JP6031122B2 - 抗微生物療法のための三環式ホウ素化合物 - Google Patents

抗微生物療法のための三環式ホウ素化合物 Download PDF

Info

Publication number
JP6031122B2
JP6031122B2 JP2014548243A JP2014548243A JP6031122B2 JP 6031122 B2 JP6031122 B2 JP 6031122B2 JP 2014548243 A JP2014548243 A JP 2014548243A JP 2014548243 A JP2014548243 A JP 2014548243A JP 6031122 B2 JP6031122 B2 JP 6031122B2
Authority
JP
Japan
Prior art keywords
compound
compounds
mixture
alkyl
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2014548243A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015502974A5 (https=
JP2015502974A (ja
Inventor
フェドロビッチ ゴルデエフ ミハイル
フェドロビッチ ゴルデエフ ミハイル
リウ ジンキアン
リウ ジンキアン
ユアン ズヘンギュ
ユアン ズヘンギュ
ワング ジングハイ
ワング ジングハイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2015502974A publication Critical patent/JP2015502974A/ja
Publication of JP2015502974A5 publication Critical patent/JP2015502974A5/ja
Application granted granted Critical
Publication of JP6031122B2 publication Critical patent/JP6031122B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP2014548243A 2011-12-22 2012-12-20 抗微生物療法のための三環式ホウ素化合物 Expired - Fee Related JP6031122B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161579271P 2011-12-22 2011-12-22
US61/579,271 2011-12-22
PCT/IB2012/002880 WO2013093615A1 (en) 2011-12-22 2012-12-20 Tricyclic boron compounds for antimicrobial therapy

Publications (3)

Publication Number Publication Date
JP2015502974A JP2015502974A (ja) 2015-01-29
JP2015502974A5 JP2015502974A5 (https=) 2016-02-12
JP6031122B2 true JP6031122B2 (ja) 2016-11-24

Family

ID=47664367

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014548243A Expired - Fee Related JP6031122B2 (ja) 2011-12-22 2012-12-20 抗微生物療法のための三環式ホウ素化合物

Country Status (7)

Country Link
US (1) US8530452B2 (https=)
EP (1) EP2793901A1 (https=)
JP (1) JP6031122B2 (https=)
KR (1) KR20140114380A (https=)
CN (1) CN104136032B (https=)
CA (1) CA2858799A1 (https=)
WO (1) WO2013093615A1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
US9585396B2 (en) 2013-01-30 2017-03-07 Agrofresh Inc. Volatile applications against pathogens
MA38319A1 (fr) * 2013-01-30 2016-08-31 Dow Agrosciences Llc Utilisation des benzoxaboroles à titre d'agents antimicrobiens volatils sur les viandes, les plantes, ou des parties de plantes
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
KR101636431B1 (ko) * 2013-07-30 2016-07-05 동아에스티 주식회사 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
US20160251380A1 (en) 2013-08-09 2016-09-01 Glaxosmithkline Intellectual Property (No.2) Limited Tricyclic benzoxaborole compounds and uses thereof
EA038093B1 (ru) * 2013-12-20 2021-07-05 Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед Способ лечения заболевания, вызванного инфекцией комплекса mycobacterium tuberculosis, с использованием (s)-(3-хлор-7,8-дигидро-2h-1,6,9-триокса-9a-борабензо[cd]азулен-2-ил)метанамина или его фармацевтически приемлемой соли
EP3164404B1 (en) 2014-07-01 2019-04-03 Daiichi Sankyo Company, Limited Tricyclic benzoxaboroles as antibacterial agents
CN104177226A (zh) * 2014-07-31 2014-12-03 河北国蓬化工有限公司 一种聚醚用催化剂的制备方法
MA41494B1 (fr) * 2015-02-12 2020-10-28 Glaxosmithkline Ip No 2 Ltd Composés benzoxaborole substitués en position 4 et utilisations associées
RS64770B1 (sr) 2016-03-07 2023-11-30 Agrofresh Inc Sinergistički postupci upotrebe jedinjenja benzoksaborola i gasova za prezerviranje kao antimikrobnih agenasa za useve
KR101925338B1 (ko) 2016-12-22 2018-12-05 엘에스산전 주식회사 전력기기 진단 장치
EP3850029A1 (en) 2019-08-09 2021-07-21 Safas Saf Plastik Sanayi Ve Ticaret Anonim Sirketi Boron-modified flexible polyurethane foam for hygiene and a method of production therefor
EP4384527A4 (en) * 2022-06-23 2025-09-03 Micurx Pharmaceuticals Inc PRODRUGS OF BORON COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS
CA3239096A1 (en) * 2022-06-23 2023-12-28 Shanghai Micurx Pharmaceutical Co., Ltd. Methods and uses of boron compounds in the treatment of nontuberculous mycobacterium infections and pharmaceutical compositions for treatment of same
WO2025140370A1 (zh) * 2023-12-27 2025-07-03 上海盟科药业股份有限公司 硼化合物前药的盐型、晶型及其药物组合物和用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
BRPI0411582A (pt) 2003-06-16 2006-08-08 Anacor Pharmaceuticals Inc substáncias terapêuticas contendo boro hidroliticamente resistentes e método de uso
PT1988779E (pt) * 2006-02-16 2015-09-04 Anacor Pharmaceuticals Inc Moléculas pequenas contendo boro como agentes antiinflamatórios
EP2015757A4 (en) 2006-05-02 2011-01-26 Anacor Pharmaceuticals Inc HYDROLYSERESISTENT, BOROYED THERAPEUTIC USES
US20070286822A1 (en) * 2006-06-12 2007-12-13 Anacor Pharmaceuticals Inc. Compounds for the Treatment of Periodontal Disease
JO3396B1 (ar) * 2007-06-20 2019-10-20 Anacor Pharmaceuticals Inc جزيئات صغيرة تحتوي على البورون
EP2285384A4 (en) 2008-05-12 2012-04-25 Anacor Pharmaceuticals Inc BORN SMALL MOLECULES
US20110259250A1 (en) * 2008-08-21 2011-10-27 Mcknight James T Systems And Methods For Converting Biomass In The Field To A Combustible Fluid For Direct Replacement Or Supplement To Liquid Fossil Fuels
WO2010080558A1 (en) 2008-12-17 2010-07-15 Anacor Pharmaceuticals, Inc. Polymorphs of (s)-3-aminomethyl-7-(3-hydroxy-propoxy)-3h-benzo[c][1,2] oxaborol-1-ol
MX2012001156A (es) 2009-07-28 2012-05-08 Anacor Pharmaceuticals Inc Moleculas que contienen boro trisustituidas.
ES2710105T3 (es) 2010-04-07 2019-04-23 Glaxosmithkline Llc Proceso para preparar benzoxaboroles
SI3251678T1 (sl) * 2010-09-07 2022-01-31 Anacor Pharmaceuticals, Inc. Derivati benzoksaborola za zdravljenje bakterijskih okužb

Also Published As

Publication number Publication date
US20130165411A1 (en) 2013-06-27
EP2793901A1 (en) 2014-10-29
WO2013093615A1 (en) 2013-06-27
CA2858799A1 (en) 2013-06-27
CN104136032B (zh) 2018-11-13
CN104136032A (zh) 2014-11-05
US8530452B2 (en) 2013-09-10
KR20140114380A (ko) 2014-09-26
JP2015502974A (ja) 2015-01-29

Similar Documents

Publication Publication Date Title
JP6031122B2 (ja) 抗微生物療法のための三環式ホウ素化合物
US9597341B2 (en) Phosphate compounds, a process for their preparation and pharmaceutical compositions containing them
JP2022043078A (ja) 抗菌化合物
KR20210143803A (ko) Tead 전사인자의 신규한 소분자 저해제
JP2021513534A (ja) 抗癌剤として有用なテトラヒドロキナゾリン誘導体
CN114409653A (zh) 一种桥环并嘧啶并环类化合物及其用途
WO2019042445A1 (zh) 一类具有抑制并降解布鲁顿酪氨酸蛋白激酶Btk活性的化合物
WO2019134539A1 (zh) 二氢吡唑酮并嘧啶类化合物及其制备方法和用途
JP6130600B2 (ja) トリサイクリックベンズオキサボロール化合物、その製造方法および用途
WO2016169421A1 (zh) 咪唑并异吲哚类衍生物、其制备方法及其在医药上的应用
JP2020529968A (ja) 置換５員および６員複素環式化合物、その調製方法、薬剤の組み合わせおよびその使用
JP2023513373A (ja) Ｐ２ｘ３修飾薬
US20120065170A1 (en) Antimicrobial Cyclocarbonyl Heterocyclic Compounds For Treatment Of Bacterial Infections
EP4289847A1 (en) Pim kinase inhibitor
EP4539936A1 (en) Prodrugs of stat3 inhibitors
US20200331887A1 (en) Indoleamine 2,3-dioxygenase inhibitors and use of same in medicine
JP2005530691A (ja) 新規なチロインジシンとその関連プロセス、薬学的組成物および方法
CN103214422B (zh) 一类新型取代胺基咪唑酮衍生物的制备方法及抗癌作用
CN116419753B (zh) 作为bcl-2抑制剂的杂环化合物
TW202313578A (zh) 雙環類化合物的製備方法及作為抗菌劑的應用
US20230116602A1 (en) Mcl1 inhibitors and uses thereof
JP2021011492A (ja) ４Ｈ−ピリド［１，２−ａ］ピリミジン−４−オン化合物
CN115304502B (zh) Foxm1抑制剂及其制备方法和应用
EP3717490A1 (en) Anti-bacterial heterocyclic compounds and their synthesis
CN113801135B (zh) 噻吩并吡唑类化合物，包含其的药物组合物及其用途

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151218

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20151218

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20160921

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20161004

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20161021

R150 Certificate of patent or registration of utility model

Ref document number: 6031122

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees