CN103492569B - 碱基经修饰的寡核苷酸 - Google Patents

碱基经修饰的寡核苷酸 Download PDF

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Publication number
CN103492569B
CN103492569B CN201180064239.XA CN201180064239A CN103492569B CN 103492569 B CN103492569 B CN 103492569B CN 201180064239 A CN201180064239 A CN 201180064239A CN 103492569 B CN103492569 B CN 103492569B
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base
antisense oligonucleotide
oligonucleotide
modified
nucleotides
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Chinese (zh)
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CN103492569A (zh
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K.瓦格勒
C.达尔比
W.S.马歇尔
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Viridian Therapeutics Inc
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Miragen Therapeutics Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/3525—MOE, methoxyethoxy
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    • C12N2310/3527—Other alkyl chain
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    • C12N2310/3529—Aromatic substituent
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
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CN201180064239.XA 2010-11-05 2011-11-07 碱基经修饰的寡核苷酸 Expired - Fee Related CN103492569B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41067210P 2010-11-05 2010-11-05
US61/410,672 2010-11-05
PCT/US2011/059588 WO2012061810A1 (en) 2010-11-05 2011-11-07 Base modified oligonucleotides

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CN103492569A CN103492569A (zh) 2014-01-01
CN103492569B true CN103492569B (zh) 2020-04-07

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US (1) US9416360B2 (https=)
EP (1) EP2635681B8 (https=)
JP (1) JP5995855B2 (https=)
CN (1) CN103492569B (https=)
AU (1) AU2011323085B2 (https=)
CA (1) CA2817002C (https=)
WO (1) WO2012061810A1 (https=)

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CN107236735B (zh) * 2012-06-21 2019-11-08 米拉根医疗股份有限公司 包含锁核酸基序的基于寡核苷酸的抑制剂
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US20130296402A1 (en) 2013-11-07
EP2635681A1 (en) 2013-09-11
JP2014503192A (ja) 2014-02-13
CN103492569A (zh) 2014-01-01
EP2635681A4 (en) 2015-01-14
AU2011323085A1 (en) 2013-03-21
AU2011323085B2 (en) 2014-10-30
CA2817002C (en) 2019-01-15
EP2635681B8 (en) 2017-10-04
WO2012061810A1 (en) 2012-05-10
JP5995855B2 (ja) 2016-09-21
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CA2817002A1 (en) 2012-05-10
EP2635681B1 (en) 2017-08-23

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