Th17细胞及其培养方法和应用及其诱导液 |
| US20250215087A1 (en) | 2023-12-29 | 2025-07-03 | Bristol-Myers Squibb Company | Combination therapy of kras inhibitor and treg depleting agent |
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| FR2437213A1 (fr) | 1978-09-28 | 1980-04-25 | Cm Ind | Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation |
| US4736866A (en) | 1984-06-22 | 1988-04-12 | President And Fellows Of Harvard College | Transgenic non-human mammals |
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| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| DK1136556T3 (da) | 1991-11-25 | 2005-10-03 | Enzon Inc | Fremgangsmåde til fremstilling af multivalente antigen-bindende proteiner |
| US5776427A (en) | 1992-03-05 | 1998-07-07 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| DE69332948T2 (de) | 1992-03-05 | 2003-11-27 | Board Of Regents, The University Of Texas System | Verwendung von Immunokonjugate zur Diagnose und/oder Therapie der vaskularisierten Tumoren |
| AU2004201168A1 (en) | 1999-01-15 | 2004-04-22 | Millennium Pharmaceuticals, Inc. | Anti-CCR4 antibodies and methods of use therefor |
| US6488930B1 (en) * | 1999-01-15 | 2002-12-03 | Millennium Pharmaceuticals, Inc. | Anti-CCR4 antibodies and methods of use therefor |
| US6245332B1 (en) * | 1999-01-15 | 2001-06-12 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of systemic memory T cell trafficking |
| EP1050307A1 (en) * | 1999-05-06 | 2000-11-08 | Applied Research Systems ARS Holding N.V. | CCR4 antagonists in sepsis |
| WO2001064754A1 (en) | 2000-03-03 | 2001-09-07 | Kyowa Hakko Kogyo Co., Ltd. | Gene recombinant antibody and its fragment |
| AU2002254076A1 (en) | 2001-02-28 | 2002-09-12 | Protein Desing Labs, Inc. | Chemokine receptors and disease |
| ATE490277T1 (de) | 2001-08-31 | 2010-12-15 | Kyowa Hakko Kirin Co Ltd | Mit humanem cdr gepfropfte antikörper und antikörperfragmente davon |
| CA2542037A1 (en) * | 2003-10-08 | 2005-04-21 | Kyowa Hakko Kogyo Co., Ltd. | Composition of antibody capable of specifically binding ccr4 |
| GB0718167D0 (en) | 2007-09-18 | 2007-10-31 | Cancer Rec Tech Ltd | Cancer marker and therapeutic target |
| US8962806B2 (en) * | 2007-12-28 | 2015-02-24 | Dana-Farber Cancer Institute, Inc. | Humanized monoclonal antibodies and methods of use |
| GB0909906D0 (en) * | 2009-06-09 | 2009-07-22 | Affitech As | Antibodies |
| US8802442B2 (en) | 2011-11-30 | 2014-08-12 | Eric B. Wheeldon | Apparatus and method for the remote sensing of blood in human feces and urine |
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| BR112013014235A2 (pt) | 2016-09-27 |
| US20120164161A1 (en) | 2012-06-28 |
| JP2014513519A (ja) | 2014-06-05 |
| EA201390813A1 (ru) | 2013-11-29 |
| US9458238B2 (en) | 2016-10-04 |
| MX2013006167A (es) | 2013-09-06 |
| GB201020738D0 (en) | 2011-01-19 |
| IL226427A0 (en) | 2013-07-31 |
| CO6761356A2 (es) | 2013-09-30 |
| SG190299A1 (en) | 2013-06-28 |
| WO2012076883A1 (en) | 2012-06-14 |
| AU2011340264A1 (en) | 2013-07-11 |
| ZA201304723B (en) | 2014-02-26 |
| US8895007B2 (en) | 2014-11-25 |
| US20150104831A1 (en) | 2015-04-16 |
| AU2011340264B2 (en) | 2016-05-26 |
| EP2649097A1 (en) | 2013-10-16 |
| CA2818313A1 (en) | 2012-06-14 |
| NZ612175A (en) | 2015-02-27 |
| CN103328513A (zh) | 2013-09-25 |
| CN103328513B (zh) | 2016-04-27 |
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