JP6008457B1 - 処置後皮膚手当系、組成物、及びその使用方法 - Google Patents
処置後皮膚手当系、組成物、及びその使用方法 Download PDFInfo
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- JP6008457B1 JP6008457B1 JP2016113662A JP2016113662A JP6008457B1 JP 6008457 B1 JP6008457 B1 JP 6008457B1 JP 2016113662 A JP2016113662 A JP 2016113662A JP 2016113662 A JP2016113662 A JP 2016113662A JP 6008457 B1 JP6008457 B1 JP 6008457B1
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Abstract
Description
本明細書で使用する用語「約」とは、この用語が使用される状況によってある程度変動する、分量、レベル、値、寸法、大きさ、又は量を指す。たとえば、そのような変動は、5%程度までとすることができる。少なくとも、各数値的パラメーターは、報告された有効桁数を踏まえ、通常の四捨五入技術を適用して解釈することができる。
たとえば、ここに記載する局所用生体適合性組成物として、たとえば、収斂剤溶液粉末、局所用無痛化組成物、及び表皮修復組成物を含む、局所用治癒組成物を挙げることができる。
ここに記載する局所用創傷治癒組成物は、任意の形態で提供してもよい。たとえば、局所用創傷治癒組成物は、水と混合されると溶液となる、流動性のある水溶性粉末の形で提供することができる。溶液は、弱った皮膚に適用されると、刺激を鎮め、炎症を軽減し、痂皮化を防ぐ、及び/又は処置後反応を予防し、若しくは回復させることができる。
局所用無痛化組成物は、多機能の保湿及び脂質補充を実現して、崩壊したバリア機能又は他の状況の弱った皮膚を元に戻す軟膏にすることができる。局所用無痛化組成物は、たとえば、炎症応答を抑えて治癒/回復プロセスの間の快適度を改善しうる抗刺激剤でもよい。加えて、局所用無痛化組成物は、弱った又は露出した皮膚を環境の攻撃要素から保護するものでもよい。
表皮/真皮修復組成物は、弱った皮膚の症状を修復する、治療する、又は回復させることができる。
ここに記載する局所用生体適合性組成物は、局所用創傷治癒組成物、局所用無痛化組成物、及び表皮/真皮修復組成物を含む。本明細書では、皮膚状態を治療するための生体適合性組成物の使用方法も提供される。本組成物の局所投与によって治療することのできる非限定的な状態には、限定はしないが、弱った皮膚、処置後皮膚、皮膚刺激、皮膚炎症、皮膚損傷、皮膚の熱傷、及び皮膚日焼けの1つ又は複数が含まれる。
ここに記載する生体適合性局所用組成物は、任意の形で局所投与してもよい。十分な量の局所用組成物は、たとえば、患部を取り囲む周辺の健康な皮膚又は組織を加えて、可能なら、たとえば、約0.5インチの余裕をもって、患部を覆うのに十分な量で、患部及び周囲の皮膚に適用することができる。組成物は、たとえば、顔面の皮膚、並びに手、首、及び/又は胸の皮膚を含めて、任意の皮膚表面に適用できる。
A.製剤
本案件に従い、局所用治癒組成物を、以下の表1に示すとおりに製剤化した。
上述の収斂剤を調製するために、乾燥粉末形態の原材料を、以下の表2に示す量で合わせ、均質な混合物が得られるまで原材料を混合することにより、1,000ポンドのバルク混合物を調製する。均質な混合物が得られたら、塊をばらすために、均質なバルク混合物をメッシュスクリーンでふるいにかけてもよい。
A.製剤
本案件に従い、局所用無痛化組成物を、以下の表4に示すとおりに製剤化した。
上述の局所用無痛化組成物を調製するために、以下に示す表5のA部に示す原材料を、主混合容器に入れて合わせ、中身を約70℃に加熱することにより、1,000ポンドのバルク混合物を調製した。加熱された製品を、得られる混合製品が均質になるまで撹拌する。別個のタンクにおいて、表5のB部に挙げる原材料を合わせ、約70℃に加熱する。加熱されたら、B部の原材料を含む別個のタンクの中身を、主混合容器に加え、滑らかで均質になるまで、15分間均質化する。混合物を45℃に冷却する。A部及びB部からの原材料を含む主混合容器に、C部に挙げる原材料を、いずれかの順序で、又は挙げられた特定の順序で加える。C部からの各原材料は、混合/撹拌しながら加え、滑らかで均質になるまでよく混合する。混合物を35℃に冷却する。
A.製剤
本案件に従い、表皮/真皮修復クリームを、以下の表7に示す次のものを有するように製剤化した。
