JP6068443B2 - 透明ウェットスプレーおよびジェル - Google Patents
透明ウェットスプレーおよびジェル Download PDFInfo
- Publication number
- JP6068443B2 JP6068443B2 JP2014508609A JP2014508609A JP6068443B2 JP 6068443 B2 JP6068443 B2 JP 6068443B2 JP 2014508609 A JP2014508609 A JP 2014508609A JP 2014508609 A JP2014508609 A JP 2014508609A JP 6068443 B2 JP6068443 B2 JP 6068443B2
- Authority
- JP
- Japan
- Prior art keywords
- sun care
- benzophenone
- care product
- stearate
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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- 239000007921 spray Substances 0.000 title claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 92
- 230000000475 sunscreen effect Effects 0.000 claims description 45
- 239000000516 sunscreening agent Substances 0.000 claims description 45
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Ethylhexyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 claims description 36
- -1 cinoxalate Chemical compound 0.000 claims description 36
- 239000008365 aqueous carrier Substances 0.000 claims description 25
- 150000002148 esters Chemical class 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 15
- 239000004615 ingredient Substances 0.000 claims description 15
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 15
- 239000013543 active substance Substances 0.000 claims description 13
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 claims description 12
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 12
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 12
- 229960005193 avobenzone Drugs 0.000 claims description 11
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 claims description 10
- 229960001173 oxybenzone Drugs 0.000 claims description 10
- 229960001679 octinoxate Drugs 0.000 claims description 9
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 claims description 8
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 8
- 229940031578 diisopropyl adipate Drugs 0.000 claims description 8
- 229920000642 polymer Polymers 0.000 claims description 8
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 claims description 7
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 claims description 7
- 229960003921 octisalate Drugs 0.000 claims description 7
- MEZZCSHVIGVWFI-UHFFFAOYSA-N 2,2'-Dihydroxy-4-methoxybenzophenone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1O MEZZCSHVIGVWFI-UHFFFAOYSA-N 0.000 claims description 6
- 229960004050 aminobenzoic acid Drugs 0.000 claims description 6
- QQQMUBLXDAFBRH-UHFFFAOYSA-N dodecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)O QQQMUBLXDAFBRH-UHFFFAOYSA-N 0.000 claims description 6
