ES2565200T3 - Derivados de indol sustituido para el tratamiento de trastornos inmunológicos - Google Patents
Derivados de indol sustituido para el tratamiento de trastornos inmunológicos Download PDFInfo
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- ES2565200T3 ES2565200T3 ES12726226.9T ES12726226T ES2565200T3 ES 2565200 T3 ES2565200 T3 ES 2565200T3 ES 12726226 T ES12726226 T ES 12726226T ES 2565200 T3 ES2565200 T3 ES 2565200T3
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- immune disorders
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/499—Spiro-condensed pyrazines or piperazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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| US201161486808P | 2011-05-17 | 2011-05-17 | |
| US201161486808P | 2011-05-17 | ||
| PCT/IB2012/052473 WO2012156936A1 (en) | 2011-05-17 | 2012-05-16 | Substituted indole derivatives for the treatment of immunological disorders |
Publications (1)
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| ES2565200T3 true ES2565200T3 (es) | 2016-04-01 |
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| MX2015005737A (es) * | 2012-11-07 | 2015-09-16 | Novartis Ag | Derivados de indol sustituido. |
| MX378263B (es) * | 2013-08-14 | 2025-03-10 | Novartis Ag | Terapia de combinación para el tratamiento del cáncer. |
| JP6998657B2 (ja) | 2013-09-18 | 2022-02-04 | エピアクシス セラピューティクス プロプライエタリー リミテッド | 幹細胞調節ｉｉ |
| EP3185858A4 (en) | 2014-08-25 | 2017-12-27 | University of Canberra | Compositions for modulating cancer stem cells and uses therefor |
| WO2025091442A1 (zh) * | 2023-11-03 | 2025-05-08 | 北京凯因科技股份有限公司 | 一种神经氨酸酶抑制剂及在流感病毒中的应用 |
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| US4925860A (en) | 1987-08-05 | 1990-05-15 | E. I. Du Pont De Nemours And Company | Stable pharmaceutical composition of 3-(hydroxymethyl)-5,5-diphenylhydantoin disodium phosphate ester |
| DE4005970A1 (de) | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| GB9721069D0 (en) | 1997-10-03 | 1997-12-03 | Pharmacia & Upjohn Spa | Polymeric derivatives of camptothecin |
| US6204257B1 (en) | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| NZ518038A (en) | 1999-10-12 | 2004-02-27 | F | Substituted pyrroles as antiproliferative agents for the treatment of cancer |
| PE20020544A1 (es) * | 2000-11-07 | 2002-07-30 | Novartis Ag | Derivados de indolilmaleimida |
| CA2470423C (en) | 2001-12-21 | 2011-03-15 | Guilford Pharmaceuticals, Inc. | Process for preparing water-soluble phosphonooxymethyl derivatives of alcohol and phenol |
| CA2470500C (en) | 2001-12-28 | 2012-05-15 | Guilford Pharmaceuticals, Inc. | Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol |
| AR039209A1 (es) | 2002-04-03 | 2005-02-09 | Novartis Ag | Derivados de indolilmaleimida |
| EP1492544A4 (en) | 2002-04-08 | 2005-10-12 | Guilford Pharm Inc | PHARMACEUTICAL COMPOSITIONS CONTAINING PROPOFOL-BASED WATER-SOLUBLE PRODRUGS AND METHODS OF ADMINISTRATION THEREOF |
| CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| AU2003223104A1 (en) | 2003-03-19 | 2004-10-11 | Suven Life Sciences Limited | A process for the preparation of indolymaleimides |
| US7449458B2 (en) | 2005-01-19 | 2008-11-11 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
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| US20070203236A1 (en) | 2006-01-11 | 2007-08-30 | Smith Jeffrey W | Novel antagonists of the human fatty acid synthase thioesterase |
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| US8163902B2 (en) | 2006-11-21 | 2012-04-24 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
| WO2011057204A2 (en) | 2009-11-06 | 2011-05-12 | The Johns Hopkins University | Lrrk2-mediated neuronal toxicity |
| CN101812097B (zh) | 2010-04-17 | 2012-04-25 | 中国海洋大学 | 吲哚咔唑和双吲哚马来酰亚胺生物碱及其制备方法和应用 |
| UY34072A (es) | 2011-05-17 | 2013-01-03 | Novartis Ag | Derivados sustituidos de indol |
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| US9029396B2 (en) | 2015-05-12 |
| BR112013029416A2 (pt) | 2017-01-31 |
| CA2835169A1 (en) | 2012-11-22 |
| US8703782B2 (en) | 2014-04-22 |
| CA2835169C (en) | 2019-05-14 |
| UY34072A (es) | 2013-01-03 |
| TW201249858A (en) | 2012-12-16 |
| CN103534250B (zh) | 2016-05-11 |
| EP2709998B1 (en) | 2016-01-06 |
| CN103534250A (zh) | 2014-01-22 |
| US20130157980A1 (en) | 2013-06-20 |
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| EP2709998A1 (en) | 2014-03-26 |
| JP2014518870A (ja) | 2014-08-07 |
| AR088414A1 (es) | 2014-06-11 |
| JP6043344B2 (ja) | 2016-12-14 |
| KR20140023354A (ko) | 2014-02-26 |
| MX2013013436A (es) | 2013-12-06 |
| EA023238B1 (ru) | 2016-05-31 |
| US20140179634A1 (en) | 2014-06-26 |
| WO2012156936A1 (en) | 2012-11-22 |
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