JP6104805B2 - 対称に分布した検体感知領域を有する電気化学センサ - Google Patents
対称に分布した検体感知領域を有する電気化学センサ Download PDFInfo
- Publication number
- JP6104805B2 JP6104805B2 JP2013532067A JP2013532067A JP6104805B2 JP 6104805 B2 JP6104805 B2 JP 6104805B2 JP 2013532067 A JP2013532067 A JP 2013532067A JP 2013532067 A JP2013532067 A JP 2013532067A JP 6104805 B2 JP6104805 B2 JP 6104805B2
- Authority
- JP
- Japan
- Prior art keywords
- electrode
- regions
- sensor
- electrochemical sensor
- electrode regions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000012491 analyte Substances 0.000 title description 11
- 239000000758 substrate Substances 0.000 claims description 43
- 210000001124 body fluid Anatomy 0.000 claims description 35
- 238000009826 distribution Methods 0.000 claims description 31
- 239000004020 conductor Substances 0.000 claims description 29
- 229910021607 Silver chloride Inorganic materials 0.000 claims description 27
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 claims description 27
- 239000000463 material Substances 0.000 claims description 25
- 239000010839 body fluid Substances 0.000 claims description 24
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 20
- 229910052799 carbon Inorganic materials 0.000 claims description 20
- 238000001727 in vivo Methods 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 13
- 230000009972 noncorrosive effect Effects 0.000 claims description 11
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 9
- 229910052737 gold Inorganic materials 0.000 claims description 9
- 239000010931 gold Substances 0.000 claims description 9
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 8
- 229910052697 platinum Inorganic materials 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 238000012360 testing method Methods 0.000 claims description 4
- 230000001568 sexual effect Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 18
- 238000005259 measurement Methods 0.000 description 14
- 230000005684 electric field Effects 0.000 description 11
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 10
- 230000008859 change Effects 0.000 description 10
- 230000000739 chaotic effect Effects 0.000 description 10
- 239000003153 chemical reaction reagent Substances 0.000 description 10
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 7
- 239000008103 glucose Substances 0.000 description 7
- 239000012528 membrane Substances 0.000 description 7
- 238000010586 diagram Methods 0.000 description 5
- 229910052763 palladium Inorganic materials 0.000 description 5
- 229910052709 silver Inorganic materials 0.000 description 5
- 239000004332 silver Substances 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 239000004642 Polyimide Substances 0.000 description 4
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 4
- 229920000728 polyester Polymers 0.000 description 4
- 229920001721 polyimide Polymers 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000002847 impedance measurement Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000007639 printing Methods 0.000 description 3
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 231100000135 cytotoxicity Toxicity 0.000 description 2
- 230000003013 cytotoxicity Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000003487 electrochemical reaction Methods 0.000 description 2
- 210000003722 extracellular fluid Anatomy 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000011810 insulating material Substances 0.000 description 2
- 239000012212 insulator Substances 0.000 description 2
