JP6204369B2 - カルシウム模倣薬およびその使用方法 - Google Patents

カルシウム模倣薬およびその使用方法 Download PDF

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Publication number
JP6204369B2
JP6204369B2 JP2014541386A JP2014541386A JP6204369B2 JP 6204369 B2 JP6204369 B2 JP 6204369B2 JP 2014541386 A JP2014541386 A JP 2014541386A JP 2014541386 A JP2014541386 A JP 2014541386A JP 6204369 B2 JP6204369 B2 JP 6204369B2
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seq
calcimimetic
subject
dose
pth
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JP2014541386A
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Japanese (ja)
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JP2015502346A (ja
JP2015502346A5 (enExample
Inventor
サラ ワルター，
サラ ワルター，
グレゴリー ベル，
グレゴリー ベル，
ジェイムス イー． トムリンソン，
ジェイムス イー． トムリンソン，
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Kai Pharmaceuticals Inc
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Kai Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2014541386A 2011-11-10 2012-11-12 カルシウム模倣薬およびその使用方法 Active JP6204369B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161558389P 2011-11-10 2011-11-10
US61/558,389 2011-11-10
PCT/US2012/064717 WO2013071262A1 (en) 2011-11-10 2012-11-12 Calcimimetics and methods for their use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017123032A Division JP2017160269A (ja) 2011-11-10 2017-06-23 カルシウム模倣薬およびその使用方法

Publications (3)

Publication Number Publication Date
JP2015502346A JP2015502346A (ja) 2015-01-22
JP2015502346A5 JP2015502346A5 (enExample) 2016-01-07
JP6204369B2 true JP6204369B2 (ja) 2017-09-27

Family

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Family Applications (2)

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JP2014541386A Active JP6204369B2 (ja) 2011-11-10 2012-11-12 カルシウム模倣薬およびその使用方法
JP2017123032A Withdrawn JP2017160269A (ja) 2011-11-10 2017-06-23 カルシウム模倣薬およびその使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017123032A Withdrawn JP2017160269A (ja) 2011-11-10 2017-06-23 カルシウム模倣薬およびその使用方法

Country Status (9)

Country Link
US (3) US20140315809A1 (enExample)
EP (1) EP2776129B2 (enExample)
JP (2) JP6204369B2 (enExample)
CN (2) CN109985228A (enExample)
AU (1) AU2012335009B2 (enExample)
CA (1) CA2854911C (enExample)
HK (1) HK1202086A1 (enExample)
MX (1) MX355063B (enExample)
WO (1) WO2013071262A1 (enExample)

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JP4874954B2 (ja) 2004-04-21 2012-02-15 エノビア ファーマ インコーポレイティド 骨送達複合体ならびにタンパク質に骨を標的化させるためのその使用方法
CN107674114B (zh) 2009-07-29 2022-10-25 凯伊药品公司 用于降低甲状旁腺激素水平的治疗剂
PL3013318T3 (pl) 2013-06-28 2018-03-30 Amgen Inc. Stabilny ciekły preparat związku amg 416 (welkalcetyd)
WO2016007873A1 (en) 2014-07-11 2016-01-14 The Regents Of The University Of Michigan Compositions and methods for treating craniosynostosis
US20170304228A1 (en) * 2014-10-24 2017-10-26 Launx Biomedical Co., Ltd. New indication of cinacalcet hcl pharmaceutical composition for treating cancer
ES3038086T3 (en) 2014-12-05 2025-10-09 Alexion Pharma Inc Treating seizure with recombinant alkaline phosphatase
US9539264B2 (en) * 2014-12-30 2017-01-10 Wisconsin Alumni Research Foundation Use of 2-methylene-19-nor-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat secondary hyperparathyroidism in patients previously treated with calcimimetics
EP3250227A2 (en) * 2015-01-28 2017-12-06 Alexion Pharmaceuticals, Inc. Methods of treating a subject with an alkaline phosphatase deficiency
KR102644116B1 (ko) 2015-08-17 2024-03-05 알렉시온 파마슈티칼스, 인코포레이티드 알칼린 포스파타제의 제조
US11229686B2 (en) 2015-09-28 2022-01-25 Alexion Pharmaceuticals, Inc. Reduced frequency dosage regimens for tissue non-specific alkaline phosphatase (TNSALP)-enzyme replacement therapy of hypophosphatasia
EP3368062A4 (en) 2015-10-30 2019-07-03 Alexion Pharmaceuticals, Inc. METHODS OF TREATING CRANIOSYNOSTOSIS IN A PATIENT
CN106928320B (zh) 2015-12-31 2021-01-15 深圳翰宇药业股份有限公司 一种合成Etelcalcetide的方法
WO2017155569A1 (en) 2016-03-08 2017-09-14 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in children
EP3436020A4 (en) 2016-04-01 2019-12-25 Alexion Pharmaceuticals, Inc. METHOD FOR TREATING HYPOPHOSPHATASIE IN TEENS AND ADULTS
JP7613826B2 (ja) 2016-04-01 2025-01-15 アレクシオン ファーマシューティカルズ， インコーポレイテッド アルカリホスファターゼによって筋力低下を治療すること
US10988744B2 (en) 2016-06-06 2021-04-27 Alexion Pharmaceuticals, Inc. Method of producing alkaline phosphatase
EP3500289B1 (en) 2016-08-18 2024-10-09 Alexion Pharmaceuticals, Inc. Asfotase alfa for use in treating tracheobronchomalacia
KR20240158374A (ko) 2017-03-31 2024-11-04 알렉시온 파마슈티칼스, 인코포레이티드 성인 및 청소년에서 저포스파타제증 (hpp)을 치료하는 방법
US11913039B2 (en) 2018-03-30 2024-02-27 Alexion Pharmaceuticals, Inc. Method for producing recombinant alkaline phosphatase
US12268733B2 (en) 2018-08-10 2025-04-08 Alexion Pharmaceuticals, Inc. Methods of treating neurofibromatosis type 1 and related conditions with alkaline phosphatase
EP3867650A1 (en) * 2018-10-18 2021-08-25 Fresenius Medical Care Holdings, Inc. Techniques for modeling parathyroid gland functionality and calcimimetic drug activity
JP7796013B2 (ja) * 2019-12-09 2026-01-08 北京拓界生物医薬科技有限公司 カルシウム感知受容体アゴニスト化合物及びその使用
AU2020398898A1 (en) 2019-12-09 2022-07-21 Alexion Pharmaceuticals, Inc. Alkaline phosphatase polypeptides and methods of use thereof
US20230331779A1 (en) * 2020-09-10 2023-10-19 Shaanxi Micot Technology Co., Ltd. Bispecific fusion polypeptide compound
BR112023016048A2 (pt) 2021-02-12 2023-11-14 Alexion Pharma Inc Polipeptídeos de fosfatase alcalina e métodos de uso dos mesmos
CN117500820A (zh) * 2021-06-08 2024-02-02 北京拓界生物医药科技有限公司 钙敏感受体激动剂化合物的盐酸盐及药物组合物和其应用
US20240269227A1 (en) * 2021-06-08 2024-08-15 Beijing Tuo Jie Biopharmaceutical Co. Ltd. Calcium-sensing receptor agonist composition and application thereof

