JP6092883B2 - 無効赤血球生成を処置するための方法および組成物 - Google Patents

無効赤血球生成を処置するための方法および組成物 Download PDF

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JP6092883B2
JP6092883B2 JP2014537186A JP2014537186A JP6092883B2 JP 6092883 B2 JP6092883 B2 JP 6092883B2 JP 2014537186 A JP2014537186 A JP 2014537186A JP 2014537186 A JP2014537186 A JP 2014537186A JP 6092883 B2 JP6092883 B2 JP 6092883B2
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actriib
polypeptide
seq
gdf trap
amino acid
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JP2014530253A5 (enExample
JP2014530253A (ja
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ジャスバー シーラー，
ジャスバー シーラー，
ロバート スコット ピアソール，
ロバート スコット ピアソール，
ラビンドラ クマール，
ラビンドラ クマール，
ナガ ベンカタ サイ ラジャセカール スラガニ，
ナガ ベンカタ サイ ラジャセカール スラガニ，
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アクセルロン ファーマ， インコーポレイテッド
アクセルロン ファーマ， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/1103—Receptor protein serine/threonine kinase (2.7.11.30)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2014537186A 2011-10-17 2012-10-17 無効赤血球生成を処置するための方法および組成物 Active JP6092883B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161547932P 2011-10-17 2011-10-17
US61/547,932 2011-10-17
PCT/US2012/060650 WO2013059347A1 (en) 2011-10-17 2012-10-17 Methods and compositions for treating ineffective erythropoiesis

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JP2017022176A Division JP6383821B2 (ja) 2011-10-17 2017-02-09 無効赤血球生成を処置するための方法および組成物

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JP2014530253A JP2014530253A (ja) 2014-11-17
JP2014530253A5 JP2014530253A5 (enExample) 2015-12-10
JP6092883B2 true JP6092883B2 (ja) 2017-03-08

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JP2014537186A Active JP6092883B2 (ja) 2011-10-17 2012-10-17 無効赤血球生成を処置するための方法および組成物
JP2017022176A Active JP6383821B2 (ja) 2011-10-17 2017-02-09 無効赤血球生成を処置するための方法および組成物
JP2018147507A Active JP6796626B2 (ja) 2011-10-17 2018-08-06 無効赤血球生成を処置するための方法および組成物
JP2020140889A Pending JP2020186277A (ja) 2011-10-17 2020-08-24 無効赤血球生成を処置するための方法および組成物

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JP2018147507A Active JP6796626B2 (ja) 2011-10-17 2018-08-06 無効赤血球生成を処置するための方法および組成物
JP2020140889A Pending JP2020186277A (ja) 2011-10-17 2020-08-24 無効赤血球生成を処置するための方法および組成物

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US (4) US20130243743A1 (enExample)
EP (3) EP2797620B1 (enExample)
JP (4) JP6092883B2 (enExample)
KR (4) KR20140084211A (enExample)
CN (3) CN107837390A (enExample)
AU (4) AU2012326207B2 (enExample)
BR (3) BR122019023174B1 (enExample)
CA (1) CA2852683A1 (enExample)
DK (2) DK3520805T3 (enExample)
EA (2) EA034563B1 (enExample)
ES (3) ES3010483T3 (enExample)
HK (2) HK1250341A1 (enExample)
WO (1) WO2013059347A1 (enExample)

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AU2017201580B2 (en) 2018-07-12
HK1203413A1 (en) 2015-10-30
ES2869168T3 (es) 2021-10-25
EA202090053A3 (ru) 2020-06-30
BR112014009528B1 (pt) 2020-12-29
EA201490809A1 (ru) 2014-09-30
KR20200019261A (ko) 2020-02-21
AU2018247262A1 (en) 2018-11-01
HK1250341A1 (zh) 2018-12-14
KR102079482B1 (ko) 2020-02-19
US20210207107A1 (en) 2021-07-08
DK3520805T3 (da) 2021-04-19
ES3010483T3 (en) 2025-04-03
CN107837390A (zh) 2018-03-27
JP2014530253A (ja) 2014-11-17
CN107693776A (zh) 2018-02-16
AU2012326207A1 (en) 2014-05-15
EP3520805A1 (en) 2019-08-07
BR112014009528A2 (pt) 2017-05-09
KR20190105113A (ko) 2019-09-11
CA2852683A1 (en) 2013-04-25
EP2797620B1 (en) 2019-04-24
AU2012326207B2 (en) 2016-12-15
EA034563B1 (ru) 2020-02-20
EA202090053A2 (ru) 2020-04-30
ES2741477T3 (es) 2020-02-11
JP2020186277A (ja) 2020-11-19
EP3875104A1 (en) 2021-09-08
BR112014009528A8 (pt) 2019-12-10
AU2018247262B2 (en) 2020-12-24
BR122019023174B1 (pt) 2021-02-23
US20170137791A1 (en) 2017-05-18
CN103987403A (zh) 2014-08-13
JP2017101060A (ja) 2017-06-08
AU2017201580A1 (en) 2017-03-30
EP2797620A1 (en) 2014-11-05
KR20220075438A (ko) 2022-06-08
WO2013059347A1 (en) 2013-04-25
BR122019023166B1 (pt) 2021-02-23
EP3875104B1 (en) 2025-01-22
EP2797620A4 (en) 2015-05-20
EP3520805B1 (en) 2021-03-10
JP6383821B2 (ja) 2018-08-29
US20130243743A1 (en) 2013-09-19
HK1252940A1 (zh) 2019-06-06
DK3875104T3 (da) 2025-02-03
KR20140084211A (ko) 2014-07-04
JP2018165287A (ja) 2018-10-25
JP6796626B2 (ja) 2020-12-09
AU2020286229A1 (en) 2021-01-07
CN103987403B (zh) 2017-12-01
US20170327800A1 (en) 2017-11-16

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