JP6174692B2 - 酸化ストレスの処置のためのナノセリア - Google Patents

酸化ストレスの処置のためのナノセリア Download PDF

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Publication number
JP6174692B2
JP6174692B2 JP2015517244A JP2015517244A JP6174692B2 JP 6174692 B2 JP6174692 B2 JP 6174692B2 JP 2015517244 A JP2015517244 A JP 2015517244A JP 2015517244 A JP2015517244 A JP 2015517244A JP 6174692 B2 JP6174692 B2 JP 6174692B2
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nanoparticles
cerium
edta
nanoceria
ceria
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JP2015525228A (ja
Inventor
ケネス ジョセフ リード
ケネス ジョセフ リード
ウェンディ アン コスタンゾ
ウェンディ アン コスタンゾ
ジョセフ サミュエル アーリックマン
ジョセフ サミュエル アーリックマン
エリック レスリー ベル
エリック レスリー ベル
Original Assignee
セリオン エンタープライジズ リミテッド ライアビリティ カンパニー
セリオン エンタープライジズ リミテッド ライアビリティ カンパニー
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/244Lanthanides; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1694Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5123Organic compounds, e.g. fats, sugars
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01PINDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00Particle morphology
    • C01P2004/60Particles characterised by their size
    • C01P2004/64Nanometer sized, i.e. from 1-100 nanometer

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
JP2015517244A 2012-06-13 2013-03-15 酸化ストレスの処置のためのナノセリア Expired - Fee Related JP6174692B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201261689806P 2012-06-13 2012-06-13
US61/689,806 2012-06-13
US201261690100P 2012-06-18 2012-06-18
US61/690,100 2012-06-18
US201261795241P 2012-10-12 2012-10-12
US61/795,241 2012-10-12
US201261796639P 2012-11-16 2012-11-16
US61/796,639 2012-11-16
PCT/US2013/032318 WO2013187980A1 (en) 2012-06-13 2013-03-15 Nanoceria for the treatment of oxidative stress

Publications (2)

Publication Number Publication Date
JP2015525228A JP2015525228A (ja) 2015-09-03
JP6174692B2 true JP6174692B2 (ja) 2017-08-02

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JP2015517244A Expired - Fee Related JP6174692B2 (ja) 2012-06-13 2013-03-15 酸化ストレスの処置のためのナノセリア

Country Status (12)

Country Link
US (4) US9034392B2 (https=)
EP (1) EP2861212B1 (https=)
JP (1) JP6174692B2 (https=)
KR (1) KR101990070B1 (https=)
CN (1) CN104812375B (https=)
AU (1) AU2013274901B2 (https=)
CA (1) CA2875206C (https=)
DK (1) DK2861212T3 (https=)
ES (1) ES2617528T3 (https=)
IN (1) IN2014DN10550A (https=)
MX (1) MX2014015251A (https=)
WO (1) WO2013187980A1 (https=)