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 6
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical group C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 claims description 6
- 229960000601 octocrylene Drugs 0.000 claims description 6
- LXTZRIBXKVRLOA-UHFFFAOYSA-N padimate a Chemical compound CCCCCOC(=O)C1=CC=C(N(C)C)C=C1 LXTZRIBXKVRLOA-UHFFFAOYSA-N 0.000 claims description 6
- OSORMYZMWHVFOZ-UHFFFAOYSA-N phenethyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCCC1=CC=CC=C1 OSORMYZMWHVFOZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000011787 zinc oxide Substances 0.000 claims description 6
- KGKQNDQDVZQTAG-UHFFFAOYSA-N 8-methylnonyl 2,2-dimethylpropanoate Chemical compound CC(C)CCCCCCCOC(=O)C(C)(C)C KGKQNDQDVZQTAG-UHFFFAOYSA-N 0.000 claims description 5
- MCPKSFINULVDNX-UHFFFAOYSA-N drometrizole Chemical compound CC1=CC=C(O)C(N2N=C3C=CC=CC3=N2)=C1 MCPKSFINULVDNX-UHFFFAOYSA-N 0.000 claims description 5
- 229960004881 homosalate Drugs 0.000 claims description 5
- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 claims description 5
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 4
- XNEFYCZVKIDDMS-UHFFFAOYSA-N avobenzone Chemical compound C1=CC(OC)=CC=C1C(=O)CC(=O)C1=CC=C(C(C)(C)C)C=C1 XNEFYCZVKIDDMS-UHFFFAOYSA-N 0.000 claims description 4
- 229960001716 benzalkonium Drugs 0.000 claims description 4
- CYDRXTMLKJDRQH-UHFFFAOYSA-N benzododecinium Chemical compound CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 CYDRXTMLKJDRQH-UHFFFAOYSA-N 0.000 claims description 4
- DCAYPVUWAIABOU-UHFFFAOYSA-N hexadecane Chemical compound CCCCCCCCCCCCCCCC DCAYPVUWAIABOU-UHFFFAOYSA-N 0.000 claims description 4
- 229960000368 sulisobenzone Drugs 0.000 claims description 4
- 239000004408 titanium dioxide Substances 0.000 claims description 4
- DHWLRNPWPABRBG-UHFFFAOYSA-N tridecyl 2,2-dimethylpropanoate Chemical compound CCCCCCCCCCCCCOC(=O)C(C)(C)C DHWLRNPWPABRBG-UHFFFAOYSA-N 0.000 claims description 4
- HEOCBCNFKCOKBX-RELGSGGGSA-N (1s,2e,4r)-4,7,7-trimethyl-2-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-3-one Chemical group C1=CC(C)=CC=C1\C=C/1C(=O)[C@]2(C)CC[C@H]\1C2(C)C HEOCBCNFKCOKBX-RELGSGGGSA-N 0.000 claims description 3
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims description 3
- WHQOKFZWSDOTQP-UHFFFAOYSA-N 2,3-dihydroxypropyl 4-aminobenzoate Chemical compound NC1=CC=C(C(=O)OCC(O)CO)C=C1 WHQOKFZWSDOTQP-UHFFFAOYSA-N 0.000 claims description 3
- ZXDDPOHVAMWLBH-UHFFFAOYSA-N 2,4-Dihydroxybenzophenone Chemical compound OC1=CC(O)=CC=C1C(=O)C1=CC=CC=C1 ZXDDPOHVAMWLBH-UHFFFAOYSA-N 0.000 claims description 3
- JGUMTYWKIBJSTN-UHFFFAOYSA-N 2-ethylhexyl 4-[[4,6-bis[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 JGUMTYWKIBJSTN-UHFFFAOYSA-N 0.000 claims description 3
- ORWUQAQITKSSRZ-UHFFFAOYSA-N 2-hydroxyethyl 4-[bis[2-(2-hydroxyethoxy)ethyl]amino]benzoate Chemical compound OCCOCCN(CCOCCO)C1=CC=C(C(=O)OCCO)C=C1 ORWUQAQITKSSRZ-UHFFFAOYSA-N 0.000 claims description 3
- KKJKXQYVUVWWJP-JLHYYAGUSA-N 4-[(e)-(4,7,7-trimethyl-3-oxo-2-bicyclo[2.2.1]heptanylidene)methyl]benzenesulfonic acid Chemical compound CC1(C)C2CCC1(C)C(=O)\C2=C\C1=CC=C(S(O)(=O)=O)C=C1 KKJKXQYVUVWWJP-JLHYYAGUSA-N 0.000 claims description 3
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 3
- WYWZRNAHINYAEF-UHFFFAOYSA-N Padimate O Chemical compound CCCCC(CC)COC(=O)C1=CC=C(N(C)C)C=C1 WYWZRNAHINYAEF-UHFFFAOYSA-N 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 3
- WYWZRNAHINYAEF-AWEZNQCLSA-N [(2s)-2-ethylhexyl] 4-(dimethylamino)benzoate Chemical compound CCCC[C@H](CC)COC(=O)C1=CC=C(N(C)C)C=C1 WYWZRNAHINYAEF-AWEZNQCLSA-N 0.000 claims description 3
- UBNYRXMKIIGMKK-RMKNXTFCSA-N amiloxate Chemical compound COC1=CC=C(\C=C\C(=O)OCCC(C)C)C=C1 UBNYRXMKIIGMKK-RMKNXTFCSA-N 0.000 claims description 3
- 229940111759 benzophenone-2 Drugs 0.000 claims description 3
- 229940079894 benzophenone-9 Drugs 0.000 claims description 3
- WXNRYSGJLQFHBR-UHFFFAOYSA-N bis(2,4-dihydroxyphenyl)methanone Chemical compound OC1=CC(O)=CC=C1C(=O)C1=CC=C(O)C=C1O WXNRYSGJLQFHBR-UHFFFAOYSA-N 0.000 claims description 3
- SODJJEXAWOSSON-UHFFFAOYSA-N bis(2-hydroxy-4-methoxyphenyl)methanone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=C(OC)C=C1O SODJJEXAWOSSON-UHFFFAOYSA-N 0.000 claims description 3
- 229960004960 dioxybenzone Drugs 0.000 claims description 3
- QDCHWIWENYCPIL-UHFFFAOYSA-L disodium;4-hydroxy-5-(2-hydroxy-4-methoxy-5-sulfonatobenzoyl)-2-methoxybenzenesulfonate Chemical compound [Na+].[Na+].C1=C(S([O-])(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC(S([O-])(=O)=O)=C(OC)C=C1O QDCHWIWENYCPIL-UHFFFAOYSA-L 0.000 claims description 3
- 229960000979 drometrizole Drugs 0.000 claims description 3
- 229960004697 enzacamene Drugs 0.000 claims description 3
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims description 3
- 229940114124 ferulic acid Drugs 0.000 claims description 3
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims description 3
- 235000001785 ferulic acid Nutrition 0.000 claims description 3
- 229930195733 hydrocarbon Natural products 0.000 claims description 3
- 150000002430 hydrocarbons Chemical class 0.000 claims description 3
- PVWXTVUZGJXFJQ-CCEZHUSRSA-N methyl (E)-4-methyl-3-phenyl-2-propan-2-ylpent-2-enoate Chemical compound COC(=O)C(\C(C)C)=C(/C(C)C)C1=CC=CC=C1 PVWXTVUZGJXFJQ-CCEZHUSRSA-N 0.000 claims description 3
- 229960002638 padimate o Drugs 0.000 claims description 3
- 229940098888 phenethyl benzoate Drugs 0.000 claims description 3
- 229940100498 polysilicone-15 Drugs 0.000 claims description 3
- 229920002282 polysilicones-15 Polymers 0.000 claims description 3
- KJCLYACXIWMFCC-UHFFFAOYSA-M sodium;5-benzoyl-4-hydroxy-2-methoxybenzenesulfonate Chemical compound [Na+].C1=C(S([O-])(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 KJCLYACXIWMFCC-UHFFFAOYSA-M 0.000 claims description 3
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims description 3
- UUGLJVMIFJNVFH-UHFFFAOYSA-N Benzoesaeure-n-hexylester Natural products CCCCCCOC(=O)C1=CC=CC=C1 UUGLJVMIFJNVFH-UHFFFAOYSA-N 0.000 claims description 2
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims description 2
- 229940086555 cyclomethicone Drugs 0.000 claims description 2
- HUVYTMDMDZRHBN-UHFFFAOYSA-N drometrizole trisiloxane Chemical compound C[Si](C)(C)O[Si](C)(O[Si](C)(C)C)CC(C)CC1=CC(C)=CC(N2N=C3C=CC=CC3=N2)=C1O HUVYTMDMDZRHBN-UHFFFAOYSA-N 0.000 claims description 2
- 229940051250 hexylene glycol Drugs 0.000 claims description 2
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- 229960002824 padimate a Drugs 0.000 claims description 2
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- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 claims description 2
- 229960001860 salicylate Drugs 0.000 claims description 2
- JSOVGYMVTPPEND-UHFFFAOYSA-N 16-methylheptadecyl 2,2-dimethylpropanoate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)C(C)(C)C JSOVGYMVTPPEND-UHFFFAOYSA-N 0.000 claims 2
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 claims 1
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- 239000006185 dispersion Substances 0.000 claims 1
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- WCJLCOAEJIHPCW-UHFFFAOYSA-N octyl 2-hydroxybenzoate Chemical compound CCCCCCCCOC(=O)C1=CC=CC=C1O WCJLCOAEJIHPCW-UHFFFAOYSA-N 0.000 claims 1
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- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 20
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- 125000000217 alkyl group Chemical group 0.000 description 14
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- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
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- OCSUWZNUCVLTNY-UHFFFAOYSA-N tetratriacontan-15-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCCCC(CCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCCCC OCSUWZNUCVLTNY-UHFFFAOYSA-N 0.000 description 1
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- 238000002834 transmittance Methods 0.000 description 1
