JP6087293B2 - アッセイカートリッジ及びその使用方法 - Google Patents
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- JP6087293B2 JP6087293B2 JP2013548528A JP2013548528A JP6087293B2 JP 6087293 B2 JP6087293 B2 JP 6087293B2 JP 2013548528 A JP2013548528 A JP 2013548528A JP 2013548528 A JP2013548528 A JP 2013548528A JP 6087293 B2 JP6087293 B2 JP 6087293B2
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- C—CHEMISTRY; METALLURGY
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
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Landscapes
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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| PCT/US2012/020278 WO2012094459A2 (en) | 2011-01-06 | 2012-01-05 | Assay cartridges and methods of using the same |
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| CA2934220C (en) | 2007-10-02 | 2019-11-05 | Theranos, Inc. | Modular point-of-care devices and uses thereof |
| JP6087293B2 (ja) * | 2011-01-06 | 2017-03-01 | メソ スケール テクノロジーズ エルエルシー | アッセイカートリッジ及びその使用方法 |
| JP5945282B2 (ja) | 2011-01-21 | 2016-07-05 | セラノス， インコーポレイテッド | 試料使用の極大化のためのシステム及び方法 |
| EP2699700B8 (en) | 2011-04-20 | 2016-08-24 | Mesa Biotech, Inc. | Integrated device for nucleic acid detection and identification |
| US8475739B2 (en) | 2011-09-25 | 2013-07-02 | Theranos, Inc. | Systems and methods for fluid handling |
| US20140170735A1 (en) | 2011-09-25 | 2014-06-19 | Elizabeth A. Holmes | Systems and methods for multi-analysis |
| US9664702B2 (en) | 2011-09-25 | 2017-05-30 | Theranos, Inc. | Fluid handling apparatus and configurations |
| US9632102B2 (en) | 2011-09-25 | 2017-04-25 | Theranos, Inc. | Systems and methods for multi-purpose analysis |
| US10012664B2 (en) | 2011-09-25 | 2018-07-03 | Theranos Ip Company, Llc | Systems and methods for fluid and component handling |
| US9810704B2 (en) | 2013-02-18 | 2017-11-07 | Theranos, Inc. | Systems and methods for multi-analysis |
| DE102012205171B3 (de) * | 2012-03-29 | 2013-09-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Integriertes Einweg-Chipkartuschensystem für mobile Multiparameteranalysen chemischer und/oder biologischer Substanzen |
| FR2991457B1 (fr) | 2012-06-01 | 2014-07-18 | Commissariat Energie Atomique | Procede et systeme de caracterisation de la vitesse de deplacement de particules contenues dans un liquide, telles que des particules sanguines |
| US9176154B2 (en) | 2012-12-12 | 2015-11-03 | Bio-Rad Laboratories, Inc. | Calibration process and system |
| US20140170678A1 (en) * | 2012-12-17 | 2014-06-19 | Leukodx Ltd. | Kits, compositions and methods for detecting a biological condition |
| CN105051538B (zh) | 2012-12-17 | 2018-06-15 | 伦珂德克斯有限公司 | 用于检测生物状况的系统和方法 |
| GB201302610D0 (en) * | 2013-02-14 | 2013-04-03 | Eluceda Ltd | Assay for detecting an analyte in a biological sample |
| US10401373B1 (en) | 2013-02-18 | 2019-09-03 | Theranos Ip Company, Llc | Systems and methods for analyte testing and laboratory oversight |
| US11008628B1 (en) | 2013-02-18 | 2021-05-18 | Labrador Diagnostics Llc | Systems and methods for analyte testing and laboratory oversight |
| US10031100B2 (en) * | 2013-03-13 | 2018-07-24 | Robert Bosch Gmbh | Generation of pH/temperature/ionic gradients on a lateral flow platform with multiple parallel lanes for modulating protein interactions |
| CA2911195A1 (en) * | 2013-04-05 | 2014-10-09 | Mo Bio Laboratories, Inc. | Kits and methods for isolating protein from biological and environmental samples |
