JP6078067B2 - 炎症誘発性状態の治療および予防のためのhdl関連分子の使用 - Google Patents
炎症誘発性状態の治療および予防のためのhdl関連分子の使用 Download PDFInfo
- Publication number
- JP6078067B2 JP6078067B2 JP2014528563A JP2014528563A JP6078067B2 JP 6078067 B2 JP6078067 B2 JP 6078067B2 JP 2014528563 A JP2014528563 A JP 2014528563A JP 2014528563 A JP2014528563 A JP 2014528563A JP 6078067 B2 JP6078067 B2 JP 6078067B2
- Authority
- JP
- Japan
- Prior art keywords
- cells
- hdl
- hif
- mice
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Marine Sciences & Fisheries (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161528447P | 2011-08-29 | 2011-08-29 | |
| US61/528,447 | 2011-08-29 | ||
| US201261624333P | 2012-04-15 | 2012-04-15 | |
| US61/624,333 | 2012-04-15 | ||
| US201261646772P | 2012-05-14 | 2012-05-14 | |
| US61/646,772 | 2012-05-14 | ||
| PCT/US2012/052925 WO2013033260A1 (en) | 2011-08-29 | 2012-08-29 | Use of hdl-related molecules to treat and prevent proinflammatory conditions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014526440A JP2014526440A (ja) | 2014-10-06 |
| JP2014526440A5 JP2014526440A5 (enExample) | 2016-02-12 |
| JP6078067B2 true JP6078067B2 (ja) | 2017-02-08 |
Family
ID=47756845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014528563A Expired - Fee Related JP6078067B2 (ja) | 2011-08-29 | 2012-08-29 | 炎症誘発性状態の治療および予防のためのhdl関連分子の使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9241976B2 (enExample) |
| EP (1) | EP2751126B1 (enExample) |
| JP (1) | JP6078067B2 (enExample) |
| KR (1) | KR20140063747A (enExample) |
| CN (1) | CN104039810A (enExample) |
| AU (1) | AU2012301955A1 (enExample) |
| CA (1) | CA2846865A1 (enExample) |
| WO (1) | WO2013033260A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10426817B2 (en) | 2017-01-24 | 2019-10-01 | Macregen, Inc. | Treatment of age-related macular degeneration and other eye diseases with apolipoprotein mimetics |
| WO2018190896A1 (en) * | 2017-04-13 | 2018-10-18 | Lipimetix Development, Inc. | Apoe mimetic peptide compositions |
| CN120085016A (zh) * | 2025-03-14 | 2025-06-03 | 北京大学第三医院(北京大学第三临床医学院) | 一种apoa1作为生物标志物在制备用于监测结肠炎症活动度的产品中的应用 |
Family Cites Families (51)
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| US4769330A (en) | 1981-12-24 | 1988-09-06 | Health Research, Incorporated | Modified vaccinia virus and methods for making and using the same |
| US4603112A (en) | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
| US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
| DK145385D0 (da) | 1985-03-29 | 1985-04-01 | Novo Industri As | Monoklonalt antistof til immunkemisk analyse |
| GB8508845D0 (en) | 1985-04-04 | 1985-05-09 | Hoffmann La Roche | Vaccinia dna |
| US4777127A (en) | 1985-09-30 | 1988-10-11 | Labsystems Oy | Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus |
| US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
| US5114863A (en) | 1986-09-30 | 1992-05-19 | Board Of Supervisors Of Louisiana State University & Agricultural & Mechanical College | Immunosorbant assay for α-1-antitrypsin, kit employing said assay, monoclonal antibody to α-1-antitrypsin, and hybridoma for producing said monoclonal antibody |
| GB8702816D0 (en) | 1987-02-07 | 1987-03-11 | Al Sumidaie A M K | Obtaining retrovirus-containing fraction |
| WO1989001973A2 (en) | 1987-09-02 | 1989-03-09 | Applied Biotechnology, Inc. | Recombinant pox virus for immunization against tumor-associated antigens |