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 229920003223 poly(pyromellitimide-1,4-diphenyl ether) Polymers 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- WOCIAKWEIIZHES-UHFFFAOYSA-N ruthenium(iv) oxide Chemical compound O=[Ru]=O WOCIAKWEIIZHES-UHFFFAOYSA-N 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000002747 voluntary effect Effects 0.000 description 2
- POAOYUHQDCAZBD-UHFFFAOYSA-N 2-butoxyethanol Chemical compound CCCCOCCO POAOYUHQDCAZBD-UHFFFAOYSA-N 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 108010015776 Glucose oxidase Proteins 0.000 description 1
- 239000004366 Glucose oxidase Substances 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- QVWVQSFHZPVTJI-UHFFFAOYSA-N [4-methyl-3-oxo-1-(trimethylazaniumyl)pent-4-en-2-yl] hydrogen phosphate Chemical compound CC(=C)C(=O)C(C[N+](C)(C)C)OP(O)([O-])=O QVWVQSFHZPVTJI-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000003486 chemical etching Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000001312 dry etching Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 229920005570 flexible polymer Polymers 0.000 description 1
- 229940116332 glucose oxidase Drugs 0.000 description 1
- 235000019420 glucose oxidase Nutrition 0.000 description 1
- 238000001453 impedance spectrum Methods 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000012623 in vivo measurement Methods 0.000 description 1
- AMGQUBHHOARCQH-UHFFFAOYSA-N indium;oxotin Chemical compound [In].[Sn]=O AMGQUBHHOARCQH-UHFFFAOYSA-N 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 229910052741 iridium Inorganic materials 0.000 description 1
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000011112 polyethylene naphthalate Substances 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007650 screen-printing Methods 0.000 description 1
- -1 silver ions Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1477—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means non-invasive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
- A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/2415—Measuring direct current [DC] or slowly varying biopotentials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/263—Bioelectric electrodes therefor characterised by the electrode materials
- A61B5/265—Bioelectric electrodes therefor characterised by the electrode materials containing silver or silver chloride
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/04—Constructional details of apparatus
- A61B2560/0462—Apparatus with built-in sensors
- A61B2560/0468—Built-in electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/04—Arrangements of multiple sensors of the same type
- A61B2562/043—Arrangements of multiple sensors of the same type in a linear array
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/301—Reference electrodes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- General Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Electrochemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/901,078 US9084570B2 (en) | 2010-10-08 | 2010-10-08 | Electrochemical sensor having symmetrically distributed analyte sensitive areas |
| US12/901,078 | 2010-10-08 | ||
| PCT/EP2011/004913 WO2012045425A1 (en) | 2010-10-08 | 2011-10-01 | Electrochemical sensor having symmetrically distributed analyte sensitive areas |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013543405A JP2013543405A (ja) | 2013-12-05 |
| JP2013543405A5 JP2013543405A5 (enExample) | 2014-10-23 |
| JP6104805B2 true JP6104805B2 (ja) | 2017-03-29 |
Family
ID=44799976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013532067A Expired - Fee Related JP6104805B2 (ja) | 2010-10-08 | 2011-10-01 | 対称に分布した検体感知領域を有する電気化学センサ |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US9084570B2 (enExample) |
| EP (2) | EP2624756B1 (enExample) |
