JP6097479B2 - 新規の間葉系幹細胞及び骨形成性細胞 - Google Patents

新規の間葉系幹細胞及び骨形成性細胞 Download PDF

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JP6097479B2
JP6097479B2 JP2011507925A JP2011507925A JP6097479B2 JP 6097479 B2 JP6097479 B2 JP 6097479B2 JP 2011507925 A JP2011507925 A JP 2011507925A JP 2011507925 A JP2011507925 A JP 2011507925A JP 6097479 B2 JP6097479 B2 JP 6097479B2
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バドエル，シンディー
バスティアネリ，エンリコ
ペセッセ，サビエル
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ボーン セラピューティクス エス．アー．
ボーン セラピューティクス エス．アー．
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    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
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  • Oral & Maxillofacial Surgery (AREA)
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JP2011507925A 2008-05-07 2009-05-07 新規の間葉系幹細胞及び骨形成性細胞 Expired - Fee Related JP6097479B2 (ja)

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EP08155764.7 2008-05-07
EP08155764 2008-05-07
PCT/EP2009/055549 WO2009135905A2 (en) 2008-05-07 2009-05-07 Novel mesenchymal stem cells and bone-forming cells

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JP2011520434A JP2011520434A (ja) 2011-07-21
JP2011520434A5 JP2011520434A5 (cg-RX-API-DMAC7.html) 2013-05-09
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US (3) US9371515B2 (cg-RX-API-DMAC7.html)
EP (1) EP2291516B1 (cg-RX-API-DMAC7.html)
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KR (2) KR20110013450A (cg-RX-API-DMAC7.html)
CN (1) CN102016008A (cg-RX-API-DMAC7.html)
AU (1) AU2009245751B2 (cg-RX-API-DMAC7.html)
BE (1) BE1018748A3 (cg-RX-API-DMAC7.html)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017099386A (ja) * 2008-05-07 2017-06-08 ボーン セラピューティクス エス．アー． 新規の間葉系幹細胞及び骨形成性細胞

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9192695B2 (en) 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
US20130089529A1 (en) * 2010-06-11 2013-04-11 University-Industry Cooperation Group Of Kyunghee University Agent for osteogenesis using substance-p and preparation process thereof
CN104136034B (zh) * 2011-11-30 2018-04-24 安斯泰来再生医药协会 间充质基质细胞及其相关用途
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
CN104471059B (zh) 2012-07-12 2018-04-17 珠海横琴爱姆斯坦生物科技有限公司 人胚胎干细胞衍生的间充质样干细胞、方法及其应用
CN102827807B (zh) * 2012-09-19 2014-04-16 北京京蒙高科干细胞技术有限公司 一种间充质干细胞无血清培养基
WO2014113704A2 (en) * 2013-01-18 2014-07-24 Escape Therapeutics, Inc. Enhanced differentiation of mesenchymal stem cells
CA2899713C (en) 2013-03-15 2022-07-19 Allosource Cell repopulated collagen matrix for soft tissue repair and regeneration
KR101528305B1 (ko) * 2013-06-25 2015-06-11 사회복지법인 삼성생명공익재단 중간엽 줄기세포로부터 유래된, 내피세포의 특성을 포함하는 신규한 줄기세포
GB2536366B (en) * 2013-12-19 2019-10-23 Univ Liege Mammalian muscle-derived stem cells
AU2015245963B2 (en) * 2014-04-10 2019-02-28 Bonus Therapeutics Ltd. Bone repair compositions
CA3017772C (en) 2016-03-16 2023-02-21 Cynata Therapeutics Limited Colony forming medium and use thereof
EP3645066A1 (en) 2017-06-30 2020-05-06 Allosource Cellular bone grafts, and methods of manufacture and use
US20210404961A1 (en) * 2018-09-25 2021-12-30 Bone Therapeutics S.A. Methods and uses for determining osteogenic potential of in vitro differentiated cells
WO2023090346A1 (ja) * 2021-11-18 2023-05-25 国立大学法人東京医科歯科大学 間葉系幹細胞を含む細胞集団、細胞シート及び細胞シートの製造方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811094A (en) 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
US5837539A (en) 1990-11-16 1998-11-17 Osiris Therapeutics, Inc. Monoclonal antibodies for human mesenchymal stem cells
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
DE69418865T2 (de) 1993-03-29 2000-02-17 Zymogenetics, Inc. Osteoblastswachstumfordernde zusammensetzungen die pdgf und vitamin-d enthalten
US5972703A (en) 1994-08-12 1999-10-26 The Regents Of The University Of Michigan Bone precursor cells: compositions and methods
US5736396A (en) 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US5827740A (en) 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
WO2000007639A1 (en) 1998-08-07 2000-02-17 Tissue Engineering, Inc. Bone precursor compositions
EP1099754A1 (en) * 1999-11-10 2001-05-16 Universiteit Leiden Mesenchymal stem cells and/or progenitor cells, their isolation and use
US20030032034A1 (en) * 2001-03-05 2003-02-13 Tang Y. Tom Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
DE10158680B4 (de) * 2001-11-30 2004-04-08 Universitätsklinikum Hamburg-Eppendorf Verfahren zur ex vivo-Expansion und -Differenzierung von multipotenten Stammzellen
EP1464698A4 (en) * 2001-12-13 2006-04-12 Japan Science & Tech Agency HUMAN CELL CULTURE MEDIUM AND CULTIVATION PROCESS
US7470538B2 (en) 2002-12-05 2008-12-30 Case Western Reserve University Cell-based therapies for ischemia
US20060205071A1 (en) * 2003-07-17 2006-09-14 Gamida-Cell Ltd. Methods for ex-vivo expanding stem/progenitor cells
US9074190B2 (en) * 2003-10-07 2015-07-07 Biomaster, Inc. Cell differentiation of adipose-derived precursor cells
JP2005287479A (ja) 2004-03-31 2005-10-20 Kazuhisa Maeda 組織幹細胞採取方法及びそれを利用した装置
WO2006062989A1 (en) * 2004-12-07 2006-06-15 Bacterin International, Inc. Three-dimensional cell culsture system
JP2006230316A (ja) 2005-02-25 2006-09-07 Japan Health Science Foundation 瘢痕のない創傷治癒能を有する細胞およびその調製方法
WO2006134951A1 (ja) * 2005-06-13 2006-12-21 Biomaster, Inc. 脂肪由来幹細胞の長期培養増殖法
WO2007044418A2 (en) * 2005-10-06 2007-04-19 Moscatello David K Cell culture media, kits and methods of use
CZ301148B6 (cs) * 2006-01-25 2009-11-18 Univerzita Karlova V Praze Zpusob pestování lidských mezenchymových kmenových bunek, zejména pro lécbu nehojících se fraktur, a bioreaktor k provádení tohoto zpusobu
PL1989295T3 (pl) * 2006-02-16 2021-02-22 Université Libre de Bruxelles Różnicowanie osteogenne komórek macierzystych szpiku kostnego oraz komórki i populacje osteoprogenitorowe lub osteoblastyczne
JP5155530B2 (ja) * 2006-07-25 2013-03-06 株式会社カネカ 成体幹細胞分離・培養システム
WO2008018190A1 (en) * 2006-08-09 2008-02-14 Biomaster, Inc. Fat-derived neural crest cells
AU2009245751B2 (en) * 2008-05-07 2014-09-18 Bone Therapeutics S.A. Mesenchymal stem cells and bone-forming cells

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017099386A (ja) * 2008-05-07 2017-06-08 ボーン セラピューティクス エス．アー． 新規の間葉系幹細胞及び骨形成性細胞

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