| JP2015021906A (ja) * | 2013-07-22 | 2015-02-02 | 東亜ディーケーケー株式会社 | 測定方法、測定用のカートリッジ及び測定装置 |
| US10422806B1 (en) | 2013-07-25 | 2019-09-24 | Theranos Ip Company, Llc | Methods for improving assays of biological samples |
| GB2516666B (en) * | 2013-07-29 | 2015-09-09 | Atlas Genetics Ltd | Fluidic cartridge for nucleic acid amplification and detection |
| CN113789372B (zh) | 2013-08-08 | 2025-02-25 | 伊鲁米那股份有限公司 | 用于向流动池的试剂输送的流体系统 |
| JP6178161B2 (ja) * | 2013-08-21 | 2017-08-09 | 株式会社日立ハイテクノロジーズ | フローセル固定装置及び核酸分析装置 |
| DE102013221525A1 (de) * | 2013-10-23 | 2015-04-23 | Robert Bosch Gmbh | Analyseeinheit zur Durchführung einer Polymerase-Kettenreaktion, Analysevorrichtung, Verfahren zum Betrieb einer solchen Analyseeinheit und Verfahren zum Herstellen einer solchen Analyseeinheit |
| US11360107B1 (en) | 2014-02-25 | 2022-06-14 | Labrador Diagnostics Llc | Systems and methods for sample handling |
| DE102014205531B4 (de) * | 2014-03-25 | 2025-01-09 | Robert Bosch Gmbh | Mikrofluidische Vorrichtung und Verfahren zum Analysieren einer Probe biologischen Materials |
| DK3669985T3 (da) * | 2014-06-05 | 2022-05-09 | Illumina Inc | Systemer inklusive en rotationsventil til mindst en af prøveforberedelse eller prøveanalyse |
| EP3168287A4 (en) * | 2014-07-08 | 2018-01-24 | National Institute of Advanced Industrial Science and Technology | Nucleic acid amplification device, nucleic acid amplification method, and chip for nucleic acid amplification |
| WO2016019428A1 (en) * | 2014-08-08 | 2016-02-11 | Kimiya Pty. Ltd. | Diagnostic, prognostic, and analytical system |
| WO2016020775A1 (en) * | 2014-08-08 | 2016-02-11 | Kimiya Pty. Ltd. | Diagnostic, prognostic, and analytical system |
| US11066636B2 (en) | 2014-08-29 | 2021-07-20 | Nec Corporation | Microchip, microchip controlling apparatus and microchip controlling system technical field |
| GB201416459D0 (en) * | 2014-09-17 | 2014-10-29 | Atlas Genetics Ltd | Detection method |
| WO2016069853A2 (en) * | 2014-10-30 | 2016-05-06 | Cepheid | Methods of detecting ebola |
| TWI824991B (zh) * | 2015-04-24 | 2023-12-11 | 美商梅薩生物科技股份有限公司 | 用於檢測目標核酸的卡匣及控制通過在用於檢測目標核酸的卡匣中之腔室的流體之垂直流的方法 |
| WO2017056748A1 (ja) * | 2015-09-28 | 2017-04-06 | パナソニックヘルスケアホールディングス株式会社 | アナライトを分析するセンサ、測定装置、及びアナライトの分析方法 |
| ES2863232T3 (es) * | 2015-12-01 | 2021-10-11 | Aist | Recipiente de reacción de PCR, dispositivo para PCR y procedimiento de PCR |
| US10852310B2 (en) * | 2015-12-11 | 2020-12-01 | Opko Diagnostics, Llc | Fluidic systems involving incubation of samples and/or reagents |
| WO2017119382A1 (ja) * | 2016-01-05 | 2017-07-13 | 日本板硝子株式会社 | 反応処理装置、反応処理容器および反応処理方法 |
| US20190046972A1 (en) * | 2016-02-23 | 2019-02-14 | Bigtec Private Limited | A cartridge for purifying a sample and analysis |
| EP3443357A1 (en) * | 2016-04-13 | 2019-02-20 | Shenzhen Genorivision Technology Co., Ltd. | A multi-functional microfluidics device for biological sample screening |
| JP6561209B2 (ja) * | 2016-05-18 | 2019-08-14 | 日本板硝子株式会社 | 反応処理装置および反応処理装置の制御方法 |
| WO2018002693A1 (en) * | 2016-07-01 | 2018-01-04 | Tubitak | Mobile hand-held device with reusable biosensor cartridge |
| US10829810B2 (en) * | 2016-09-30 | 2020-11-10 | Gen-Probe Incorporated | Compositions on plasma-treated surfaces |
| CA3038716C (en) * | 2016-09-30 | 2024-05-21 | Tel-Array Diagnostics Inc. | Microfluidic device |