| JP (1) | JP6104805B2 (enExample) |
| KR (1) | KR20130057477A (enExample) |
| CN (1) | CN103140170B (enExample) |
| AU (1) | AU2011313631A1 (enExample) |
| ES (2) | ES2983452T3 (enExample) |
| HU (2) | HUE067577T2 (enExample) |
| MX (1) | MX2013003471A (enExample) |
| WO (1) | WO2012045425A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8560039B2 (en) | 2008-09-19 | 2013-10-15 | Dexcom, Inc. | Particle-containing membrane and particulate electrode for analyte sensors |
| US9084570B2 (en) * | 2010-10-08 | 2015-07-21 | Roche Diagnostics Operations, Inc. | Electrochemical sensor having symmetrically distributed analyte sensitive areas |
| CN103261433A (zh) * | 2010-12-09 | 2013-08-21 | 雅培糖尿病护理股份有限公司 | 具有包括小型感测斑点的感测表面的分析物传感器 |
| US9535027B2 (en) * | 2012-07-25 | 2017-01-03 | Abbott Diabetes Care Inc. | Analyte sensors and methods of using same |
| CN104055526A (zh) * | 2013-12-05 | 2014-09-24 | 庞德兴 | 一种无源微创皮下生化参数检测芯片 |
| EP3216076B1 (en) * | 2014-11-03 | 2024-03-06 | F. Hoffmann-La Roche AG | Method of using electrochemical test elements having multiple electrode arrangements |
| KR20190091569A (ko) | 2014-12-19 | 2019-08-06 | 에프. 호프만-라 로슈 아게 | 적어도 하나의 분석물을 전기 화학적으로 검출하기 위한 테스트 엘리먼트 |
| EP3610791A1 (en) * | 2015-11-19 | 2020-02-19 | Roche Diabetes Care GmbH | Sensor and sensor assembly for detecting an analyte in a body fluid |
| BR112019012600B1 (pt) * | 2016-12-22 | 2023-10-03 | Sanvita Medical Corporation | Conjunto de inserção para a implantação de um sensor |
| EP3639018A1 (en) | 2017-06-11 | 2020-04-22 | Epymetrics AG | Chip-based multi-channel electrochemical transducer and method of use thereof |
| ES3023573T3 (en) * | 2017-09-18 | 2025-06-02 | Hoffmann La Roche | Electrochemical sensor for detecting at least one analyte |
| ES2831076T3 (es) | 2017-11-08 | 2021-06-07 | Hoffmann La Roche | Sensor para detectar un analito en un líquido corporal y procedimiento de fabricación del mismo |
| US12076145B2 (en) * | 2018-04-19 | 2024-09-03 | Abbott Diabetes Care Inc. | Lactate sensors and associated methods |
| CN109959679B (zh) * | 2019-03-08 | 2020-06-05 | 浙江大学 | 一种用于3d肿瘤细胞迁移实时监测的垂直多电极阻抗传感器及制备方法 |
| JP7264465B2 (ja) * | 2019-06-24 | 2023-04-25 | テクノグローバル株式会社 | 電極構造体、電気化学測定装置、及び電気化学測定方法 |
| EP3798628B1 (en) * | 2019-09-27 | 2025-04-16 | Heraeus Medevio GmbH & Co. KG | Method for manufacturing an electrochemical sensor |
| KR102296827B1 (ko) | 2019-11-08 | 2021-09-01 | 재단법인대구경북과학기술원 | 삽입형 바이오센서 |
| WO2021110279A1 (en) * | 2019-12-06 | 2021-06-10 | Bright Spark B.V. | Amperometric sensor for measuring free chlorine with reference electrode having a gold electrode surface composed of a string of electrically connected, spaced apart surface parts |
| US11877847B2 (en) * | 2020-01-31 | 2024-01-23 | Taiwan Semiconductor Manufacturing Company, Ltd. | Biosensor apparatus |
| KR102346784B1 (ko) * | 2020-08-06 | 2022-01-04 | 알사란 자빕 | 생화학 키트 및 이를 이용한 생화학 정보 측정방법 |
| US12239442B2 (en) * | 2020-12-23 | 2025-03-04 | Abbott Diabetes Care Inc. | Analyte sensors with reduced interferent signal and methods |
| EP4085829A1 (en) | 2021-05-06 | 2022-11-09 | Roche Diabetes Care GmbH | Analyte sensor and a method for its producing |
| ES3010357T3 (en) | 2021-08-18 | 2025-04-02 | Hoffmann La Roche | Analyte sensor and a method for its producing |
| CN113740400B (zh) * | 2021-08-18 | 2023-10-24 | 淮阴工学院 | 带有对称参比电极的封闭式双极电极阵列的分析检测装置 |
| CN114184661B (zh) * | 2021-11-26 | 2025-03-14 | 北京大学 | 一种电化学传感器及其制造方法 |
| US20240108257A1 (en) * | 2022-03-11 | 2024-04-04 | Integrated Medical Sensors, Inc. | Wired implantable multianalyte monolithic integrated sensor circuit |
| WO2023215836A2 (en) * | 2022-05-05 | 2023-11-09 | Cercacor Laboratories, Inc. | An analyte sensor for measuring at varying depths within a user |
