JP6011543B2 - 糖尿病、肥満および関連疾患の治療のためのgpr119モジュレーターとしての縮合ジヒドロフラン - Google Patents
糖尿病、肥満および関連疾患の治療のためのgpr119モジュレーターとしての縮合ジヒドロフラン Download PDFInfo
- Publication number
- JP6011543B2 JP6011543B2 JP2013543816A JP2013543816A JP6011543B2 JP 6011543 B2 JP6011543 B2 JP 6011543B2 JP 2013543816 A JP2013543816 A JP 2013543816A JP 2013543816 A JP2013543816 A JP 2013543816A JP 6011543 B2 JP6011543 B2 JP 6011543B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- piperidine
- dihydro
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- DHSVJKQZMXUZPB-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1C(C)(C1)Oc(cn2)c1cc2Cl)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1C(C)(C1)Oc(cn2)c1cc2Cl)=O DHSVJKQZMXUZPB-UHFFFAOYSA-N 0.000 description 1
- UIZVKQNUGBSIGA-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1C(C)(C1)Oc2c1cc(-c1ccc(CS(C)(=O)=O)cc1F)nc2)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1C(C)(C1)Oc2c1cc(-c1ccc(CS(C)(=O)=O)cc1F)nc2)=O UIZVKQNUGBSIGA-UHFFFAOYSA-N 0.000 description 1
- ICOQDFXFLUFJSG-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1C(C1)Oc(cc2)c1cc2Br)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1C(C1)Oc(cc2)c1cc2Br)=O ICOQDFXFLUFJSG-UHFFFAOYSA-N 0.000 description 1
- SIFJASGBCRJHRJ-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1C(C1)Oc2c1cc(-c(c(F)c1)ccc1S(C)(=O)=O)nc2)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1C(C1)Oc2c1cc(-c(c(F)c1)ccc1S(C)(=O)=O)nc2)=O SIFJASGBCRJHRJ-UHFFFAOYSA-N 0.000 description 1
- MNSTXTCYFOYKAE-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1C(C1)Oc2c1cc(-c1cnc[o]1)nc2)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1C(C1)Oc2c1cc(-c1cnc[o]1)nc2)=O MNSTXTCYFOYKAE-UHFFFAOYSA-N 0.000 description 1
- ZLLIBFJKXXPAQT-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1C(Cc1c2)Oc1cnc2-[n]1cncc1)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1C(Cc1c2)Oc1cnc2-[n]1cncc1)=O ZLLIBFJKXXPAQT-UHFFFAOYSA-N 0.000 description 1
- JGVNAKKLHCGAMA-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1c1cc(cc(-c(c(F)c2)ccc2S(C)(=O)=O)nc2)c2[o]1)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1c1cc(cc(-c(c(F)c2)ccc2S(C)(=O)=O)nc2)c2[o]1)=O JGVNAKKLHCGAMA-UHFFFAOYSA-N 0.000 description 1
- JHAUMLNWDJJAAD-UHFFFAOYSA-N CC(C)OC(N(CC1)CCC1C(C1)Oc(cc2)c1cc2-c(nc1)ccc1S(C)(=O)=O)=O Chemical compound CC(C)OC(N(CC1)CCC1C(C1)Oc(cc2)c1cc2-c(nc1)ccc1S(C)(=O)=O)=O JHAUMLNWDJJAAD-UHFFFAOYSA-N 0.000 description 1
- VMVOYOJAZRDMGM-UHFFFAOYSA-N CC(C)OC(N(CC1)CCC1C(C1)Oc(cc2)c1cc2-c1ccc(NC(C)=O)nn1)=O Chemical compound CC(C)OC(N(CC1)CCC1C(C1)Oc(cc2)c1cc2-c1ccc(NC(C)=O)nn1)=O VMVOYOJAZRDMGM-UHFFFAOYSA-N 0.000 description 1
- BOSVWISOESDXBE-UHFFFAOYSA-N CC(C)OC(N(CC1)CCC1C(C1)Oc2c1cc(C(CC1)=CCN1S(C)(=O)=O)nc2)=O Chemical compound CC(C)OC(N(CC1)CCC1C(C1)Oc2c1cc(C(CC1)=CCN1S(C)(=O)=O)nc2)=O BOSVWISOESDXBE-UHFFFAOYSA-N 0.000 description 1
- KPKVTYDGJLWILC-UHFFFAOYSA-N CC(C1)(C2CCNCC2)Oc2c1cc(-c(cc1)ccc1[SH2+2]C)nc2 Chemical compound CC(C1)(C2CCNCC2)Oc2c1cc(-c(cc1)ccc1[SH2+2]C)nc2 KPKVTYDGJLWILC-UHFFFAOYSA-N 0.000 description 1
