JP6068487B2 - ケモカイン媒介性病変の処置に使用するための二置換３，４−ジアミノ−３−シクロブテン−１，２−ジオン化合物 - Google Patents

ケモカイン媒介性病変の処置に使用するための二置換３，４−ジアミノ−３−シクロブテン−１，２−ジオン化合物 Download PDF

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JP6068487B2
JP6068487B2 JP2014537705A JP2014537705A JP6068487B2 JP 6068487 B2 JP6068487 B2 JP 6068487B2 JP 2014537705 A JP2014537705 A JP 2014537705A JP 2014537705 A JP2014537705 A JP 2014537705A JP 6068487 B2 JP6068487 B2 JP 6068487B2
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methyl
amino
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hydroxy
enylamino
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JP2014530895A (ja
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ブラニスラフ・ミュージッキ
ジェローム・オベール
ジャン−ギー・ボワトー
ロランス・クラリー
パトリシア・ロッシオ
マルレーヌ・シュプリ−ノレ
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ガルデルマ・リサーチ・アンド・デヴェロップメント
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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JP2014537705A 2011-10-28 2012-10-26 ケモカイン媒介性病変の処置に使用するための二置換３，４−ジアミノ−３−シクロブテン−１，２−ジオン化合物 Expired - Fee Related JP6068487B2 (ja)

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Application Number Priority Date Filing Date Title
US201161552829P 2011-10-28 2011-10-28
FR1159829 2011-10-28
FR1159829A FR2981934B1 (fr) 2011-10-28 2011-10-28 Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines.
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PCT/FR2012/052479 WO2013061005A1 (fr) 2011-10-28 2012-10-26 Composés di-substitués de la diamino-3,4-cyclobutène-3-dione-1,2 utiles dans le traitement de pathologies médiées par des chimiokines

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FR2981934B1 (fr) * 2011-10-28 2013-12-20 Galderma Res & Dev Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines.
CN105960237B (zh) 2013-12-02 2020-03-31 凯莫森特里克斯股份有限公司 Ccr6化合物
TWI724056B (zh) * 2015-11-19 2021-04-11 美商卡默森屈有限公司 Ｃｘｃｒ２抑制劑
TWI734715B (zh) * 2015-11-19 2021-08-01 美商卡默森屈有限公司 趨化因子受體調節劑
US10660909B2 (en) 2016-11-17 2020-05-26 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
KR20200037857A (ko) * 2017-08-14 2020-04-09 알러간, 인코포레이티드 3,4-이치환된 3-시클로부텐-1,2-디온 및 그의 용도
ES3067325T3 (en) * 2018-01-08 2026-05-21 Chemocentryx Inc Methods of treating generalized pustular psoriasis with an antagonist of ccr6 or cxcr2
WO2019165315A1 (en) 2018-02-23 2019-08-29 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists alone or in combination
PE20211070A1 (es) 2018-09-21 2021-06-09 Pfizer Dioxociclobutenilamino-3-hidroxi-picolinamidas n-sustituidas utiles como inhibidores de ccr6
CN111362878B (zh) * 2020-03-18 2023-09-19 湖南复瑞生物医药技术有限责任公司 一种4-氨基-1,3-二氢-苯并咪唑-2-酮的制备方法
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NZ535314A (en) * 2002-03-18 2007-08-31 Schering Corp Combination treatments for chemokine-mediated diseases
JP2009542700A (ja) * 2006-07-07 2009-12-03 シェーリング コーポレイション Ｃｘｃケモカイン受容体リガンドとしての３，４−ジ置換シクロブテン−１，２−ジオン
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UA103198C2 (en) * 2008-08-04 2013-09-25 Новартис Аг Squaramide derivatives as cxcr2 antagonists
KR200444641Y1 (ko) * 2008-12-03 2009-05-27 강민수 헤드작동형 다기능 스패너
WO2010063802A1 (en) * 2008-12-05 2010-06-10 Novartis Ag 3, 4-di-substituted cyclobutene- 1, 2 -diones as cxcr2 receptor antagonists
WO2010131145A1 (en) * 2009-05-12 2010-11-18 Pfizer Limited Cyclobutenedione derivatives
FR2981934B1 (fr) * 2011-10-28 2013-12-20 Galderma Res & Dev Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines.

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MX2014004858A (es) 2014-05-27
FR2981934B1 (fr) 2013-12-20
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JP2014530895A (ja) 2014-11-20
EP2771334B1 (fr) 2015-08-19
BR112014009950A2 (pt) 2017-05-02
CA2849977A1 (fr) 2013-05-02
KR20140090166A (ko) 2014-07-16
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RU2014121394A (ru) 2015-12-10
US9526732B2 (en) 2016-12-27
CN103958505A (zh) 2014-07-30
US20150374708A1 (en) 2015-12-31
FR2981934A1 (fr) 2013-05-03

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