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- GKAVWWCJCPVMNR-UHFFFAOYSA-N tridecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCC GKAVWWCJCPVMNR-UHFFFAOYSA-N 0.000 description 1
- 229940118594 trimethylolpropane triisostearate Drugs 0.000 description 1
- ZQTYRTSKQFQYPQ-UHFFFAOYSA-N trisiloxane Chemical compound [SiH3]O[SiH2]O[SiH3] ZQTYRTSKQFQYPQ-UHFFFAOYSA-N 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
- PSVXZQVXSXSQRO-UHFFFAOYSA-N undecaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO PSVXZQVXSXSQRO-UHFFFAOYSA-N 0.000 description 1
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- 235000019155 vitamin A Nutrition 0.000 description 1
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- 239000008170 walnut oil Substances 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
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- A61Q19/00—Preparations for care of the skin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
- A61K2800/31—Anhydrous
Description
本発明による組成物は、UV活性物質および/または化粧品的に許容可能な、実質的に非水性の担体の共成分を溶解、分布、運搬、および/または送達するのを助けるように作用することができる、少なくとも1つのアルコールを含む。
サンケア製品配合は少なくとも1つのUV活性物質も含む。UV活性物質の例としては:サリチル酸オクチル(サリチル酸2−エチルへキシル、Escalol(登録商標)587);ペンチルジメチルPABA;オクチルジメチルPABA(パジメートO、Escalol(登録商標)507);ベンゾフェノン−1;ベンゾフェノン−6(Uvinul(登録商標)D−49);2−(2H−ベンゾトリアゾール−2−イル)−4,6−ジ−tert−ペンチルフェノール(Uvinul(登録商標)3028);エチル−2−シアノ−3,3−ジフェニルアクリレート(Uvinul(登録商標)3035);サリチル酸ホモメンチル(ホモサレート);ビス−エチルヘキシルオキシフェノールメトキシフェニルトリアジン(ベモトリジノール、Escalol(登録商標)S);メチル−(1,2,2,6,6−ペンタメチル−4−ピぺリジル)−セバケート(Uvinul(登録商標)4092H);ベンゼンプロパン酸、3,5−ビス(1,1−ジメチル−エチル)−4−ヒドロキシ−;C7〜C9分岐アルキルエステル(Irganox(登録商標)1135);2−(2H−ベンゾトリアゾール−2−イル)−4−メチルフェノール(Uvinul(登録商標)3033P);ジエチルヘキシルブタミドトリアゾン(イスコトリジノール、Uvasorb(登録商標)HEB);アミルジメチルPABA(リサジメート、グリセリルPABA);4,6−ビス(オクチルチオメチル)−o−クレゾール(Irganox(登録商標)1520);CAS番号65447−77−0(Uvinul(登録商標)5062H、Uvinul(登録商標)5062GR);赤石油;エチルヘキシルトリアゾン(Uvinul(登録商標)T−150);オクトクリレン(Escalol(登録商標)597);イソアミル−p−メトキシシンナメート(アミロキサート、Neo Heliopan(登録商標)E1000);ドロメトリゾール;二酸化チタン;2,4−ジ−tert−ブチル−6−(5−クロロ−2H−ベンゾトリアゾール−2−イル)−フェノール(Uvinul(登録商標)3027);2−ヒドロキシ−4−オクチルオキシベンゾフェノン(Uvinul(登録商標)3008);ベンゾフェノン−2(Uvinul(登録商標)D−50);メチルケイ皮酸ジイソプロピル;PEG−25 PABA;アクリル酸2−(1,1−ジメチルエチル)−6−[3−(1,1−ジメチルエチル)−2−ヒドロキシ−5−メチルフェニル]メチル−4−メチルフェニル(Irganox(登録商標)3052);ドロメトリゾールトリシロキサン(Mexoryl(登録商標)XL);アントラニル酸メンチル(メラジメート);ビス−(1,2,2,6,6−ペンタメチル−4−ピぺリジル)−セバケート;ブチルメトキシジベンゾイルメタン(アボベンゾン、Escalol(登録商標)517);p−メトキシケイ皮酸2−エトキシエチル(シンノキサート);ベンジリデンカンファースルホン酸(Mexoryl(登録商標)SL);ジメトキシフェニル−[1−(3,4)]−4,4−ジメチル1,3−ペンタンジオン;酸化亜鉛;N,N’−ヘキサン−1,6−ジイル−ビス[3−(3,5−ジ−tert−ブチル−4−ヒドロキシフェニルプロピオンアミド)](Irganox(登録商標)1098);テトラキス[3−(3,5−ジ−tert−ブチル−4−ヒドロキシフェニル)プロピオン酸]ペンタエリスリトール(Irganox(登録商標)1010);2,6−ジ−tert−ブチル−4−[4,6−ビス(オクチルチオ)−1,3,5−トリアジン−2−イルアミノ]フェノール