CN103958505B - 用于治疗趋化因子介导的病理的二取代的3,4-二氨基-3-环丁烯-1,2-二酮化合物 - Google Patents

用于治疗趋化因子介导的病理的二取代的3,4-二氨基-3-环丁烯-1,2-二酮化合物 Download PDF

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CN103958505B
CN103958505B CN201280052893.3A CN201280052893A CN103958505B CN 103958505 B CN103958505 B CN 103958505B CN 201280052893 A CN201280052893 A CN 201280052893A CN 103958505 B CN103958505 B CN 103958505B
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methyl
methylfuran
amino
hydroxy
methyloxetan
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CN103958505A (zh
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B·穆西基
杰罗姆·奥伯特
J-G·博伊托
L·克拉里
P·罗西奥
M·舒普利-诺埃尔
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Galderma Research and Development SNC
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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CN201280052893.3A 2011-10-28 2012-10-26 用于治疗趋化因子介导的病理的二取代的3,4-二氨基-3-环丁烯-1,2-二酮化合物 Expired - Fee Related CN103958505B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161552829P 2011-10-28 2011-10-28
US61/552,829 2011-10-28
FR1159829A FR2981934B1 (fr) 2011-10-28 2011-10-28 Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines.
FR1159829 2011-10-28
PCT/FR2012/052479 WO2013061005A1 (fr) 2011-10-28 2012-10-26 Composés di-substitués de la diamino-3,4-cyclobutène-3-dione-1,2 utiles dans le traitement de pathologies médiées par des chimiokines

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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2981934B1 (fr) * 2011-10-28 2013-12-20 Galderma Res & Dev Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines.
AU2014360743C1 (en) 2013-12-02 2021-01-28 Chemocentryx, Inc. CCR6 compounds
TWI724056B (zh) 2015-11-19 2021-04-11 美商卡默森屈有限公司 Ｃｘｃｒ２抑制劑
TWI734715B (zh) 2015-11-19 2021-08-01 美商卡默森屈有限公司 趨化因子受體調節劑
US10660909B2 (en) 2016-11-17 2020-05-26 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
RU2020106383A (ru) 2017-08-14 2021-09-16 Аллерган, Инк. 3,4-двузамещенные 3-циклобутен-1,2-дионы и их применение
IL275839B2 (en) * 2018-01-08 2024-02-01 Chemocentryx Inc Methods for the treatment of generalized abscess psoriasis using a CCR6 or CXCR2 antagonist
WO2019165315A1 (en) 2018-02-23 2019-08-29 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists alone or in combination
GEP20237476B (en) * 2018-09-21 2023-03-27 Pfizer N-substituted-dioxocyclobutenylamino-3-hydroxypicolinamides useful as ccr6 inhibitors
CN111362878B (zh) * 2020-03-18 2023-09-19 湖南复瑞生物医药技术有限责任公司 一种4-氨基-1,3-二氢-苯并咪唑-2-酮的制备方法
IL297675A (en) 2020-04-30 2022-12-01 Idorsia Pharmaceuticals Ltd History of aztidine-3-ylmethanol as ccr6 receptor modulators
WO2023057548A1 (en) 2021-10-07 2023-04-13 Idorsia Pharmaceuticals Ltd Ccr6 receptor modulators
JP2024539987A (ja) 2021-10-26 2024-10-31 イドルシア・ファーマシューティカルズ・リミテッド Ｃｃｒ６受容体調節剤
CA3236396A1 (en) 2021-10-28 2023-05-04 Oliver Allemann Ccr6 receptor modulators

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1516687A (zh) * 2001-04-16 2004-07-28 ���鹫˾ 作为cxc-趋化因子受体配体的3,4-二取代的环丁烯-1,2-二酮
CN101511809A (zh) * 2006-07-07 2009-08-19 先灵公司 作为cxc-趋化因子受体配体的3,4-二取代的环丁烯-1,2-二酮
WO2010063802A1 (en) * 2008-12-05 2010-06-10 Novartis Ag 3, 4-di-substituted cyclobutene- 1, 2 -diones as cxcr2 receptor antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100444839C (zh) * 2002-03-18 2008-12-24 先灵公司 式(i)化合物在制备治疗化学激活物中介的疾病的药物中的应用
MX2009013276A (es) * 2007-06-06 2010-01-25 Novartis Ag Compuestos anti-inflamatorios de ciclobutenodiona sustituida.
UA103198C2 (en) * 2008-08-04 2013-09-25 Новартис Аг Squaramide derivatives as cxcr2 antagonists
KR200444641Y1 (ko) * 2008-12-03 2009-05-27 강민수 헤드작동형 다기능 스패너
WO2010131147A1 (en) * 2009-05-12 2010-11-18 Pfizer Limited Cyclobutenedione derivatives
FR2981934B1 (fr) * 2011-10-28 2013-12-20 Galderma Res & Dev Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1516687A (zh) * 2001-04-16 2004-07-28 ���鹫˾ 作为cxc-趋化因子受体配体的3,4-二取代的环丁烯-1,2-二酮
CN101511809A (zh) * 2006-07-07 2009-08-19 先灵公司 作为cxc-趋化因子受体配体的3,4-二取代的环丁烯-1,2-二酮
WO2010063802A1 (en) * 2008-12-05 2010-06-10 Novartis Ag 3, 4-di-substituted cyclobutene- 1, 2 -diones as cxcr2 receptor antagonists

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
C(4)-alkyl substituted furanyl cyclobutenediones as potent,orally bioavailable CXCR2 and CXCR1 receptor antagonists;Jianhua Chao，等;《Bioorganic & Medicinal Chemistry Letters》;20070410;第17卷;第3778–3783页 *
Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region;Cynthia Aki，等;《Bioorganic & Medicinal Chemistry Letters》;20090518;第19卷;第4446–4449页 *
Synthesis and structure–activity relationships of heteroaryl substituted-3,4-diamino-3-cyclobut-3-ene-1,2-dione CXCR2/CXCR1 receptor antagonists;Younong Yu,等;《Bioorganic & Medicinal Chemistry Letters》;20080111;第18卷;第1318–1322页 *
Synthesis and structure–activity relationships of new disubstituted phenyl-containing 3,4-diamino-3-cyclobutene-1,2-diones as CXCR2 receptor antagonists;Gaifa Lai，等;《Bioorganic & Medicinal Chemistry Letters》;20080210;第18卷;第1864-1868页 *

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