| AP129A (en) | 1988-06-03 | 1991-04-17 | Smithkline Biologicals S A | Expression of retrovirus gag protein eukaryotic cells |
| EP1645635A3 (en) | 1989-08-18 | 2010-07-07 | Oxford Biomedica (UK) Limited | Replication defective recombinant retroviruses expressing a palliative |
| SE8904007D0 (sv) | 1989-11-28 | 1989-11-28 | Ferring Ab | Monoklona antikroppar och diagnostiseringsmetod |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| RU2152787C2 (ru) * | 1994-06-02 | 2000-07-20 | Дан Рига | Лекарство против стресса, против снижения уровня активности и против старения и способ его получения |
| US20030027216A1 (en) | 2001-07-02 | 2003-02-06 | Kiernan Urban A. | Analysis of proteins from biological fluids using mass spectrometric immunoassay |
| US5891641A (en) | 1997-02-21 | 1999-04-06 | The Regents Of The University Of California | Assay for disease related conformation of a protein |
| US5955582A (en) | 1997-09-26 | 1999-09-21 | Beckman Coulter, Inc. | Antibody against a 3-aminophenylboronic-glycated protein complex and its use in an immunoassay |
| US7723303B2 (en) * | 2000-08-24 | 2010-05-25 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| US20050214760A1 (en) | 2002-01-07 | 2005-09-29 | Johns Hopkins University | Biomarkers for detecting ovarian cancer |
| US6930085B2 (en) * | 2002-04-05 | 2005-08-16 | The Regents Of The University Of California | G-type peptides to ameliorate atherosclerosis |
| WO2004001010A2 (en) | 2002-06-21 | 2003-12-31 | Ptc Therapeutics, Inc. | METHODS FOR IDENTIFYING SMALL MOLECULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY |
| AU2003252136A1 (en) | 2002-07-24 | 2004-02-09 | Ptc Therapeutics, Inc. | METHODS FOR IDENTIFYING SMALL MOLEDULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY |
| EP1540010B8 (en) | 2002-08-06 | 2010-07-14 | The Johns Hopkins University | Use of biomarkers for detecting ovarian cancer |
| US7191068B2 (en) | 2003-03-25 | 2007-03-13 | Proteogenix, Inc. | Proteomic analysis of biological fluids |
| AU2004239338A1 (en) | 2003-05-12 | 2004-11-25 | The Children's Hospital Of Philadelphia | GRP94-based compositions and methods of use thereof |
| US7510881B2 (en) | 2003-08-25 | 2009-03-31 | Marc Ramael | Method and kit for the quantitative and/or qualitative detection of components in a sample |
| WO2005065720A1 (en) | 2004-01-09 | 2005-07-21 | Mogam Biotechnology Research Institute | Therapeutic agent for treatment of cancer comprising human apolipoprotein (a) kringles lk68 or lk8 genes as effective ingredient, and method for treating cancer using the same |
| EP1713900A4 (en) | 2004-01-27 | 2009-06-17 | Compugen Ltd | METHOD AND SYSTEMS FOR COMMENTING BIOMOLECULAR SEQUENCES |
| WO2005093413A2 (en) | 2004-03-22 | 2005-10-06 | Yale University | Diagnosis and treatment of preeclampsia |
| DK2199801T3 (da) | 2004-07-14 | 2013-08-05 | Univ California | Biomarkører til tidlig påvisning af ovariecancer |
| US7670792B2 (en) | 2004-07-14 | 2010-03-02 | The Regents Of The University Of California | Biomarkers for early detection of ovarian cancer |
| WO2012047930A2 (en) | 2010-10-04 | 2012-04-12 | The Regents Of The University Of California | Compositions and methods for treatment of gynecologic cancers |
| US9488655B2 (en) | 2004-07-14 | 2016-11-08 | The Regents Of The University Of California | Biomarkers for detection of early- and late-stage endometrial cancer |
| EP2801366A3 (en) * | 2004-09-02 | 2015-04-29 | Cognosci, Inc. | Improved apo E analogs and methods for their use |
