JP6163165B2 - レボセチリジンまたはその医薬的に許容される塩およびモンテルカストまたはその医薬的に許容される塩を含む経口投与用安定医薬製剤 - Google Patents

レボセチリジンまたはその医薬的に許容される塩およびモンテルカストまたはその医薬的に許容される塩を含む経口投与用安定医薬製剤 Download PDF

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JP6163165B2
JP6163165B2 JP2014551191A JP2014551191A JP6163165B2 JP 6163165 B2 JP6163165 B2 JP 6163165B2 JP 2014551191 A JP2014551191 A JP 2014551191A JP 2014551191 A JP2014551191 A JP 2014551191A JP 6163165 B2 JP6163165 B2 JP 6163165B2
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acid
levocetirizine
pharmaceutically acceptable
montelukast
oral administration
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JP2015503579A5 (cg-RX-API-DMAC10.html
JP2015503579A (ja
Inventor
クォン・テグワン
キム・ドンホ
キム・ギョンス
キム・ヨンイル
パク・ジェヒョン
ウ・ジョンス
Original Assignee
ハンミ ファーム． シーオー．， エルティーディー．
ハンミ ファーム． シーオー．， エルティーディー．
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Application filed by ハンミ ファーム． シーオー．， エルティーディー．, ハンミ ファーム． シーオー．， エルティーディー． filed Critical ハンミ ファーム． シーオー．， エルティーディー．
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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JP2014551191A 2012-01-06 2013-01-04 レボセチリジンまたはその医薬的に許容される塩およびモンテルカストまたはその医薬的に許容される塩を含む経口投与用安定医薬製剤 Expired - Fee Related JP6163165B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020120001954A KR101418404B1 (ko) 2012-01-06 2012-01-06 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
KR10-2012-0001954 2012-01-06
PCT/KR2013/000057 WO2013103262A1 (en) 2012-01-06 2013-01-04 Stable pharmaceutical formulation for oral administration comprising levocetirizine or a pharmaceutically acceptable salt thereof, and montelukast or a pharmaceutically acceptable salt thereof

Publications (3)

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JP2015503579A JP2015503579A (ja) 2015-02-02
JP2015503579A5 JP2015503579A5 (cg-RX-API-DMAC10.html) 2016-02-18
JP6163165B2 true JP6163165B2 (ja) 2017-07-12

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JP2014551191A Expired - Fee Related JP6163165B2 (ja) 2012-01-06 2013-01-04 レボセチリジンまたはその医薬的に許容される塩およびモンテルカストまたはその医薬的に許容される塩を含む経口投与用安定医薬製剤

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US (1) US9486528B2 (cg-RX-API-DMAC10.html)
EP (1) EP2800558B1 (cg-RX-API-DMAC10.html)
JP (1) JP6163165B2 (cg-RX-API-DMAC10.html)
KR (1) KR101418404B1 (cg-RX-API-DMAC10.html)
CN (1) CN104039314B (cg-RX-API-DMAC10.html)
AR (1) AR089666A1 (cg-RX-API-DMAC10.html)
BR (1) BR112014016472B1 (cg-RX-API-DMAC10.html)
ES (1) ES2671428T3 (cg-RX-API-DMAC10.html)
JO (1) JO3388B1 (cg-RX-API-DMAC10.html)
MX (1) MX354073B (cg-RX-API-DMAC10.html)
PH (1) PH12014501545B1 (cg-RX-API-DMAC10.html)
PL (1) PL2800558T3 (cg-RX-API-DMAC10.html)
PT (1) PT2800558T (cg-RX-API-DMAC10.html)
RU (1) RU2614382C2 (cg-RX-API-DMAC10.html)
SG (1) SG11201403811VA (cg-RX-API-DMAC10.html)
SI (1) SI2800558T1 (cg-RX-API-DMAC10.html)
TR (1) TR201807978T4 (cg-RX-API-DMAC10.html)
TW (1) TWI565482B (cg-RX-API-DMAC10.html)
WO (1) WO2013103262A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201405756B (cg-RX-API-DMAC10.html)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9717684B2 (en) 2014-04-25 2017-08-01 R.P. Scherer Technologies, Llc Stable montelukast solution
KR101669556B1 (ko) * 2014-07-02 2016-10-28 한미약품 주식회사 몬테루카스트 또는 이의 약제학적으로 허용가능한 염의 경구투여용 액상제제
JP6575031B2 (ja) * 2014-07-28 2019-09-18 日本ケミファ株式会社 モンテルカストナトリウム製剤
RU2580303C1 (ru) * 2015-02-18 2016-04-10 Общество с ограниченной ответственностью "ПРОФИТ ФАРМ" Состав таблетированной формы лекарственного средства с действующим веществом пророксан
PL3222279T3 (pl) 2016-03-21 2022-05-09 Invest Bielany Spółka Z Ograniczoną Odpowiedzialnością Doustny preparat farmaceutyczny montelukastu i lewocetyryzyny oraz sposób jego wytwarzania
KR102481517B1 (ko) * 2021-08-30 2022-12-27 주식회사 클라시아 약제학적 제제
JP2024514989A (ja) * 2021-10-21 2024-04-03 ハン ファ ファーマ カンパニー、リミテッド モンテルカストまたはその薬学的に許容可能な塩、及びレボセチリジンまたはその薬学的に許容可能な塩を含有する、安定性が改善されたフィルムコーティング錠剤
KR20240045586A (ko) 2022-09-30 2024-04-08 주식회사 제뉴원사이언스 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 포함하는 안정성이 향상된 이층정 정제 및 그의 제조방법
KR20250005771A (ko) 2023-07-03 2025-01-10 경동제약 주식회사 레보세티리진 및 몬테루카스트를 포함하는 복합 조성물
KR20250081149A (ko) * 2023-11-29 2025-06-05 알리코제약(주) 안정성이 향상된 몬테루카스트 및 루파타딘 함유 조성물 및 이의 제조 방법

