JP6010227B2 - 細胞質残留性細胞膜透過ペプチド及びポリエチレングリコールが結合されたインターフェロン−α融合タンパク質 - Google Patents
細胞質残留性細胞膜透過ペプチド及びポリエチレングリコールが結合されたインターフェロン−α融合タンパク質 Download PDFInfo
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
Landscapes
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- Chemical & Material Sciences (AREA)
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- Toxicology (AREA)
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- Biomedical Technology (AREA)
- Peptides Or Proteins (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2012-0088610 | 2012-08-13 | ||
| KR20120088610 | 2012-08-13 | ||
| PCT/KR2013/007136 WO2014027789A1 (ko) | 2012-08-13 | 2013-08-07 | 세포질 잔류성 세포막 투과 펩타이드 및 폴리에틸렌글리콜이 결합된 인터페론 알파 융합 단백질 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015526084A JP2015526084A (ja) | 2015-09-10 |
| JP6010227B2 true JP6010227B2 (ja) | 2016-10-19 |
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| US (1) | US9682152B2 (enExample) |
| JP (1) | JP6010227B2 (enExample) |
| KR (1) | KR102012025B1 (enExample) |
| CN (1) | CN104583240B (enExample) |
| IN (1) | IN2015DN01371A (enExample) |
| WO (1) | WO2014027789A1 (enExample) |
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| CN104987381B (zh) * | 2015-06-11 | 2018-11-27 | 吉林大学 | 重组正电荷多肽干扰素及在抗肿瘤和抗病毒治疗中的应用 |
| WO2021062181A1 (en) * | 2019-09-26 | 2021-04-01 | Orionis Biosciences, Inc. | Conjugated chimeric proteins |
| KR20230099956A (ko) * | 2021-12-28 | 2023-07-05 | 제이더블유크레아젠 주식회사 | 면역세포에 항원을 전달하기 위한 폴리펩타이드 |
| CN114853911B (zh) * | 2022-05-23 | 2024-06-28 | 复旦大学 | 三叶因子2/干扰素α2融合蛋白及其防治病毒感染性疾病的应用 |
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| ATE441661T1 (de) * | 2002-03-29 | 2009-09-15 | Creagene Inc | Zytoplasmatische transduktionspeptide und deren verwendungen |
| RU2008109649A (ru) * | 2005-08-15 | 2009-09-27 | Ф.Хоффманн-Ля Рош Аг (Ch) | ПЭГ-IFNα И РИБАВИРИН ДЛЯ ЛЕЧЕНИЯ ВИРУСА ГЕПАТИТА В |
| JP2010529859A (ja) * | 2007-06-15 | 2010-09-02 | ジェンザイム、コーポレーション | ＴＧＦ−βＩＩ型受容体の２つのＴＧＦ−β結合ドメインを含有する融合タンパク質 |
| US20090286725A1 (en) * | 2008-05-15 | 2009-11-19 | Fibrex Medical Research & Development Gmbh | Peptides and derivatives thereof, the manufacturing thereof as well as their use for preparing a therapeutically and/or preventively active pharmaceutical composition |
| KR101183826B1 (ko) * | 2009-03-27 | 2012-09-18 | 제이더블유중외제약 주식회사 | 인터페론-알파 및 세포질 잔류성 세포막 투과 펩타이드를 포함하는 ＩＦＮ-α 융합 단백질 |
| EP2412730B1 (en) * | 2009-03-27 | 2014-09-10 | JW Pharmaceutical Corporation | Interferon-alpha (ifn-alpha ) fused protein having ifn-alpha and cytoplasmic transduction peptide (ctp) |
| CN101942026B (zh) * | 2010-10-14 | 2014-08-27 | 成都正能生物技术有限责任公司 | 长效干扰素融合蛋白及其用途 |
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- 2013-08-07 JP JP2015527364A patent/JP6010227B2/ja not_active Expired - Fee Related
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- 2013-08-07 KR KR1020157006439A patent/KR102012025B1/ko not_active Expired - Fee Related
- 2013-08-07 IN IN1371DEN2015 patent/IN2015DN01371A/en unknown
- 2013-08-07 WO PCT/KR2013/007136 patent/WO2014027789A1/ko not_active Ceased
Also Published As
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|---|---|
| CN104583240A (zh) | 2015-04-29 |
| IN2015DN01371A (enExample) | 2015-07-03 |
| KR102012025B1 (ko) | 2019-08-19 |
| JP2015526084A (ja) | 2015-09-10 |
| US20150202312A1 (en) | 2015-07-23 |
| KR20150063375A (ko) | 2015-06-09 |
| US9682152B2 (en) | 2017-06-20 |
| WO2014027789A1 (ko) | 2014-02-20 |
| CN104583240B (zh) | 2017-11-28 |
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