JP6190819B2 - 糖尿病に対するイソオキサゾール処置 - Google Patents

糖尿病に対するイソオキサゾール処置 Download PDF

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JP6190819B2
JP6190819B2 JP2014543573A JP2014543573A JP6190819B2 JP 6190819 B2 JP6190819 B2 JP 6190819B2 JP 2014543573 A JP2014543573 A JP 2014543573A JP 2014543573 A JP2014543573 A JP 2014543573A JP 6190819 B2 JP6190819 B2 JP 6190819B2
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substituted
hydrogen
alkyl
insulin
unsubstituted
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JP2015510493A (ja
JP2015510493A5 (enExample
Inventor
エルハッジ ジウム
エルハッジ ジウム
ジェイ シュナイダー
ジェイ シュナイダー
ダグ フランツ
ダグ フランツ
ヘクター アギラール
ヘクター アギラール
メラニー カッブ
メラニー カッブ
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University of Texas System
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University of Texas System
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2014543573A 2011-11-23 2012-11-21 糖尿病に対するイソオキサゾール処置 Expired - Fee Related JP6190819B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161563419P 2011-11-23 2011-11-23
US61/563,419 2011-11-23
US201161566056P 2011-12-02 2011-12-02
US61/566,056 2011-12-02
PCT/US2012/066346 WO2013078376A2 (en) 2011-11-23 2012-11-21 Isoxazole treatments for diabetes

Publications (3)

Publication Number Publication Date
JP2015510493A JP2015510493A (ja) 2015-04-09
JP2015510493A5 JP2015510493A5 (enExample) 2016-01-14
JP6190819B2 true JP6190819B2 (ja) 2017-08-30

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ID=48470419

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Application Number Title Priority Date Filing Date
JP2014543573A Expired - Fee Related JP6190819B2 (ja) 2011-11-23 2012-11-21 糖尿病に対するイソオキサゾール処置

Country Status (9)

Country Link
US (2) US8722716B2 (enExample)
EP (1) EP2782913A4 (enExample)
JP (1) JP6190819B2 (enExample)
CN (1) CN104350051B (enExample)
AU (2) AU2012340622A1 (enExample)
CA (1) CA2854039A1 (enExample)
IL (1) IL232566A0 (enExample)
MX (1) MX2014006286A (enExample)
WO (1) WO2013078376A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150297638A1 (en) * 2014-04-17 2015-10-22 Muhammad Ashraf Chemically induced pluripotent stem cells for safe therapeutic applications
US10443044B2 (en) 2014-04-17 2019-10-15 Ips Heart Generating cardiac progenitor cells from pluripotent stem cells using isoxazole or isoxazole like compounds
US20190169574A1 (en) * 2016-02-04 2019-06-06 Nestec S.A. In vitro production of pancreatic beta cells
JP6835899B2 (ja) * 2018-03-29 2021-02-24 株式会社 バイオミメティクスシンパシーズ Ｕｃｐ１発現細胞の培養方法
CN116270635B (zh) * 2021-12-13 2025-06-17 清华大学 杂环化合物用于减轻化疗药物引起的不良反应的用途
CN116421605B (zh) * 2022-01-04 2024-08-02 中国科学院脑科学与智能技术卓越创新中心 Isx-9在治疗衰老相关的昼夜节律幅度下降和睡眠障碍方面的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001124A (en) * 1990-02-02 1991-03-19 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
JP3542827B2 (ja) 1994-07-15 2004-07-14 帝国臓器製薬株式会社 新規な５−置換イソキサゾール−３−カルボン酸アミド誘導体
US20060089398A1 (en) * 2003-03-19 2006-04-27 Gang Liu Isoxazole carboxamide derivatives as ghrelin receptor modulators
US20060036451A1 (en) 2004-08-10 2006-02-16 Lundberg Steven W Patent mapping
MX2007004021A (es) * 2004-10-08 2007-05-24 Novartis Ag Combinacion de compuestos organicos.
DE102004054666A1 (de) 2004-11-12 2006-05-18 Bayer Cropscience Gmbh Substituierte Pyrazol-3-carboxamide, Verfahren zur Herstellung und Verwendung als Herbizide und Pflanzenwachstumsregulatoren
EP1910358A2 (en) 2005-07-14 2008-04-16 Astellas Pharma Inc. Heterocyclic janus kinase 3 inhibitors
WO2007075896A2 (en) * 2005-12-22 2007-07-05 Kemia, Inc. Heterocyclic cytokine inhibitors
KR101394245B1 (ko) * 2005-12-30 2014-05-14 에스케이바이오팜 주식회사 아이속사졸 유도체 및 이의 용도
US8193225B2 (en) 2006-10-13 2012-06-05 The Board Of Regents Of The University Of Texas System Isoxazole amides, derivatives and methods of chemical induction of neurogenesis
US7638541B2 (en) * 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
CA2725316A1 (en) * 2008-06-02 2009-12-10 Banyu Pharmaceutical Co., Ltd. Novel isoxazole derivative

Also Published As

Publication number Publication date
JP2015510493A (ja) 2015-04-09
US9221800B2 (en) 2015-12-29
EP2782913A2 (en) 2014-10-01
MX2014006286A (es) 2014-10-24
WO2013078376A3 (en) 2014-12-04
US20130178506A1 (en) 2013-07-11
CA2854039A1 (en) 2013-05-30
CN104350051A (zh) 2015-02-11
CN104350051B (zh) 2017-03-08
AU2012340622A1 (en) 2014-05-22
US8722716B2 (en) 2014-05-13
US20140315966A1 (en) 2014-10-23
IL232566A0 (en) 2014-06-30
WO2013078376A2 (en) 2013-05-30
AU2017202134A1 (en) 2017-04-20
EP2782913A4 (en) 2015-10-28

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