(Irganox(登録商標)565);2−(2H−ベンゾトリアゾール−2−イル)−4,6−ビス(1−メチル−1−フェニルエチル)フェノール(Uvinul(登録商標)3034);サリチル酸トロラミン(サリチル酸トリエタノールアミン);p−メトキシケイ皮酸ジエチラノールアミン(メトキシケイ皮酸DEA);ポリシリコーン−15(Parsol(登録商標)SLX);CAS番号152261−33−1(Uvinul(登録商標)5050H);4−メチルベンジリデンカンファー(Eusolex(登録商標)6300、Parsol(登録商標)5000);ビスオクトリゾール(Tinosorb(登録商標)M);ベンゼンアミン、N−フェニル−、2,4,4−トリメチルペンテンとの反応生成物(Irganox(登録商標)50507);スルイソベンゾン(Escalol(登録商標)577);(2−エチルヘキシル)−2−シアノ−3,3−ジフェニルアクリレート(Uvinul(登録商標)3039);トリオレイン酸ジガロイル;ポリアクリルアミドメチルベンジリデンカンファー;ジメトキシケイ皮酸エチルヘキサン酸グリセリル;1,3−ビス−[(2’−シアノ−3’,3’−ジフェニルアクリロイル)オキシ]−2,2−ビス−{[2’−シアノ−ビス−(2,2,6,6−テトラメチル−4−ピペリジル)−セバケート(Uvinul(登録商標)4077H);ベンゾフェノン−5(スリソベンゾンナトリウム);1,3,5−トリス(3,5−ジ−tert−ブチル−4−ヒドロキシベンジル)−1,3,5−トリアジン−2,4,6(1H,3H,5H)−トリオン(Irganox(登録商標)3114);ヘキサメチレンジアミン(Uvinul(登録商標)4050H);ベンゾフェノン−8(ジオキシベンゾン);アミノ安息香酸エチル−4−ビス(ヒドロキシプロピル)(ロキサジメート);6−tert−ブチル−2−(5−クロロ−2H−ベンゾトリアゾール−2−イル)−4−メチルフェノール(Uvinul(登録商標)3026);p−アミノ安息香酸(PABA);3,3’,3”,5,5’,5”−ヘキサ−tert−ブチル−α−α’−α”−(メシチレン−2,4,6−トリイル)トリ−p−クレゾール(Irganox(登録商標)1130);ジヒドロキシアセトンを有するローソン;ベンゾフェノン−9(Uvinul(登録商標)DS−49);ベンゾフェノン−4(スルイソベンゾン);ジメトキシベンジリデンジオキソイミダゾリンプロピオン酸エチルヘキシル;N,N’−ビスホルミル−N,N’−ビス−(2,2,6,6−テトラメチル−4−ピペリジニル)−;3−ベンジリデンカンファー(Mexoryl(登録商標)SD);テレフタルイリデンジカンファースルホン酸;カンファーメト硫酸ベンザルコニウム(Mexoryl(登録商標)SO);ビスジスルイゾール二ナトリウム(Neo Heliopan(登録商標)AP);エトクリレン;フェルラ酸;2−(2H−ベンゾトリアゾール−2−イル)−4−(1,1,3,3−テトラメチルブチル)−フェノール(Uvinul(登録商標)3029);エカムスール(Mexoryl(登録商標)SX);4,6−ビス(ドデシルチオメチル)−o−クレゾール(Irganox(登録商標)1726);β−2−グルコピラノキシプロピルヒドロキシベンゾフェノン;フェニルベンズイミダゾールスルホン酸(エンスリゾール、Eusolex(登録商標)232、Parsol(登録商標)HS);ベンゾフェノン−3(オキシベンゾン、Escalol(登録商標)567);ジエチルアミンヒドロキシベンゾイル安息香酸へキシル(Uvinul(登録商標)A Plus);3’,3’−ジフェニルアクリロイル]オキシ]メチル}−プロパン(Uvinul(登録商標)3030);およびp−メトキシケイ皮酸エチルヘキシル(Escalol(登録商標)557)が挙げられる。
−アボベンゾンおよびエカムスール、
−アボベンゾンおよびエンスリゾール、
−アボベンゾンおよびオキシベンゾン、
−アボベンゾンおよび酸化亜鉛、
−エンスリゾールおよびオクチノキサート、
−オクチノキサートおよびオキシベンゾン、
−二酸化チタンおよび酸化亜鉛
−アボベンゾン、オキシベンゾン、ホモサレート、およびオクチサレート
−アボベンゾン、オキシベンゾン、ホモサレート、オクチサレート、およびオクトクリレン、ならびに
−オクチノキサート、オクチサレート、オクトクリレン、オキシベンゾン、および酸化亜鉛が挙げられる。
本出願によるサンケア製品は、ケラチン物質上のサンケア製品を溶解、分布、運搬、送達、接着、および/または維持を補助することができる化粧品的に許容可能な、実質的に非水性な担体も含む。この担体はさまざまな程度の耐水性、防水性、および/もしくは撥水性を与えることができ、ならびに/または膜透過性(例えば、水蒸気、酸素)を可能にする。いくつかの出願について、この担体は、輝き、滑らかな皮膚の感触、毛髪のまとまりやすさ、および/または毛髪のコンディショニングを与えるように選択することが望ましくあり得る。
表1に示す配合を有する無水スプレーサンスクリーンを調製した。濡れた皮膚上にスプレーした場合、サンスクリーンは乳白色になった。
表3に示す成分および添加レベルを有する、3つの無水耐水性スプレーサンスクリーンを生成した。これらのサンスクリーンは30の理論的な日焼け止め指数(SPF)を有した。
すべての3つのサンスクリーンは濡れた皮膚上にスプレーした後透明のままだった。
実施例2のサンスクリーン配合120−1のエタノール含有量を増加し(表4)、濡れた皮膚上にスプレーした場合サンスクリーンが白くなる前の最大量を割り出した。これらのサンスクリーンの理論的なSPF値も30だった。
配合126−1は濡れた皮膚上に透明にスプレーされ、126−2(45%のエタノールを有する)は最小限の白化を示した。
実施例2の無水耐水性スプレーサンスクリーンを、より高レベルのUV活性物質を含有するように変更した(表5)。サンスクリーンは50の理論的SPFを有した。
すべての3つのサンスクリーンは濡れた皮膚上にスプレー後透明のままだった。