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US5602116A (en) 1988-08-02 1997-02-11 Bone Care International, Inc. Method for treating and preventing secondary hyperparathyroidism
US5869473A (en) 1988-08-02 1999-02-09 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
US5246925A (en) 1989-03-09 1993-09-21 Wisconsin Alumni Research Foundation 19-nor-vitamin D compounds for use in treating hyperparathyroidism
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US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US6011068A (en) 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6031003A (en) 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5994341A (en) 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
EP0917537B1 (en) * 1996-07-31 2005-09-07 The General Hospital Corporation Novel parathyroid hormone-related peptide analogs
US6051567A (en) 1999-08-02 2000-04-18 Abbott Laboratories Low oxygen content compositions of 1α, 25-dihydroxycholecalciferol
US6274169B1 (en) 1999-08-02 2001-08-14 Abbott Laboratories Low oxygen content compostions of 1α, 25-dihydroxycholecalciferol
AU2001278956B2 (en) 2000-07-18 2007-04-05 Genzyme Corporation Stabilized 1alpha-hydroxy vitamin d
US6998404B2 (en) * 2001-08-08 2006-02-14 Genomed, Llc Treatment or prevention of acute renal failure
BRPI0609524A2 (pt) * 2005-03-17 2011-10-18 Amgen Inc uso de uma quantidade terapeuticamente eficaz de um composto calcimimético
JP5645408B2 (ja) 2006-11-16 2014-12-24 カイ ファーマシューティカルズ インコーポレーティッド 副甲状腺機能亢進症および高カルシウム血症性障害の治療のためのポリカチオン性カルシウムモジュレーターペプチド
CA2701638A1 (en) * 2007-04-02 2008-10-09 Concert Pharmaceuticals Inc. Pharmaceutical calcimimetics
CN107674114B (zh) * 2009-07-29 2022-10-25 凯伊药品公司 用于降低甲状旁腺激素水平的治疗剂
GB0913525D0 (en) * 2009-08-03 2009-09-16 Ineos Healthcare Ltd Method

Also Published As

Publication number Publication date
CA2854911C (en) 2019-09-24
CN109985228A (zh) 2019-07-09
AU2012335009A1 (en) 2014-05-29
MX2014005662A (es) 2014-11-10
US20160175383A1 (en) 2016-06-23
EP2776129A1 (en) 2014-09-17
HK1202086A1 (en) 2015-09-18
CA2854911A1 (en) 2013-05-16
EP2776129B1 (en) 2017-03-29
US20170252397A1 (en) 2017-09-07
EP2776129B2 (en) 2020-06-17
US20140315809A1 (en) 2014-10-23
WO2013071262A1 (en) 2013-05-16
AU2012335009B2 (en) 2017-08-31
JP2015502346A (ja) 2015-01-22
MX355063B (es) 2018-04-04
JP2017160269A (ja) 2017-09-14
CN104168955A (zh) 2014-11-26

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