JP6181040B2 - 二特異性抗ｃｘｃｒ７免疫グロブリン単一可変ドメイン - Google Patents
二特異性抗ｃｘｃｒ７免疫グロブリン単一可変ドメイン Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161468250P | 2011-03-28 | 2011-03-28 | |
| US61/468,250 | 2011-03-28 | ||
| US201161540272P | 2011-09-28 | 2011-09-28 | |
| US61/540,272 | 2011-09-28 | ||
| US201261600263P | 2012-02-17 | 2012-02-17 | |
| US61/600,263 | 2012-02-17 | ||
| PCT/EP2012/055499 WO2012130874A1 (en) | 2011-03-28 | 2012-03-28 | Bispecific anti-cxcr7 immunoglobulin single variable domains |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014511680A JP2014511680A (ja) | 2014-05-19 |
| JP2014511680A5 JP2014511680A5 (OSRAM) | 2015-05-07 |
| JP6181040B2 true JP6181040B2 (ja) | 2017-08-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014501588A Expired - Fee Related JP6181040B2 (ja) | 2011-03-28 | 2012-03-28 | 二特異性抗ｃｘｃｒ７免疫グロブリン単一可変ドメイン |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20150158948A9 (OSRAM) |
| EP (1) | EP2691418A1 (OSRAM) |
| JP (1) | JP6181040B2 (OSRAM) |
| CN (1) | CN103917560B (OSRAM) |
| AU (1) | AU2012234284B2 (OSRAM) |
| CA (1) | CA2831415A1 (OSRAM) |
| WO (1) | WO2012130874A1 (OSRAM) |
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| US9512236B2 (en) | 2006-12-19 | 2016-12-06 | Ablynx N.V. | Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders |
| WO2009138519A1 (en) | 2008-05-16 | 2009-11-19 | Ablynx Nv | AMINO ACID SEQUENCES DIRECTED AGAINST CXCR4 AND OTHER GPCRs AND COMPOUNDS COMPRISING THE SAME |
| EP2552962B1 (en) | 2010-03-26 | 2016-03-23 | Ablynx N.V. | Immunoglobulin single variable domains directed against cxcr7 |
| WO2014081029A1 (ja) * | 2012-11-26 | 2014-05-30 | 学校法人近畿大学 | 抗がん剤による末梢神経障害の予防、治療、または軽減剤 |
| SI3248986T1 (sl) | 2014-05-16 | 2022-04-29 | Ablynx Nv | Variabilne domene imunoglobulina |
| JP2018533620A (ja) * | 2015-09-14 | 2018-11-15 | ギャラクシー・バイオテック・リミテッド・ライアビリティ・カンパニーＧａｌａｘｙ Ｂｉｏｔｅｃｈ， ＬＬＣ | 血管新生因子に対する高力価のモノクローナル抗体 |
| NO2768984T3 (OSRAM) | 2015-11-12 | 2018-06-09 | ||
| AU2016351710B2 (en) * | 2015-11-13 | 2023-08-03 | Ablynx Nv | Improved serum albumin-binding immunoglobulin variable domains |
| MA43260A (fr) | 2015-11-18 | 2018-09-26 | Merck Sharp & Dohme | Liants pd1 et/ou lag3 |
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| IL263704B2 (en) * | 2016-06-23 | 2024-09-01 | Ablynx Nv | Improved pharmacokinetic assays for immunoglobulin single variable domains |
| JP7266611B2 (ja) * | 2018-02-26 | 2023-04-28 | アブリンクス・エヌ・フェー | ペプチドリンカーをコードする改良されたヌクレオチド配列 |
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| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
| EP0542810A1 (en) | 1990-08-02 | 1993-05-26 | B.R. Centre Limited | Methods for the production of proteins with a desired function |
| ATE452975T1 (de) | 1992-08-21 | 2010-01-15 | Univ Bruxelles | Immunoglobuline ohne leichte ketten |
| EP0702721B1 (en) | 1993-06-09 | 2001-01-03 | Unilever N.V. | Process for producing fusion proteins comprising scfv fragments by a transformed mould |
| US6091639A (en) | 1993-08-27 | 2000-07-18 | Kabushiki Kaisha Toshiba | Non-volatile semiconductor memory device and data programming method |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
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| JP4786793B2 (ja) | 1998-03-30 | 2011-10-05 | ノースウエスト バイオセラピューティクス，インコーポレイティド | 腫瘍形成におけるｃｘｃｒ−４遺伝子の役割に基く治療的および診断的応用 |
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- 2012-03-28 EP EP12713656.2A patent/EP2691418A1/en not_active Withdrawn
- 2012-03-28 JP JP2014501588A patent/JP6181040B2/ja not_active Expired - Fee Related
- 2012-03-28 CN CN201280026571.1A patent/CN103917560B/zh not_active Expired - Fee Related
- 2012-03-28 WO PCT/EP2012/055499 patent/WO2012130874A1/en not_active Ceased
- 2012-03-28 CA CA2831415A patent/CA2831415A1/en not_active Abandoned
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|---|---|
| AU2012234284A1 (en) | 2013-03-28 |
| JP2014511680A (ja) | 2014-05-19 |
| US20140227270A1 (en) | 2014-08-14 |
| US20180355048A1 (en) | 2018-12-13 |
| US20140178390A1 (en) | 2014-06-26 |
| CN103917560A (zh) | 2014-07-09 |
| EP2691418A1 (en) | 2014-02-05 |
| AU2012234284B2 (en) | 2015-10-08 |
| WO2012130874A1 (en) | 2012-10-04 |
| US20150158948A9 (en) | 2015-06-11 |
| CN103917560B (zh) | 2017-05-24 |
| CA2831415A1 (en) | 2012-10-04 |
| US9994639B2 (en) | 2018-06-12 |
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