JP5944986B2 - プロテアソーム阻害剤、ならびにそれらの調製、精製、および使用のためのプロセス - Google Patents

プロテアソーム阻害剤、ならびにそれらの調製、精製、および使用のためのプロセス Download PDF

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JP5944986B2
JP5944986B2 JP2014517144A JP2014517144A JP5944986B2 JP 5944986 B2 JP5944986 B2 JP 5944986B2 JP 2014517144 A JP2014517144 A JP 2014517144A JP 2014517144 A JP2014517144 A JP 2014517144A JP 5944986 B2 JP5944986 B2 JP 5944986B2
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formula
optionally substituted
boronic ester
compound
boronic
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JP2014520155A5 (enExample
JP2014520155A (ja
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ピー． バケイル、ロジャー
ピー． バケイル、ロジャー
ピー． マラモ、ジョン
ピー． マラモ、ジョン
キャロライン ローメール、レニー
キャロライン ローメール、レニー
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セファロン、インク．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014517144A 2011-06-22 2012-06-21 プロテアソーム阻害剤、ならびにそれらの調製、精製、および使用のためのプロセス Expired - Fee Related JP5944986B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161499962P 2011-06-22 2011-06-22
US61/499,962 2011-06-22
PCT/US2012/043485 WO2012177835A1 (en) 2011-06-22 2012-06-21 Proteasome inhibitors and processes for their preparation, purification and use

Publications (3)

Publication Number Publication Date
JP2014520155A JP2014520155A (ja) 2014-08-21
JP2014520155A5 JP2014520155A5 (enExample) 2015-08-06
JP5944986B2 true JP5944986B2 (ja) 2016-07-05

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JP2014517144A Expired - Fee Related JP5944986B2 (ja) 2011-06-22 2012-06-21 プロテアソーム阻害剤、ならびにそれらの調製、精製、および使用のためのプロセス

Country Status (6)

Country Link
US (1) US20140121182A1 (enExample)
EP (1) EP2723751A1 (enExample)
JP (1) JP5944986B2 (enExample)
CA (1) CA2833775A1 (enExample)
MX (1) MX2013015308A (enExample)
WO (1) WO2012177835A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160058886A (ko) * 2013-10-03 2016-05-25 밀레니엄 파머슈티컬스 인코퍼레이티드 전신 홍반성 낭창 및/또는 낭창성 신염의 예방 또는 치료 방법
US9546928B2 (en) 2014-05-30 2017-01-17 General Electric Company Methods for producing strain sensors on turbine components
US10415964B2 (en) * 2014-05-30 2019-09-17 General Electric Company Methods for producing passive strain indicator on turbine components
MA41505A (fr) * 2015-02-11 2017-12-19 Millennium Pharm Inc Nouvelle forme cristalline d'un inhibiteur de protéasome
CZ2015233A3 (cs) 2015-04-03 2016-10-12 Zentiva, K.S. Způsob přípravy Ixazomib citrátu
CZ2015253A3 (cs) 2015-04-15 2016-10-26 Zentiva, K.S. Nové formy Ixazomib citrátu
US10144761B2 (en) 2015-06-19 2018-12-04 Hanlin Scientific Inc. Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis
CN106608883A (zh) * 2015-10-21 2017-05-03 北京大学 蛋白酶体抑制剂mln9708的合成方法
CN106986884A (zh) * 2016-01-20 2017-07-28 成都贝斯凯瑞生物科技有限公司 一种高效的高纯度含硼化合物制备方法
CN105732683B (zh) * 2016-03-25 2018-10-16 南京林业大学 一类羧酸与α氨基酸组成的二肽硼酸及其酯类化合物、制备方法及其用途
CZ2016204A3 (cs) 2016-04-08 2017-11-01 Zentiva, K.S. Formulace Ixazomib citrátu formy 3
CN107400142B (zh) * 2016-05-19 2019-11-19 成都奥璟生物科技有限公司 一种硼酸和硼酸酯类化合物及其应用
CN108440583B (zh) * 2017-01-23 2020-12-04 成都奥璟生物科技有限公司 一种新的硼酸衍生物及其药物组合物
US11414437B2 (en) 2017-07-28 2022-08-16 Chengdu Origin Biotechnology Limited Company Borate compound, and synthesis method therefor and uses thereof
CN112513052B (zh) * 2018-08-02 2022-12-16 正大天晴药业集团股份有限公司 氮杂环丁烷衍生物的硼酸酯

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083903A (en) * 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
PL4008721T3 (pl) 2004-03-30 2024-05-13 Millennium Pharmaceuticals, Inc. Synteza związków estrów i kwasów boronowych
US7442830B1 (en) 2007-08-06 2008-10-28 Millenium Pharmaceuticals, Inc. Proteasome inhibitors
GEP20125599B (en) * 2007-08-06 2012-08-10 Millennium Pharm Inc Proteasome inhibitors
BR122014008753A2 (pt) 2008-06-17 2015-12-29 Millennium Pharm Inc compostos de éster boronato e composições farmacêuticas dos mesmos
EP2238973A1 (en) * 2009-04-07 2010-10-13 Cephalon France Lyophilized preparations of proteasome inhibitors

Also Published As

Publication number Publication date
WO2012177835A1 (en) 2012-12-27
MX2013015308A (es) 2014-05-20
EP2723751A1 (en) 2014-04-30
CA2833775A1 (en) 2012-12-27
JP2014520155A (ja) 2014-08-21
US20140121182A1 (en) 2014-05-01

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