JP6086566B2 - 薬剤送達用のキャリア、コンジュゲートおよびこれらを含んでなる組成物並びにこれらの投与方法 - Google Patents
薬剤送達用のキャリア、コンジュゲートおよびこれらを含んでなる組成物並びにこれらの投与方法 Download PDFInfo
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- JP6086566B2 JP6086566B2 JP2015548997A JP2015548997A JP6086566B2 JP 6086566 B2 JP6086566 B2 JP 6086566B2 JP 2015548997 A JP2015548997 A JP 2015548997A JP 2015548997 A JP2015548997 A JP 2015548997A JP 6086566 B2 JP6086566 B2 JP 6086566B2
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- 0 CC(c1ccccc1)OC(CO*(C)CCOCCN)[C@]1O[C@@]2OC(C)(C)OC2C1O Chemical compound CC(c1ccccc1)OC(CO*(C)CCOCCN)[C@]1O[C@@]2OC(C)(C)OC2C1O 0.000 description 3
- HFHDRYCKIJPFJU-COPDNJDCSA-N CC(c1ccccc1)OC(CO)[C@H]1O[C@@H]2OC(C)(C)OC2C1O Chemical compound CC(c1ccccc1)OC(CO)[C@H]1O[C@@H]2OC(C)(C)OC2C1O HFHDRYCKIJPFJU-COPDNJDCSA-N 0.000 description 1
- INOBOKRMTFSIHZ-WCGQKQAISA-N CCOCC([C@H]1O[C@@H]2OC(C)(C)OC2C1O)OC(C)c1ccccc1 Chemical compound CCOCC([C@H]1O[C@@H]2OC(C)(C)OC2C1O)OC(C)c1ccccc1 INOBOKRMTFSIHZ-WCGQKQAISA-N 0.000 description 1
- KGYORMZBANFIHF-UHFFFAOYSA-N CNCCC1[O]=C1CC(C1OC1=O)N Chemical compound CNCCC1[O]=C1CC(C1OC1=O)N KGYORMZBANFIHF-UHFFFAOYSA-N 0.000 description 1
- FAGUFWYHJQFNRV-UHFFFAOYSA-N NCCNCCNCCNCCN Chemical compound NCCNCCNCCNCCN FAGUFWYHJQFNRV-UHFFFAOYSA-N 0.000 description 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013242347 | 2013-11-22 | ||
| JP2013242347 | 2013-11-22 | ||
| JP2014096935 | 2014-05-08 | ||
| JP2014096935 | 2014-05-08 | ||
| PCT/JP2014/005856 WO2015075942A1 (ja) | 2013-11-22 | 2014-11-21 | 薬剤送達用のキャリア、コンジュゲートおよびこれらを含んでなる組成物並びにこれらの投与方法 |
Related Child Applications (1)
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| JP2017105802A (ja) * | 2013-11-22 | 2017-06-15 | 国立大学法人 東京大学 | 薬剤送達用のキャリア、コンジュゲートおよびこれらを含んでなる組成物並びにこれらの投与方法 |
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| JP6797415B2 (ja) * | 2015-07-02 | 2020-12-09 | 国立大学法人 東京大学 | 薬剤送達用キャリア及びこれを含む組成物 |
| EP3492512A4 (en) * | 2016-07-30 | 2020-04-08 | Nippon Kayaku Kabushiki Kaisha | NEW POLYMER DERIVATIVES, AND NEW POLYMER DERIVATIVE IMAGING PROBE USING SAID NEW POLYMER DERIVATIVES |
| JP7043078B2 (ja) * | 2016-09-23 | 2022-03-29 | 国立大学法人 東京医科歯科大学 | 血液脳関門通過型ヘテロ2本鎖核酸 |
| US11364259B2 (en) * | 2016-12-27 | 2022-06-21 | The University Of Tokyo | MRNA functionalization method |
| WO2018207864A1 (ja) * | 2017-05-11 | 2018-11-15 | 公益財団法人川崎市産業振興財団 | 脳への薬剤送達用のキャリアおよびこれを含んでなる組成物 |
| JPWO2019009434A1 (ja) * | 2017-07-06 | 2020-07-02 | 学校法人京都薬科大学 | 薬物送達用高分子ミセル |
| JP2019069933A (ja) * | 2017-10-05 | 2019-05-09 | 公益財団法人川崎市産業振興財団 | 体内における薬物動態を制御する組成物 |
| WO2019181946A1 (ja) | 2018-03-19 | 2019-09-26 | 国立大学法人東京医科歯科大学 | 毒性が軽減した核酸 |
| JPWO2019240223A1 (ja) * | 2018-06-13 | 2021-07-01 | 公益財団法人川崎市産業振興財団 | 数平均分子量が3kDa〜10kDaであるPEGブロックとカチオン性ポリマーとのブロックコポリマーと、アンチセンスオリゴヌクレオチドとを含む、ポリイオンコンプレックスミセル |
| JPWO2020116635A1 (ja) * | 2018-12-07 | 2021-10-21 | 国立大学法人 東京大学 | 輸送担体を用いた環状化合物の送達 |
| JP7600101B2 (ja) | 2019-04-26 | 2024-12-16 | 公益財団法人川崎市産業振興財団 | 抗体の抗原結合性断片を脳へ送達するための方法および組成物 |
| WO2020230793A1 (ja) * | 2019-05-13 | 2020-11-19 | 国立大学法人東京大学 | 血中からの中空ナノ粒子の脳への移行制御技術 |
| WO2021193393A1 (en) * | 2020-03-26 | 2021-09-30 | Kawasaki Institute Of Industrial Promotion | A method of administering a nanoparticle |
| WO2021207382A1 (en) * | 2020-04-08 | 2021-10-14 | The Johns Hopkins University | D-glucose and its analogs as tracers to assess the glucose transporter function |
| US20250073349A1 (en) | 2021-05-10 | 2025-03-06 | Kawasaki Institute Of Industrial Promotion | Antibody having reduced binding affinity for antigen |
| JP2024536844A (ja) * | 2021-09-25 | 2024-10-08 | ヌタリア リミテッド | 処置様式のための標的封入戦略 |
| WO2023210233A1 (ja) * | 2022-04-27 | 2023-11-02 | 国立大学法人東海国立大学機構 | 糖連結ポリヌクレオチド |
| WO2025221757A1 (en) * | 2024-04-15 | 2025-10-23 | Board Of Regents, The University Of Texas System | Carbohydrate-polymer conjugates for tunable protein binding on the blood brain barrier and methods of use |
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| US8765172B2 (en) * | 2007-12-10 | 2014-07-01 | Epitarget As | Acoustically sensitive drug delivery particles comprising non-lamellar forming lipids |
| UA104742C2 (uk) | 2008-12-19 | 2014-03-11 | Эли Лилли Энд Компани | Похідні арилциклопропілацетаміду, застосовні як активатори глюкокінази |
| EP2382994A1 (en) * | 2010-04-26 | 2011-11-02 | Maurizio Victor Cattaneo | Ligand targeted nanocapsules for the delivery of RNAi and other agents |
| JP5843763B2 (ja) | 2010-05-21 | 2016-01-13 | 国立研究開発法人科学技術振興機構 | 物質内包ベシクル及びその製造方法 |
| EP3072506B1 (en) * | 2013-11-22 | 2022-04-20 | The University of Tokyo | Carrier for drug delivery and conjugate, composition containing same, and method for administering same |
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| JPN6015006731; European Journal of Medicinal Chemistry Vol.72, 20131120, p.110-118 * |
| JPN6015006733; 高分子学会予稿集 62巻2号, 20130828, p.4823-4824 * |
Cited By (1)
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| JP2017105802A (ja) * | 2013-11-22 | 2017-06-15 | 国立大学法人 東京大学 | 薬剤送達用のキャリア、コンジュゲートおよびこれらを含んでなる組成物並びにこれらの投与方法 |
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| JP2017105802A (ja) | 2017-06-15 |
| US9937263B2 (en) | 2018-04-10 |
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| JP2019194220A (ja) | 2019-11-07 |
| WO2015075942A1 (ja) | 2015-05-28 |
| US20180185501A1 (en) | 2018-07-05 |
| CN105899192B (zh) | 2019-08-13 |
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