| KR20190066619A (ko) | 2016-10-07 | 2019-06-13 | 베링거잉겔하임베트메디카게엠베하 | 샘플을 테스트하기 위한 방법 및 분석 시스템 |
| KR20190065364A (ko) * | 2016-10-07 | 2019-06-11 | 베링거잉겔하임베트메디카게엠베하 | 샘플을 테스트하기 위한 분석 시스템 및 방법 |
| RU2739951C2 (ru) * | 2016-11-01 | 2020-12-30 | Ниппон Шит Глас Кампани, Лимитед | Реакционный сосуд и реакционное устройство, предназначенные для проведения полимеразной цепной реакции |
| WO2018173390A1 (ja) * | 2017-03-21 | 2018-09-27 | ソニー株式会社 | マイクロウェル封止用蓋板及びマイクロチップ |
| EP3583228A4 (en) * | 2017-04-07 | 2020-04-01 | Hewlett-Packard Development Company, L.P. | MICROFLUIDIC DEVICES |
| WO2018225577A1 (ja) * | 2017-06-06 | 2018-12-13 | 日本板硝子株式会社 | 反応処理装置 |
| CN107225006B (zh) * | 2017-07-03 | 2018-04-03 | 南京岚煜生物科技有限公司 | 基于主动控制液体流动的多通量微流控芯片 |
| US12071657B2 (en) * | 2017-10-20 | 2024-08-27 | Hewlett-Packard Development Company, L.P. | Nucleic acid amplification |
| EP3706906B1 (en) * | 2017-11-10 | 2025-03-26 | Visca, LLC | Rapid assessment device for radiation exposure |
| US11491489B2 (en) | 2017-12-28 | 2022-11-08 | Stmicroelectronics S.R.L. | Microfluidic connector group, microfluidic device and manufacturing process thereof, in particular for a cartridge for sample preparation and molecule analysis |
| US11717825B2 (en) | 2017-12-28 | 2023-08-08 | Stmicroelectronics S.R.L. | Magnetically controllable valve and portable microfluidic device having a magnetically controllable valve, in particular cartridge for sample preparation and molecule analysis |
| US11110457B2 (en) | 2017-12-28 | 2021-09-07 | Stmicroelectronics S.R.L. | Analysis unit for a transportable microfluidic device, in particular for sample preparation and molecule analysis |
| US11511278B2 (en) * | 2017-12-28 | 2022-11-29 | Stmicroelectronics S.R.L. | Solid reagent containment unit, in particular for a portable microfluidic device for sample preparation and molecule analysis |
| US11278897B2 (en) | 2017-12-28 | 2022-03-22 | Stmicroelectronics S.R.L. | Cartridge for sample preparation and molecule analysis, cartridge control machine, sample preparation system and method using the cartridge |
| EP3735315A4 (en) * | 2018-01-05 | 2021-09-29 | SiMPore Inc. | SAMPLE PREPARATION AND FLOW SENSORS USING FUNCTIONALIZED SILICON MEMBRANES |
| US10994272B2 (en) * | 2018-03-16 | 2021-05-04 | Zepto Life Technology, LLC | Cardiac biomarker assay cartridge or card |
| EP3556841A1 (en) * | 2018-04-19 | 2019-10-23 | Aglaris Ltd | Disposable cartridge cooperating with a platform in a flexible system for handling and/or manipulating fluids |
| CN118547045A (zh) | 2018-04-24 | 2024-08-27 | 凯杰科技有限公司 | 从复杂样品中分离核酸并去除抑制剂 |
| US11541385B2 (en) * | 2018-07-06 | 2023-01-03 | Qorvo Us, Inc. | Methods of measuring hematocrit in fluidic channels including conductivity sensor |
| CN110699432A (zh) * | 2018-07-10 | 2020-01-17 | Tdk株式会社 | 采用恒温扩增技术检测核酸的装置与方法 |
| WO2020023903A1 (en) | 2018-07-27 | 2020-01-30 | Zepto Life Technology, LLC | System and method for gmr-based detection of biomarkers |
| US11445901B2 (en) * | 2018-08-10 | 2022-09-20 | The Moein Family Trust | One-time use expandable speculum |
| WO2020053111A1 (en) | 2018-09-11 | 2020-03-19 | F. Hoffmann-La Roche Ag | Cartridge with liquid pack |
| US10753986B2 (en) | 2018-10-04 | 2020-08-25 | Genmark Diagnostics, Inc. | Systems and methods for assessing electrical connectivity between elements of assay devices |