上述の表皮/真皮修復クリームを調製するために、第一の容器においてカルボポール(Carbopol)を水和させた。A部に挙げた残りの原材料を主容器に加え、約75℃に加熱し、均質になるまで混合した。第二の容器において、B部に挙げた原材料を合わせ、約75℃に加熱し、完全に融解し均質になるまで混合した。第二の容器からの混合物を第一の容器に加え、得られる混合物を均質になるまで混合した。C部に挙げた原材料を第一の容器の混合物に加え、均質になるまで約20分間混合した。得られる混合物を45℃に冷却した。45℃に到達したら、D部に挙げた原材料を、第一の容器の混合物に加えた。原材料は、挙げられた順序で加え、各原材料を加えた後、実質的に均質になるまで混合物をよく混合した。均質になったら、得られる混合物を35℃に冷却した。
本組成物及びキットの有効性を評価するために、本組成物及び方法を、処置後の治癒について、以前より知られている組成物と比較する、対照分析を行った。詳細には、25%トリクロル酢酸(「TCA」)剥離の後、50才の女性患者に、本案件による組成物を自身の顔面の右側に、比較用組成物を自身の顔面の左側に適用するように指導した。
Claims (10)
- 局所用創傷治癒組成物の重量を基準として、40.0重量%〜55.0重量%の量で存在する硫酸アルミニウム14水和物と、
局所用創傷治癒組成物の重量を基準として、28.0重量%〜39.0重量%の量で存在する酢酸カルシウム一水和物と、
局所用創傷治癒組成物の重量を基準として、0.01重量%〜20重量%の量で存在するアヴェナ・サティバ穀粒タンパク質と、
局所用創傷治癒組成物の重量を基準として、0.01重量%〜20重量%の量のダイズタンパク質と、
局所用創傷治癒組成物の重量を基準として、0.01重量%〜20重量%の量で存在するホエータンパク質と、
局所用創傷治癒組成物の重量を基準として、0.25重量%〜50重量%の量で存在するキトサンと、
局所用創傷治癒組成物の重量を基準として、0.25重量%〜10重量%の量で存在するソルビン酸カリウムと、
局所用創傷治癒組成物の重量を基準として、5重量%〜50重量%の量で存在するデキストリンと
から本質的になる、局所用創傷治癒組成物。 - アヴェナ・サティバ穀粒タンパク質が、創傷治癒組成物の重量を基準として、1.5重量%〜4.5重量%の量で存在する、請求項1に記載の創傷治癒組成物。
- ダイズタンパク質が、創傷治癒組成物の重量を基準として、0.5重量%〜2.5重量%の量で存在する、請求項1に記載の創傷治癒組成物。
- ホエータンパク質が、創傷治癒組成物の重量を基準として、0.25重量%〜1.75重量%の量で存在する、請求項1に記載の創傷治癒組成物。
- キトサンが、創傷治癒組成物の重量を基準として、0.25重量%〜1.75重量%の量で存在する、請求項1に記載の創傷治癒組成物。
- 請求項1に記載の局所用創傷治癒組成物を含む、流動性のある水溶性粉末。
- 請求項1に記載の局所用創傷治癒組成物を含む溶液。
- 請求項1に記載の創傷治癒組成物を含む、クリーム、ローション、軟膏、フォーム、エアロゾル、粉末、溶液、乳濁液、及びセラムからなる群から選択される外用剤。
- グルテン、シリカ、EU26香料アレルゲン、パラベン、ホルムアルデヒド放出性保存剤、成長因子、又はビタミンDの1種又は複数を含まない、請求項1に記載の局所用創傷治癒組成物。
- 請求項1に記載の局所用創傷治癒組成物を含むキット。
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CN103110935B (zh) * | 2013-01-25 | 2014-06-11 | 江苏圣宝罗药业有限公司 | 皮肤局部用水解胶原蛋白脂质体及其制备方法 |
CN103405353A (zh) * | 2013-07-18 | 2013-11-27 | 石磊 | 一种皮肤外用贴膜及其密集渗透生产技术 |
CN103784372B (zh) * | 2014-02-19 | 2016-05-11 | 北京德喜天地科贸有限公司 | 一种含有壳聚糖的化妆品 |
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BR102016015576A2 (pt) | 2017-01-31 |
IL246763A (en) | 2017-01-31 |
MX353942B (es) | 2018-02-07 |
EP3124033A1 (en) | 2017-02-01 |
US9248160B1 (en) | 2016-02-02 |
CN106390093A (zh) | 2017-02-15 |
MX2016009852A (es) | 2017-02-20 |
RU2640504C2 (ru) | 2018-01-09 |
JP2017031135A (ja) | 2017-02-09 |
CA2935916A1 (en) | 2016-10-21 |
RU2016122026A (ru) | 2017-12-07 |
CN106390093B (zh) | 2019-04-05 |
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