JP5997387B2 - 少なくとも1つの熱的弾性感覚剤を含む皮膚係合部材 - Google Patents
少なくとも1つの熱的弾性感覚剤を含む皮膚係合部材 Download PDFInfo
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- JP5997387B2 JP5997387B2 JP2015533294A JP2015533294A JP5997387B2 JP 5997387 B2 JP5997387 B2 JP 5997387B2 JP 2015533294 A JP2015533294 A JP 2015533294A JP 2015533294 A JP2015533294 A JP 2015533294A JP 5997387 B2 JP5997387 B2 JP 5997387B2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A61Q9/02—Shaving preparations
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26B—HAND-HELD CUTTING TOOLS NOT OTHERWISE PROVIDED FOR
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- A—HUMAN NECESSITIES
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Description
冷涼又は冷たいという感覚は、低温又は化学冷感剤などの刺激による末梢神経繊維での受容体の活性化によるものであり、これは脳へ移動する電気化学信号を作り出し、次いで到着信号を解釈し、整理し、知覚又は感覚に統合するということは、今や広く確立されている。異なる部類の受容体が、哺乳類の知覚神経繊維において冷温又は化学冷感剤の刺激を感じることに関係していると見なされてきた。それらの受容体のうち、寒冷を感知することに関与する主要な候補は、寒冷感受性及びメントール感受性の受容体(CMR1)又はTRPM8であることが特定されかつ指定されている。受容体のTRPM8という専門用語は、低温、メントール、及びその他の化学冷感剤を含む刺激により活性化される一過性受容体電位(TRP)ファミリーの非選択的カチオンチャネルとしてのその特徴付けから来ている。しかしながら、皮膚又は口腔表面上での心地よい冷涼感の知覚に潜在する正確な機構は、現在明確には理解されていない。TRPM8受容体がメントール及びその他の冷感剤により活性化されることが立証されている一方で、知覚される全体的な感覚が心地よく、冷涼感があり、清涼であるために、他のどの受容体が関与している可能性があり、それらの受容体がどの程度刺激される又は場合によっては抑制される必要があるのかについては、完全には理解されていない。感覚剤は、様々な出願に記載されてきた。例えば、米国特許出願公開第2010/0086498号を参照のこと。
a.メンタンカルボン酸−N−(4−メトキシフェニル)−アミド
いくつかの好ましい実施形態では、熱的弾性感覚剤は、特に以下の式Iで表わされるN−置換メンタンカルボキサミドも含む。
いくつかの実施形態では、皮膚係合部材は、上記で開示された熱的弾性感覚剤以外の1つ以上の追加の感覚剤を更に含む。例えば、メントールは冷感剤として広く使用されているが、メントールは、刺痛感、灼熱感、穿痛感、及び刺すような感覚、並びにミントの匂い及び苦い味を含むその他の感覚も生じさせ得る。従って、メントールは、寒冷、温熱、痛み及び味覚受容体を含む多くの異なる受容体に作用することが推測される。しかしながら、苦味又は刺激等の望ましくない感覚のない心地よい冷涼感等の特定の感覚をどの受容体活性がもたらすかの分離方法は容易には識別できない。特定の感覚剤の使用から望ましい感覚だけが引き出されるように冷感剤又はその他の感覚剤の活性をどのように制御するかも明らかではない。このようにして、本発明は、除毛工程の間にユーザーに対して冷涼効果を提供するための感覚剤として機能する、シクロヘキサン(上述)の特定の合成誘導体の追加に注目する。冷涼感を更に補うために、追加の感覚剤を使用することができる。
皮膚係合部材は、熱的弾性感覚剤が存在する範囲内でマトリックス材料を更に含む。マトリックス材料は、様々な形であることができ、それらの混合物/組み合わせでもよい。
いくつかの実施形態では、マトリックスは、水溶性ポリマー、例えばポリエチレンオキシド、ポリビニルピロリドン、ポリアクリルアミド、ポリヒドロキシメタクリレート、ポリビニルイミダゾリン、ポリエチレングリコール、ポリビニルアルコール、ポリヒドロキシエチルメタクリレート、シリコーンポリマー、及びこれらの混合物を含む。いくつかの実施形態では、かかる水溶性ポリマーは、ポリエチレンオキシド、ポリエチレングリコール、及びこれらの混合物からなる群から選択される。