| GB202218073D0 (en) * | 2022-12-01 | 2023-01-18 | Freeman Neville | Electrochemical electrode assembly |
| WO2025178614A1 (en) * | 2024-02-21 | 2025-08-28 | Roche Diabetes Care, Inc. | Continuous analyte monitor |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4655880A (en) | 1983-08-01 | 1987-04-07 | Case Western Reserve University | Apparatus and method for sensing species, substances and substrates using oxidase |
| US5711861A (en) * | 1995-11-22 | 1998-01-27 | Ward; W. Kenneth | Device for monitoring changes in analyte concentration |
| US6139718A (en) | 1997-03-25 | 2000-10-31 | Cygnus, Inc. | Electrode with improved signal to noise ratio |
| KR100349000B1 (ko) | 1998-07-09 | 2003-03-26 | 주식회사 아이센스 | 친수성폴리우레탄을사용한바이오센서의제조방법 |
| US6501976B1 (en) | 2001-06-12 | 2002-12-31 | Lifescan, Inc. | Percutaneous biological fluid sampling and analyte measurement devices and methods |
| US7813780B2 (en) | 2005-12-13 | 2010-10-12 | Medtronic Minimed, Inc. | Biosensors and methods for making and using them |
| US7467003B2 (en) | 2003-12-05 | 2008-12-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US8060174B2 (en) * | 2005-04-15 | 2011-11-15 | Dexcom, Inc. | Analyte sensing biointerface |
| US20070173712A1 (en) * | 2005-12-30 | 2007-07-26 | Medtronic Minimed, Inc. | Method of and system for stabilization of sensors |
| US7985330B2 (en) | 2005-12-30 | 2011-07-26 | Medtronic Minimed, Inc. | Method and system for detecting age, hydration, and functional states of sensors using electrochemical impedance spectroscopy |
| US7826879B2 (en) | 2006-02-28 | 2010-11-02 | Abbott Diabetes Care Inc. | Analyte sensors and methods of use |
| US7653425B2 (en) | 2006-08-09 | 2010-01-26 | Abbott Diabetes Care Inc. | Method and system for providing calibration of an analyte sensor in an analyte monitoring system |
| US20070299617A1 (en) | 2006-06-27 | 2007-12-27 | Willis John P | Biofouling self-compensating biosensor |
| US7751864B2 (en) | 2007-03-01 | 2010-07-06 | Roche Diagnostics Operations, Inc. | System and method for operating an electrochemical analyte sensor |
| EP1987761B1 (de) * | 2007-05-03 | 2019-10-23 | F. Hoffmann-La Roche AG | Schlauchförmiger Sensor zum Nachweis eines Analyten |
| ES2547574T3 (es) * | 2007-09-24 | 2015-10-07 | Bayer Healthcare Llc | Procedimiento de ensayo multielectrodo |
| DE102008005065A1 (de) * | 2008-01-18 | 2009-07-30 | Cellasys Gmbh | Referenzelektrode |
| US9309550B2 (en) | 2008-01-29 | 2016-04-12 | Medtronic Minimed, Inc. | Analyte sensors having nanostructured electrodes and methods for making and using them |
| US8396528B2 (en) | 2008-03-25 | 2013-03-12 | Dexcom, Inc. | Analyte sensor |
| US20100025238A1 (en) | 2008-07-31 | 2010-02-04 | Medtronic Minimed, Inc. | Analyte sensor apparatuses having improved electrode configurations and methods for making and using them |
| EP2163190A1 (de) | 2008-09-11 | 2010-03-17 | Roche Diagnostics GmbH | Elektrodensystem für Messung einer Analytkonzentration in-vivo |
| US8986208B2 (en) | 2008-09-30 | 2015-03-24 | Abbott Diabetes Care Inc. | Analyte sensor sensitivity attenuation mitigation |
| US9084570B2 (en) * | 2010-10-08 | 2015-07-21 | Roche Diagnostics Operations, Inc. | Electrochemical sensor having symmetrically distributed analyte sensitive areas |
| US9645111B2 (en) | 2012-06-08 | 2017-05-09 | Medtronic Minimed, Inc. | Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods |
-
2010
- 2010-10-08 US US12/901,078 patent/US9084570B2/en active Active
-
2011
- 2011-10-01 KR KR1020137008692A patent/KR20130057477A/ko not_active Ceased
- 2011-10-01 WO PCT/EP2011/004913 patent/WO2012045425A1/en not_active Ceased