| US10352983B1 (en) * | 2018-10-04 | 2019-07-16 | Genmark Diagnostics, Inc. | Systems and methods for assessing electrical connectivity between elements of assay devices |
| AU2019392932B2 (en) | 2018-12-07 | 2023-11-02 | Element Biosciences, Inc. | Flow cell device and use thereof |
| EP3894841A4 (en) | 2018-12-14 | 2022-09-28 | Luminultra Technologies Ltd. | PORTABLE SYSTEM FOR ANALYZING A MICROBIAL POPULATION IN A FLUID |
| JP7516388B2 (ja) | 2019-01-03 | 2024-07-16 | メソ スケール テクノロジーズ エルエルシー | アッセイ測定を実行するための組成物および方法 |
| US12411102B2 (en) | 2019-01-11 | 2025-09-09 | Fredsense Technologies Corp. | Systems and methods for voltammetric detection |
| US10981950B2 (en) * | 2019-01-31 | 2021-04-20 | Joanna Pezzini | Therapeutic protein flow kit for a continuous purification system |
| WO2020204067A1 (ja) * | 2019-04-02 | 2020-10-08 | 合同会社Ｈ．Ｕ．グループ中央研究所 | 流路デバイス、及び検査システム |
| KR20220044681A (ko) | 2019-05-03 | 2022-04-11 | 메소 스케일 테크놀러지즈, 엘엘시 | 샘플내 하나 이상의 표적 핵산 분석물을 검출하기 위한 키트, 및 이를 제조 및 이용하는 방법 |
| CN110564607B (zh) * | 2019-09-11 | 2022-10-28 | 长春技特生物技术有限公司 | 全自动核酸提取扩增微流控芯片动态定量检测一体化装置 |
| WO2021161171A1 (en) * | 2020-02-10 | 2021-08-19 | Yuk Lun Tsang | Point-of-care microfluidic in vitro diagnostic system |
| AU2021219847A1 (en) * | 2020-02-12 | 2022-10-13 | Massachusetts Institute Of Technology | Field deployable CRISPR-Cas diagnostics and methods of use thereof |
| CN113275046B (zh) * | 2020-02-20 | 2023-08-08 | 北京京东方健康科技有限公司 | 检测芯片及其使用方法、检测装置 |
| CN113275044B (zh) * | 2020-02-20 | 2022-07-12 | 北京京东方健康科技有限公司 | 检测芯片及其使用方法、检测装置 |
| US11851702B2 (en) | 2020-03-23 | 2023-12-26 | The Broad Institute, Inc. | Rapid diagnostics |
| EP4127211B1 (en) * | 2020-03-26 | 2025-08-27 | Siemens Healthcare Diagnostics Inc. | Random access automated molecular testing system |
| US20210299668A1 (en) * | 2020-03-30 | 2021-09-30 | Singular Genomics Systems, Inc. | Sequencing system with preheating |
| US11609207B2 (en) | 2020-03-31 | 2023-03-21 | Analog Devices International Unlimited Company | Electrochemical sensor and method of forming thereof |
| WO2021222131A1 (en) * | 2020-04-29 | 2021-11-04 | Hatami Farzin | Improved pathogen capture using active surface modification |
| US12128260B2 (en) | 2020-04-29 | 2024-10-29 | Farzin HATAMI | Pathogen capture using active surface modification |
| WO2021222832A1 (en) | 2020-05-01 | 2021-11-04 | Meso Scale Technologies, Llc. | Viral serology ace2 competition assays |
| EP4154008A1 (en) | 2020-05-19 | 2023-03-29 | Meso Scale Technologies, LLC | Methods, compositions, and kits for nucleic acid detection |
| EP4176263A1 (en) | 2020-07-01 | 2023-05-10 | Meso Scale Technologies, LLC | Compositions and methods for assay measurements |
| US11898197B2 (en) | 2020-07-30 | 2024-02-13 | Wainamics, Inc. | System and self-metering cartridges for point of care bioassays |
| US11904314B2 (en) | 2020-07-30 | 2024-02-20 | Wainamics, Inc. | System and self-metering cartridges for point of care bioassays |
| US12428674B2 (en) | 2020-07-30 | 2025-09-30 | Wainamics, Inc. | System and self-metering cartridges for point of care bioassays |
| US20230285977A1 (en) * | 2020-08-11 | 2023-09-14 | Kyorin Pharmaceutical Co., Ltd. | Nucleic acid amplification device, nucleic acid amplification method, and sample solution position control method |
| IL300973A (en) | 2020-09-02 | 2023-04-01 | Meso Scale Technologies Llc | Kits for detecting one or more target analytes in a sample and methods for making and using the same |
