JP6066499B2 - インスリンポンプ - Google Patents
インスリンポンプ Download PDFInfo
- Publication number
- JP6066499B2 JP6066499B2 JP2014525413A JP2014525413A JP6066499B2 JP 6066499 B2 JP6066499 B2 JP 6066499B2 JP 2014525413 A JP2014525413 A JP 2014525413A JP 2014525413 A JP2014525413 A JP 2014525413A JP 6066499 B2 JP6066499 B2 JP 6066499B2
- Authority
- JP
- Japan
- Prior art keywords
- insulin
- patient
- value
- blood glucose
- gain factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims description 786
- 102000004877 Insulin Human genes 0.000 title claims description 392
- 108090001061 Insulin Proteins 0.000 title claims description 392
- 229940125396 insulin Drugs 0.000 title claims description 392
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 221
- 239000008103 glucose Substances 0.000 claims description 221
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- 108010065920 Insulin Lispro Proteins 0.000 description 1
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
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- WNRQPCUGRUFHED-DETKDSODSA-N humalog Chemical compound C([C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(O)=O)C1=CC=C(O)C=C1.C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 WNRQPCUGRUFHED-DETKDSODSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
- A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/60—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M2005/14208—Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
- A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
- A61M2005/1726—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure the body parameters being measured at, or proximate to, the infusion site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
- A61M2230/201—Glucose concentration
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Vascular Medicine (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Primary Health Care (AREA)
- Medical Informatics (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1113933.4 | 2011-08-12 | ||
| GB1113933.4A GB2493712B (en) | 2011-08-12 | 2011-08-12 | Insulin pump |
| PCT/EP2012/065725 WO2013024044A2 (en) | 2011-08-12 | 2012-08-10 | Insulin pump |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014524294A JP2014524294A (ja) | 2014-09-22 |
| JP2014524294A5 JP2014524294A5 (enExample) | 2015-10-08 |
| JP6066499B2 true JP6066499B2 (ja) | 2017-01-25 |
Family
ID=44764429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014525413A Expired - Fee Related JP6066499B2 (ja) | 2011-08-12 | 2012-08-10 | インスリンポンプ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9283323B2 (enExample) |
| EP (1) | EP2742449A2 (enExample) |
| JP (1) | JP6066499B2 (enExample) |
| CN (1) | CN104054081A (enExample) |
| GB (1) | GB2493712B (enExample) |
| WO (1) | WO2013024044A2 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8417311B2 (en) * | 2008-09-12 | 2013-04-09 | Optiscan Biomedical Corporation | Fluid component analysis system and method for glucose monitoring and control |
| WO2012058694A2 (en) | 2010-10-31 | 2012-05-03 | Trustees Of Boston University | Blood glucose control system |
| US9465910B2 (en) | 2012-05-15 | 2016-10-11 | James Minor | Diagnostic methods and devices for monitoring chronic glycemia |
| US11798685B2 (en) | 2012-05-15 | 2023-10-24 | James M. Minor | Diagnostic methods and devices for controlling acute glycemia |
| US9171343B1 (en) | 2012-09-11 | 2015-10-27 | Aseko, Inc. | Means and method for improved glycemic control for diabetic patients |
