JO3388B1 - تركيبة دوائية ثابتة للإعطاء عن طريق الفم تضم ليفوسيتيريزين أو ملح منه مقبول دوائياً، و منتولوكاست أو ملح منه مقبول دوائياً - Google Patents

تركيبة دوائية ثابتة للإعطاء عن طريق الفم تضم ليفوسيتيريزين أو ملح منه مقبول دوائياً، و منتولوكاست أو ملح منه مقبول دوائياً

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Publication number
JO3388B1
JO3388B1 JOP/2013/0004A JOP20130004A JO3388B1 JO 3388 B1 JO3388 B1 JO 3388B1 JO P20130004 A JOP20130004 A JO P20130004A JO 3388 B1 JO3388 B1 JO 3388B1
Authority
JO
Jordan
Prior art keywords
pharmaceutically acceptable
acceptable salt
levocetirizine
montelukast
pharmaceutical formulation
Prior art date
Application number
JOP/2013/0004A
Other languages
English (en)
Inventor
Kwan Kwon Taek
Hyun Park Jae
Soo Woo Jong
Ho Kim Dong
Soo Kim Kyeong
Ii Kim Yong
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48745292&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3388(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Application granted granted Critical
Publication of JO3388B1 publication Critical patent/JO3388B1/ar

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
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    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
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    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
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    • A61K9/2022—Organic macromolecular compounds
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    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

يتعلق الإختراع الحالي بتركيبة دوائية تعطى بالفم لتثبيط أو علاج التهاب الأنف الأرجي أو داء الربو، وتشتمل على: (أ) جزء جسيمات أولى تشتمل على الليفوسيتريزين أو ملح منه مقبول دوائياً وحمض عضوي، و(ب) جزء جسيمات ثاني يشتمل على المونتيلوكاست أو ملح منه مقبول دوائياً. وتشتمل التركيبة الدوائية وفقاً للإختراع الحالي على حمض عضوي كعامل إستقرار والتي يمكن أن يثبط بشكل فعال المركب من المواد التقعلقة بالليفوسيتريزين والمونتيلوكاست وبالتالي، يظهر هذا المركب إسقرارية جيدة
JOP/2013/0004A 2012-01-06 2013-01-03 تركيبة دوائية ثابتة للإعطاء عن طريق الفم تضم ليفوسيتيريزين أو ملح منه مقبول دوائياً، و منتولوكاست أو ملح منه مقبول دوائياً JO3388B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020120001954A KR101418404B1 (ko) 2012-01-06 2012-01-06 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제

Publications (1)

Publication Number Publication Date
JO3388B1 true JO3388B1 (ar) 2019-03-13

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ID=48745292

Family Applications (1)

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JOP/2013/0004A JO3388B1 (ar) 2012-01-06 2013-01-03 تركيبة دوائية ثابتة للإعطاء عن طريق الفم تضم ليفوسيتيريزين أو ملح منه مقبول دوائياً، و منتولوكاست أو ملح منه مقبول دوائياً

Country Status (21)

Country Link
US (1) US9486528B2 (ar)
EP (1) EP2800558B1 (ar)
JP (1) JP6163165B2 (ar)
KR (1) KR101418404B1 (ar)
CN (1) CN104039314B (ar)
AR (1) AR089666A1 (ar)
BR (1) BR112014016472B1 (ar)
ES (1) ES2671428T3 (ar)
HK (1) HK1200337A1 (ar)
JO (1) JO3388B1 (ar)
MX (1) MX354073B (ar)
PH (1) PH12014501545A1 (ar)
PL (1) PL2800558T3 (ar)
PT (1) PT2800558T (ar)
RU (1) RU2614382C2 (ar)
SG (1) SG11201403811VA (ar)
SI (1) SI2800558T1 (ar)
TR (1) TR201807978T4 (ar)
TW (1) TWI565482B (ar)
WO (1) WO2013103262A1 (ar)
ZA (1) ZA201405756B (ar)

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EP2800558A4 (en) 2015-08-12
BR112014016472B1 (pt) 2022-03-15
ES2671428T3 (es) 2018-06-06
WO2013103262A1 (en) 2013-07-11
BR112014016472A2 (pt) 2017-06-13
PH12014501545B1 (en) 2014-10-08
MX2014008059A (es) 2014-10-06
CN104039314B (zh) 2017-07-14
EP2800558B1 (en) 2018-04-11
US20140356422A1 (en) 2014-12-04
TWI565482B (zh) 2017-01-11
MX354073B (es) 2018-02-12
SG11201403811VA (en) 2014-08-28
KR101418404B1 (ko) 2014-07-10
SI2800558T1 (en) 2018-06-29
AR089666A1 (es) 2014-09-10
RU2614382C2 (ru) 2017-03-24
EP2800558A1 (en) 2014-11-12
JP6163165B2 (ja) 2017-07-12
CN104039314A (zh) 2014-09-10
KR20130081013A (ko) 2013-07-16
TW201332590A (zh) 2013-08-16
PL2800558T3 (pl) 2018-08-31
HK1200337A1 (en) 2015-08-07
TR201807978T4 (tr) 2018-06-21
BR112014016472A8 (pt) 2017-07-04
PT2800558T (pt) 2018-06-05
RU2014132428A (ru) 2016-02-27
JP2015503579A (ja) 2015-02-02
ZA201405756B (en) 2016-08-31
PH12014501545A1 (en) 2014-10-08
US9486528B2 (en) 2016-11-08

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