- 2011-10-01 HU HUE21180905A patent/HUE067577T2/hu unknown
- 2011-10-01 AU AU2011313631A patent/AU2011313631A1/en not_active Abandoned
- 2011-10-01 ES ES21180905T patent/ES2983452T3/es active Active
- 2011-10-01 JP JP2013532067A patent/JP6104805B2/ja not_active Expired - Fee Related
- 2011-10-01 EP EP11769782.1A patent/EP2624756B1/en active Active
- 2011-10-01 MX MX2013003471A patent/MX2013003471A/es unknown
- 2011-10-01 CN CN201180048231.4A patent/CN103140170B/zh active Active
- 2011-10-01 ES ES11769782T patent/ES2906449T3/es active Active
- 2011-10-01 EP EP21180905.8A patent/EP3926339B1/en active Active
- 2011-10-01 HU HUE11769782A patent/HUE057419T2/hu unknown
-
2015
- 2015-07-20 US US14/803,770 patent/US9757060B2/en not_active Expired - Fee Related
-
2017
- 2017-09-11 US US15/700,392 patent/US10349878B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9084570B2 (en) | 2015-07-21 |
| KR20130057477A (ko) | 2013-05-31 |
| ES2906449T3 (es) | 2022-04-18 |
| CN103140170A (zh) | 2013-06-05 |
| US9757060B2 (en) | 2017-09-12 |
| EP2624756A1 (en) | 2013-08-14 |
| EP3926339A1 (en) | 2021-12-22 |
| CN103140170B (zh) | 2016-03-16 |
| MX2013003471A (es) | 2013-05-31 |
| EP3926339B1 (en) | 2024-05-15 |
| US20170367628A1 (en) | 2017-12-28 |
| US20150320345A1 (en) | 2015-11-12 |
| WO2012045425A1 (en) | 2012-04-12 |
| HUE057419T2 (hu) | 2022-05-28 |
| HK1185780A1 (zh) | 2014-02-28 |
| US10349878B2 (en) | 2019-07-16 |
| AU2011313631A1 (en) | 2013-02-07 |
| EP3926339C0 (en) | 2024-05-15 |
| EP2624756B1 (en) | 2021-12-15 |
| JP2013543405A (ja) | 2013-12-05 |
| US20120088993A1 (en) | 2012-04-12 |
| HUE067577T2 (hu) | 2024-10-28 |
| ES2983452T3 (es) | 2024-10-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6104805B2 (ja) | 対称に分布した検体感知領域を有する電気化学センサ | |
| US20230346273A1 (en) | Electrochemical sensor having symmetrically distributed analyte sensitive areas | |
| ES2960443T3 (es) | Método y unidad electrónica para detectar propiedades in vivo de un biosensor | |
| ES3032635T3 (en) | Medical device and method for manufacturing a medical device | |
| JP6817111B2 (ja) | 電気化学式バイオセンサを用いた物質の測定方法及び測定装置 | |
| CN108780058A (zh) | 用于检测生物传感器中的干扰物贡献的方法 | |
| JP5988965B2 (ja) | 所定のサイズ及び分布の電気化学的活性及び不活性領域を有する電極を備えた分析検査ストリップ | |
| RU2753170C1 (ru) | Электрохимический сенсор и сенсорная система для определения по меньшей мере одного аналита | |
| CN115884713A (zh) | 分析物传感器及用于生产分析物传感器的方法 | |
| JP5021678B2 (ja) | 少なくとも一つの電極を有する基板を用いる電気化学センサーシステム及び同システムの形成方法 | |
| HK1185780B (en) | Electrochemical sensor having symmetrically distributed analyte sensitive areas | |
| CN111278360B (zh) | 用于检测体液中的分析物的传感器以及制造传感器的方法 | |
| EP4370910A2 (en) | Sensor having contoured membrane | |
| HK40029615B (en) | Electrochemical sensor and sensor system for detecting at least one analyte | |
| HK40029615A (en) | Electrochemical sensor and sensor system for detecting at least one analyte |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140903 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20140903 |
|
| RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20140903 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20150527 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150630 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20150915 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20151124 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160510 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160805 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20170131 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20170301 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6104805 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |