JP5959083B2 - （１Ｒ−ｔｒａｎｓ）−Ｎ−［［２−（２，３−ジヒドロ−４−ベンゾフラニル）シクロプロピル］メチル］プロパンアミドの代謝物 - Google Patents

（１Ｒ−ｔｒａｎｓ）−Ｎ−［［２−（２，３−ジヒドロ−４−ベンゾフラニル）シクロプロピル］メチル］プロパンアミドの代謝物 Download PDF

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JP5959083B2
JP5959083B2 JP2015512886A JP2015512886A JP5959083B2 JP 5959083 B2 JP5959083 B2 JP 5959083B2 JP 2015512886 A JP2015512886 A JP 2015512886A JP 2015512886 A JP2015512886 A JP 2015512886A JP 5959083 B2 JP5959083 B2 JP 5959083B2
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trans
methyl
propanamide
benzofuranyl
metabolites
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JP2015522541A (ja
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マリーン， ミシェル ドレスマン，
マリーン， ミシェル ドレスマン，
ディーパック ファドケ，
ディーパック ファドケ，
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ヴァンダ ファーマシューティカルズ インコーポレイテッド
ヴァンダ ファーマシューティカルズ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/133—Amines having hydroxy groups, e.g. sphingosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
JP2015512886A 2012-05-18 2013-05-17 （１Ｒ−ｔｒａｎｓ）−Ｎ−［［２−（２，３−ジヒドロ−４−ベンゾフラニル）シクロプロピル］メチル］プロパンアミドの代謝物 Active JP5959083B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261649220P 2012-05-18 2012-05-18
US61/649,220 2012-05-18
PCT/US2013/041573 WO2013173707A1 (en) 2012-05-18 2013-05-17 Metabolites of (1r-trans)-n-[[2-(2,3-dihydro-4-benzofuranyl)cyclopropyl]methyl]propanamide

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JP2015522541A JP2015522541A (ja) 2015-08-06
JP5959083B2 true JP5959083B2 (ja) 2016-08-02

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US (4) US9212129B2 (enExample)
EP (1) EP2855424B1 (enExample)
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KR (3) KR20150005691A (enExample)
CN (2) CN104583178A (enExample)
AU (1) AU2013262631B2 (enExample)
BR (1) BR112014028446A2 (enExample)
CA (1) CA2872324C (enExample)
CL (1) CL2014003126A1 (enExample)
CO (1) CO7151504A2 (enExample)
ES (1) ES2648987T3 (enExample)
IL (1) IL235485A (enExample)
IN (1) IN2014DN10691A (enExample)
MX (1) MX2014014010A (enExample)
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Publication number Priority date Publication date Assignee Title
SI2806863T1 (sl) 2012-01-26 2017-12-29 Vanda Pharmaceuticals Inc. Zdravljenje motenj cirkadianega ritma
AU2013262631B2 (en) 2012-05-18 2016-02-04 Vanda Pharmaceuticals Inc. Metabolites of (1R-trans)-N-[[2-(2,3-dihydro-4-benzofuranyl) cyclopropyl]methyl]propanamide
WO2015117048A1 (en) * 2014-01-31 2015-08-06 Vanda Pharmaceuticals Inc. Treatment of circadian rhythm disorders
BR112021004214A2 (pt) * 2018-09-12 2021-05-25 Vanda Pharmaceuticals Inc. método para aperfeiçoar o sono, desempenho pós-sono ou ambos, e, aperfeiçoamento em um método
WO2020138027A1 (ja) 2018-12-25 2020-07-02 株式会社クボタ 作業機
MX2021009616A (es) * 2019-02-13 2022-01-31 Vanda Pharmaceuticals Inc Metodo para mejorar el sue?o.

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Publication number Priority date Publication date Assignee Title
CA2176854A1 (en) * 1995-06-07 1996-12-08 Daniel J. Keavy N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics
CN1152679C (zh) 1996-12-10 2004-06-09 布里斯托尔-迈尔斯斯奎布公司 苯并二氧杂环戊烯、苯并呋喃、二氢苯并呋喃和苯并二噁烷类化合物褪黑激素能药剂
CN1578664A (zh) 2001-10-30 2005-02-09 诺瓦提斯公司 伊潘立酮和星状聚合物的贮库制剂
GB0216416D0 (en) 2002-07-15 2002-08-21 Novartis Ag Organic compounds
EP2029136A4 (en) 2006-05-22 2010-01-06 Vanda Pharmaceuticals Inc TREATMENT FOR DEPRESSION DISEASES
SI2806863T1 (sl) * 2012-01-26 2017-12-29 Vanda Pharmaceuticals Inc. Zdravljenje motenj cirkadianega ritma
AU2013262631B2 (en) * 2012-05-18 2016-02-04 Vanda Pharmaceuticals Inc. Metabolites of (1R-trans)-N-[[2-(2,3-dihydro-4-benzofuranyl) cyclopropyl]methyl]propanamide

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AU2013262631B2 (en) 2016-02-04
NZ701515A (en) 2016-03-31
US20180099924A1 (en) 2018-04-12
RU2632889C2 (ru) 2017-10-11
CL2014003126A1 (es) 2015-02-20
ZA201408014B (en) 2017-04-26
US9850199B2 (en) 2017-12-26
EP2855424A1 (en) 2015-04-08
KR20170065682A (ko) 2017-06-13
RU2014151161A (ru) 2016-07-10
US20150148419A1 (en) 2015-05-28
CN108997160A (zh) 2018-12-14
US20170174617A1 (en) 2017-06-22
ES2648987T3 (es) 2018-01-09
MX2014014010A (es) 2015-02-12
CO7151504A2 (es) 2014-12-29
CN104583178A (zh) 2015-04-29
US9617203B2 (en) 2017-04-11
US9212129B2 (en) 2015-12-15
IN2014DN10691A (enExample) 2015-08-28
US10233142B2 (en) 2019-03-19
CA2872324A1 (en) 2013-11-21
WO2013173707A1 (en) 2013-11-21
CA2872324C (en) 2017-06-06
KR101891299B1 (ko) 2018-08-23
US20160060212A1 (en) 2016-03-03
AU2013262631A1 (en) 2014-11-20
BR112014028446A2 (pt) 2017-10-24
EP2855424B1 (en) 2017-10-11
IL235485A (en) 2017-12-31
KR20150005691A (ko) 2015-01-14
KR20180095737A (ko) 2018-08-27
JP2015522541A (ja) 2015-08-06

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