他の実施形態において、マトリックス材料は、少なくとも1つの皮膚軟化剤を含む。いくつかの実施形態では、皮膚軟化剤には疎水性がある。所定の実施形態において、組成物は、本質的に1つ以上の皮膚軟化剤から構成されてもよく、25℃で流体を形成し得る。皮膚軟化剤が流体形態の場合、流体は好ましくは以下に開示するように皮膚係合リザーバ内に含有される。そのような実施形態では、組成物粘度に応じて、様々な開口部のサイズは、使用中に皮膚軟化剤の投与を制御するために使用されてもよい。
マトリックス材料は、石鹸基剤、すなわち、少なくとも1つの石鹸又は断続性の石鹸、例えば、流入石鹸基剤又は押出成形石鹸基剤を含んでもよい。石鹸基剤の基本的な構成要素は、基剤を形成する鹸化若しくは中和された植物油又は獣脂であってもよく、あるいは合成流入石鹸基剤であってもよい。また、ココナツ酸又は他の脂肪酸の過脂肪材料含有部分(例えば、約25重量%を超える)が使用されてもよい。いくつかの実施形態では、マトリックス材料は、鹸化若しくは中和された植物油又は獣脂等、又は前述の材料の組み合わせを含む、基材を含む。植物油若しくは獣脂の鹸化又は中和は、基剤を形成する脂肪酸のグリセロール及び塩の生成をもたらす。マトリックスは、約50重量%〜約100重量%の鹸化又は中和された基材(例えば、約75重量%〜約100重量%鹸化又は中和された基材)を含むことができ、不透明、半透明、又は透明であってよい。生成され得る例示的な脂肪酸の塩には、最大で約22個の炭素原子を有する、カルボン酸ナトリウム塩が挙げられる。
いくつかの実施形態では、皮膚係合部材は、担体を更に含み、マトリックス、感覚剤及び他の任意の材料は、担体内及び/又は担体上に含有されてもよい。担体は、マトリックス材料及び封入状有効成分が適用されるトレーの形状であってよく、又は担体は、マトリックス及び封入された材料を少なくとも部分的に含有する保持構造を形成してよい。いくつかの実施形態では、担体は、例えば担体及び皮膚間に直接接触して又はせずに皮膚へ剃毛補助剤が投与されるリザーバ、及び米国特許第6,298,558号及び同第7,581,318号で開示されたシース等を形成する。特に、マトリックス材料が、汎用的であるが、流体形態中に皮膚軟化剤を含む場合、担体は、好ましくは皮膚係合部材の1つ以上の材料の投与を管理するための1つ以上の投与開口部を有するシースである。皮膚係合部材の構成に関するとき、本明細書で定義される重量パーセントは、特に定めがない限り、担体ではなく本明細書で開示される皮膚係合部材の他の構成要素に基づいて決定される。
i.任意の冷感剤
マトリックス材料は、未封入の不揮発性冷涼剤又は皮膚鎮静剤のシクロデキストリンとの包接錯体を、好ましくは皮膚係合部材の最大約25重量%、最も好ましくは約10重量%〜約20重量%の量で更に含んでもよい。本明細書で用いるとき「未封入」とは、追加の有効成分が封入体の外側に存在し、マトリックス材料の残部内に分散されていることを意味する。不揮発性冷感剤は、皮膚への生理学的冷涼効果を有し、メントールより揮発性がかなり低い作用剤を意味する。好ましくは、不揮発性冷感剤は、熱重量分析(例えば、Dupontの951 Thermogravimetric Analyzerを1分あたり20℃の温度上昇で使用)にかけると、160℃の温度において初期重量の少なくとも約50%、更に好ましくは160℃の温度において初期重量の少なくとも約80%、最も好ましくは175℃の温度において初期重量の少なくとも約50%を保持するものである。
いくつかの実施形態では、本発明の皮膚係合部材は、少なくとも1つの封入状有効成分を更に含む。封入状有効成分は、(例えば)熱的弾性感覚剤、追加の感覚剤、芳香剤又は他のスキンケア有効成分又は組成物であってもよい。いくつかの実施形態では、かかる少なくとも1つの封入状有効成分の濃度(カプセル及び封入状有効成分の重量を含む)は、かかる皮膚係合部材の約0.01重量%〜約50重量%、あるいは約10重量%〜45重量%、あるいは約15重量%〜約35重量%である。封入状有効成分は、同一の成分又は異なる成分を含有することができる。また、封入状有効成分は、成分の混合物を含むこともできる。
局所適用に一般的に使用される様々なスキンケア有効成分(「複数の活性剤」)は、未封入の生成物として及び/又は封入状態で、皮膚係合部材の中に含まれてもよい。
発明のいくつかの実施形態によると、除毛装置は、通常除毛ヘッド並びに柄又はグリップ部分を含み、除毛ヘッドが装着されているところに設けられている。除毛装置は、手動又は電動であってよく、湿式及び/又は乾燥用途で用いてよい。除毛装置は、脱毛剤と共に使用される除毛装置等の幅広い掻き取り表面を含んでもよく、又は装置が剃毛かみそりの場合、かみそりカートリッジであってよい。除毛ヘッドは、取り替え可能及び/又は駆動可能にカートリッジ連結構造体へ、そして順番に又は独立して(例えば、完全に固定して)柄に接続される。いくつかの実施形態では、カートリッジ連結構造体は、除毛ヘッドを解除可能に係合するために少なくとも1つのアームを含む。
本発明の皮膚係合部材は、射出成形、押型成型、含浸処理、スプレーコーティング、カレンダー加工及び押出成形、又はそそのようなステップの組み合わせを含む、任意の適切な方法によって作成されてもよい。熱的弾性感覚剤を含むストリップの組成物の全ては、成形又は押出成形の前に配合されてもよい。最良の結果として、構成成分は乾燥していることが好ましい。
図1及び図2を参照して、かみそりカートリッジ(除毛ヘッドの例)14は、ハウジング16を含み、これは3つのブレード18、フィン付きエラストマーガード20、及びカートリッジの皮膚係合部分(この場合はキャップ)上に配置された皮膚係合部材22と、を含む。皮膚係合部材22は2層を有するように表示され、第1の層はマトリックス及び本発明の封入状有効成分であってよく、第2の層は、従来の剃毛補助剤、又はその逆であってよい。皮膚係合部材は、カートリッジ後部の開口部の中に(接着剤、嵌合具、又は溶融結合により)好ましくは固定される。図3に示す皮膚係合部材32は、皮膚係合部材32が全体的に均質な組成物及び均一でわずかに湾曲した平坦上面を有すること以外は、皮膚係合部材22と同様である。この種の皮膚係合部材も、楔形状断面又は他の任意の所望する形状で作成してもよい。皮膚係合部材は、サンドイッチ又はシース/コア構成体等、2つ以上の層で構成されてもよい。
Claims (13)
- 除毛装置であって、
a.除毛ヘッド(14)と、
b.前記カートリッジ上に位置する1つ以上の伸長縁部(18)と、
c.前記カートリッジ上に位置する皮膚係合部材と、
を含み、前記皮膚係合部材(22)が、
a.ポリエチレンオキシド、ポリビニルピロリドン、ポリアクリルアミド、ポリヒドロキシメタクリレート、ポリビニルイミダゾリン、ポリエチレングリコール、ポリビニルアルコール、ポリヒドロキシエチルメタクリレート、シリコーンポリマー、及びこれらの混合物から選択される水溶性ポリマー、皮膚軟化剤、石鹸基剤、及びこれらの混合物の少なくとも1つを含むマトリックスと、
b.以下の式
を含む、除毛装置。 - 前記熱的弾性感覚剤が、以下の式
- Xが4位にあるか、好ましくはXが4位にあり、かつY及びZが、H、OH、Me又はOMeである、請求項3に記載の除毛装置。
- L−メントール、p−メンタン−3,8−ジオール、イソプレゴール、メントキシプロパン−1,2,−ジオール、クルクミン、メンチルラクテート(Symrise製Frescolat ML等)、ジンゲロール、イシリン、茶木油、サリチル酸メチル、樟脳、ペパーミント油、N−エチル−p−メンタン−3−カルボキサミド、エチル3−(p−メンタン−3−カルボキサミド)アセテート、2−イソプロピル−N,2,3−トリメチルブチルアミド、メントングリセロールケタール、メントングリセリンアセタール、及びこれらの混合物、からなる群から選択される追加の冷感剤を更に含み、好ましくは前記追加の冷感剤が、メントールとメンチルラクテートの混合物であり、更に好ましくは重量比が1:4〜4:1であるメントールとメンチルラクテートの混合物である、請求項1〜5のいずれか一項に記載の除毛装置。
- 前記熱的弾性感覚剤の濃度が、前記皮膚係合部材の0.01重量%〜25重量%である、請求項1〜6のいずれか一項に記載の除毛装置。
- 前記水溶性ポリマーが、前記マトリックスの約50重量%〜約90重量%の濃度で存在する、請求項1〜7のいずれか一項に記載の除毛装置。
- 前記マトリックスが、非水溶性ポリマーを更に含み、好ましくは前記非水溶性ポリマーが、ポリエチレン、ポリプロピレン、ポリスチレン、耐衝撃性ポリスチレン、ブタジエンスチレンコポリマー、ポリアセタール、アクリロニトリル−ブタジエンスチレンコポリマー、エチレン酢酸ビニルコポリマー、及びこれらの混合物の少なくとも1つを含み、前記非水溶性ポリマーが、好ましくは前記皮膚係合部材の5重量%〜40重量%、好ましくは15重量%〜35重量%の濃度で存在する、請求項1〜8のいずれか一項に記載の除毛装置。
- 前記カートリッジに位置する第2の皮膚係合部材を更に含み、前記第2の皮膚係合部材が、請求項1〜9のいずれか一項に記載する皮膚係合部材であるか、又は
a.ポリエチレンオキシド、ポリビニルピロリドン、ポリアクリルアミド、ポリヒドロキシメタクリレート、ポリビニルイミダゾリン、ポリエチレングリコール、ポリビニルアルコール、ポリヒドロキシエチルメタクリレート、シリコーンポリマー、及びこれらの混合物から選択される水溶性ポリマー、皮膚軟化剤、石鹸基剤、及びこれらの混合物の少なくとも1つを含むマトリックスと、
b.以下の式
を含む、請求項1に記載の除毛装置。 - 前記除毛装置がかみそりであり、前記除毛ヘッドがかみそりカートリッジであり、かつ前記1つ以上の伸長縁部がブレードである、請求項1又は10に記載の除毛装置。
- 請求項1〜11のいずれか一項に記載の除毛装置を作製する方法であって、
a.マトリックス及び熱的弾性感覚剤を用意して、1回分の供給物を形成する工程と、
b.好ましくは前記供給物を約120℃〜約200℃の温度に熱する工程と、
c.皮膚係合部材を形成する工程と、
を含む、方法。 - 前記形成する工程が、前記供給物を成形して前記皮膚係合部材とすること、前記供給物を成形して前記皮膚係合部材とすること、前記供給物を射出成形して皮膚係合部材と射すること、及びこれらの組み合わせを含む群から選択される、請求項12に記載の方法。
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DE102008015426A1 (de) | 2008-03-20 | 2009-09-24 | Beiersdorf Ag | Kühlende kosmetische oder dermatologische Zubereitungen mit einem Gehalt an (1R,2S,5R)-2-Isopropyl-5-methyl-N-(2-(pyridyn-2-yl)ethyl-cyclohexancarboxamid und/oder (1R,2S,5R)-N-(4-(Cyanomethyl)-phenyl)-2-isopropyl-5-methylcyclohexancarboxamid zu Reduktion von Hautrötungen |
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-
2013
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- 2013-09-25 JP JP2015533294A patent/JP5997387B2/ja active Active
- 2013-09-25 WO PCT/US2013/061584 patent/WO2014052390A2/en active Application Filing
- 2013-09-25 MX MX2015003828A patent/MX355922B/es active IP Right Grant
- 2013-09-25 EP EP13773536.1A patent/EP2900333B1/en active Active
- 2013-09-25 PL PL13773536T patent/PL2900333T3/pl unknown
- 2013-09-25 ES ES13773536.1T patent/ES2644137T3/es active Active
- 2013-09-25 CA CA2882090A patent/CA2882090C/en active Active
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- 2013-09-25 AU AU2013323690A patent/AU2013323690B2/en active Active
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KR20150050567A (ko) | 2015-05-08 |
WO2014052390A3 (en) | 2014-10-23 |
MX355922B (es) | 2018-05-03 |
CN104884129B (zh) | 2017-09-29 |
EP2900333B1 (en) | 2017-08-02 |
CN104884129A (zh) | 2015-09-02 |
BR112015006844B1 (pt) | 2020-02-04 |
SG11201501430VA (en) | 2015-03-30 |
EP2900333A2 (en) | 2015-08-05 |
AU2013323690A1 (en) | 2015-03-19 |
WO2014052390A2 (en) | 2014-04-03 |
CA2882090A1 (en) | 2014-04-03 |
IN2015DN01440A (ja) | 2015-07-03 |
PL2900333T3 (pl) | 2018-01-31 |
ES2644137T3 (es) | 2017-11-27 |
RU2015105517A (ru) | 2016-11-20 |
JP2015530162A (ja) | 2015-10-15 |
BR112015006844A2 (pt) | 2017-07-04 |
CA2882090C (en) | 2018-07-10 |
RU2664731C2 (ru) | 2018-08-22 |
MX2015003828A (es) | 2016-01-12 |
AU2013323690B2 (en) | 2016-09-22 |
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