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US10182994B2 (en) * 2014-06-10 2019-01-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nanoparticulate complex of nicotine and cerium oxide and use thereof
BR112017000800A8 (pt) * 2014-07-17 2023-04-25 Biocurity Holdings Inc Tratamento do câncer com uma combinação de radiação, nanoparticulas de óxido de cério, e um agente quimioterápico
JP2018508568A (ja) 2015-01-20 2018-03-29 セリオン,リミティド ライアビリティ カンパニー カタラーゼ様活性を有するeddsでキレート化されたナノセリア
KR101765557B1 (ko) 2015-02-27 2017-08-23 서울대학교산학협력단 생흡수성 전자 스텐트
US11389536B2 (en) 2015-07-17 2022-07-19 BioCurity Pharmaceuticals Inc. Treatment of cancer with a combination of radiation, cerium oxide nanoparticles, and a chemotherapeutic agent
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AU2017384425B2 (en) * 2016-12-21 2023-08-31 Nanobiotix Nanoparticles for use for treating a neuronal disorder
AU2018390163B2 (en) 2017-12-19 2024-05-02 Nanobiotix Nanoparticles for use in enhancing brain performances or in treating stress
HUE068741T2 (hu) 2017-12-19 2025-01-28 Nanobiotix Nanorészecskék idegi zavarok kezelésére
WO2020069292A1 (en) * 2018-09-28 2020-04-02 The Regents Of The University Of Colorado, A Body Corporate Methods for preventing and treating pulmonary inflammation and fibrosis
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CN109806278B (zh) * 2019-02-01 2021-08-10 浙江大学 磷脂聚乙二醇修饰的超小型氧化铈纳米晶的应用
FR3093640B1 (fr) * 2019-03-15 2021-10-01 Biophytis Phytoecdysones et leurs dérivés pour leur utilisation dans le traitement de maladies neuromusculaires
CN109939125B (zh) * 2019-04-22 2021-05-18 南昌大学第二附属医院 一种抗氧化剂及其制备方法与应用
FR3098723B1 (fr) * 2019-07-18 2023-01-13 Bionuclei Traitement ecobiologique des effets secondaires de la radiotherapie.
KR102107760B1 (ko) * 2019-08-28 2020-05-07 한국콜마주식회사 피부 장벽 강화, 피부 보습 및/또는 미세 먼지 차단용 세륨옥사이드 분산액 및 이를 포함하는 화장료 조성물
JP7740020B2 (ja) * 2020-05-27 2025-09-17 東レ株式会社 酸化セリウムのナノ粒子、抗菌剤、抗ウイルス剤および酸化セリウムのナノ粒子の製造方法
CN111773243B (zh) * 2020-07-17 2022-09-23 南京大学 炎症性肠病的药物及其制备方法和用途
CN112007016B (zh) * 2020-09-07 2021-07-23 南京大学 一种纳米缓释制剂及其制备方法和在制备治疗线粒体功能障碍疾病的药物中的应用
CN112494513A (zh) * 2020-12-15 2021-03-16 中国药科大学 一种二氧化铈纳米粒及其制备方法与应用
CN112516294B (zh) * 2020-12-22 2023-04-07 浙江大学 一种氧化铈纳米稳定剂在制备预防过敏性疾病药物中的应用及预防过敏性疾病的药物组合物
CN113546093A (zh) * 2021-07-20 2021-10-26 中国人民解放军陆军军医大学 氧化铈纳米颗粒在制备治疗和预防肾缺血再灌注损伤的药物中的应用
CN113842469B (zh) * 2021-08-25 2024-04-02 中国科学院过程工程研究所 一种囊泡表面原位结晶高催化活性铈纳米晶的递药系统及其制备方法和应用
CN114470326B (zh) * 2021-12-06 2022-09-13 中国人民解放军空军军医大学 一种仿生矿化胶原-糖胺聚糖材料制备方法及其应用
KR102810481B1 (ko) * 2022-01-21 2025-05-19 성균관대학교산학협력단 다발성경화증 치료용 백신
US12521414B2 (en) * 2022-06-08 2026-01-13 National Health Research Institutes Method for preventing or treating urological chronic pelvic pain syndrome
CN116270729A (zh) * 2022-11-09 2023-06-23 西安交通大学医学院第一附属医院 多孔纳米棒状氧化铈在制备治疗特应性皮炎的药物中的应用
CN115737678B (zh) * 2022-11-30 2024-12-20 浙江大学金华研究院 载三苯基膦修饰的氧化铈和全反式维甲酸的脂质体凝胶
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CN116850147B (zh) * 2023-06-05 2024-05-14 中南大学 Ppc纳米颗粒、其制备方法以及在治疗心肌梗死的药物中的应用

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Publication number Publication date
IN2014DN10550A (https=) 2015-08-21
JP2015525228A (ja) 2015-09-03
WO2013187980A1 (en) 2013-12-19
US20180250333A1 (en) 2018-09-06
US9962406B2 (en) 2018-05-08
CN104812375B (zh) 2017-08-22
EP2861212A1 (en) 2015-04-22
KR101990070B1 (ko) 2019-06-17
AU2013274901A1 (en) 2014-12-18
US20130337083A1 (en) 2013-12-19
AU2013274901B2 (en) 2017-09-14
ES2617528T3 (es) 2017-06-19
US20150231174A1 (en) 2015-08-20
US9533007B2 (en) 2017-01-03
CA2875206C (en) 2020-07-14
MX2014015251A (es) 2015-04-13
KR20150028293A (ko) 2015-03-13
DK2861212T3 (en) 2017-03-06
CA2875206A1 (en) 2013-12-19
CN104812375A (zh) 2015-07-29
US9034392B2 (en) 2015-05-19
US20170100430A1 (en) 2017-04-13
US10729717B2 (en) 2020-08-04
EP2861212B1 (en) 2016-12-07

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