- MUIOFFJMRCFAGL-UHFFFAOYSA-N CC1(CC1)OC(N(CC1)CCC1C(C1)Oc2c1cc(C(CC1)=CCN1S(C)(=O)=O)nc2)=O Chemical compound CC1(CC1)OC(N(CC1)CCC1C(C1)Oc2c1cc(C(CC1)=CCN1S(C)(=O)=O)nc2)=O MUIOFFJMRCFAGL-UHFFFAOYSA-N 0.000 description 1
- YOPPCFMQXJTPOZ-VWLOTQADSA-N CC1(CC1)OC(N(CC1)CCC1[C@](C)(C1)Oc2c1cc(-c(cc1)ccc1S(C)(=O)=O)nc2)=O Chemical compound CC1(CC1)OC(N(CC1)CCC1[C@](C)(C1)Oc2c1cc(-c(cc1)ccc1S(C)(=O)=O)nc2)=O YOPPCFMQXJTPOZ-VWLOTQADSA-N 0.000 description 1
- KEPJWNVAQRQSSA-UHFFFAOYSA-N CS(Cc(cc1)ccc1-c(nc1)cc(C2)c1OC2C(CC1)CCN1C(OC1CCC1)=O)(=O)=O Chemical compound CS(Cc(cc1)ccc1-c(nc1)cc(C2)c1OC2C(CC1)CCN1C(OC1CCC1)=O)(=O)=O KEPJWNVAQRQSSA-UHFFFAOYSA-N 0.000 description 1
- WSJHKZQZBBLRRG-UHFFFAOYSA-N CS(c(cc1)ccc1-c(nc1)cc(C2)c1OC2C1CCNCC1)(=O)=O Chemical compound CS(c(cc1)ccc1-c(nc1)cc(C2)c1OC2C1CCNCC1)(=O)=O WSJHKZQZBBLRRG-UHFFFAOYSA-N 0.000 description 1
- JPNDTPNCYOHHFX-UHFFFAOYSA-N Cc(cc(c(C#N)c1)F)c1F Chemical compound Cc(cc(c(C#N)c1)F)c1F JPNDTPNCYOHHFX-UHFFFAOYSA-N 0.000 description 1
- OKDUYWXZUOTFAI-UHFFFAOYSA-N Cc(cc1)c(C)cc1S(C)(=O)=O Chemical compound Cc(cc1)c(C)cc1S(C)(=O)=O OKDUYWXZUOTFAI-UHFFFAOYSA-N 0.000 description 1
- VCZNNAKNUVJVGX-UHFFFAOYSA-N Cc(cc1)ccc1C#N Chemical compound Cc(cc1)ccc1C#N VCZNNAKNUVJVGX-UHFFFAOYSA-N 0.000 description 1
- YYDNBUBMBZRNQQ-UHFFFAOYSA-N Cc(cc1)ccc1S(C)(=O)=O Chemical compound Cc(cc1)ccc1S(C)(=O)=O YYDNBUBMBZRNQQ-UHFFFAOYSA-N 0.000 description 1
- JXSMDKCYNPJOFK-UHFFFAOYSA-N Cc(cc1)cnc1S(C)(=O)=O Chemical compound Cc(cc1)cnc1S(C)(=O)=O JXSMDKCYNPJOFK-UHFFFAOYSA-N 0.000 description 1
- WCGNLBCJPBKXCN-UHFFFAOYSA-N Cc(cc1F)ccc1C#N Chemical compound Cc(cc1F)ccc1C#N WCGNLBCJPBKXCN-UHFFFAOYSA-N 0.000 description 1
- GHLKMUFOKGPMRY-UHFFFAOYSA-N Cc(cc1F)ccc1S(C)(=O)=O Chemical compound Cc(cc1F)ccc1S(C)(=O)=O GHLKMUFOKGPMRY-UHFFFAOYSA-N 0.000 description 1
- KUQQONVKIURIQU-UHFFFAOYSA-N Cc(ccc(C#N)c1)c1F Chemical compound Cc(ccc(C#N)c1)c1F KUQQONVKIURIQU-UHFFFAOYSA-N 0.000 description 1
- JVSGZPNRSFBICJ-UHFFFAOYSA-N Cc(ccc(S(C)(=O)=O)c1)c1F Chemical compound Cc(ccc(S(C)(=O)=O)c1)c1F JVSGZPNRSFBICJ-UHFFFAOYSA-N 0.000 description 1
- GHUZKFWDASVPEO-UHFFFAOYSA-N Cc(nc1)ccc1S(C)(=O)=O Chemical compound Cc(nc1)ccc1S(C)(=O)=O GHUZKFWDASVPEO-UHFFFAOYSA-N 0.000 description 1
- SEJKMIGLIXGOFY-UHFFFAOYSA-N Cc1c(C)ncc(S(C)(=O)=O)c1 Chemical compound Cc1c(C)ncc(S(C)(=O)=O)c1 SEJKMIGLIXGOFY-UHFFFAOYSA-N 0.000 description 1
- AIKUBOPKWKZULG-UHFFFAOYSA-N Cc1ccnnc1 Chemical compound Cc1ccnnc1 AIKUBOPKWKZULG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10195814.8 | 2010-12-17 | ||
| EP10195814 | 2010-12-17 | ||
| PCT/EP2011/073067 WO2012080476A1 (en) | 2010-12-17 | 2011-12-16 | Fused dihydropyrans as gpr119 modulators for the treatment of diabetes, obesity and related diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013545791A JP2013545791A (ja) | 2013-12-26 |
| JP2013545791A5 JP2013545791A5 (enExample) | 2015-02-05 |
| JP6011543B2 true JP6011543B2 (ja) | 2016-10-19 |
Family
ID=45470522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013543816A Active JP6011543B2 (ja) | 2010-12-17 | 2011-12-16 | 糖尿病、肥満および関連疾患の治療のためのgpr119モジュレーターとしての縮合ジヒドロフラン |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8669271B2 (enExample) |
| EP (1) | EP2651931B1 (enExample) |
| JP (1) | JP6011543B2 (enExample) |
| AR (1) | AR084349A1 (enExample) |
| UY (1) | UY33805A (enExample) |
| WO (1) | WO2012080476A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012530758A (ja) | 2009-06-24 | 2012-12-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規化合物、医薬組成物及びそれに関する方法 |
| UY33805A (es) | 2010-12-17 | 2012-07-31 | Boehringer Ingelheim Int | ?Derivados de dihidrobenzofuranil-piperidinilo, aza-dihidrobenzofuranilpiperidinilo y diaza-dihidrobenzofuranil-piperidinilo, composiciones farmacéuticas que los contienen y usos de los mismos?. |
| CN103443097A (zh) * | 2011-01-21 | 2013-12-11 | 勃林格殷格翰国际有限公司 | 作为gpr119调节剂用于治疗糖尿病、肥胖症以及相关病症的稠合的二氢呋喃化合物 |
| JP5935154B2 (ja) | 2011-03-14 | 2016-06-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Gpr119モジュレーターとしてのn−シクロプロピル−n−ピペリジニルベンズアミド |
| US8921398B2 (en) | 2011-06-09 | 2014-12-30 | Boehringer Ingelheim International Gmbh | N-cyclopropyl-N-piperidinyl-amide derivatives, pharmaceutical compositions and uses thereof |
| CN103958495B (zh) * | 2011-06-09 | 2018-06-22 | 理森制药股份公司 | 作为gpr-119的调节剂的化合物 |
| US8853239B2 (en) | 2011-12-09 | 2014-10-07 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
| US9012456B2 (en) * | 2012-02-28 | 2015-04-21 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
| US8809361B2 (en) * | 2012-05-07 | 2014-08-19 | Boehringer Ingelheim International Gmbh | 2,3-dihydrofuro[2,3-c]pyridines, their use as modulators of the G-protein-coupled receptor GPR119 and pharmaceutical compositions thereof |
| EP2858996B1 (en) | 2012-06-12 | 2016-12-07 | Boehringer Ingelheim International GmbH | 4-(2,3-Dihydro-furo[2,3-c]pyridin-2-yl)-piperidine-1-carboxylic acid ester derivatives as G-protein-coupled receptor 119 (GPR119) agonists for the treatment of metabolic disorders, such as diabetes, dyslipidemia and obesity |
| EP2872127A1 (en) | 2012-07-11 | 2015-05-20 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| US9668481B2 (en) | 2013-04-12 | 2017-06-06 | Bayer Cropscience Aktiengesellschaft | Triazole derivatives |
| US9822099B2 (en) | 2013-04-12 | 2017-11-21 | Bayer Cropscience Aktiengesellschaft | Triazole derivatives |
| JP2016522800A (ja) | 2013-04-12 | 2016-08-04 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 新規トリアゾリンチオン誘導体 |
| DK3105218T3 (da) | 2014-02-13 | 2019-11-04 | Incyte Corp | Cyclopropylaminer som lsd1-inhibitorer |
| TWI720451B (zh) | 2014-02-13 | 2021-03-01 | 美商英塞特控股公司 | 作為lsd1抑制劑之環丙胺 |
| TW201613860A (en) | 2014-02-13 | 2016-04-16 | Incyte Corp | Cyclopropylamines as LSD1 inhibitors |
| US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
| US9695168B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors |
| WO2016007722A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
| WO2016007736A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Imidazopyrazines as lsd1 inhibitors |
| WO2016007727A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
| WO2016156294A1 (en) | 2015-04-02 | 2016-10-06 | Bayer Cropscience Aktiengesellschaft | Triazol derivatives as fungicides |
| PE20180455A1 (es) | 2015-04-03 | 2018-03-05 | Incyte Corp | Compuestos heterociclicos como inhibidores de lsd1 |
| UA126277C2 (uk) | 2015-08-12 | 2022-09-14 | Інсайт Корпорейшн | Солі інгібітору lsd1 |
| US10208030B2 (en) | 2016-04-08 | 2019-02-19 | Mankind Pharma Ltd. | GPR119 agonist compounds |
| US10526345B2 (en) * | 2016-04-08 | 2020-01-07 | Mankind Pharma Ltd. | Compounds as GPR119 agonists |
| US10954229B2 (en) | 2016-04-08 | 2021-03-23 | Mankind Pharma Ltd. | GPR119 agonist compounds |
| MA44725A (fr) | 2016-04-22 | 2019-02-27 | Incyte Corp | Formulations d'un inhibiteur de lsd1 |
| WO2020047198A1 (en) | 2018-08-31 | 2020-03-05 | Incyte Corporation | Salts of an lsd1 inhibitor and processes for preparing the same |
| JP7745559B2 (ja) | 2020-02-28 | 2025-09-29 | キャリーオペ,インク. | Gpr40アゴニスト |
| CA3178994A1 (en) | 2020-05-19 | 2021-11-25 | Iyassu Sebhat | Ampk activators |
| CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008545008A (ja) * | 2005-06-30 | 2008-12-11 | プロシディオン・リミテッド | Gpcrアゴニスト |
| AU2007291252A1 (en) * | 2006-08-30 | 2008-03-06 | Inovacia Ab | Pyridine compounds for treating GPR119 related disorders |
| BRPI0719941A2 (pt) * | 2006-12-06 | 2014-04-22 | Smithkline Beecham Corp | Composto, uso de um composto, método para o tratamento de distúrbios ou condições metabólicos, composição farmacêutica, e, processo para a preparação de uma composição farmacêutica |
| JP2010526145A (ja) * | 2007-05-04 | 2010-07-29 | ブリストル−マイヤーズ スクイブ カンパニー | [6,6]および[6,7]−二環式gpr119gタンパク質結合受容体アゴニスト |
| US8093257B2 (en) * | 2007-05-04 | 2012-01-10 | Bristol-Myers Squibb Company | [6,5]-bicyclic GPR119 G protein-coupled receptor agonists |
| EP2197873B1 (en) * | 2007-09-20 | 2014-07-16 | Irm Llc | Compounds and compositions as modulators of gpr119 activity |
| WO2009106565A1 (en) * | 2008-02-27 | 2009-09-03 | Biovitrum Ab (Publ) | Agonists of gpr119 |
| WO2009150144A1 (en) * | 2008-06-10 | 2009-12-17 | Inovacia Ab | New gpr119modulators |
| EP2390254A1 (en) * | 2009-01-22 | 2011-11-30 | Mitsubishi Tanabe Pharma Corporation | NOVEL PYRROLOÝ2,3-d¨PYRIMIDINE COMPOUND |
| US8410089B2 (en) * | 2009-02-18 | 2013-04-02 | Takeda Pharmaceutical Company Limited | Fused heterocyclic ring compound |
| JP2012530758A (ja) | 2009-06-24 | 2012-12-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規化合物、医薬組成物及びそれに関する方法 |
| US8293729B2 (en) | 2009-06-24 | 2012-10-23 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical composition and methods relating thereto |
| US8729084B2 (en) | 2010-05-06 | 2014-05-20 | Bristol-Myers Squibb Company | Benzofuranyl analogues as GPR119 modulators |
| US8772323B2 (en) | 2010-05-07 | 2014-07-08 | Boehringer Ingelheim International Gmbh | Benzoxazole- and tetrahydrobenzoxazole-substituted pyridazinones as GPR119 agonists |