| US9897565B1 (en) | 2012-09-11 | 2018-02-20 | Aseko, Inc. | System and method for optimizing insulin dosages for diabetic subjects |
| EP2862586B1 (en) * | 2013-10-21 | 2021-09-01 | F. Hoffmann-La Roche AG | Control unit for infusion pump units, including a controlled intervention unit |
| AU2015211258A1 (en) | 2014-01-31 | 2016-08-11 | Trustees Of Boston University | Offline glucose control based on preceding periods |
| US9486580B2 (en) | 2014-01-31 | 2016-11-08 | Aseko, Inc. | Insulin management |
| US9898585B2 (en) | 2014-01-31 | 2018-02-20 | Aseko, Inc. | Method and system for insulin management |
| AU2015339576B2 (en) | 2014-10-27 | 2020-02-06 | Glytec, Llc | Subcutaneous outpatient management |
| US11081226B2 (en) | 2014-10-27 | 2021-08-03 | Aseko, Inc. | Method and controller for administering recommended insulin dosages to a patient |
| CN105688308A (zh) * | 2014-11-13 | 2016-06-22 | 上海泽生科技开发有限公司 | 注射泵控制方法、控制单元及注射泵 |
| US10548528B2 (en) * | 2015-08-07 | 2020-02-04 | Ryan James Appleby | Smartphone device for body analysis |
| WO2017027459A1 (en) | 2015-08-07 | 2017-02-16 | Trustees Of Boston University | Glucose control system with automatic adaptation of glucose target |
| EP3337402B1 (en) | 2015-08-20 | 2026-01-07 | Glytec, LLC | Diabetes management therapy advisor |
| CN105457123A (zh) * | 2015-11-26 | 2016-04-06 | 北京大学第一医院 | 一种大剂量甲氨蝶呤用药控制系统 |
| US10332632B2 (en) * | 2016-06-01 | 2019-06-25 | Roche Diabetes Care, Inc. | Control-to-range failsafes |
| US20190240406A1 (en) * | 2016-10-13 | 2019-08-08 | Centre National De La Recherche Scientifique | Artificial pancreas |
| EP3318294A1 (en) | 2016-11-08 | 2018-05-09 | Defymed | Kit for in situ delivery of a compound of interest |
| US11311668B2 (en) * | 2016-12-15 | 2022-04-26 | Verily Life Sciences Llc | Auto-calibration of physiological response estimates for closed-loop insulin delivery using patient-selected standardized meals |
| CN108261591B (zh) * | 2016-12-30 | 2021-10-08 | 上海移宇科技股份有限公司 | 一种人工胰腺的闭环控制算法 |
| WO2018147483A1 (ko) * | 2017-02-09 | 2018-08-16 | 최규동 | 연속 혈당 감지를 이용한 인슐린 투여 시스템 |
| US11147920B2 (en) * | 2017-04-18 | 2021-10-19 | Lifescan Ip Holdings, Llc | Diabetes management system with automatic basal and manual bolus insulin control |
| CN116531603A (zh) | 2017-05-05 | 2023-08-04 | 伊莱利利公司 | 生理葡萄糖的闭环控制 |
| EP3438858A1 (en) | 2017-08-02 | 2019-02-06 | Diabeloop | Closed-loop blood glucose control systems and methods |
| JP7133625B2 (ja) | 2017-12-21 | 2022-09-08 | イーライ リリー アンド カンパニー | 生理的グルコースの閉ループ制御 |
| US11915151B2 (en) * | 2018-08-27 | 2024-02-27 | Zoe Limited | Accuracy of test data outside the clinic |
| US11565043B2 (en) | 2018-05-04 | 2023-01-31 | Insulet Corporation | Safety constraints for a control algorithm based drug delivery system |
| CA3103479A1 (en) | 2018-06-22 | 2019-12-26 | Eli Lilly And Company | Insulin and pramlintide delivery systems, methods, and devices |
| EP3906562A4 (en) * | 2019-01-04 | 2022-10-12 | Abbott Diabetes Care Inc. | SYSTEMS, DEVICES AND METHODS FOR IMPROVED MEAL AND THERAPY INTERFACES IN ANALYTICAL MONITORING SYSTEMS |
| EP3986258A4 (en) * | 2019-06-19 | 2023-06-21 | Dexcom, Inc. | DYNAMIC ESTIMATOR OF AN ACTIVE EQUIVALENT |
| JP7657428B2 (ja) | 2019-07-16 | 2025-04-07 | ベータ バイオニクス，インコーポレイテッド | 血糖制御システム |
| US11957876B2 (en) | 2019-07-16 | 2024-04-16 | Beta Bionics, Inc. | Glucose control system with automated backup therapy protocol generation |
| CA3146965C (en) | 2019-07-16 | 2025-07-08 | Beta Bionics, Inc. | BLOOD SUGAR REGULATION SYSTEM |
