JP5993010B2 - ピリミド−ピリダジノン化合物及びその使用 - Google Patents
ピリミド−ピリダジノン化合物及びその使用 Download PDFInfo
- Publication number
- JP5993010B2 JP5993010B2 JP2014527282A JP2014527282A JP5993010B2 JP 5993010 B2 JP5993010 B2 JP 5993010B2 JP 2014527282 A JP2014527282 A JP 2014527282A JP 2014527282 A JP2014527282 A JP 2014527282A JP 5993010 B2 JP5993010 B2 JP 5993010B2
- Authority
- JP
- Japan
- Prior art keywords
- amino
- pyridazin
- phenyl
- oxo
- dihydropyrimido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *c1ccc(C*2CCOCC2)cc1 Chemical compound *c1ccc(C*2CCOCC2)cc1 0.000 description 17
- GOIQCTBTMZMOKZ-UHFFFAOYSA-N CN(CC1)CCC1(C1)C1C(O)=O Chemical compound CN(CC1)CCC1(C1)C1C(O)=O GOIQCTBTMZMOKZ-UHFFFAOYSA-N 0.000 description 2
- FWBLWCHBUNETHJ-UHFFFAOYSA-N CN(CC1)CCC1(CC(N1)=O)CC1=O Chemical compound CN(CC1)CCC1(CC(N1)=O)CC1=O FWBLWCHBUNETHJ-UHFFFAOYSA-N 0.000 description 2
- QIJZCLCCTDBHEC-UHFFFAOYSA-N CN1CCC2(CC2)CC1 Chemical compound CN1CCC2(CC2)CC1 QIJZCLCCTDBHEC-UHFFFAOYSA-N 0.000 description 2
- CHLICZRVGGXEOD-UHFFFAOYSA-N Cc(cc1)ccc1OC Chemical compound Cc(cc1)ccc1OC CHLICZRVGGXEOD-UHFFFAOYSA-N 0.000 description 2
- GAZSRVQLCOTTDV-UHFFFAOYSA-N CC(C)(CO)N1CCN(C)CCC1 Chemical compound CC(C)(CO)N1CCN(C)CCC1 GAZSRVQLCOTTDV-UHFFFAOYSA-N 0.000 description 1
- VSRCRHIFCPVDAA-WAYWQWQTSA-N CC[O](C)C(/C=C(/C)\N)=O Chemical compound CC[O](C)C(/C=C(/C)\N)=O VSRCRHIFCPVDAA-WAYWQWQTSA-N 0.000 description 1
- MBBBILGWINGTRS-UHFFFAOYSA-N CN(CC1)CCC1(C1)NC1O Chemical compound CN(CC1)CCC1(C1)NC1O MBBBILGWINGTRS-UHFFFAOYSA-N 0.000 description 1
- GGDIQKJRQHTMQT-UHFFFAOYSA-N CN(CC1)CCC11C(CO)C1 Chemical compound CN(CC1)CCC11C(CO)C1 GGDIQKJRQHTMQT-UHFFFAOYSA-N 0.000 description 1
- CZPYRMHRSAYAQO-UHFFFAOYSA-N CN(CC1)CCC1C(C1)C1C(O)=O Chemical compound CN(CC1)CCC1C(C1)C1C(O)=O CZPYRMHRSAYAQO-UHFFFAOYSA-N 0.000 description 1
- RAAHJJBDPCXYJS-UHFFFAOYSA-N CN1CCC(CC(N(CCO)CCO)=O)CC1 Chemical compound CN1CCC(CC(N(CCO)CCO)=O)CC1 RAAHJJBDPCXYJS-UHFFFAOYSA-N 0.000 description 1
- LTOVBVCCHAYNFB-UHFFFAOYSA-N CN1CCC2(COC2)CC1 Chemical compound CN1CCC2(COC2)CC1 LTOVBVCCHAYNFB-UHFFFAOYSA-N 0.000 description 1
- AFADJPINXSRBIF-UHFFFAOYSA-N CN1CCN(CC(O)=O)CCC1 Chemical compound CN1CCN(CC(O)=O)CCC1 AFADJPINXSRBIF-UHFFFAOYSA-N 0.000 description 1
- LLAMGYUWYUMHCH-UHFFFAOYSA-N CNc(cc1)ccc1C(OC)=O Chemical compound CNc(cc1)ccc1C(OC)=O LLAMGYUWYUMHCH-UHFFFAOYSA-N 0.000 description 1
- ZFIQGRISGKSVAG-UHFFFAOYSA-N CNc(cc1)ccc1O Chemical compound CNc(cc1)ccc1O ZFIQGRISGKSVAG-UHFFFAOYSA-N 0.000 description 1
- LZXXNPOYQCLXRS-UHFFFAOYSA-N COC(c(cc1)ccc1N)=O Chemical compound COC(c(cc1)ccc1N)=O LZXXNPOYQCLXRS-UHFFFAOYSA-N 0.000 description 1
- BHAAPTBBJKJZER-UHFFFAOYSA-N COc(cc1)ccc1N Chemical compound COc(cc1)ccc1N BHAAPTBBJKJZER-UHFFFAOYSA-N 0.000 description 1
- VMPITZXILSNTON-UHFFFAOYSA-N COc(cccc1)c1N Chemical compound COc(cccc1)c1N VMPITZXILSNTON-UHFFFAOYSA-N 0.000 description 1
- NCBZRJODKRCREW-UHFFFAOYSA-N COc1cc(N)ccc1 Chemical compound COc1cc(N)ccc1 NCBZRJODKRCREW-UHFFFAOYSA-N 0.000 description 1
- RZXMPPFPUUCRFN-UHFFFAOYSA-N Cc(cc1)ccc1N Chemical compound Cc(cc1)ccc1N RZXMPPFPUUCRFN-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161526525P | 2011-08-23 | 2011-08-23 | |
| US61/526,525 | 2011-08-23 | ||
| PCT/US2012/051980 WO2013028818A1 (en) | 2011-08-23 | 2012-08-23 | Pyrimido- pyridazinone compounds and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014524475A JP2014524475A (ja) | 2014-09-22 |
| JP2014524475A5 JP2014524475A5 (https=) | 2015-10-15 |
| JP5993010B2 true JP5993010B2 (ja) | 2016-09-14 |
Family
ID=46829884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014527282A Active JP5993010B2 (ja) | 2011-08-23 | 2012-08-23 | ピリミド−ピリダジノン化合物及びその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US8729079B2 (https=) |
| EP (4) | EP4327886A3 (https=) |
| JP (1) | JP5993010B2 (https=) |
| CN (2) | CN108707151B (https=) |
| BR (1) | BR112014003981A2 (https=) |
| CA (1) | CA2846187A1 (https=) |
| DK (2) | DK3392252T3 (https=) |
| ES (2) | ES2690971T3 (https=) |
| FI (1) | FI3392252T3 (https=) |
| HU (1) | HUE065564T2 (https=) |
| IL (1) | IL231082A (https=) |
| MX (1) | MX361458B (https=) |
| PL (1) | PL2748166T3 (https=) |
| WO (1) | WO2013028818A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2748166T3 (pl) * | 2011-08-23 | 2019-05-31 | Asana Biosciences Llc | Związki pirimido-pirydazynonowe oraz ich zastosowanie |
| AR106830A1 (es) * | 2015-12-04 | 2018-02-21 | Asana Biosciences Llc | Usos de piridazinonas para tratar el cáncer |
| WO2018187294A1 (en) * | 2017-04-03 | 2018-10-11 | Asana Biosciences, Llc | Pyrimido-pyridazinone compound combinations, methods, kits and formulations thereof |
| CN118105392A (zh) * | 2017-04-28 | 2024-05-31 | 自由生物有限公司 | 治疗特应性皮炎以及提高活性药物成分稳定性的制剂、方法、试剂盒和剂型 |
| CN111961035B (zh) * | 2019-05-20 | 2022-11-01 | 南京科技职业学院 | 一类含有羟基异喹啉类结构的化合物、药物组合物以及其应用 |
| CN114174298B (zh) * | 2019-08-14 | 2023-08-01 | 正大天晴药业集团南京顺欣制药有限公司 | 哒嗪酮并嘧啶类衍生物及其医药用途 |
| CN113583026B (zh) * | 2020-04-30 | 2024-06-14 | 杭州英创医药科技有限公司 | 一类含有稠合三环结构的化合物 |
| TW202202498A (zh) * | 2020-07-01 | 2022-01-16 | 大陸商四川海思科製藥有限公司 | 一種並環雜環衍生物及其在醫藥上的應用 |
| TW202340202A (zh) * | 2021-12-22 | 2023-10-16 | 美國加利福尼亞大學董事會 | Gtp酶抑制劑及其用途 |
| KR20240151808A (ko) | 2022-02-23 | 2024-10-18 | 테바 파마슈티컬스 인터내셔널 게엠베하 | 구사시티닙의 고체 상태 형태 |
| US20260055079A1 (en) * | 2022-04-01 | 2026-02-26 | Azkarra Therapeutics, Inc. | Phthalazinone compounds as parp7 inhibitors |
