JP6072810B2 - 第ｖｉｉｉ因子の生物学的利用能を改善するための硫酸化グリコサミノグリカンの使用 - Google Patents
第ｖｉｉｉ因子の生物学的利用能を改善するための硫酸化グリコサミノグリカンの使用 Download PDFInfo
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
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- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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| PCT/EP2012/070615 WO2013057167A1 (en) | 2011-10-18 | 2012-10-18 | Use of sulfated glycosaminoglycans for improving the bioavailability of factor viii |
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| JP2014530246A JP2014530246A (ja) | 2014-11-17 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2768521B1 (en) | 2011-10-18 | 2016-07-13 | CSL Behring GmbH | Combined use of a sulfated glycosaminoglycan and a hyaluronidase for improving the bioavailability of factor viii |
| BR112016026842A2 (pt) | 2014-06-06 | 2017-12-12 | Octapharma Ag | preparação compreendendo fator viii e peptídeos de fator de von willebrand |
| CA2960282C (en) * | 2014-09-12 | 2025-09-09 | The Regents Of The University Of California | Human anti-CD46 macropinosome-forming antibodies and target anti-cancer therapeutic agents |
| CN114106146B (zh) * | 2015-02-06 | 2025-05-06 | 北卡罗来纳大学查珀尔希尔分校 | 优化的人类凝血因子viii基因表达盒及其用途 |
| SE539575C2 (en) * | 2015-07-30 | 2017-10-17 | Tx Medic Ab | Dextran sulfate for use in treating, inhibiting or preventing cardiac fibrosis |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
| EP0218712B1 (en) | 1985-04-12 | 1992-02-26 | Genetics Institute, Inc. | Novel procoagulant proteins |
| FR2673632A1 (fr) | 1991-03-08 | 1992-09-11 | Lille Transfusion Sanguine | Procede de preparation de concentre de facteur von willebrand humain de tres haute purete, approprie a un usage therapeutique. |
| SE504074C2 (sv) | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
| IL113010A0 (en) * | 1994-03-31 | 1995-10-31 | Pharmacia Ab | Pharmaceutical formulation comprising factor VIII or factor ix with an activity of at least 200 IU/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration |
| DE4435485C1 (de) | 1994-10-04 | 1996-03-21 | Immuno Ag | Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor |
| JP3987114B2 (ja) | 1996-04-24 | 2007-10-03 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン | 不活性化耐性第▲８▼因子 |
| WO2000024759A1 (en) | 1998-10-23 | 2000-05-04 | The Trustees Of The University Of Pennsylvania | Systemic delivery of gene products via skin |
| CA2450125A1 (en) | 2001-06-15 | 2002-12-27 | Andre C. Schuh | Gene therapy for hemophilia a |
| US7041635B2 (en) | 2003-01-28 | 2006-05-09 | In2Gen Co., Ltd. | Factor VIII polypeptide |
| ES2558102T3 (es) | 2003-05-06 | 2016-02-02 | Biogen Hemophilia Inc. | Proteínas quiméricas del factor de coagulación para el tratamiento de un trastorno hemostático |
| WO2009062100A1 (en) * | 2007-11-09 | 2009-05-14 | Baxter International Inc. | Modified recombinant factor viii and von willebrand factor and methods of use |
| EP2626080A3 (en) * | 2008-02-27 | 2014-03-05 | Novo Nordisk A/S | Conjugated factor VIII molecules |
| KR20120061898A (ko) * | 2009-08-20 | 2012-06-13 | 체에스엘 베링 게엠베하 | 출혈성 장애의 치료요법 및 예방 치료에 있어서의 비정맥내 투여를 위한 알부민 융합 응고 인자 |
| WO2011095604A1 (en) * | 2010-02-04 | 2011-08-11 | Octapharma Biopharmaceuticals Gmbh | Half-life prolongation of proteins |
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2012
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- 2012-10-18 AU AU2012318279A patent/AU2012318279B2/en not_active Ceased
- 2012-10-18 US US14/352,540 patent/US9393289B2/en not_active Expired - Fee Related
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- 2012-10-18 CN CN201280051236.7A patent/CN103889445A/zh active Pending
- 2012-10-18 WO PCT/EP2012/070615 patent/WO2013057167A1/en not_active Ceased
- 2012-10-18 CA CA2852397A patent/CA2852397A1/en not_active Abandoned
- 2012-10-18 KR KR1020147013300A patent/KR20140083036A/ko not_active Withdrawn
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| CA2852397A1 (en) | 2013-04-25 |
| AU2012318279A1 (en) | 2013-05-02 |
| EP2768522B1 (en) | 2016-07-27 |
| ES2600081T3 (es) | 2017-02-07 |
| US9393289B2 (en) | 2016-07-19 |
| US20140315815A1 (en) | 2014-10-23 |
| EP2768522A1 (en) | 2014-08-27 |
| AU2012318279B2 (en) | 2015-06-04 |
| WO2013057167A1 (en) | 2013-04-25 |
| DK2768522T3 (en) | 2016-11-14 |
| KR20140083036A (ko) | 2014-07-03 |
| CN103889445A (zh) | 2014-06-25 |
| JP2014530246A (ja) | 2014-11-17 |
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