JP6178843B2 - 透過性グリコシダーゼインヒビターおよびその用途 - Google Patents
透過性グリコシダーゼインヒビターおよびその用途 Download PDFInfo
- Publication number
- JP6178843B2 JP6178843B2 JP2015511546A JP2015511546A JP6178843B2 JP 6178843 B2 JP6178843 B2 JP 6178843B2 JP 2015511546 A JP2015511546 A JP 2015511546A JP 2015511546 A JP2015511546 A JP 2015511546A JP 6178843 B2 JP6178843 B2 JP 6178843B2
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- tetrahydro
- pyrano
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CC(O[C@@]([C@@]1N=C(N(C)C)S[C@]1O[C@@]1C*)[C@@]1OC(C)=O)=O Chemical compound CC(O[C@@]([C@@]1N=C(N(C)C)S[C@]1O[C@@]1C*)[C@@]1OC(C)=O)=O 0.000 description 7
- PSKWHGLUXFFPNH-VFZPANTDSA-N CC(C)(C)OC(N(C)C(S[C@H]1O[C@H]([C@H](C(F)(F)F)OC)[C@H]2O)=N[C@@H]1[C@H]2O)=O Chemical compound CC(C)(C)OC(N(C)C(S[C@H]1O[C@H]([C@H](C(F)(F)F)OC)[C@H]2O)=N[C@@H]1[C@H]2O)=O PSKWHGLUXFFPNH-VFZPANTDSA-N 0.000 description 1
- HUNQQCIVZAHDGF-HWTGPMJESA-N CN(C)C(S[C@H]1O[C@H](C(C(F)(F)F)Oc2ccccc2)[C@H]2OCc3ccccc3)=N[C@@H]1[C@H]2OCc1ccccc1 Chemical compound CN(C)C(S[C@H]1O[C@H](C(C(F)(F)F)Oc2ccccc2)[C@H]2OCc3ccccc3)=N[C@@H]1[C@H]2OCc1ccccc1 HUNQQCIVZAHDGF-HWTGPMJESA-N 0.000 description 1
- XZLBZKHLKVSWGY-BSKUUZOQSA-N CNC(S[C@H]1O[C@H]([C@@H](C(F)(F)F)Oc2ccccc2)[C@H]2O)=N[C@@H]1[C@H]2O Chemical compound CNC(S[C@H]1O[C@H]([C@@H](C(F)(F)F)Oc2ccccc2)[C@H]2O)=N[C@@H]1[C@H]2O XZLBZKHLKVSWGY-BSKUUZOQSA-N 0.000 description 1
- XZLBZKHLKVSWGY-PQCBQTOFSA-N CNC(S[C@H]1O[C@H]([C@H](C(F)(F)F)Oc2ccccc2)[C@H]2O)=N[C@@H]1[C@H]2O Chemical compound CNC(S[C@H]1O[C@H]([C@H](C(F)(F)F)Oc2ccccc2)[C@H]2O)=N[C@@H]1[C@H]2O XZLBZKHLKVSWGY-PQCBQTOFSA-N 0.000 description 1
- DNCMJHKNHROSET-NTXXKDEISA-N C[C@H]([C@H]1N=C(NC)S[C@H]1O[C@@H]1[C@H](C(F)(F)F)OC)[C@@H]1O Chemical compound C[C@H]([C@H]1N=C(NC)S[C@H]1O[C@@H]1[C@H](C(F)(F)F)OC)[C@@H]1O DNCMJHKNHROSET-NTXXKDEISA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/005—Sugars; Derivatives thereof; Nucleosides; Nucleotides; Nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2012/075185 WO2013166654A1 (en) | 2012-05-08 | 2012-05-08 | Permeable glycosidase inhibitors and uses thereof |
| CNPCT/CN2012/075185 | 2012-05-08 | ||
| US201261655641P | 2012-06-05 | 2012-06-05 | |
| US61/655,641 | 2012-06-05 | ||
| PCT/US2013/039377 WO2013169576A1 (en) | 2012-05-08 | 2013-05-03 | Permeable glycosidase inhibitors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015516420A JP2015516420A (ja) | 2015-06-11 |
| JP2015516420A5 JP2015516420A5 (hr) | 2016-06-23 |
| JP6178843B2 true JP6178843B2 (ja) | 2017-08-09 |
Family
ID=49551168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015511546A Active JP6178843B2 (ja) | 2012-05-08 | 2013-05-03 | 透過性グリコシダーゼインヒビターおよびその用途 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9611275B2 (hr) |
| EP (1) | EP2847199B1 (hr) |
| JP (1) | JP6178843B2 (hr) |
| KR (1) | KR102108586B1 (hr) |
| CN (1) | CN104395323B (hr) |
| AU (1) | AU2013259892B2 (hr) |
| BR (1) | BR112014027724B1 (hr) |
| CA (1) | CA2871920C (hr) |
| RU (1) | RU2707292C2 (hr) |
| WO (1) | WO2013169576A1 (hr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9079868B2 (en) | 2008-08-01 | 2015-07-14 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| WO2011140640A1 (en) | 2010-05-11 | 2011-11-17 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| US8933040B2 (en) | 2010-11-08 | 2015-01-13 | Craig A. Coburn | Selective glycosidase inhibitors and uses thereof |
| JP5861194B2 (ja) | 2010-12-23 | 2016-02-16 | アレクトス・セラピューティクス・インコーポレイテッド | 選択的グルコシダーゼインヒビターおよびその使用 |
| US8927507B2 (en) | 2011-03-24 | 2015-01-06 | Ernest J. McEachern | Selective glycosidase inhibitors and uses thereof |
| US9718854B2 (en) | 2011-03-31 | 2017-08-01 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| WO2013000084A1 (en) | 2011-06-27 | 2013-01-03 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| US9701693B2 (en) | 2011-06-27 | 2017-07-11 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| EP2726468B1 (en) | 2011-06-27 | 2017-04-12 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| US9670195B2 (en) | 2012-08-31 | 2017-06-06 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
| US9809537B2 (en) | 2012-08-31 | 2017-11-07 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
| WO2014067003A1 (en) | 2012-10-31 | 2014-05-08 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
| WO2014100934A1 (en) | 2012-12-24 | 2014-07-03 | Merck Sharp & Dohme Corp. | Glycosidase inhibitors and uses thereof |
| KR102205234B1 (ko) | 2013-06-11 | 2021-01-20 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | SC-β 세포 및 조성물 그리고 그 생성 방법 |
| WO2016073693A2 (en) | 2014-11-05 | 2016-05-12 | Voyager Therapeutics, Inc. | Aadc polynucleotides for the treatment of parkinson's disease |
| SG11201703419UA (en) | 2014-11-14 | 2017-05-30 | Voyager Therapeutics Inc | Modulatory polynucleotides |
| KR20240056729A (ko) | 2016-05-18 | 2024-04-30 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
| EP3458589A4 (en) | 2016-05-18 | 2020-01-01 | Voyager Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR TREATING HUNTINGTON'S DISEASE |
| JP2020518259A (ja) | 2017-05-05 | 2020-06-25 | ボイジャー セラピューティクス インコーポレイテッドＶｏｙａｇｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ハンチントン病治療組成物および方法 |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| CN109160873A (zh) * | 2018-08-14 | 2019-01-08 | 重庆市化工研究院 | 一种芳香族烯丙基醚及其合成方法和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1441749A1 (ru) * | 1987-03-16 | 1996-01-10 | Институт Тонкой Органической Химии Им.А.Л.Мнджояна | 2-АМИНО-5,5-ДИМЕТИЛ-4,5-ДИГИДРО-7Н-ПИРАНО [4,3-d] ТИАЗОЛ, ОБЛАДАЮЩИЙ ТРАНКВИЛИЗИРУЮЩЕЙ АКТИВНОСТЬЮ |
| US20080166323A1 (en) | 2004-04-14 | 2008-07-10 | Uab Research Foundation | Activators of Hexosamine Biosynthesis as Inhibitors of Injury Induced by Ischemia or Hermorrhagic Shock |
| CA2599843C (en) | 2005-03-01 | 2013-08-27 | Simon Fraser University | Selective glycosidase inhibitors, methods of making inhibitors, and uses thereof |
| CN101595111A (zh) * | 2006-08-31 | 2009-12-02 | 西蒙·弗雷瑟大学 | 选择性糖苷酶抑制剂及其用途 |
| WO2008025170A1 (en) * | 2006-08-31 | 2008-03-06 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| US9079868B2 (en) | 2008-08-01 | 2015-07-14 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| AU2009276222B2 (en) | 2008-08-01 | 2015-03-05 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| AU2009299073B2 (en) | 2008-09-16 | 2015-04-02 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| WO2011140640A1 (en) * | 2010-05-11 | 2011-11-17 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| TW201249848A (en) * | 2010-11-08 | 2012-12-16 | Merck Sharp & Dohme | Selective glycosidase inhibitors and uses thereof |
| WO2012061972A1 (en) * | 2010-11-08 | 2012-05-18 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| WO2012159262A1 (en) * | 2011-05-24 | 2012-11-29 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| EP2744338B1 (en) * | 2011-08-18 | 2016-04-27 | Merck Sharp & Dohme Corp. | Selective glycosidase inhibitors and uses thereof |
-
2013
- 2013-05-03 EP EP13787989.6A patent/EP2847199B1/en active Active
- 2013-05-03 US US14/399,146 patent/US9611275B2/en active Active
- 2013-05-03 WO PCT/US2013/039377 patent/WO2013169576A1/en active Application Filing
- 2013-05-03 RU RU2014149183A patent/RU2707292C2/ru active
- 2013-05-03 CA CA2871920A patent/CA2871920C/en active Active
- 2013-05-03 CN CN201380023214.4A patent/CN104395323B/zh active Active
- 2013-05-03 JP JP2015511546A patent/JP6178843B2/ja active Active
- 2013-05-03 BR BR112014027724-9A patent/BR112014027724B1/pt active IP Right Grant
- 2013-05-03 AU AU2013259892A patent/AU2013259892B2/en active Active
- 2013-05-03 KR KR1020147031131A patent/KR102108586B1/ko active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CN104395323B (zh) | 2017-08-01 |
| CN104395323A (zh) | 2015-03-04 |
| EP2847199A1 (en) | 2015-03-18 |
| JP2015516420A (ja) | 2015-06-11 |
| KR20150006841A (ko) | 2015-01-19 |
| EP2847199A4 (en) | 2015-11-11 |
| US9611275B2 (en) | 2017-04-04 |
| KR102108586B1 (ko) | 2020-05-07 |
| BR112014027724A2 (hr) | 2017-08-22 |
| CA2871920A1 (en) | 2013-11-14 |
| WO2013169576A1 (en) | 2013-11-14 |
| AU2013259892B2 (en) | 2017-09-14 |
| AU2013259892A1 (en) | 2014-10-30 |
| RU2707292C2 (ru) | 2019-11-26 |
| US20150152127A1 (en) | 2015-06-04 |
| BR112014027724B1 (pt) | 2022-05-03 |
| RU2014149183A (ru) | 2016-06-27 |
| CA2871920C (en) | 2021-03-09 |
| EP2847199B1 (en) | 2017-10-25 |
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