| TWI781450B (zh) * | 2020-09-24 | 2022-10-21 | 國立中央大學 | 複合刺激生物反應器 |
| EP4000729A1 (en) * | 2020-11-19 | 2022-05-25 | Ttp Plc | Method for determining the presence of a pathogen |
| US12458908B2 (en) | 2020-11-30 | 2025-11-04 | PAK Biosolutions Inc. | End-to-end continuous purification system |
| EP4516402A3 (en) * | 2020-12-21 | 2025-06-04 | F. Hoffmann-La Roche AG | Sensor assembly |
| EP4277998A4 (en) * | 2021-01-12 | 2025-01-01 | Definitive Biotechnologies LLC | Device and method for detecting nucleic acids in biological samples |
| CN117242188A (zh) * | 2021-01-12 | 2023-12-15 | 权威生物技术有限责任公司 | 用于检测生物样品中的核酸的装置和方法 |
| US20220323963A1 (en) * | 2021-04-09 | 2022-10-13 | The Johns Hopkins University | Sample processing cartridge for use with a dna sequencer |
| WO2022219758A1 (ja) * | 2021-04-14 | 2022-10-20 | 株式会社日立ハイテク | サンプルのｐｃｒ解析を実行するためのデバイス、ｐｃｒ反応装置、ｐｃｒシステムおよびｐｃｒ方法 |
| WO2022221660A1 (en) | 2021-04-16 | 2022-10-20 | Meso Scale Technologies, Llc. | Methods, compositions, and kits for detecting hydrolase enzyme activity |
| WO2022246213A1 (en) | 2021-05-21 | 2022-11-24 | Meso Scale Techologies, Llc. | Assays for viral strain determination |
| CA3225576A1 (en) | 2021-06-28 | 2023-01-05 | Meso Scale Technologies, Llc. | Methods, compositions, and kits for assay signal amplification |
| CN113667582A (zh) * | 2021-08-17 | 2021-11-19 | 圣湘生物科技股份有限公司 | 核酸检测装置及核酸检测方法 |
| EP4399331B1 (en) | 2021-09-09 | 2025-05-28 | Meso Scale Technologies, LLC | Method for detecting sense and antisense strands in an oligonucleotide duplex |
| US12415183B1 (en) * | 2021-12-09 | 2025-09-16 | Amazon Technologies, Inc. | Microfluidic systems and methods |
| JP2024547179A (ja) | 2021-12-30 | 2024-12-26 | メソ スケール テクノロジーズ，エルエルシー | 電気化学発光検出のための方法 |
| EP4486509A1 (en) * | 2022-03-01 | 2025-01-08 | Definitive Biotechnologies LLC | Non-toxic formulation for collecting biological samples, and device for capturing and eluting nucleic acids in the samples |
| EP4540610A1 (en) | 2022-06-17 | 2025-04-23 | Meso Scale Technologies, LLC | Viral strain serology assays |
| JP2024008492A (ja) * | 2022-07-08 | 2024-01-19 | 株式会社日立製作所 | 送液方法、流路デバイスおよび送液装置 |
| US20240103002A1 (en) | 2022-09-23 | 2024-03-28 | Meso Scale Technologies, Llc. | Orthopoxvirus serology assays |
| CN117417819A (zh) * | 2022-11-03 | 2024-01-19 | 深圳先进技术研究院 | 一种集成全封闭式核酸检测系统以及检测装置 |
| AU2023408595A1 (en) | 2022-12-20 | 2025-07-17 | Meso Scale Technologies, Llc. | Assay methods and kits |
| EP4651962A1 (en) * | 2023-01-17 | 2025-11-26 | Pak Biosolutions Inc. | End-to-end continuous purification system |
| GB202305080D0 (en) * | 2023-04-05 | 2023-05-17 | Anglia Ruskin Univ Higher Education Corporation | Methods and devices for nucleic acid amplification |
| WO2025049305A1 (en) | 2023-08-25 | 2025-03-06 | Meso Scale Technologies, Llc. | Viral strain serology assays |
| US20250196144A1 (en) * | 2023-10-25 | 2025-06-19 | Idexx Laboratories, Inc. | Methods, Systems, and Device for Bead Dispersion |
| WO2025160285A1 (en) | 2024-01-25 | 2025-07-31 | Meso Scale Technologies, Llc. | Methods for multiplex detection of sense and antisense strands in an oligonucleotide duplex |
Family Cites Families (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3918435A (en) | 1974-01-24 | 1975-11-11 | Miles Lab | Transport swab tube |
| JPS57132038A (en) | 1981-02-10 | 1982-08-16 | Olympus Optical Co Ltd | Photometric device |
| US4849330A (en) | 1984-04-27 | 1989-07-18 | Molecular Devices Corporation | Photoresponsive redox detection and discrimination |
| US4586604A (en) | 1984-06-28 | 1986-05-06 | Continental Plastic Corporation | Culture collection instrument and sealed swab holder therefor |
| DE8500471U1 (de) | 1985-01-10 | 1985-05-02 | Burkhardt, Friedrich, Prof. Dr. med., 8520 Erlangen | Kunststoff-Versandgefäß zur Konservierung von medizinischem Untersuchungsmaterial |
| US5030310A (en) | 1985-06-28 | 1991-07-09 | Miles Inc. | Electrode for electrochemical sensors |
| US4803998A (en) | 1986-01-27 | 1989-02-14 | Ncs Diagnostics, Inc. | Swab retaining vial cap and method of use |
| US5066372A (en) | 1986-05-02 | 1991-11-19 | Ciba Corning Diagnostics Corp. | Unitary multiple electrode sensor |
| US4813432A (en) | 1987-10-13 | 1989-03-21 | Saint-Amand Manufacturing, Inc. | Swab transport system |
| US5266266A (en) | 1988-02-09 | 1993-11-30 | Nason Frederic L | Specimen test unit |
| US4978504A (en) | 1988-02-09 | 1990-12-18 | Nason Frederic L | Specimen test unit |
| US5218312A (en) | 1988-07-20 | 1993-06-08 | Ricardo Moro | Measurement apparatus for measuring a biological substance within a fluid substrate |
| NO168369C (no) | 1989-09-18 | 1992-02-12 | Bionor As | Oppsamlings- og transportsystem for kulturer av mikroorganismer |
| US5527670A (en) | 1990-09-12 | 1996-06-18 | Scientific Generics Limited | Electrochemical denaturation of double-stranded nucleic acid |
| US5776672A (en) | 1990-09-28 | 1998-07-07 | Kabushiki Kaisha Toshiba | Gene detection method |
| WO1992017606A1 (en) | 1991-04-01 | 1992-10-15 | Brigham And Women's Hospital | Microassay system and neutrophil derived secretagogue |
| US5187096A (en) | 1991-08-08 | 1993-02-16 | Rensselaer Polytechnic Institute | Cell substrate electrical impedance sensor with multiple electrode array |
| US5264103A (en) | 1991-10-18 | 1993-11-23 | Matsushita Electric Industrial Co., Ltd. | Biosensor and a method for measuring a concentration of a substrate in a sample |
| US5632957A (en) | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
| US5849486A (en) | 1993-11-01 | 1998-12-15 | Nanogen, Inc. | Methods for hybridization analysis utilizing electrically controlled hybridization |
| IL103674A0 (en) | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
| EP0609431B1 (en) | 1992-08-24 | 1997-10-08 | Dade MicroScan Inc. | Sealable vessel for containing and processing analytical samples |
| US5389215A (en) | 1992-11-05 | 1995-02-14 | Nippon Telegraph And Telephone Corporation | Electrochemical detection method and apparatus therefor |
| US5547555A (en) | 1993-02-22 | 1996-08-20 | Ohmicron Technology, Inc. | Electrochemical sensor cartridge |
| AU6268994A (en) | 1993-02-25 | 1994-09-14 | Diametrics Medical, Inc. | Disposable electrochemical measurement cartridge |
| US5437999A (en) | 1994-02-22 | 1995-08-01 | Boehringer Mannheim Corporation | Electrochemical sensor |
| US5429735A (en) | 1994-06-27 | 1995-07-04 | Miles Inc. | Method of making and amperometric electrodes |
| US5648213A (en) | 1994-08-30 | 1997-07-15 | Beckman Instruments, Inc. | Compositions and methods for use in detection of analytes |
| US5866434A (en) | 1994-12-08 | 1999-02-02 | Meso Scale Technology | Graphitic nanotubes in luminescence assays |
| NZ306051A (en) | 1995-03-10 | 1999-11-29 | Meso Scale Technologies Llc | Testing using electrochemiluminescence |