| CA2591926A1 (en) | 2004-09-20 | 2006-03-30 | Proteogenix, Inc. | Diagnosis of fetal aneuploidy |
| RU2414236C2 (ru) | 2004-12-06 | 2011-03-20 | Зе Риджентс Оф Зи Юнивесити Оф Кэлифонье | Способ улучшения структуры и/или функций артериол |
| US7427662B2 (en) | 2005-02-01 | 2008-09-23 | Baord Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Inhibition of angiogenesis and destruction of angiogenic vessels by apolipoprotein A-I and high density lipoprotein |
| NZ560976A (en) | 2005-03-11 | 2011-06-30 | Univ Johns Hopkins | Biomarkers for ovarian cancer and endometrial cancer: hepcidin |
| EA200900786A1 (ru) * | 2005-04-29 | 2009-10-30 | Зе Риджентс Оф Зи Юнивесити Оф Кэлифонье | Пептид в качестве лекарственного средства и способ лечения патологий, связанных с воспалительными процессами, посредством пептида |
| US20080293639A1 (en) * | 2005-04-29 | 2008-11-27 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| US7604948B2 (en) | 2005-05-05 | 2009-10-20 | The Regents Of The University Of California | Biomarkers for diagnosing an autism spectrum disorder |
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| US7575876B2 (en) | 2005-10-27 | 2009-08-18 | The University Of Washington | Biomarkers for neurodegenerative disorders |
| US9095549B2 (en) | 2005-12-16 | 2015-08-04 | Electrophoretics Limited | Diagnosis and prognosis of colorectal cancer |
| KR100725642B1 (ko) * | 2006-01-20 | 2007-06-07 | 충남대학교산학협력단 | 저밀도 지단백질에 대해 항산화성을 갖는 펩타이드 |
| US7723045B2 (en) | 2006-02-10 | 2010-05-25 | The Regents Of The University Of California | Assays to predict atherosclerosis and dysfunctional high-density lipoprotein |
| AU2008266753A1 (en) * | 2007-06-20 | 2008-12-24 | Istituto Di Recerche Di Biologia Molecolare P. Angeletti S.P.A. | ApoA-1 peptide mimetics |
| JP2010537638A (ja) * | 2007-08-28 | 2010-12-09 | ユーエービー リサーチ ファウンデーション | 合成アポリポ蛋白質e模倣ポリペプチドおよび使用方法 |
| AU2008296478B9 (en) * | 2007-08-28 | 2015-03-19 | The Uab Research Foundation | Synthetic apolipoprotein E mimicking polypeptides and methods of use |
| JP2009092440A (ja) | 2007-10-04 | 2009-04-30 | Shimadzu Corp | 卵巣癌の診断システム及び卵巣癌の診断方法 |
-
2012
- 2012-08-29 CN CN201280052367.7A patent/CN104039810A/zh active Pending
- 2012-08-29 WO PCT/US2012/052925 patent/WO2013033260A1/en not_active Ceased
- 2012-08-29 KR KR1020147008207A patent/KR20140063747A/ko not_active Withdrawn
- 2012-08-29 JP JP2014528563A patent/JP6078067B2/ja not_active Expired - Fee Related
- 2012-08-29 AU AU2012301955A patent/AU2012301955A1/en not_active Abandoned
- 2012-08-29 US US14/239,530 patent/US9241976B2/en not_active Expired - Fee Related
- 2012-08-29 CA CA2846865A patent/CA2846865A1/en not_active Abandoned
- 2012-08-29 EP EP12826789.5A patent/EP2751126B1/en not_active Not-in-force
-
2016
- 2016-01-22 US US15/004,604 patent/US10208103B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2846865A1 (en) | 2013-03-07 |
| US20170204160A1 (en) | 2017-07-20 |
| US9241976B2 (en) | 2016-01-26 |
| US20140323410A1 (en) | 2014-10-30 |
| EP2751126A1 (en) | 2014-07-09 |
| KR20140063747A (ko) | 2014-05-27 |
| CN104039810A (zh) | 2014-09-10 |
| EP2751126A4 (en) | 2015-11-04 |
| JP2014526440A (ja) | 2014-10-06 |
| AU2012301955A1 (en) | 2014-03-06 |
| US10208103B2 (en) | 2019-02-19 |
| WO2013033260A1 (en) | 2013-03-07 |
| EP2751126B1 (en) | 2018-03-07 |
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