JP6086326B2 - 二環式ヘテロアリールキナーゼ阻害剤および使用方法 - Google Patents

二環式ヘテロアリールキナーゼ阻害剤および使用方法 Download PDF

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JP6086326B2
JP6086326B2 JP2013512166A JP2013512166A JP6086326B2 JP 6086326 B2 JP6086326 B2 JP 6086326B2 JP 2013512166 A JP2013512166 A JP 2013512166A JP 2013512166 A JP2013512166 A JP 2013512166A JP 6086326 B2 JP6086326 B2 JP 6086326B2
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compound
mmol
pyrrolo
phenyl
pyridin
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JP2013526609A (ja
JP2013526609A5 (enExample
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ハリス エイ ゲルバード
ハリス エイ ゲルバード
スティーヴン デューハースト
スティーヴン デューハースト
ヴァル エス グッドフェロー
ヴァル エス グッドフェロー
トルステン ウィーマン
トルステン ウィーマン
サティーシュ バブ ラヴーラ
サティーシュ バブ ラヴーラ
コリン ジェイ ロウェス
コリン ジェイ ロウェス
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ユニヴァーシティー オブ ロチェスター
ユニヴァーシティー オブ ロチェスター
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
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JP2013512166A 2010-05-24 2011-05-24 二環式ヘテロアリールキナーゼ阻害剤および使用方法 Active JP6086326B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34769410P 2010-05-24 2010-05-24
US61/347,694 2010-05-24
PCT/US2011/037758 WO2011149950A2 (en) 2010-05-24 2011-05-24 Bicyclic heteroaryl kinase inhibitors and methods of use

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JP2013526609A JP2013526609A (ja) 2013-06-24
JP2013526609A5 JP2013526609A5 (enExample) 2014-07-10
JP6086326B2 true JP6086326B2 (ja) 2017-03-01

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US (1) US8846909B2 (enExample)
EP (1) EP2576549A4 (enExample)
JP (1) JP6086326B2 (enExample)
CN (1) CN103153994B (enExample)
AU (1) AU2011258465B2 (enExample)
CA (1) CA2800176C (enExample)
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WO2011149950A2 (en) 2010-05-24 2011-12-01 University Of Rochester Bicyclic heteroaryl kinase inhibitors and methods of use
US9102614B2 (en) 2010-07-02 2015-08-11 Gilead Sciences, Inc. Naphth-2-ylacetic acid derivatives to treat AIDS
WO2012003498A1 (en) 2010-07-02 2012-01-05 Gilead Sciences, Inc. 2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds
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US9376392B2 (en) 2012-01-04 2016-06-28 Gilead Sciences, Inc. 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS
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CN102627646A (zh) * 2012-03-19 2012-08-08 苏州四同医药科技有限公司 一种3-碘-5-溴-4,7-二氮杂吲哚的制备方法
PH12014500842A1 (en) 2012-04-20 2014-06-09 Gilead Sciences Inc Benzothiazol-6-yl acetic acid derivatives and their use for treating an hiv infection
KR102091895B1 (ko) * 2012-05-03 2020-04-14 제넨테크, 인크. 파킨슨병의 치료에 사용하기 위한 lrrk2 조절제로서의 피라졸 아미노피리미딘 유도체
JP2015533151A (ja) * 2012-10-16 2015-11-19 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト セリン／スレオニンキナーゼ阻害剤
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NZ603644A (en) 2014-10-31
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CA2800176A1 (en) 2011-12-01
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