可変レベルのエタノールを有する2つのSPF50配合を調製し(表6)、濡れた皮膚上にスプレーした場合配合が白くなる前にどれくらいのアルコールを含むことができたかを割り出した。他の成分の割合は一定のままだった。
両配合は濡れた皮膚上にスプレーした場合45%のエタノールまで透明のままだった。
実施例5の配合より多い、50%のエタノールを有するSPF50配合を生成した(表7)。
この配合は濡れた皮膚上に塗布した場合白くなった。
実施例4のSPF50配合115−2を、VA/マレイン酸ブチル/アクリル酸イソボルニルコポリマーおよびアクリレート/オクチルアクリルアミドコポリマーの両方を含有するように変更した(表8)。
配合は濡れた皮膚上にスプレーした場合透明のままだった。
1つはポリジメチルシロキサンを有する2つの配合を生成し(表9)、これは気体(例えば、水蒸気、酸素)に対する膜透過性、および結果として皮膚呼吸を向上することができる。
両サンスクリーンは濡れた皮膚上にスプレー後透明のままだった。
SPFを70の理論値まで増加するため、実施例4の3つの無水スプレーサンスクリーンを、オクトクリレンの量を増加することにより変更した(表10)。
すべての3つのサンスクリーンは濡れた皮膚上にスプレー後透明のままだった。
実施例8のSPF70(理論値)サンスクリーンを:(a)皮膚上でのより大きな撥水性を与えるためより多量のVA/マレイン酸ブチル/アクリル酸イソボルニルコポリマーで、または(b)ヘキシレングリコールを添加することにより再製剤した(表11)。
両サンスクリーンは濡れた皮膚上にスプレー後透明だった。製剤変更のため、これらのスプレーされたサンスクリーンは濡れた皮膚上に光沢を残し、撥水性を向上した。
実施例8の配合118−1を研究し、スプレーしたサンスクリーンが濡れた皮膚上で白くなる前の最大エタノール含有量を割り出した(表12)。
これらの配合中の最大エタノールレベルは、濡れた皮膚上にスプレーした場合それらが白くなる前に45%であることが見出された。
2つのSPF70サンスクリーンを調製し(表13)、測定されたSPF値に対するVA/マレイン酸ブチル/アクリル酸イソブチルコポリマーの効果を割り出した。スプレー可能であると見出された透明な配合を、部分製剤Iの成分を混合した後、部分製剤IIを添加して混合した後、部分製剤III中の成分中で混合することにより生成した。SPF値をLabsphere UV 1000S Ultraviolet Transmittance Analyzer上で測定した。
VA/マレイン酸ブチル/アクリル酸イソボルニルコポリマー(65−1)なしの配合のSPFは59であり、コポリマーは他の配合(65−2)についてSPFを93まで増加することが見出された。
アクリレート/C12〜C22メタクリル酸アルキルコポリマー(Allianz(商標)OPT)およびイソヘキサデカン、シクロメチコーン、またはアジピン酸ジイソプロピル/マレイン酸ジエチルヘキシルを有する3つのエタノール系サンスクリーンを生成した(表14)。まず、Allianz(商標)OPTを予め生成したSPF−70ベース中添加および混合した。次に、エタノール、その後残りの成分を混合しながら添加した。
すべての3つのサンスクリーンは濁っていた。イソヘキサデカンを有する配合85−1は配合85−2および85−3に対して透明度の利点を示した。
本発明の予め生成した透明スプレー可能サンスクリーン製剤を、1%のアクリレート/C12〜C22メタクリル酸アルキルコポリマー(Allianz(商標)OPT)を含有するように再製剤した(表15)。この予め生成した配合は40%(w/w)のエタノールを含有した。
製剤後のサンスクリーンはわずかな濁りを示したが、濡れた皮膚上にスプレーした場合透明であると見出された。配合を一晩−20℃の冷凍庫に入れ、翌日分離または沈殿なく安定であることが見出された。86−1のSPF値は、Labsphere UV 2000S Ultraviolet Transmittance Analyzerを用いて67であると測定された。
実施例11の配合65−1を、VA/マレイン酸ブチル/アクリル酸イソボルニルコポリマーを除去し、1%のアクリレート/C12〜C22メタクリル酸アルキルコポリマー(Allianz(商標)OPT)を含むことにより変更した(表16)。
製品はやや濁りを示したが、濡れた皮膚上に透明にスプレーされた。配合65−1より耐水性のようだった。濡れた皮膚上にスプレーし、乾燥させた後、配合87は皮膚に上品な感触を与え、アクリレート/C12〜C22メタクリル酸アルキルコポリマーなしの配合よりは輝きを残さなかった。SPFは、Labsphere UV 2000S Ultraviolet Transmittance Analyzerにより測定されたように、102であると見出され、製品は−20℃の冷凍庫に一晩放置した後安定だった。
アクリレート/C12〜C22メタクリル酸アルキルコポリマー(Allianz(商標)OPT)およびエタノールで2つのスプレー可能SPF−70サンスクリーン配合を生成した(表17)。第1配合は50%(w/w)のエタノールを含有し、第2配合は60%(w/w)のエタノールを含有した。それらを、まず部分製剤I(予め生成)を45℃まで加熱した後、部分製剤II中にブレンドすることにより調製した。加熱を止め、次にアクリレート/C12〜C22メタクリル酸アルキルコポリマーを添加した。エタノールを最後にサンスクリーン全体が均一になるまで混合した。
50%のエタノールを含有した配合102−1は生成後濁っていたが、濡れた皮膚上に透明にスプレーされた。60%のエタノールを含有した配合102−2は調製後ほぼ不透明だったが、濡れた皮膚上にスプレーした場合白くなった。両製剤は5回の−20℃での冷凍/解凍サイクル後に沈殿物を示した。
軽度〜中程度架橋されたPVPを含有する透明ジェルSPF−50サンスクリーン配合を生成した(表18)。サンスクリーンを生成するため、まず部分製剤Iの架橋PVPを均質化しながらエタノールに添加した。(予め生成した)部分製剤IIを部分製剤Iに添加した。次に、部分製剤IIIの成分を混合しながら添加した。得られた生成物は透明で黄金色だった。