| US6140045A (en) | 1995-03-10 | 2000-10-31 | Meso Scale Technologies | Multi-array, multi-specific electrochemiluminescence testing |
| US6207369B1 (en) | 1995-03-10 | 2001-03-27 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
| US5589136A (en) | 1995-06-20 | 1996-12-31 | Regents Of The University Of California | Silicon-based sleeve devices for chemical reactions |
| US6127127A (en) | 1995-06-27 | 2000-10-03 | The University Of North Carolina At Chapel Hill | Monolayer and electrode for detecting a label-bearing target and method of use thereof |
| US5968745A (en) | 1995-06-27 | 1999-10-19 | The University Of North Carolina At Chapel Hill | Polymer-electrodes for detecting nucleic acid hybridization and method of use thereof |
| US20020022261A1 (en) * | 1995-06-29 | 2002-02-21 | Anderson Rolfe C. | Miniaturized genetic analysis systems and methods |
| DE19610354C1 (de) | 1996-03-15 | 1997-11-20 | Innova Gmbh | Vorrichtung, Verfahren und Einrichtung zur Isolierung von Nukleinsäuren |
| DE19646505A1 (de) | 1996-11-12 | 1998-05-14 | Itt Ind Gmbh Deutsche | Vorrichtung zur Durchführung von Untersuchungen an Zellproben und dergleichen |
| AU6646398A (en) | 1996-12-31 | 1998-07-31 | Genometrix Incorporated | Multiplexed molecular analysis apparatus and method |
| US5972694A (en) | 1997-02-11 | 1999-10-26 | Mathus; Gregory | Multi-well plate |
| FI970593A7 (fi) | 1997-02-12 | 1998-08-13 | Ala Kleme Timo | Pinnoitettujen johteiden käyttö analyyttisiin tarkoituksiin |
| US6391558B1 (en) | 1997-03-18 | 2002-05-21 | Andcare, Inc. | Electrochemical detection of nucleic acid sequences |
| DE19725190A1 (de) | 1997-06-14 | 1998-12-17 | Innova Gmbh | Vorrichtungen mit integrierten Elektroden aus elektrisch leitfähigen Kunststoffen |
| US6258326B1 (en) | 1997-09-20 | 2001-07-10 | Ljl Biosystems, Inc. | Sample holders with reference fiducials |
| US6413783B1 (en) | 1997-09-18 | 2002-07-02 | Meso Scale Technologies, Llc | Assay sonication apparatus and methodology |
| US6486947B2 (en) | 1998-07-22 | 2002-11-26 | Ljl Biosystems, Inc. | Devices and methods for sample analysis |
| US6238869B1 (en) | 1997-12-19 | 2001-05-29 | High Throughput Genomics, Inc. | High throughput assay system |
| US7297312B2 (en) | 1998-03-16 | 2007-11-20 | University Of Cincinnati | Simultaneous multianalyte electrochemical assay based on spatial resolution |
| US6438497B1 (en) | 1998-12-11 | 2002-08-20 | Symyx Technologies | Method for conducting sensor array-based rapid materials characterization |
| US6251685B1 (en) | 1999-02-18 | 2001-06-26 | Agilent Technologies, Inc. | Readout method for molecular biological electronically addressable arrays |
| US6706519B1 (en) * | 1999-06-22 | 2004-03-16 | Tecan Trading Ag | Devices and methods for the performance of miniaturized in vitro amplification assays |
| US7527821B2 (en) | 2000-05-02 | 2009-05-05 | Smiths Detection Inc. | Sensor fabricating method |
| US6645432B1 (en) | 2000-05-25 | 2003-11-11 | President & Fellows Of Harvard College | Microfluidic systems including three-dimensionally arrayed channel networks |
| US6686193B2 (en) | 2000-07-10 | 2004-02-03 | Vertex Pharmaceuticals, Inc. | High throughput method and system for screening candidate compounds for activity against target ion channels |
| US7749388B2 (en) * | 2001-06-15 | 2010-07-06 | Life Technologies Corporation | Low volume filtration column devices and methods of filtering therewith |
| CA2764307C (en) | 2001-06-29 | 2015-03-03 | Meso Scale Technologies, Llc. | Assay plates, reader systems and methods for luminescence test measurements |
| US7419821B2 (en) | 2002-03-05 | 2008-09-02 | I-Stat Corporation | Apparatus and methods for analyte measurement and immunoassay |
| US6689258B1 (en) | 2002-04-30 | 2004-02-10 | Advanced Micro Devices, Inc. | Electrochemically generated reactants for chemical mechanical planarization |
| US6801041B2 (en) | 2002-05-14 | 2004-10-05 | Abbott Laboratories | Sensor having electrode for determining the rate of flow of a fluid |
| EP1583950B1 (en) | 2002-12-26 | 2017-04-05 | Meso Scale Technologies, LLC. | Assay cartridges and methods of using the same |
| US7338637B2 (en) * | 2003-01-31 | 2008-03-04 | Hewlett-Packard Development Company, L.P. | Microfluidic device with thin-film electronic devices |
| EP1473084B1 (en) * | 2003-03-31 | 2015-07-29 | Canon Kabushiki Kaisha | Biochemical reaction cartridge |
| US7776583B2 (en) * | 2004-06-03 | 2010-08-17 | Meso Scale Technologies, Llc | Methods and apparatuses for conducting assays |
| WO2006042013A2 (en) | 2004-10-05 | 2006-04-20 | Plain Sight Systems, Inc. | Systems, method and devices for monitoring fluids |
| US20060153745A1 (en) * | 2005-01-11 | 2006-07-13 | Applera Corporation | Fluid processing device for oligonucleotide synthesis and analysis |
| JP2007117084A (ja) * | 2005-09-28 | 2007-05-17 | Fujifilm Corp | 核酸抽出法 |
| JP2007120399A (ja) | 2005-10-27 | 2007-05-17 | Konica Minolta Medical & Graphic Inc | マイクロ流体チップおよびマイクロ総合分析システム |
| GB2433259A (en) | 2005-11-30 | 2007-06-20 | Deltadot Ltd | Nucleic acid amplification method and microfluidic apparatus therefore |
| US9040288B2 (en) * | 2006-03-24 | 2015-05-26 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
| US8007999B2 (en) | 2006-05-10 | 2011-08-30 | Theranos, Inc. | Real-time detection of influenza virus |
| WO2008055257A2 (en) * | 2006-11-02 | 2008-05-08 | Vectrant Technologies Inc. | Cartridge for conducting diagnostic assays |
| US20080153152A1 (en) * | 2006-11-22 | 2008-06-26 | Akira Wakabayashi | Microfluidic chip |
| EP2265375A1 (en) * | 2007-10-12 | 2010-12-29 | Rheonix, Inc. | Integrated microfluidic device and methods |
| WO2009108260A2 (en) * | 2008-01-22 | 2009-09-03 | Microchip Biotechnologies, Inc. | Universal sample preparation system and use in an integrated analysis system |
| WO2009149115A1 (en) * | 2008-06-04 | 2009-12-10 | Vectrant Technologies Inc. | Cartridge for conducting biochemical assays |
| EP2138587A1 (en) * | 2008-06-23 | 2009-12-30 | Koninklijke Philips Electronics N.V. | Amplification of nucleic acids using temperature zones |
| EP2391883B1 (en) * | 2009-01-30 | 2018-03-07 | Micronics, Inc. | Portable high gain fluorescence detection system |
| KR20120031218A (ko) * | 2009-06-05 | 2012-03-30 | 인터젠엑스 인크. | 만능 샘플 제조 시스템 및 집적 분석 시스템에서의 사용 |
| EP2440672B1 (en) * | 2009-06-12 | 2016-03-30 | Micronics, Inc. | Compositions and methods for dehydrated storage of on-board reagents in microfluidic devices |
| EP3109618B1 (en) * | 2009-12-07 | 2019-02-27 | Meso Scale Technologies, LLC. | Assay cartridge comprising a sample chamber |
| JP6087293B2 (ja) | 2011-01-06 | 2017-03-01 | メソ スケール テクノロジーズ エルエルシー | アッセイカートリッジ及びその使用方法 |
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| EP2661485A2 (en) | 2013-11-13 |
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