| US11213623B2 (en) | 2019-09-20 | 2022-01-04 | Medtronic Minimed, Inc. | Infusion systems and related personalized bolusing methods |
| EP4096752A4 (en) * | 2020-01-30 | 2024-06-12 | Willow Laboratories, Inc. | DISEASE TREATMENT SYSTEM WITH REDUNDANT OFFSET GLUCOSE SENSORS |
| EP3892259A1 (en) | 2020-04-09 | 2021-10-13 | Defymed | Membranes for medical devices |
| CA3179703A1 (en) | 2020-04-09 | 2021-10-14 | Defymed | Membranes for medical devices |
| CN111632228B (zh) * | 2020-05-19 | 2021-05-25 | 中国科学院深圳先进技术研究院 | 一种基于可穿戴监测方法的闭环人工胰腺系统 |
| KR20220020108A (ko) * | 2020-08-11 | 2022-02-18 | 삼성전자주식회사 | 약물 전달 장치 및 약물 전달 장치의 동작 방법 |
| US12465686B2 (en) | 2021-03-25 | 2025-11-11 | Beta Bionics, Inc. | Emergency medicament dose control |
| EP4380649A4 (en) * | 2021-08-02 | 2025-06-18 | Tandem Diabetes Care, Inc. | Systems and methods for processing continuous glucose monitor values in automated insulin delivery |
| EP4380650A4 (en) * | 2021-08-03 | 2025-06-11 | Tandem Diabetes Care, Inc. | SYSTEMS AND METHODS FOR AUTOMATED INSULIN DELIVERY RESPONSE TO MEAL ANNOUNCEMENTS |
| WO2023070245A1 (en) * | 2021-10-25 | 2023-05-04 | Medtrum Technologies Inc. | Closed-loop artificial pancreas insulin infusion control system |
| WO2023070250A1 (en) * | 2021-10-25 | 2023-05-04 | Medtrum Technologies Inc. | Closed-loop artificial pancreas insulin infusion personalized control system |
| WO2024036147A2 (en) | 2022-08-12 | 2024-02-15 | Luminoah, Inc. | Wearable fluid delivery system |
| USD1029236S1 (en) | 2022-08-12 | 2024-05-28 | Luminoah, Inc. | Fluid pouch assembly |
| USD1029235S1 (en) | 2022-08-12 | 2024-05-28 | Luminoah, Inc. | Fluid delivery system |
| USD1033628S1 (en) | 2022-08-12 | 2024-07-02 | Luminoah, Inc. | Fluid delivery module |
| WO2025188770A1 (en) * | 2024-03-04 | 2025-09-12 | University Of Virginia Patent Foundation | System and method for automated insulin delivery using artificial neural network |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7806886B2 (en) * | 1999-06-03 | 2010-10-05 | Medtronic Minimed, Inc. | Apparatus and method for controlling insulin infusion with state variable feedback |
| RU2341529C2 (ru) | 2004-02-03 | 2008-12-20 | Ниппон Синяку Ко., Лтд. | Гликозидное пролекарство 5-аминосалициловой кислоты |
| US9056165B2 (en) * | 2006-09-06 | 2015-06-16 | Medtronic Minimed, Inc. | Intelligent therapy recommendation algorithm and method of using the same |
| US20080146994A1 (en) * | 2006-10-10 | 2008-06-19 | Allen Gerber | Retrofittable aspiration prevention mechanism for patients |
| US20080172028A1 (en) * | 2006-10-17 | 2008-07-17 | Blomquist Michael L | Insulin pump having selectable insulin absorption models |
| US10154804B2 (en) * | 2007-01-31 | 2018-12-18 | Medtronic Minimed, Inc. | Model predictive method and system for controlling and supervising insulin infusion |
| US20080206799A1 (en) * | 2007-02-27 | 2008-08-28 | Michael Blomquist | Carbohydrate ratio testing using frequent blood glucose input |
| US8827979B2 (en) * | 2007-03-19 | 2014-09-09 | Insuline Medical Ltd. | Drug delivery device |
| EP2139540A1 (en) * | 2007-03-19 | 2010-01-06 | Medingo Ltd. | User interface for selecting bolus doses in a drug delivery device |
| CN101801262A (zh) * | 2007-07-09 | 2010-08-11 | 弗吉尼亚大学专利基金会 | 糖尿病胰岛素敏感度、碳水化合物比、校正因子数据自我监测产品 |
| WO2010135670A2 (en) * | 2009-05-22 | 2010-11-25 | Abbott Diabetes Care Inc. | Safety layer for integrated insulin delivery system |
| US9687194B2 (en) * | 2009-06-17 | 2017-06-27 | Medtronic Minimed, Inc. | Closed-loop glucose and/or insulin control system |
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