透明ジェルサンスクリーンは9,600cPのブルックフィールド粘度(スピンドルT−B、10rpm、室温)を有することが見出された。サンスクリーンは乾燥した皮膚上に絹のように滑らかな層を形成した。さらに、サンスクリーンは濡れた皮膚上に塗布した場合透明なままであり、白くならなかった。
軽度〜中程度架橋されたPVPおよびアクリレート/C12〜C22メタクリル酸アルキルコポリマーを含有するジェルSPF−50サンスクリーン配合を生成した(表19)。まず、部分製剤Iを45℃まで緩やかに加熱しながら混合した。次に、部分製剤IIの成分をブレンドし、加熱を止めた。アクリレート/C12〜C22メタクリル酸アルキルコポリマーを添加し、滑らかになるまで十分に混合した。この時エタノール、その後PVPを添加し、均一なサンスクリーンが生成されるまで均質化した。最終生成物はほとんど気づかないほどの濁りを有することが見出された。
軽度〜中程度架橋されたPVPおよびアクリレート/C12〜C22メタクリル酸アルキルコポリマーを含有する透明ジェルSPF−50サンスクリーン配合を生成した(表20)。その生成手順は実施例17と同じだった。最終生成物はほとんど気づかないほどの濁りを有することが見出された。
軽度〜中程度架橋されたPVP、アクリレート/C12〜C22メタクリル酸アルキルコポリマー、およびヒドロキシプロピルセルロースを含有するジェルのSPF−50サンスクリーン配合を生成した(表21)。まず、部分製剤I下に挙げられた成分を45℃まで緩やかに加熱しながら混合した。次に、部分製剤IIの成分を混合しながら添加した。加熱を止めた後、滑らかかつ透明になるまでヒドロキシプロピルセルロースを添加、分散およびブレンドした。次に、アクリレート/C12〜C22メタクリル酸アルキルコポリマーをブレンドした後、エタノールおよび軽度〜中程度架橋されたPVPを別々に添加した。
Claims (10)
- (A)化粧品的に許容可能な、実質的に非水性の担体、および(B)UV活性物質を含む実質的に無水のサンケア製品において、該非水性の担体が該サンケア製品の重量に対して20〜48%(w/w)の量のアルコールおよびエステルを含み、
前記非水性の担体が前記非水性の担体の合計重量に対して20重量%〜50重量%のエステルを含み、
前記エステルが、アジピン酸ジイソプロピルと安息香酸フェネチルの組合せ、アジピン酸ジイソプロピルとネオペンタン酸イソデシルとネオペンタン酸イソステアリルの組合せ、アジピン酸ジイソプロピルとネオペンタン酸イソデシルの組合せ、アジピン酸ジイソプロピルとネオペンタン酸トリデシルと乳酸ラウリルの組合せ、および、ネオペンタン酸トリデシルと乳酸ラウリルの組合せのいずれかより選択され、
前記アルコールがエタノールであり、
該サンケア製品が濡れた皮膚への塗布後実質的に白くならない、サンケア製品。 - 10%(w/w)以下の水を有する、請求項1に記載のサンケア製品。
- 30%(w/w)〜45%(w/w)のアルコールを有する、請求項1に記載のサンケア製品。
- 前記UV活性物質が4−メチルベンジリデンカンファー、アボベンゾン、ベモトリジノール、ベンゾフェノン−1、ベンゾフェノン−2、ベンゾフェノン−3(オキシベンゾン)、ベンゾフェノン−4(スリソベンゾン)、ベンゾフェノン−5(スリソベンゾンナトリウム)、ベンゾフェノン−6、ベンゾフェノン−8(ジオキシベンゾン)、ベンゾフェノン−9、ベンジリデンカンファースルホン酸、ビスジスリゾール二ナトリウム、ビスオクトリゾール、カンファーメト硫酸ベンザルコニウム、シノキサート、メトキシケイ皮酸DEA、ジエチルアミンヒドロキシベンゾイル安息香酸ヘキシル、トリオレイン酸ジガロイル、メチルケイ皮酸ジイソプロピル、ジメトキシフェニル−[1−(3,4)]−4,4−ジメチル1,3−ペンタンジオン、ドロメトリゾール、ドロメトリゾールトリシロキサン、エカムスール、エンスリゾール、p−メトキシケイ皮酸エチルヘキシル、エチルヘキシルトリアゾン、フェルラ酸、ジメトキシケイ皮酸エチルヘキサン酸グリセリル、サリチル酸ホモメンチル(ホモサレート)、イスコトリジノール、イソアミル−p−メトキシシンナメート、リサジメート、メラジメート、カンファーメト硫酸ベンザルコニウム、オクトクリレン、オクチルジメチルPABA(パジメートO)、サリチル酸オクチル(オクチサレート)、p−アミノ安息香酸(PABA)、PEG−25 PABA、ペンチルジメチルPABA(パジメートA)、ポリシリコーン−15、ロキサジメート、二酸化チタン、サリチル酸トロラミン、酸化亜鉛、およびこれらの組み合わせからなる群から選択される、請求項1に記載のサンケア製品。
- 前記UV活性物質がそれぞれ0.5%(w/w)〜40%(w/w)の量で存在する、請求項4に記載のサンケア製品。
- 50%(w/w)〜99%(w/w)の前記非水性の担体を有する、請求項1に記載のサンケア製品。
- 前記非水性の担体がエステル、グリコール、炭化水素、油、ポリマーおよびこれらの組み合わせからなる群から選択される成分を含む、請求項6に記載のサンケア製品。
- 前記非水性の担体がアジピン酸ジイソプロピル、ヘキシレングリコール、ネオペンタン酸イソデシル、ネオペンタン酸イソステアリル、安息香酸フェネチル、ポリジメチルシロキサン、シリコーン、イソセチルアルコール、ネオペンタン酸トリデシル、乳酸ラウリル、シクロメチコーン、イソヘキサデカン、およびこれらの組み合わせからなる群から選択される成分を含む、請求項7に記載のサンケア製品。
- 少なくとも15の日焼け止め指数(SPF)を有する、請求項1に記載のサンケア製品。
- ミスト、スプレー、エアロゾル、ムース、ジェル、溶液、または分散液である、請求項1に記載のサンケア製品。
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US61/488,237 | 2011-05-20 | ||
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Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |