JP5995855B2 - 塩基修飾オリゴヌクレオチド - Google Patents

塩基修飾オリゴヌクレオチド Download PDF

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Publication number
JP5995855B2
JP5995855B2 JP2013537906A JP2013537906A JP5995855B2 JP 5995855 B2 JP5995855 B2 JP 5995855B2 JP 2013537906 A JP2013537906 A JP 2013537906A JP 2013537906 A JP2013537906 A JP 2013537906A JP 5995855 B2 JP5995855 B2 JP 5995855B2
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oligonucleotide
modified
modification
antisense oligonucleotide
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JP2014503192A5 (https=
JP2014503192A (ja
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ヴェイグル，カート
ダルビー，クリスティーナ
エス． マーシャル，ウィリアム
エス． マーシャル，ウィリアム
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ミラゲン セラピューティクス，インコーポレイテッド
ミラゲン セラピューティクス，インコーポレイテッド
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/35—Nature of the modification
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    • C12N2310/3521—Methyl
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3523—Allyl
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525—MOE, methoxyethoxy
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3527—Other alkyl chain
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3529—Aromatic substituent
    • C—CHEMISTRY; METALLURGY
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/52—Methods for regulating/modulating their activity modulating the physical stability, e.g. GC-content

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Zoology (AREA)
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  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
JP2013537906A 2010-11-05 2011-11-07 塩基修飾オリゴヌクレオチド Expired - Fee Related JP5995855B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41067210P 2010-11-05 2010-11-05
US61/410,672 2010-11-05
PCT/US2011/059588 WO2012061810A1 (en) 2010-11-05 2011-11-07 Base modified oligonucleotides

Publications (3)

Publication Number Publication Date
JP2014503192A JP2014503192A (ja) 2014-02-13
JP2014503192A5 JP2014503192A5 (https=) 2014-12-25
JP5995855B2 true JP5995855B2 (ja) 2016-09-21

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JP2013537906A Expired - Fee Related JP5995855B2 (ja) 2010-11-05 2011-11-07 塩基修飾オリゴヌクレオチド

Country Status (7)

Country Link
US (1) US9416360B2 (https=)
EP (1) EP2635681B8 (https=)
JP (1) JP5995855B2 (https=)
CN (1) CN103492569B (https=)
AU (1) AU2011323085B2 (https=)
CA (1) CA2817002C (https=)
WO (1) WO2012061810A1 (https=)

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US20130296402A1 (en) 2013-11-07
EP2635681A1 (en) 2013-09-11
JP2014503192A (ja) 2014-02-13
CN103492569A (zh) 2014-01-01
EP2635681A4 (en) 2015-01-14
AU2011323085A1 (en) 2013-03-21
AU2011323085B2 (en) 2014-10-30
CA2817002C (en) 2019-01-15
CN103492569B (zh) 2020-04-07
EP2635681B8 (en) 2017-10-04
WO2012061810A1 (en) 2012-05-10
US9416360B2 (en) 2016-08-16
CA2817002A1 (en) 2012-05-10
EP2635681B1 (en) 2017-08-23

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