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1204580A (en) 1968-10-05 1970-09-09 Aspro Nicholas Ltd Pharmaceutical dosage forms
NO155805C (no) 1981-02-06 1987-06-10 Ucb Sa Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter.
US4800162A (en) 1987-04-01 1989-01-24 Sepracor, Inc. Method for resolution of steroisomers in multiphase and extractive membrane reactors
US5057427A (en) 1988-04-07 1991-10-15 Sepracor, Inc. Method for resolution of stereoisomers
GB8827391D0 (en) 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
GB8827390D0 (en) 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
DE4209824A1 (de) 1991-09-06 1993-03-11 Schaeffler Waelzlager Kg Waelzlager fuer linearbewegungen
GB9305282D0 (en) 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
BE1010095A3 (fr) 1996-04-10 1997-12-02 Ucb Sa Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels.
BE1010094A3 (fr) 1996-04-10 1997-12-02 Ucb Sa Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues.
DE10007203A1 (de) 2000-02-17 2001-08-23 Asta Medica Ag Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis
ATE311200T1 (de) 2000-04-12 2005-12-15 Merck Frosst Canada Inc Verfahren und zusammensetzungen zur behandlung von allergischen zuständen mit pgd2 rezeptor antagonisten
KR100795419B1 (ko) * 2006-01-03 2008-01-17 (주)네오메딕스 암로디핀 및 아스피린을 함유하는 약학 제제
KR100910848B1 (ko) * 2007-09-13 2009-08-06 재단법인서울대학교산학협력재단 알러지성 비염 치료약물을 유효성분으로 함유하는 비강분무용 마이크로스피어 및 이의 제조방법
WO2010107404A1 (en) * 2009-03-16 2010-09-23 Mahmut Bilgic Stable pharmaceutical combinations
KR20130009553A (ko) 2011-07-15 2013-01-23 한미약품 주식회사 몬테루카스트 또는 이의 약학적으로 허용가능한 염 및 레보세티리진 또는 이의 약학적으로 허용가능한 염을 함유하는 캡슐 제제
KR101861307B1 (ko) * 2011-10-13 2018-07-06 한미약품 주식회사 정제를 포함하는 경질 캡슐 복합 제형

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HK1200337A1 (en) 2015-08-07
EP2800558A4 (en) 2015-08-12
SG11201403811VA (en) 2014-08-28
CN104039314B (zh) 2017-07-14
BR112014016472A8 (pt) 2017-07-04
RU2014132428A (ru) 2016-02-27
ZA201405756B (en) 2016-08-31
BR112014016472B1 (pt) 2022-03-15
TR201807978T4 (tr) 2018-06-21
JO3388B1 (ar) 2019-03-13
PT2800558T (pt) 2018-06-05
CN104039314A (zh) 2014-09-10
PH12014501545A1 (en) 2014-10-08
ES2671428T3 (es) 2018-06-06
KR101418404B1 (ko) 2014-07-10
TW201332590A (zh) 2013-08-16
MX354073B (es) 2018-02-12
RU2614382C2 (ru) 2017-03-24
TWI565482B (zh) 2017-01-11
PL2800558T3 (pl) 2018-08-31
PH12014501545B1 (en) 2017-09-06
WO2013103262A1 (en) 2013-07-11
SI2800558T1 (en) 2018-06-29
US20140356422A1 (en) 2014-12-04
BR112014016472A2 (pt) 2017-06-13
JP2015503579A (ja) 2015-02-02
MX2014008059A (es) 2014-10-06
KR20130081013A (ko) 2013-07-16
EP2800558A1 (en) 2014-11-12
EP2800558B1 (en) 2018-04-11
US9486528B2 (en) 2016-11-08
AR089666A1 (es) 2014-09-10

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