JP6144689B2 - Ｉｌ−６受容体を拮抗することにより腫瘍増殖を阻害する方法 - Google Patents

Ｉｌ−６受容体を拮抗することにより腫瘍増殖を阻害する方法 Download PDF

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JP6144689B2
JP6144689B2 JP2014541298A JP2014541298A JP6144689B2 JP 6144689 B2 JP6144689 B2 JP 6144689B2 JP 2014541298 A JP2014541298 A JP 2014541298A JP 2014541298 A JP2014541298 A JP 2014541298A JP 6144689 B2 JP6144689 B2 JP 6144689B2
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vegf
antibody
antigen
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antagonist
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リー・チャン
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Regeneron Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2014541298A 2011-11-10 2012-11-09 Ｉｌ−６受容体を拮抗することにより腫瘍増殖を阻害する方法 Active JP6144689B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161557939P 2011-11-10 2011-11-10
US61/557,939 2011-11-10
US201261609968P 2012-03-13 2012-03-13
US61/609,968 2012-03-13
US201261613538P 2012-03-21 2012-03-21
US61/613,538 2012-03-21
PCT/US2012/064311 WO2013071016A2 (en) 2011-11-10 2012-11-09 Methods of inhibiting tumor growth by antagonizing il-6 receptor

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JP2017000818A Division JP6283754B2 (ja) 2011-11-10 2017-01-06 Ｉｌ−６受容体を拮抗することにより腫瘍増殖を阻害する方法

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JP2014534237A JP2014534237A (ja) 2014-12-18
JP2014534237A5 JP2014534237A5 (cg-RX-API-DMAC7.html) 2015-10-29
JP6144689B2 true JP6144689B2 (ja) 2017-06-07

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JP2017000818A Active JP6283754B2 (ja) 2011-11-10 2017-01-06 Ｉｌ−６受容体を拮抗することにより腫瘍増殖を阻害する方法
JP2018011135A Withdrawn JP2018083841A (ja) 2011-11-10 2018-01-26 Ｉｌ−６受容体を拮抗することにより腫瘍増殖を阻害する方法

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JP2018011135A Withdrawn JP2018083841A (ja) 2011-11-10 2018-01-26 Ｉｌ−６受容体を拮抗することにより腫瘍増殖を阻害する方法

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US (3) US20130122003A1 (cg-RX-API-DMAC7.html)
EP (1) EP2776468B1 (cg-RX-API-DMAC7.html)
JP (3) JP6144689B2 (cg-RX-API-DMAC7.html)
KR (1) KR101718748B1 (cg-RX-API-DMAC7.html)
CN (1) CN103930443B (cg-RX-API-DMAC7.html)
AR (1) AR088671A1 (cg-RX-API-DMAC7.html)
AU (2) AU2012335596B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014011211A2 (cg-RX-API-DMAC7.html)
CA (1) CA2853836C (cg-RX-API-DMAC7.html)
IL (2) IL231854A (cg-RX-API-DMAC7.html)
IN (1) IN2014CN02923A (cg-RX-API-DMAC7.html)
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US9017678B1 (en) 2014-07-15 2015-04-28 Kymab Limited Method of treating rheumatoid arthritis using antibody to IL6R
DE202014010499U1 (de) 2013-12-17 2015-10-20 Kymab Limited Targeting von humaner PCSK9 zur Cholesterinbehandlung
CN107428824A (zh) * 2014-06-28 2017-12-01 科达制药 Pdgf/vegf双重拮抗剂
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
US20180169230A1 (en) * 2015-05-29 2018-06-21 Merrimack Pharmaceuticals, Inc. Combination cancer therapies
JP7088454B2 (ja) 2015-12-30 2022-06-21 コディアック サイエンシーズ インコーポレイテッド 抗体および抗体複合体
CN110087530A (zh) 2016-12-07 2019-08-02 普罗根尼蒂公司 胃肠道检测方法、装置和系统
WO2018112237A1 (en) 2016-12-14 2018-06-21 Progenity Inc. Treatment of a disease of the gastrointestinal tract with an il-6r inhibitor
CN112203679A (zh) * 2018-03-02 2021-01-08 科达制药股份有限公司 Il-6抗体及其融合构建体和缀合物
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CN108567981A (zh) * 2018-07-17 2018-09-25 漯河医学高等专科学校 白细胞介素-6的拮抗剂在制备抑制Notch-1蛋白表达、治疗胰腺癌的药物中的应用
CN116726362A (zh) 2018-11-19 2023-09-12 比奥拉治疗股份有限公司 用生物治疗剂治疗疾病的方法和装置
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BR112014011211A2 (pt) 2017-04-25
SG11201401286QA (en) 2014-05-29
JO3370B1 (ar) 2019-03-13
KR101718748B1 (ko) 2017-03-22
IL248620A0 (en) 2016-12-29
ZA201402414B (en) 2015-03-25
CA2853836C (en) 2019-07-23
WO2013071016A3 (en) 2013-07-25
JP2018083841A (ja) 2018-05-31
MY163953A (en) 2017-11-15
AU2012335596B2 (en) 2018-05-17
KR20140095481A (ko) 2014-08-01
AR088671A1 (es) 2014-06-25
TW201716776A (zh) 2017-05-16
EP2776468A2 (en) 2014-09-17
WO2013071016A2 (en) 2013-05-16
TW201806620A (zh) 2018-03-01
RU2648150C2 (ru) 2018-03-22
JP2014534237A (ja) 2014-12-18
AU2012335596A1 (en) 2014-05-22
JP6283754B2 (ja) 2018-02-21
RU2014118739A (ru) 2015-12-20
UY34444A (es) 2013-05-31
MX2014004886A (es) 2014-07-09
TW201332569A (zh) 2013-08-16
US20170022279A1 (en) 2017-01-26
IL231854A (en) 2016-11-30
US20130122003A1 (en) 2013-05-16
TWI604852B (zh) 2017-11-11
CA2853836A1 (en) 2013-05-16
CN103930443A (zh) 2014-07-16
CN103930443B (zh) 2017-08-04
IN2014CN02923A (cg-RX-API-DMAC7.html) 2015-07-03
EP2776468B1 (en) 2018-01-24
MX357837B (es) 2018-07-26
JP2017095489A (ja) 2017-06-01
US9409990B2 (en) 2016-08-09
AU2018203666A1 (en) 2018-06-14
US20140322215A1 (en) 2014-10-30
IL231854A0 (en) 2014-05-28

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