| WO2025020171A1 (en) | 2023-07-27 | 2025-01-30 | Libertas Bio, Inc. | Crystalline forms of a jak/syk inhibitor |
| TW202510870A (zh) | 2023-07-27 | 2025-03-16 | 美商自由生物有限公司 | Jak/syk抑制劑之組合物及固體形式 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE756508A (fr) | 1969-09-24 | 1971-03-01 | Takeda Chemical Industries Ltd | Derives de pyrimidopyridazine |
| CA1004223A (en) * | 1972-05-12 | 1977-01-25 | Theodor Denzel | Amino derivatives of pyrido(2,3-d)pyridazine carboxylic acids and esters |
| JPS4948695U (https=) | 1972-07-29 | 1974-04-27 | ||
| JPS50101387A (https=) * | 1974-01-16 | 1975-08-11 | ||
| CA1052046A (en) | 1974-01-21 | 1979-04-03 | American Cyanamid Company | Unsymmetrically substituted 1,4-dioxane-2,5-diones |
| US5369086A (en) | 1993-04-28 | 1994-11-29 | Zeneca Limited | N-benzotriazoles |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| JPH0948695A (ja) | 1995-08-02 | 1997-02-18 | Toshiba Ceramics Co Ltd | シリコン単結晶の製造方法 |
| JP2002504550A (ja) | 1998-02-25 | 2002-02-12 | ファルマシア・アンド・アップジョン・カンパニー | 抗微生物剤として有用な置換アミノメチルイソオキサゾリン誘導体 |
| SK287270B6 (sk) | 1998-11-10 | 2010-05-07 | Janssen Pharmaceutica N. V. | Derivát pyrimidínu |
| CA2422054C (en) * | 2000-09-22 | 2011-01-11 | Akzo Nobel Nv | Bicyclic heteroaromatic compounds |
| DE60225127T2 (de) | 2001-04-30 | 2009-02-19 | Glaxo Group Ltd., Greenford | Kondensierte pyrimidine als antagonisten des corticotropin releasing factor (crf) |
| WO2003075828A2 (en) | 2002-03-11 | 2003-09-18 | Zetiq Technologies Ltd. | Compounds useful in the treatment of cancer |
| HRP20050089B1 (hr) | 2002-07-29 | 2015-06-19 | Rigel Pharmaceuticals | Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti |
| CA2518465A1 (en) | 2003-03-25 | 2004-10-14 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| WO2005012294A1 (en) | 2003-07-30 | 2005-02-10 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases |
| WO2005080377A1 (ja) | 2004-02-20 | 2005-09-01 | Kirin Beer Kabushiki Kaisha | TGFβ阻害活性を有する化合物およびそれを含んでなる医薬組成物 |
| WO2006035067A2 (en) | 2004-09-30 | 2006-04-06 | Tibotec Pharmaceuticals Ltd. | Hiv inhibiting 5-heterocyclyl pyrimidines |
| WO2006066361A1 (en) | 2004-12-24 | 2006-06-29 | The University Of Queensland | Method of treatment or prophylaxis |
| CN101189234B (zh) | 2005-03-25 | 2011-08-17 | 泰博特克药品有限公司 | Hcv的杂二环抑制剂 |
| US8030318B2 (en) | 2005-03-25 | 2011-10-04 | Tibotec Pharmaceuticals Ltd. | Fused bicyclic inhibitors of HCV |
| KR20080000584A (ko) | 2005-04-29 | 2008-01-02 | 얀센 파마슈티카 엔.브이. | 카나비노이드 수용체 길항제로서의 벤조트리아졸 유도체 |
| WO2007063934A1 (ja) * | 2005-12-02 | 2007-06-07 | Mitsubishi Tanabe Pharma Corporation | 脂環式複素環化合物 |
| WO2007082131A1 (en) | 2006-01-09 | 2007-07-19 | Bristol-Myers Squibb Company | Process for the preparation of hydroxy substituted heterocycles |
| CA2651072A1 (en) | 2006-05-01 | 2007-11-08 | Pfizer Products Inc. | Substituted 2-amino-fused heterocyclic compounds |
| GB0625196D0 (en) | 2006-12-18 | 2007-01-24 | 7Tm Pharma As | Modulators of cannabinoid receptor |
| ES2548353T3 (es) * | 2006-12-28 | 2015-10-15 | Abbvie Inc. | Inhibidores de poli(ADP-ribosa)polimerasa |
| SG179418A1 (en) | 2007-03-14 | 2012-04-27 | Exelixis Patent Co Llc | Inhibitors of the hedgehog pathway |
| TW200938542A (en) | 2008-02-01 | 2009-09-16 | Irm Llc | Compounds and compositions as kinase inhibitors |
| BRPI0919488A2 (pt) | 2008-09-30 | 2015-12-01 | Astrazeneca Ab | composto, uso de um composto, método para tratar câncer em um animal de sangue quente, composição farmacêutica, e, processo para preparar um composto |
| TW201016676A (en) | 2008-10-03 | 2010-05-01 | Astrazeneca Ab | Heterocyclic derivatives and methods of use thereof |
| EA022417B1 (ru) | 2008-10-21 | 2015-12-30 | Саймабэй Терапевтикс, Инк. | Арильные агонисты рецептора gpr120 и их применение |
| MX2012004846A (es) * | 2009-10-29 | 2012-10-05 | Genosco | Inhibidores de cinasa. |
| US20110152243A1 (en) * | 2009-12-23 | 2011-06-23 | Abbott Laboratories | Novel thienopyrrole compounds |
| WO2012058671A1 (en) | 2010-10-31 | 2012-05-03 | Endo Pharmaceuticals Inc. | Substituted quinazoline and pyrido-pyrimidine derivatives |
| PL2748166T3 (pl) * | 2011-08-23 | 2019-05-31 | Asana Biosciences Llc | Związki pirimido-pirydazynonowe oraz ich zastosowanie |
| US9145411B2 (en) | 2012-08-02 | 2015-09-29 | Asana Biosciences, Llc | Substituted amino-pyrimidine derivatives |
| AR106830A1 (es) * | 2015-12-04 | 2018-02-21 | Asana Biosciences Llc | Usos de piridazinonas para tratar el cáncer |
| CN118105392A (zh) * | 2017-04-28 | 2024-05-31 | 自由生物有限公司 | 治疗特应性皮炎以及提高活性药物成分稳定性的制剂、方法、试剂盒和剂型 |
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2012
- 2012-08-23 PL PL12756865T patent/PL2748166T3/pl unknown
- 2012-08-23 ES ES12756865T patent/ES2690971T3/es active Active
- 2012-08-23 WO PCT/US2012/051980 patent/WO2013028818A1/en not_active Ceased
- 2012-08-23 JP JP2014527282A patent/JP5993010B2/ja active Active
- 2012-08-23 US US13/592,511 patent/US8729079B2/en active Active
- 2012-08-23 ES ES18175788T patent/ES2969977T3/es active Active
- 2012-08-23 EP EP23201319.3A patent/EP4327886A3/en active Pending
- 2012-08-23 FI FIEP18175788.1T patent/FI3392252T3/fi active
- 2012-08-23 MX MX2014002112A patent/MX361458B/es active IP Right Grant
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