JP6043344B2 - 免疫学的障害の治療のための置換インドール誘導体 - Google Patents

免疫学的障害の治療のための置換インドール誘導体 Download PDF

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JP6043344B2
JP6043344B2 JP2014510933A JP2014510933A JP6043344B2 JP 6043344 B2 JP6043344 B2 JP 6043344B2 JP 2014510933 A JP2014510933 A JP 2014510933A JP 2014510933 A JP2014510933 A JP 2014510933A JP 6043344 B2 JP6043344 B2 JP 6043344B2
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disease
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JP2014518870A5 (enExample
JP2014518870A (ja
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ナイジェル・グレアム・クック
リタ・ラモス
カラン・カメルトアン
マウリス・ファン・エイス
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ノバルティス ティーアゲズントハイト アーゲー
ノバルティス ティーアゲズントハイト アーゲー
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/499Spiro-condensed pyrazines or piperazines
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • AHUMAN NECESSITIES
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    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Molecular Biology (AREA)
  • Neurology (AREA)
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  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • AIDS & HIV (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
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JP2014510933A 2011-05-17 2012-05-16 免疫学的障害の治療のための置換インドール誘導体 Active JP6043344B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161486808P 2011-05-17 2011-05-17
US61/486,808 2011-05-17
PCT/IB2012/052473 WO2012156936A1 (en) 2011-05-17 2012-05-16 Substituted indole derivatives for the treatment of immunological disorders

Publications (3)

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JP2014518870A JP2014518870A (ja) 2014-08-07
JP2014518870A5 JP2014518870A5 (enExample) 2015-07-02
JP6043344B2 true JP6043344B2 (ja) 2016-12-14

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JP2014510933A Active JP6043344B2 (ja) 2011-05-17 2012-05-16 免疫学的障害の治療のための置換インドール誘導体

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US (2) US8703782B2 (enExample)
EP (1) EP2709998B1 (enExample)
JP (1) JP6043344B2 (enExample)
KR (1) KR20140023354A (enExample)
CN (1) CN103534250B (enExample)
AR (1) AR088414A1 (enExample)
AU (1) AU2012257345B2 (enExample)
BR (1) BR112013029416A2 (enExample)
CA (1) CA2835169C (enExample)
EA (1) EA023238B1 (enExample)
ES (1) ES2565200T3 (enExample)
MX (1) MX2013013436A (enExample)
TW (1) TW201249858A (enExample)
UY (1) UY34072A (enExample)
WO (1) WO2012156936A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY34072A (es) 2011-05-17 2013-01-03 Novartis Ag Derivados sustituidos de indol
MX2015005737A (es) * 2012-11-07 2015-09-16 Novartis Ag Derivados de indol sustituido.
MX378263B (es) * 2013-08-14 2025-03-10 Novartis Ag Terapia de combinación para el tratamiento del cáncer.
JP6998657B2 (ja) 2013-09-18 2022-02-04 エピアクシス セラピューティクス プロプライエタリー リミテッド 幹細胞調節ii
EP3185858A4 (en) 2014-08-25 2017-12-27 University of Canberra Compositions for modulating cancer stem cells and uses therefor
WO2025091442A1 (zh) * 2023-11-03 2025-05-08 北京凯因科技股份有限公司 一种神经氨酸酶抑制剂及在流感病毒中的应用

Family Cites Families (20)

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US4925860A (en) 1987-08-05 1990-05-15 E. I. Du Pont De Nemours And Company Stable pharmaceutical composition of 3-(hydroxymethyl)-5,5-diphenylhydantoin disodium phosphate ester
DE4005970A1 (de) 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
GB9721069D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Polymeric derivatives of camptothecin
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
NZ518038A (en) 1999-10-12 2004-02-27 F Substituted pyrroles as antiproliferative agents for the treatment of cancer
PE20020544A1 (es) * 2000-11-07 2002-07-30 Novartis Ag Derivados de indolilmaleimida
CA2470423C (en) 2001-12-21 2011-03-15 Guilford Pharmaceuticals, Inc. Process for preparing water-soluble phosphonooxymethyl derivatives of alcohol and phenol
CA2470500C (en) 2001-12-28 2012-05-15 Guilford Pharmaceuticals, Inc. Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol
AR039209A1 (es) 2002-04-03 2005-02-09 Novartis Ag Derivados de indolilmaleimida
EP1492544A4 (en) 2002-04-08 2005-10-12 Guilford Pharm Inc PHARMACEUTICAL COMPOSITIONS CONTAINING PROPOFOL-BASED WATER-SOLUBLE PRODRUGS AND METHODS OF ADMINISTRATION THEREOF
CA2514733A1 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
AU2003223104A1 (en) 2003-03-19 2004-10-11 Suven Life Sciences Limited A process for the preparation of indolymaleimides
US7449458B2 (en) 2005-01-19 2008-11-11 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
WO2007008514A2 (en) 2005-07-07 2007-01-18 Georgetown University Inhibitors of glycogen synthase kinase 3
US20070203236A1 (en) 2006-01-11 2007-08-30 Smith Jeffrey W Novel antagonists of the human fatty acid synthase thioesterase
GB0605691D0 (en) 2006-03-21 2006-05-03 Novartis Ag Organic Compounds
US8163902B2 (en) 2006-11-21 2012-04-24 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
WO2011057204A2 (en) 2009-11-06 2011-05-12 The Johns Hopkins University Lrrk2-mediated neuronal toxicity
CN101812097B (zh) 2010-04-17 2012-04-25 中国海洋大学 吲哚咔唑和双吲哚马来酰亚胺生物碱及其制备方法和应用
UY34072A (es) 2011-05-17 2013-01-03 Novartis Ag Derivados sustituidos de indol

Also Published As

Publication number Publication date
EA201391710A1 (ru) 2014-03-31
US9029396B2 (en) 2015-05-12
BR112013029416A2 (pt) 2017-01-31
CA2835169A1 (en) 2012-11-22
US8703782B2 (en) 2014-04-22
ES2565200T3 (es) 2016-04-01
CA2835169C (en) 2019-05-14
UY34072A (es) 2013-01-03
TW201249858A (en) 2012-12-16
CN103534250B (zh) 2016-05-11
EP2709998B1 (en) 2016-01-06
CN103534250A (zh) 2014-01-22
US20130157980A1 (en) 2013-06-20
AU2012257345B2 (en) 2016-03-24
EP2709998A1 (en) 2014-03-26
JP2014518870A (ja) 2014-08-07
AR088414A1 (es) 2014-06-11
KR20140023354A (ko) 2014-02-26
MX2013013436A (es) 2013-12-06
EA023238B1 (ru) 2016-05-31
US20140179634A1 (en) 2014-06-26
WO2012156936A1 (en) 2012-11-22

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