IN2014CN02364A - - Google Patents

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Publication number
IN2014CN02364A
IN2014CN02364A IN2364CHN2014A IN2014CN02364A IN 2014CN02364 A IN2014CN02364 A IN 2014CN02364A IN 2364CHN2014 A IN2364CHN2014 A IN 2364CHN2014A IN 2014CN02364 A IN2014CN02364 A IN 2014CN02364A
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India
Prior art keywords
compounds
cyclobutene
diamino
general formula
treatment
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Inventor
Branislav Musicki
Jérôme Aubert
Jean Guy Boiteau
Laurence Clary
Patricia Rossio
Nollet Marlène Schuppli
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Galderma Res & Dev
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Publication of IN2014CN02364A publication Critical patent/IN2014CN02364A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/423—Oxazoles condensed with carbocyclic rings
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Abstract

The present invention relates to novel disubstituted 3 4 diamino 3 cyclobutene 1 2 dione compounds represented by the following general formula (I): the pharmaceutical compositions containing these compounds and the use of these compounds and these compositions for the treatment of chemokine mediated pathologies.
IN2364CHN2014 2011-10-28 2012-10-26 IN2014CN02364A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161552829P 2011-10-28 2011-10-28
FR1159829A FR2981934B1 (en) 2011-10-28 2011-10-28 NOVEL DI-SUBSTITUTED DIAMINO-3,4-CYCLOBUTENE-3-DIONE-1,2 COMPOUNDS USEFUL IN THE TREATMENT OF CHEMOKINE MEDIATED PATHOLOGIES.
PCT/FR2012/052479 WO2013061005A1 (en) 2011-10-28 2012-10-26 Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated pathologies

Publications (1)

Publication Number Publication Date
IN2014CN02364A true IN2014CN02364A (en) 2015-06-19

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IN2364CHN2014 IN2014CN02364A (en) 2011-10-28 2012-10-26

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US (2) US9090596B2 (en)
EP (1) EP2771334B1 (en)
JP (1) JP6068487B2 (en)
KR (1) KR20140090166A (en)
CN (1) CN103958505B (en)
AU (1) AU2012328199A1 (en)
BR (1) BR112014009950A2 (en)
CA (1) CA2849977A1 (en)
ES (1) ES2550983T3 (en)
FR (1) FR2981934B1 (en)
IN (1) IN2014CN02364A (en)
MX (1) MX2014004858A (en)
RU (1) RU2014121394A (en)
WO (1) WO2013061005A1 (en)
ZA (1) ZA201402907B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2981934B1 (en) * 2011-10-28 2013-12-20 Galderma Res & Dev NOVEL DI-SUBSTITUTED DIAMINO-3,4-CYCLOBUTENE-3-DIONE-1,2 COMPOUNDS USEFUL IN THE TREATMENT OF CHEMOKINE MEDIATED PATHOLOGIES.
AU2014360743C1 (en) 2013-12-02 2021-01-28 Chemocentryx, Inc. CCR6 compounds
TWI734715B (en) * 2015-11-19 2021-08-01 美商卡默森屈有限公司 Modulators of chemokine receptors
TWI724056B (en) 2015-11-19 2021-04-11 美商卡默森屈有限公司 Inhibitors of cxcr2
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