| UY33805A (es) | 2010-12-17 | 2012-07-31 | Boehringer Ingelheim Int | ?Derivados de dihidrobenzofuranil-piperidinilo, aza-dihidrobenzofuranilpiperidinilo y diaza-dihidrobenzofuranil-piperidinilo, composiciones farmacéuticas que los contienen y usos de los mismos?. |
| CN103443097A (zh) | 2011-01-21 | 2013-12-11 | 勃林格殷格翰国际有限公司 | 作为gpr119调节剂用于治疗糖尿病、肥胖症以及相关病症的稠合的二氢呋喃化合物 |
| JP5935154B2 (ja) | 2011-03-14 | 2016-06-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Gpr119モジュレーターとしてのn−シクロプロピル−n−ピペリジニルベンズアミド |
-
2011
- 2011-12-15 UY UY0001033805A patent/UY33805A/es not_active Application Discontinuation
- 2011-12-16 WO PCT/EP2011/073067 patent/WO2012080476A1/en not_active Ceased
- 2011-12-16 AR ARP110104756A patent/AR084349A1/es unknown
- 2011-12-16 JP JP2013543816A patent/JP6011543B2/ja active Active
- 2011-12-16 US US13/327,823 patent/US8669271B2/en active Active
- 2011-12-16 EP EP11807666.0A patent/EP2651931B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2651931B1 (en) | 2015-08-19 |
| WO2012080476A1 (en) | 2012-06-21 |
| US8669271B2 (en) | 2014-03-11 |
| JP2013545791A (ja) | 2013-12-26 |
| EP2651931A1 (en) | 2013-10-23 |
| US20120322784A1 (en) | 2012-12-20 |
| AR084349A1 (es) | 2013-05-08 |
| UY33805A (es) | 2012-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6011543B2 (ja) | 糖尿病、肥満および関連疾患の治療のためのgpr119モジュレーターとしての縮合ジヒドロフラン | |
| JP5703393B2 (ja) | 糖尿病、肥満および関連障害の治療のためのgpr119モジュレーターとしての縮合ジヒドロフラン | |
| JP5935154B2 (ja) | Gpr119モジュレーターとしてのn−シクロプロピル−n−ピペリジニルベンズアミド | |
| JP6094578B2 (ja) | 代謝性障害の治療のためのgpr119モジュレーターとしての置換ピペリジン | |
| WO2011093501A1 (ja) | Gpr119作動薬 | |
| JP6066126B2 (ja) | 新規化合物、医薬組成物及びその使用 | |
| JP6136032B2 (ja) | 新規な2,3−ジヒドロ−フロ[2,3−c]ピリジン、Gタンパク質共役受容体GPR119のモジュレーターとしてのそれらの使用、及びそれらを含む医薬組成物 | |
| JP6263789B2 (ja) | N−シクロプロピル−n−ピペリジニル−アミド、これらを含有する医薬組成物およびその使用 | |
| JP6119088B2 (ja) | 2,3−ジヒドロ−フロ[2,3−c]ピリジン−2−イル−ピペリジン誘導体、それらを含む医薬組成物及びその使用 | |
| JP6119081B2 (ja) | Gpr119に対するフロ[2,3−c]ピリジン活性物質 | |
| TW201305144A (zh) | 新穎化合物、醫藥組合物及其用途 | |
| JP2015523404A (ja) | N−シクロプロピル−n−ピペリジニル−アミド、これらを含有する医薬組成物およびその使用 | |
| OA16478A (en) | Fused dihydrofurans as GPR119 modulators for the treatment of diabetes, obesity and related disorders. | |
| TW201249837A (en) | New compounds, pharmaceutical compositions and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20141212 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20141212 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20150806 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150812 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20151111 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20151210 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160112 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160412 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160516 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160804 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20160829 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20160905 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6011543 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |