JP5960612B2 - 固定された生物学的実体 - Google Patents

固定された生物学的実体 Download PDF

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Publication number
JP5960612B2
JP5960612B2 JP2012556539A JP2012556539A JP5960612B2 JP 5960612 B2 JP5960612 B2 JP 5960612B2 JP 2012556539 A JP2012556539 A JP 2012556539A JP 2012556539 A JP2012556539 A JP 2012556539A JP 5960612 B2 JP5960612 B2 JP 5960612B2
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heparin
layer
polymer
cationic polymer
linker
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Japanese (ja)
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JP2013521838A (ja
JP2013521838A5 (cg-RX-API-DMAC7.html
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ベストベルイ ロベルト
ベストベルイ ロベルト
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カルメダ アクティエボラーグ
カルメダ アクティエボラーグ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6957—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a device or a kit, e.g. stents or microdevices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
JP2012556539A 2010-03-12 2011-03-11 固定された生物学的実体 Active JP5960612B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1004101.0 2010-03-12
GBGB1004101.0A GB201004101D0 (en) 2010-03-12 2010-03-12 Immobilised biological entities
PCT/EP2011/053745 WO2011110684A1 (en) 2010-03-12 2011-03-11 Immobilised biological entities

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016124560A Division JP6683551B2 (ja) 2010-03-12 2016-06-23 固定された生物学的実体

Publications (3)

Publication Number Publication Date
JP2013521838A JP2013521838A (ja) 2013-06-13
JP2013521838A5 JP2013521838A5 (cg-RX-API-DMAC7.html) 2014-05-01
JP5960612B2 true JP5960612B2 (ja) 2016-08-02

Family

ID=42261450

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2012556539A Active JP5960612B2 (ja) 2010-03-12 2011-03-11 固定された生物学的実体
JP2016124560A Active JP6683551B2 (ja) 2010-03-12 2016-06-23 固定された生物学的実体
JP2018034545A Active JP6693983B2 (ja) 2010-03-12 2018-02-28 固定された生物学的実体
JP2020073602A Pending JP2020108864A (ja) 2010-03-12 2020-04-16 固定された生物学的実体

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2016124560A Active JP6683551B2 (ja) 2010-03-12 2016-06-23 固定された生物学的実体
JP2018034545A Active JP6693983B2 (ja) 2010-03-12 2018-02-28 固定された生物学的実体
JP2020073602A Pending JP2020108864A (ja) 2010-03-12 2020-04-16 固定された生物学的実体

Country Status (8)

Country Link
US (3) US8501212B2 (cg-RX-API-DMAC7.html)
EP (1) EP2544728B1 (cg-RX-API-DMAC7.html)
JP (4) JP5960612B2 (cg-RX-API-DMAC7.html)
AU (1) AU2011225982B2 (cg-RX-API-DMAC7.html)
CA (1) CA2791545C (cg-RX-API-DMAC7.html)
ES (1) ES2644369T3 (cg-RX-API-DMAC7.html)
GB (1) GB201004101D0 (cg-RX-API-DMAC7.html)
WO (1) WO2011110684A1 (cg-RX-API-DMAC7.html)

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US11839698B2 (en) 2014-03-13 2023-12-12 W. L. Gore & Associates, Inc. Drug composition and coating
US10561766B2 (en) 2015-09-15 2020-02-18 W. L. Gore & Associates, Inc. Drug composition and coating
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Also Published As

Publication number Publication date
US20130273122A1 (en) 2013-10-17
JP2020108864A (ja) 2020-07-16
US10016512B2 (en) 2018-07-10
GB201004101D0 (en) 2010-04-28
WO2011110684A1 (en) 2011-09-15
CA2791545A1 (en) 2011-09-15
ES2644369T3 (es) 2017-11-28
EP2544728B1 (en) 2017-07-19
US10842880B2 (en) 2020-11-24
CA2791545C (en) 2018-12-11
JP6693983B2 (ja) 2020-05-13
JP2018099543A (ja) 2018-06-28
US20180140713A1 (en) 2018-05-24
AU2011225982B2 (en) 2014-09-04
US20110223229A1 (en) 2011-09-15
AU2011225982A1 (en) 2012-09-20
JP2016193219A (ja) 2016-11-17
EP2544728A1 (en) 2013-01-16
JP2013521838A (ja) 2013-06-13
US20160228572A9 (en) 2016-08-11
JP6683551B2 (ja) 2020-04-22
US8501212B2 (en) 2013-08-06

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